IL6R (interleukin 6 receptor)

Gene

• Entrez ID: 3570
• Gene name: Interleukin 6 receptor
• Gene symbol: IL6R
• Synonyms: CD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA, IL6Q, IL6QTL, IL6RA, IL6RQ, gp80
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein comple

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT005528	hsa-miR-23a-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	20698883
MIRT006541	hsa-miR-124-3p	ELISA, Flow, Immunohistochemistry, Immunoprecipitaion, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22153071
MIRT006541	hsa-miR-124-3p	ELISA, Flow, Immunohistochemistry, Immunoprecipitaion, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22153071
MIRT006844	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22942733
MIRT006844	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	22942733
MIRT027423	hsa-miR-98-5p	Microarray	19088304
MIRT006844	hsa-miR-125b-5p	Luciferase reporter assay, Western blot	22824797
MIRT054843	hsa-miR-451a	qRT-PCR, Western blot	24445140
MIRT438704	hsa-miR-34a-5p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT438703	hsa-miR-34b-3p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT438702	hsa-miR-34c-5p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT438704	hsa-miR-34a-5p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT438703	hsa-miR-34b-3p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT438702	hsa-miR-34c-5p	ChIP-seq, Immunofluorescence, qRT-PCR, Western blot	24642471
MIRT714013	hsa-miR-548at-3p	HITS-CLIP	19536157
MIRT714012	hsa-miR-548ay-3p	HITS-CLIP	19536157
MIRT714011	hsa-miR-1537-3p	HITS-CLIP	19536157
MIRT054843	hsa-miR-451a	HITS-CLIP	19536157
MIRT714010	hsa-miR-5197-5p	HITS-CLIP	19536157
MIRT714009	hsa-miR-5680	HITS-CLIP	19536157
MIRT714008	hsa-miR-4330	HITS-CLIP	19536157
MIRT714007	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT714006	hsa-miR-2052	HITS-CLIP	19536157
MIRT714005	hsa-miR-7641	HITS-CLIP	19536157
MIRT687901	hsa-miR-4418	HITS-CLIP	23313552
MIRT687900	hsa-miR-509-3-5p	HITS-CLIP	23313552
MIRT687899	hsa-miR-509-5p	HITS-CLIP	23313552
MIRT687898	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT687897	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT687896	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT687895	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT687894	hsa-miR-4726-3p	HITS-CLIP	23313552
MIRT687893	hsa-miR-6741-3p	HITS-CLIP	23313552
MIRT687892	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT687891	hsa-miR-1307-3p	HITS-CLIP	23313552
MIRT687890	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT687889	hsa-miR-1184	HITS-CLIP	23313552
MIRT687888	hsa-miR-6790-3p	HITS-CLIP	23313552
MIRT687887	hsa-miR-6821-3p	HITS-CLIP	23313552
MIRT687886	hsa-miR-4284	HITS-CLIP	23313552
MIRT687885	hsa-miR-192-5p	HITS-CLIP	23313552
MIRT687884	hsa-miR-215-5p	HITS-CLIP	23313552
MIRT687883	hsa-miR-7156-3p	HITS-CLIP	23313552
