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BMP8A (bone morphogenetic protein 8a)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
353500
Gene nameGene Name - the full gene name approved by the HGNC.
Bone morphogenetic protein 8a
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BMP8A
SynonymsGene synonyms aliases
OP-2, Op2
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021585 hsa-miR-142-3p Microarray 17612493
MIRT517421 hsa-miR-1910-3p PAR-CLIP 23446348
MIRT517420 hsa-miR-6511a-5p PAR-CLIP 23446348
MIRT517419 hsa-miR-25-3p PAR-CLIP 23446348
MIRT517418 hsa-miR-32-5p PAR-CLIP 23446348
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0002024 Process Diet induced thermogenesis IDA 22579288
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005615 Component Extracellular space IBA 21873635
GO:0008083 Function Growth factor activity IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q7Z5Y6
Protein name Bone morphogenetic protein 8A (BMP-8A)
Protein function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation o
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide
29 251
TGF-beta propeptide
Family
PF00019 TGF_beta
300 401
Transforming growth factor beta like domain
Domain
Sequence
Sequence length 402
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Hippo signaling pathway
Thermogenesis
 
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 30940143
Unknown
Disease name Disease term dbSNP ID References
Vascular diseases Peripheral Arterial Diseases 27082954

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