Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3554 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Interleukin 1 receptor type 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
IL1R1 |
SynonymsGene synonyms aliases
|
CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q11.2-q12.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cyt |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
|
Transcription factor |
Regulation |
Reference |
STAT1 |
Unknown |
15972639 |
STAT6 |
Activation |
8757327 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P14778 |
Protein name |
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor typ |
Protein function |
Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation |
PDB |
1G0Y
,
1IRA
,
1ITB
,
4DEP
,
4GAF
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF18452 |
Ig_6 |
70 → 117 |
Immunoglobulin domain |
Domain |
PF13895 |
Ig_2 |
121 → 213 |
Immunoglobulin domain |
Domain |
PF01582 |
TIR |
387 → 564 |
TIR domain |
Family |
|
Sequence |
|
Sequence length |
569 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Asthma |
Asthma |
rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 |
31619474, 21804549 |
Dermatitis |
Dermatitis, Atopic |
rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 |
26482879 |
Psoriasis |
Psoriasis |
rs281875215, rs587777763, rs281875213, rs281875212 |
26974007 |
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