MIRT646824	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646823	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT646822	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT646821	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT646820	hsa-miR-5096	HITS-CLIP	23824327
MIRT646819	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT523017	hsa-miR-4438	PAR-CLIP	23446348
MIRT523016	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523015	hsa-miR-4793-5p	PAR-CLIP	23446348
MIRT523014	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT523013	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT523012	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT523011	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523010	hsa-miR-4529-5p	PAR-CLIP	23446348
MIRT523008	hsa-miR-5095	PAR-CLIP	23446348
MIRT523009	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523007	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT523006	hsa-miR-3619-3p	PAR-CLIP	23446348
MIRT523005	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT054843	hsa-miR-451a	Luciferase reporter assay	25623956
MIRT732213	hsa-miR-221-5p	Luciferase reporter assay, qRT-PCR, Western blot	26645045
MIRT732213	hsa-miR-221-5p	Luciferase reporter assay, qRT-PCR, Western blot	26645045
MIRT732213	hsa-miR-221-5p	Luciferase reporter assay, qRT-PCR, Western blot	26645045
MIRT732213	hsa-miR-221-5p	Luciferase reporter assay, qRT-PCR, Western blot	26645045
MIRT438704	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25973020
MIRT438704	hsa-miR-34a-5p	Luciferase reporter assay	26091352
MIRT438704	hsa-miR-34a-5p	Luciferase reporter assay	26091352
MIRT006541	hsa-miR-124-3p	ELISA, Flow, qRT-PCR, Western blot	27824145
MIRT027423	hsa-miR-98-5p	PAR-CLIP	27292025
MIRT438704	hsa-miR-34a-5p	Luciferase reporter assay	32391256
MIRT054843	hsa-miR-451a	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry, ELISA	32989397
MIRT714013	hsa-miR-548at-3p	HITS-CLIP	19536157
MIRT714012	hsa-miR-548ay-3p	HITS-CLIP	19536157
MIRT714011	hsa-miR-1537-3p	HITS-CLIP	19536157
MIRT054843	hsa-miR-451a	HITS-CLIP	19536157
MIRT714010	hsa-miR-5197-5p	HITS-CLIP	19536157
MIRT714009	hsa-miR-5680	HITS-CLIP	19536157
MIRT714008	hsa-miR-4330	HITS-CLIP	19536157
MIRT714007	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT714006	hsa-miR-2052	HITS-CLIP	19536157
MIRT714005	hsa-miR-7641	HITS-CLIP	19536157
MIRT687901	hsa-miR-4418	HITS-CLIP	23313552
MIRT687900	hsa-miR-509-3-5p	HITS-CLIP	23313552
MIRT687899	hsa-miR-509-5p	HITS-CLIP	23313552
MIRT687898	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT687897	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT687896	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT687895	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT687894	hsa-miR-4726-3p	HITS-CLIP	23313552
MIRT687893	hsa-miR-6741-3p	HITS-CLIP	23313552
MIRT687892	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT687891	hsa-miR-1307-3p	HITS-CLIP	23313552
