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IL5 (interleukin 5)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3567
Gene nameGene Name - the full gene name approved by the HGNC.
Interleukin 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IL5
SynonymsGene synonyms aliases
EDF, IL-5, TRF
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased producti
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT017691 hsa-miR-335-5p Microarray 18185580
MIRT039253 hsa-miR-454-5p CLASH 23622248
MIRT719916 hsa-miR-3662 HITS-CLIP 19536157
MIRT719915 hsa-miR-8063 HITS-CLIP 19536157
MIRT719914 hsa-miR-1237-3p HITS-CLIP 19536157
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
CEBPA Unknown 10453008
CEBPB Unknown 10453008
EP300 Unknown 16922677
ETS1 Activation 10212281
ETS2 Activation 10212281;19487701
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0005125 Function Cytokine activity IEA
GO:0005137 Function Interleukin-5 receptor binding IEA
GO:0005515 Function Protein binding IPI 1495999, 22153509
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05113
Protein name Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
Protein function Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells
PDB 1HUL , 3QT2 , 3VA2 , 8TLD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02025 IL5
22 → 133
Interleukin 5
 Domain
Sequence
Sequence length 134
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
Th1 and Th2 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Pathways in cancer
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection 		  Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 30552067, 7540862, 23266719
Autism Autistic Disorder rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634 16360218
Dermatitis Dermatitis, Atopic, Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 11886533, 18249437, 15347381
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578 17620002
Unknown
Disease name Disease term dbSNP ID References
Alveolitis Alveolitis, Fibrosing 17620002
Autoimmune hepatitis Autoimmune Chronic Hepatitis 21227906
Eczema Eczema, Infantile 11886533, 18249437
Eosinophilia Eosinophilia, Eosinophilia, Tropical 11006010, 1988543

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