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IL1R1 (interleukin 1 receptor type 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3554
Gene nameGene Name - the full gene name approved by the HGNC.
Interleukin 1 receptor type 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IL1R1
SynonymsGene synonyms aliases
CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2-q12.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cyt
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004217 hsa-miR-197-3p Microarray 16822819
MIRT023115 hsa-miR-124-3p Microarray 18668037
MIRT024405 hsa-miR-215-5p Microarray 19074876
MIRT026961 hsa-miR-192-5p Microarray 19074876
MIRT733021 hsa-miR-636 ELISA, Luciferase reporter assay, qRT-PCR, Western blotting 31803183
Transcription factors
Transcription factor Regulation Reference
STAT1 Unknown 15972639
STAT6 Activation 8757327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IEA
GO:0004888 Function Transmembrane signaling receptor activity TAS 2530587
GO:0004908 Function Interleukin-1 receptor activity IBA 21873635
GO:0004908 Function Interleukin-1 receptor activity IDA 10383454
GO:0004909 Function Interleukin-1, type I, activating receptor activity IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P14778
Protein name Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor typ
Protein function Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation
PDB 1G0Y , 1IRA , 1ITB , 4DEP , 4GAF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18452 Ig_6
70 117
Immunoglobulin domain
Domain
PF13895 Ig_2
121 213
Immunoglobulin domain
Domain
PF01582 TIR
387 564
TIR domain
Family
Sequence
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKD
DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNL
CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDR
LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVI
EFITLEENKPTRPVIVSPANETMEVDL
GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISE
IESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK
IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG
YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQ
DGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPV
QRRSPSSKHQLLSPATKEKLQREA
HVPLG
Sequence length 569
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Osteoclast differentiation
Hematopoietic cell lineage
Th17 cell differentiation
Inflammatory mediator regulation of TRP channels
Pathogenic Escherichia coli infection
Shigellosis
Amoebiasis
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Fluid shear stress and atherosclerosis
  Interleukin-10 signaling
Interleukin-1 signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 31619474, 21804549
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 26482879
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 26974007
Unknown
Disease name Disease term dbSNP ID References
Ankylosing spondylitis Ankylosing spondylitis 26974007
Cholangitis Cholangitis, Sclerosing 26974007
Crohn disease Crohn Disease rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438 26974007
Dermatologic disorders Dermatologic disorders 22533443

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