MIRT687890	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT687889	hsa-miR-1184	HITS-CLIP	23313552
MIRT687888	hsa-miR-6790-3p	HITS-CLIP	23313552
MIRT687887	hsa-miR-6821-3p	HITS-CLIP	23313552
MIRT687886	hsa-miR-4284	HITS-CLIP	23313552
MIRT687885	hsa-miR-192-5p	HITS-CLIP	23313552
MIRT687884	hsa-miR-215-5p	HITS-CLIP	23313552
MIRT687883	hsa-miR-7156-3p	HITS-CLIP	23313552
MIRT646824	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646823	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT646822	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT646821	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT646820	hsa-miR-5096	HITS-CLIP	23824327
MIRT646819	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT523017	hsa-miR-4438	PAR-CLIP	23446348
MIRT523016	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523015	hsa-miR-4793-5p	PAR-CLIP	23446348
MIRT523014	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT523013	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT523012	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT523011	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523010	hsa-miR-4529-5p	PAR-CLIP	23446348
MIRT523008	hsa-miR-5095	PAR-CLIP	23446348
MIRT523009	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523007	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT523006	hsa-miR-3619-3p	PAR-CLIP	23446348
MIRT523005	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT1065000	hsa-let-7a	CLIP-seq
MIRT1065001	hsa-let-7b	CLIP-seq
MIRT1065002	hsa-let-7c	CLIP-seq
MIRT1065003	hsa-let-7d	CLIP-seq
MIRT1065004	hsa-let-7e	CLIP-seq
MIRT1065005	hsa-let-7f	CLIP-seq
MIRT1065006	hsa-let-7g	CLIP-seq
MIRT1065007	hsa-let-7i	CLIP-seq
MIRT1065008	hsa-miR-106a	CLIP-seq
MIRT1065009	hsa-miR-106b	CLIP-seq
MIRT1065010	hsa-miR-1183	CLIP-seq
MIRT1065011	hsa-miR-1200	CLIP-seq
MIRT1065012	hsa-miR-1207-5p	CLIP-seq
MIRT1065013	hsa-miR-122	CLIP-seq
MIRT1065014	hsa-miR-1224-3p	CLIP-seq
MIRT1065015	hsa-miR-1236	CLIP-seq
MIRT1065016	hsa-miR-1245	CLIP-seq
MIRT1065017	hsa-miR-125a-5p	CLIP-seq
MIRT1065018	hsa-miR-125b	CLIP-seq
MIRT1065019	hsa-miR-1260	CLIP-seq
MIRT1065020	hsa-miR-1260b	CLIP-seq
MIRT1065021	hsa-miR-1267	CLIP-seq
MIRT1065022	hsa-miR-1277	CLIP-seq
MIRT1065023	hsa-miR-1280	CLIP-seq
MIRT1065024	hsa-miR-1290	CLIP-seq
MIRT1065025	hsa-miR-1291	CLIP-seq
MIRT1065026	hsa-miR-1299	CLIP-seq
MIRT1065027	hsa-miR-1307	CLIP-seq
MIRT1065028	hsa-miR-136	CLIP-seq
MIRT1065029	hsa-miR-150	CLIP-seq
MIRT1065030	hsa-miR-17	CLIP-seq
MIRT1065031	hsa-miR-202	CLIP-seq
MIRT1065032	hsa-miR-2053	CLIP-seq
MIRT1065033	hsa-miR-20a	CLIP-seq
MIRT1065034	hsa-miR-20b	CLIP-seq
MIRT1065035	hsa-miR-214	CLIP-seq
MIRT1065036	hsa-miR-219-1-3p	CLIP-seq
MIRT1065037	hsa-miR-23a	CLIP-seq
MIRT1065038	hsa-miR-23b	CLIP-seq
MIRT1065039	hsa-miR-23c	CLIP-seq
MIRT1065040	hsa-miR-302a	CLIP-seq
MIRT1065041	hsa-miR-302b	CLIP-seq
MIRT1065042	hsa-miR-302c	CLIP-seq
MIRT1065043	hsa-miR-302d	CLIP-seq
MIRT1065044	hsa-miR-302e	CLIP-seq
MIRT1065045	hsa-miR-3126-3p	CLIP-seq
MIRT1065046	hsa-miR-3135b	CLIP-seq
MIRT1065047	hsa-miR-3144-5p	CLIP-seq
MIRT1065048	hsa-miR-3160-5p	CLIP-seq
MIRT1065049	hsa-miR-3167	CLIP-seq
MIRT1065050	hsa-miR-3191	CLIP-seq
MIRT1065051	hsa-miR-3194-3p	CLIP-seq
MIRT1065052	hsa-miR-323b-3p	CLIP-seq
MIRT1065053	hsa-miR-3619-5p	CLIP-seq
MIRT1065054	hsa-miR-3652	CLIP-seq
MIRT1065055	hsa-miR-3670	CLIP-seq
MIRT1065056	hsa-miR-3714	CLIP-seq
MIRT1065057	hsa-miR-371-5p	CLIP-seq
MIRT1065058	hsa-miR-371b-5p	CLIP-seq
MIRT1065059	hsa-miR-372	CLIP-seq
MIRT1065060	hsa-miR-373	CLIP-seq
MIRT1065061	hsa-miR-378	CLIP-seq
MIRT1065062	hsa-miR-378b	CLIP-seq
MIRT1065063	hsa-miR-378c	CLIP-seq
MIRT1065064	hsa-miR-378d	CLIP-seq
MIRT1065065	hsa-miR-378e	CLIP-seq
MIRT1065066	hsa-miR-378f	CLIP-seq
MIRT1065067	hsa-miR-378h	CLIP-seq
MIRT1065068	hsa-miR-378i	CLIP-seq
MIRT1065069	hsa-miR-3913-3p	CLIP-seq
MIRT1065070	hsa-miR-3922-5p	CLIP-seq
MIRT1065071	hsa-miR-3974	CLIP-seq
MIRT1065072	hsa-miR-422a	CLIP-seq
MIRT1065073	hsa-miR-4286	CLIP-seq
MIRT1065074	hsa-miR-4310	CLIP-seq
MIRT1065075	hsa-miR-4312	CLIP-seq
MIRT1065076	hsa-miR-4319	CLIP-seq
MIRT1065077	hsa-miR-4324	CLIP-seq
MIRT1065078	hsa-miR-4430	CLIP-seq
MIRT1065079	hsa-miR-4504	CLIP-seq
MIRT1065080	hsa-miR-4638-3p	CLIP-seq
MIRT1065081	hsa-miR-4652-3p	CLIP-seq
MIRT1065082	hsa-miR-4652-5p	CLIP-seq
MIRT1065083	hsa-miR-4667-5p	CLIP-seq
MIRT1065084	hsa-miR-4668-5p	CLIP-seq
MIRT1065085	hsa-miR-4691-5p	CLIP-seq
MIRT1065086	hsa-miR-4700-5p	CLIP-seq
MIRT1065087	hsa-miR-4731-5p	CLIP-seq
MIRT1065088	hsa-miR-4736	CLIP-seq
MIRT1065089	hsa-miR-4742-3p	CLIP-seq
MIRT1065090	hsa-miR-4757-5p	CLIP-seq
MIRT1065091	hsa-miR-4763-3p	CLIP-seq
MIRT1065092	hsa-miR-4778-5p	CLIP-seq
MIRT1065093	hsa-miR-4782-5p	CLIP-seq
MIRT1065094	hsa-miR-516b	CLIP-seq
MIRT1065095	hsa-miR-519d	CLIP-seq
MIRT1065096	hsa-miR-520a-3p	CLIP-seq
MIRT1065097	hsa-miR-520b	CLIP-seq
MIRT1065098	hsa-miR-520c-3p	CLIP-seq
MIRT1065099	hsa-miR-520d-3p	CLIP-seq
MIRT1065100	hsa-miR-520e	CLIP-seq
MIRT1065101	hsa-miR-520g	CLIP-seq
MIRT1065102	hsa-miR-520h	CLIP-seq
MIRT1065103	hsa-miR-532-3p	CLIP-seq
MIRT1065104	hsa-miR-542-3p	CLIP-seq
MIRT1065105	hsa-miR-544b	CLIP-seq
MIRT1065106	hsa-miR-548ad	CLIP-seq
MIRT1065107	hsa-miR-556-5p	CLIP-seq
MIRT1065108	hsa-miR-569	CLIP-seq
MIRT1065109	hsa-miR-570	CLIP-seq
MIRT1065110	hsa-miR-576-3p	CLIP-seq
MIRT1065111	hsa-miR-610	CLIP-seq
MIRT1065112	hsa-miR-653	CLIP-seq
MIRT1065113	hsa-miR-758	CLIP-seq
MIRT1065114	hsa-miR-761	CLIP-seq
MIRT1065115	hsa-miR-876-5p	CLIP-seq
MIRT1065116	hsa-miR-9	CLIP-seq
MIRT1065117	hsa-miR-93	CLIP-seq
MIRT1065118	hsa-miR-98	CLIP-seq
MIRT1550133	hsa-miR-4433	CLIP-seq
MIRT2015487	hsa-miR-1273d	CLIP-seq
MIRT2015488	hsa-miR-1285	CLIP-seq
MIRT2015489	hsa-miR-1321	CLIP-seq
MIRT2015490	hsa-miR-149	CLIP-seq
MIRT1065036	hsa-miR-219-1-3p	CLIP-seq
MIRT1065037	hsa-miR-23a	CLIP-seq
MIRT1065038	hsa-miR-23b	CLIP-seq
MIRT1065039	hsa-miR-23c	CLIP-seq
MIRT2015491	hsa-miR-3064-5p	CLIP-seq
MIRT2015492	hsa-miR-3120-5p	CLIP-seq
MIRT2015493	hsa-miR-3158-5p	CLIP-seq
MIRT2015494	hsa-miR-3187-5p	CLIP-seq
MIRT2015495	hsa-miR-34a	CLIP-seq
MIRT2015496	hsa-miR-3945	CLIP-seq
MIRT2015497	hsa-miR-3978	CLIP-seq
MIRT2015498	hsa-miR-4253	CLIP-seq
MIRT1065077	hsa-miR-4324	CLIP-seq
MIRT2015499	hsa-miR-4446-5p	CLIP-seq
MIRT2015500	hsa-miR-4464	CLIP-seq
MIRT2015501	hsa-miR-449a	CLIP-seq
MIRT2015502	hsa-miR-449b	CLIP-seq
MIRT2015503	hsa-miR-4694-3p	CLIP-seq
MIRT2015504	hsa-miR-4739	CLIP-seq
MIRT2015505	hsa-miR-4748	CLIP-seq
MIRT2015506	hsa-miR-4755-5p	CLIP-seq
MIRT2015507	hsa-miR-4756-5p	CLIP-seq
MIRT2015508	hsa-miR-4794	CLIP-seq
MIRT2015509	hsa-miR-522	CLIP-seq
MIRT1065109	hsa-miR-570	CLIP-seq
MIRT2015510	hsa-miR-593	CLIP-seq
MIRT2015511	hsa-miR-612	CLIP-seq
MIRT2015512	hsa-miR-642b	CLIP-seq
MIRT1065116	hsa-miR-9	CLIP-seq
MIRT1065011	hsa-miR-1200	CLIP-seq
MIRT2247764	hsa-miR-1207-3p	CLIP-seq
MIRT1065014	hsa-miR-1224-3p	CLIP-seq
MIRT1065016	hsa-miR-1245	CLIP-seq
MIRT1065017	hsa-miR-125a-5p	CLIP-seq
MIRT1065018	hsa-miR-125b	CLIP-seq
MIRT1065019	hsa-miR-1260	CLIP-seq
MIRT1065020	hsa-miR-1260b	CLIP-seq
MIRT2247765	hsa-miR-1270	CLIP-seq
MIRT2015487	hsa-miR-1273d	CLIP-seq
MIRT2247766	hsa-miR-128	CLIP-seq
MIRT1065023	hsa-miR-1280	CLIP-seq
MIRT1065024	hsa-miR-1290	CLIP-seq
MIRT1065025	hsa-miR-1291	CLIP-seq
MIRT2247767	hsa-miR-132	CLIP-seq
MIRT1065028	hsa-miR-136	CLIP-seq
MIRT2247768	hsa-miR-142-5p	CLIP-seq
MIRT1065029	hsa-miR-150	CLIP-seq
MIRT2247769	hsa-miR-182	CLIP-seq
MIRT2247770	hsa-miR-186	CLIP-seq
MIRT2247771	hsa-miR-1913	CLIP-seq
MIRT2247772	hsa-miR-1915	CLIP-seq
MIRT2247773	hsa-miR-192	CLIP-seq
MIRT2247774	hsa-miR-1976	CLIP-seq
MIRT2247775	hsa-miR-212	CLIP-seq
MIRT1065035	hsa-miR-214	CLIP-seq
MIRT2247776	hsa-miR-215	CLIP-seq
MIRT1065036	hsa-miR-219-1-3p	CLIP-seq
MIRT2247777	hsa-miR-22	CLIP-seq
MIRT1065037	hsa-miR-23a	CLIP-seq
MIRT1065038	hsa-miR-23b	CLIP-seq
MIRT1065039	hsa-miR-23c	CLIP-seq
MIRT2247778	hsa-miR-27a	CLIP-seq
MIRT2247779	hsa-miR-27b	CLIP-seq
MIRT2247780	hsa-miR-299-3p	CLIP-seq
MIRT2247781	hsa-miR-3121-5p	CLIP-seq
MIRT2247782	hsa-miR-3133	CLIP-seq
MIRT2247783	hsa-miR-3135	CLIP-seq
MIRT2247784	hsa-miR-3136-3p	CLIP-seq
MIRT2247785	hsa-miR-3152-5p	CLIP-seq
MIRT2247786	hsa-miR-3155	CLIP-seq
MIRT2247787	hsa-miR-3155b	CLIP-seq
MIRT2015493	hsa-miR-3158-5p	CLIP-seq
MIRT1065048	hsa-miR-3160-5p	CLIP-seq
MIRT1065049	hsa-miR-3167	CLIP-seq
MIRT2247788	hsa-miR-3189-5p	CLIP-seq
MIRT2247789	hsa-miR-320a	CLIP-seq
MIRT2247790	hsa-miR-320b	CLIP-seq
MIRT2247791	hsa-miR-320c	CLIP-seq
MIRT2247792	hsa-miR-320d	CLIP-seq
MIRT2247793	hsa-miR-320e	CLIP-seq
MIRT2247794	hsa-miR-323-3p	CLIP-seq
MIRT2247795	hsa-miR-324-3p	CLIP-seq
MIRT2247796	hsa-miR-330-3p	CLIP-seq
MIRT2247797	hsa-miR-335	CLIP-seq
MIRT2247798	hsa-miR-338-3p	CLIP-seq
MIRT2247799	hsa-miR-340	CLIP-seq
MIRT2015495	hsa-miR-34a	CLIP-seq
MIRT2247800	hsa-miR-3591-3p	CLIP-seq
MIRT2247801	hsa-miR-3617	CLIP-seq
MIRT1065053	hsa-miR-3619-5p	CLIP-seq
MIRT1065055	hsa-miR-3670	CLIP-seq
MIRT2247802	hsa-miR-3677-5p	CLIP-seq
MIRT1065069	hsa-miR-3913-3p	CLIP-seq
MIRT2247803	hsa-miR-3943	CLIP-seq
MIRT2247804	hsa-miR-4291	CLIP-seq
MIRT1065076	hsa-miR-4319	CLIP-seq
MIRT1065077	hsa-miR-4324	CLIP-seq
MIRT2247805	hsa-miR-4423-5p	CLIP-seq
MIRT2247806	hsa-miR-4429	CLIP-seq
MIRT2015501	hsa-miR-449a	CLIP-seq
MIRT2015502	hsa-miR-449b	CLIP-seq
MIRT2247807	hsa-miR-4531	CLIP-seq
MIRT2247808	hsa-miR-4646-5p	CLIP-seq
MIRT2247809	hsa-miR-4659a-3p	CLIP-seq
MIRT2247810	hsa-miR-4659b-3p	CLIP-seq
MIRT2247811	hsa-miR-4683	CLIP-seq
MIRT2247812	hsa-miR-4690-3p	CLIP-seq
MIRT2247813	hsa-miR-4725-5p	CLIP-seq
MIRT2247814	hsa-miR-4727-5p	CLIP-seq
MIRT2247815	hsa-miR-4729	CLIP-seq
MIRT1065089	hsa-miR-4742-3p	CLIP-seq
MIRT2247816	hsa-miR-4747-5p	CLIP-seq
MIRT1065090	hsa-miR-4757-5p	CLIP-seq
MIRT2247817	hsa-miR-4758-3p	CLIP-seq
MIRT1065093	hsa-miR-4782-5p	CLIP-seq
MIRT2247818	hsa-miR-484	CLIP-seq
MIRT2247819	hsa-miR-504	CLIP-seq
MIRT2247820	hsa-miR-513a-5p	CLIP-seq
MIRT2247821	hsa-miR-513c	CLIP-seq
MIRT2247822	hsa-miR-514b-5p	CLIP-seq
MIRT1065103	hsa-miR-532-3p	CLIP-seq
MIRT2247823	hsa-miR-543	CLIP-seq
MIRT1065106	hsa-miR-548ad	CLIP-seq
MIRT2247824	hsa-miR-553	CLIP-seq
MIRT2247825	hsa-miR-555	CLIP-seq
MIRT1065109	hsa-miR-570	CLIP-seq
MIRT2247826	hsa-miR-572	CLIP-seq
MIRT1065110	hsa-miR-576-3p	CLIP-seq
MIRT2247827	hsa-miR-579	CLIP-seq
MIRT2247828	hsa-miR-620	CLIP-seq
MIRT2247829	hsa-miR-621	CLIP-seq
MIRT2247830	hsa-miR-641	CLIP-seq
MIRT2247831	hsa-miR-646	CLIP-seq
MIRT2247832	hsa-miR-663b	CLIP-seq
MIRT2247833	hsa-miR-7	CLIP-seq
MIRT1065114	hsa-miR-761	CLIP-seq
MIRT1065115	hsa-miR-876-5p	CLIP-seq
MIRT1065116	hsa-miR-9	CLIP-seq
MIRT2247834	hsa-miR-922	CLIP-seq
MIRT2247803	hsa-miR-3943	CLIP-seq
MIRT2247812	hsa-miR-4690-3p	CLIP-seq
MIRT2247781	hsa-miR-3121-5p	CLIP-seq
MIRT2247788	hsa-miR-3189-5p	CLIP-seq
MIRT1065069	hsa-miR-3913-3p	CLIP-seq
MIRT2247813	hsa-miR-4725-5p	CLIP-seq
MIRT2247817	hsa-miR-4758-3p	CLIP-seq
MIRT2247819	hsa-miR-504	CLIP-seq
MIRT1065116	hsa-miR-9	CLIP-seq
MIRT2451784	hsa-miR-10a	CLIP-seq
MIRT2451785	hsa-miR-10b	CLIP-seq
MIRT2451786	hsa-miR-1283	CLIP-seq
MIRT2451787	hsa-miR-339-5p	CLIP-seq
MIRT2451788	hsa-miR-4421	CLIP-seq
MIRT2451789	hsa-miR-4684-5p	CLIP-seq
MIRT2015510	hsa-miR-593	CLIP-seq
MIRT1065013	hsa-miR-122	CLIP-seq
MIRT1065024	hsa-miR-1290	CLIP-seq
MIRT1065027	hsa-miR-1307	CLIP-seq
MIRT1065037	hsa-miR-23a	CLIP-seq
MIRT1065038	hsa-miR-23b	CLIP-seq
MIRT1065039	hsa-miR-23c	CLIP-seq
MIRT1065046	hsa-miR-3135b	CLIP-seq
MIRT1065049	hsa-miR-3167	CLIP-seq
MIRT1065054	hsa-miR-3652	CLIP-seq
MIRT1065078	hsa-miR-4430	CLIP-seq
MIRT1065093	hsa-miR-4782-5p	CLIP-seq
MIRT2247826	hsa-miR-572	CLIP-seq
MIRT2247829	hsa-miR-621	CLIP-seq
MIRT1065115	hsa-miR-876-5p	CLIP-seq
MIRT2247780	hsa-miR-299-3p	CLIP-seq
MIRT2247800	hsa-miR-3591-3p	CLIP-seq
MIRT2247825	hsa-miR-555	CLIP-seq
MIRT2682802	hsa-miR-656	CLIP-seq
MIRT2682803	hsa-miR-889	CLIP-seq
MIRT1065116	hsa-miR-9	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PPARA	Repression	14764586

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002384	Process	Hepatic immune response	TAS	12832423
GO:0002548	Process	Monocyte chemotaxis	IC	10510402
GO:0002690	Process	Positive regulation of leukocyte chemotaxis	TAS	15100312
GO:0004896	Function	Cytokine receptor activity	IBA	21873635
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IMP	12643274
GO:0004915	Function	Interleukin-6 receptor activity	IDA	2261637
GO:0004921	Function	Interleukin-11 receptor activity	IBA	21873635
GO:0005138	Function	Interleukin-6 receptor binding	IPI	12829785
GO:0005515	Function	Protein binding	IPI	11238858, 12829785, 16034137, 18775332, 28265003, 32296183
GO:0005576	Component	Extracellular region	IDA	12748171
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005896	Component	Interleukin-6 receptor complex	IDA	2261637, 12829785
GO:0006953	Process	Acute-phase response	TAS	12832423
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	2261637
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18719127
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0010536	Process	Positive regulation of activation of Janus kinase activity	IBA	21873635
GO:0010573	Process	Vascular endothelial growth factor production	IDA	12794819
GO:0016324	Component	Apical plasma membrane	IDA	16034137
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	IDA	2261637
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019899	Function	Enzyme binding	IPI	12748171
GO:0019955	Function	Cytokine binding	IBA	21873635
GO:0019970	Function	Interleukin-11 binding	IBA	21873635
GO:0019981	Function	Interleukin-6 binding	IBA	21873635
GO:0019981	Function	Interleukin-6 binding	IPI	12829785
GO:0031018	Process	Endocrine pancreas development	IC	18719127
GO:0031018	Process	Endocrine pancreas development	IMP	18719127
GO:0032722	Process	Positive regulation of chemokine production	IDA	10510402
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	10510402
GO:0034097	Process	Response to cytokine	IDA	2261637
GO:0038154	Process	Interleukin-11-mediated signaling pathway	IEA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IBA	21873635
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IMP	12643274
GO:0042803	Function	Protein homodimerization activity	IPI	12633863
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0045669	Process	Positive regulation of osteoblast differentiation	TAS	12372336
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IDA	10510402
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	11884403
GO:0050829	Process	Defense response to Gram-negative bacterium	TAS	16034137
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IBA	21873635
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IMP	12643274
GO:0070102	Process	Interleukin-6-mediated signaling pathway	TAS
GO:0070110	Component	Ciliary neurotrophic factor receptor complex	IDA	12643274
GO:0070119	Function	Ciliary neurotrophic factor binding	IPI	12643274
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IMP	12643274
GO:0072126	Process	Positive regulation of glomerular mesangial cell proliferation	IMP	26563755
GO:0072540	Process	T-helper 17 cell lineage commitment	IEA
GO:0097191	Process	Extrinsic apoptotic signaling pathway	TAS	15100312

Other IDs

• MIM: 147880
• HGNC: 6019
• e!Ensembl: ENSG00000160712

Protein

• UniProt ID: P08887
• Protein name: Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
• Protein function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-
• PDB: 1N26, 1P9M, 2ARW, 5FUC, 7DC8, 8D82, 8IOW, 8QY5, 8QY6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00047	ig	30 → 101	Immunoglobulin domain	Domain
  PF09240	IL6Ra-bind	118 → 213	Interleukin-6 receptor alpha chain, binding	Domain

• Sequence:

  MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
  VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
  CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
  PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
  PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
  GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSS
  SVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRP
  TPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR

• Sequence length: 468

Pathways

KEGG:

EGFR tyrosine kinase inhibitor resistance
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
HIF-1 signaling pathway
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Hematopoietic cell lineage
Th17 cell differentiation
Non-alcoholic fatty liver disease
Human cytomegalovirus infection
Coronavirus disease - COVID-19
Pathways in cancer

Reactome:

Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-4 and Interleukin-13 signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	25340798
Aortic aneurysm	Aortic Aneurysm, Abdominal	rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953, rs794728021, rs8046180, rs797045725, rs876657852, rs878854466, rs886038978, rs746972765, rs886039303, rs886040965, rs886040966, rs886040967, rs886229659, rs1553781304, rs1060502531, rs1553795301, rs1553803235, rs1213452826, rs869025352, rs1553780501, rs1553785222, rs1382893400, rs1554841990, rs1430822242, rs1567692384, rs1576422965, rs1596712899, rs2059732940, rs2041090817, rs1439991530	27899403
Arthritis	Systemic onset juvenile chronic arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	23603761
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21907864, 29902480, 29273806
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	30061737, 29892015
Coronary artery disease	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1, Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	23202125, 26343387, 29212778, 28714975, 23202125
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	26482879
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22552503
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	26343387
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	15995586
Papillary renal carcinoma	Papillary Renal Cell Carcinoma	rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724	7834629
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007
Renal carcinoma	Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney	rs121913668, rs121913670, rs121913243, rs786202724	7834629
Rheumatoid arthritis	Rheumatoid Arthritis, Rheumatoid Arthritis, Systemic Juvenile	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30423114, 16729287, 23143596, 24390342, 24532676, 23603761
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	8067274

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		23749187, 26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Chromophobe carcinoma	Chromophobe Renal Cell Carcinoma	rs137853247	7834629
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	22319020
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26974007
Eczema	Eczema		30595370, 31235509
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	21496483
Oligoarticular arthritis	Oligoarticular Juvenile Idiopathic Arthritis		23603761
Pauciarticular chronic arthritis	Juvenile pauciarticular chronic arthritis		23603761
Seronegative polyarthritis	Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative		23603761
Respiratory tract diseases	Respiratory Tract Diseases		30595370
Still disease	Juvenile-Onset Still Disease		23603761
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923
Ulcerative colitis	Ulcerative Colitis		26974007
Uveitis	Anterior uveitis		25200001