SLCO4C1 (solute carrier organic anion transporter family member 4C1)

Gene

• Entrez ID: 353189
• Gene name: Solute carrier organic anion transporter family member 4C1
• Gene symbol: SLCO4C1
• Synonyms: OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20
• Chromosome: 5
• Chromosome location: 5q21.1
• Summary: SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 149

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017791	hsa-miR-335-5p	Microarray	18185580
MIRT019369	hsa-miR-148b-3p	Microarray	17612493
MIRT040244	hsa-miR-615-3p	CLASH	23622248
MIRT707478	hsa-miR-124-5p	HITS-CLIP	21572407
MIRT707477	hsa-miR-4455	HITS-CLIP	21572407
MIRT707476	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT648022	hsa-miR-1264	HITS-CLIP	23824327
MIRT648021	hsa-miR-3938	HITS-CLIP	23824327
MIRT648020	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT648019	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT648018	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT648017	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT648016	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT648015	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT648014	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT648013	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT446972	hsa-miR-1185-5p	PAR-CLIP	22100165
MIRT446971	hsa-miR-3679-5p	PAR-CLIP	22100165
MIRT446970	hsa-miR-3605-5p	PAR-CLIP	22100165
MIRT446969	hsa-miR-137	PAR-CLIP	22100165
MIRT446967	hsa-miR-3915	PAR-CLIP	22100165
MIRT446968	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446966	hsa-miR-4689	PAR-CLIP	22100165
MIRT446965	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446964	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446963	hsa-miR-578	PAR-CLIP	22100165
MIRT446972	hsa-miR-1185-5p	PAR-CLIP	22100165
MIRT446971	hsa-miR-3679-5p	PAR-CLIP	22100165
MIRT446970	hsa-miR-3605-5p	PAR-CLIP	22100165
MIRT446969	hsa-miR-137	PAR-CLIP	22100165
MIRT446967	hsa-miR-3915	PAR-CLIP	22100165
MIRT446968	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446966	hsa-miR-4689	PAR-CLIP	22100165
MIRT446965	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446964	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446963	hsa-miR-578	PAR-CLIP	22100165
MIRT707476	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT707478	hsa-miR-124-5p	HITS-CLIP	21572407
MIRT707477	hsa-miR-4455	HITS-CLIP	21572407
MIRT707476	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT648022	hsa-miR-1264	HITS-CLIP	23824327
MIRT648021	hsa-miR-3938	HITS-CLIP	23824327
MIRT648020	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT648019	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT648018	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT648017	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT648016	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT648015	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT648014	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT648013	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT446972	hsa-miR-1185-5p	PAR-CLIP	22100165
MIRT446971	hsa-miR-3679-5p	PAR-CLIP	22100165
MIRT446970	hsa-miR-3605-5p	PAR-CLIP	22100165
MIRT446969	hsa-miR-137	PAR-CLIP	22100165
MIRT446967	hsa-miR-3915	PAR-CLIP	22100165
MIRT446968	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446966	hsa-miR-4689	PAR-CLIP	22100165
MIRT446965	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446964	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446963	hsa-miR-578	PAR-CLIP	22100165
MIRT446972	hsa-miR-1185-5p	PAR-CLIP	22100165
MIRT446971	hsa-miR-3679-5p	PAR-CLIP	22100165
MIRT446970	hsa-miR-3605-5p	PAR-CLIP	22100165
MIRT446969	hsa-miR-137	PAR-CLIP	22100165
MIRT446967	hsa-miR-3915	PAR-CLIP	22100165
MIRT446968	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446966	hsa-miR-4689	PAR-CLIP	22100165
MIRT446965	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446964	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446963	hsa-miR-578	PAR-CLIP	22100165
MIRT1369434	hsa-miR-125a-5p	CLIP-seq
MIRT1369435	hsa-miR-125b	CLIP-seq
MIRT1369436	hsa-miR-1288	CLIP-seq
MIRT1369437	hsa-miR-136	CLIP-seq
MIRT1369438	hsa-miR-140-3p	CLIP-seq
MIRT1369439	hsa-miR-23a	CLIP-seq
MIRT1369440	hsa-miR-23b	CLIP-seq
MIRT1369441	hsa-miR-23c	CLIP-seq
MIRT1369442	hsa-miR-300	CLIP-seq
MIRT1369443	hsa-miR-3152-5p	CLIP-seq
MIRT1369444	hsa-miR-3174	CLIP-seq
MIRT1369445	hsa-miR-3187-3p	CLIP-seq
MIRT1369446	hsa-miR-3199	CLIP-seq
MIRT1369447	hsa-miR-3613-3p	CLIP-seq
MIRT1369448	hsa-miR-3664-3p	CLIP-seq
MIRT1369449	hsa-miR-3686	CLIP-seq
MIRT1369450	hsa-miR-375	CLIP-seq
MIRT1369451	hsa-miR-381	CLIP-seq
MIRT1369452	hsa-miR-4273	CLIP-seq
MIRT1369453	hsa-miR-4276	CLIP-seq
MIRT1369454	hsa-miR-4281	CLIP-seq
MIRT1369455	hsa-miR-4319	CLIP-seq
MIRT1369456	hsa-miR-4326	CLIP-seq
MIRT1369457	hsa-miR-4424	CLIP-seq
MIRT1369458	hsa-miR-4527	CLIP-seq
MIRT1369459	hsa-miR-4529-5p	CLIP-seq
MIRT1369460	hsa-miR-4649-3p	CLIP-seq
MIRT1369461	hsa-miR-4652-3p	CLIP-seq
MIRT1369462	hsa-miR-4652-5p	CLIP-seq
MIRT1369463	hsa-miR-4663	CLIP-seq
MIRT1369464	hsa-miR-4666-3p	CLIP-seq
MIRT1369465	hsa-miR-4677-5p	CLIP-seq
MIRT1369466	hsa-miR-4682	CLIP-seq
MIRT1369467	hsa-miR-4728-3p	CLIP-seq
MIRT1369468	hsa-miR-4732-3p	CLIP-seq
MIRT1369469	hsa-miR-4742-3p	CLIP-seq
MIRT1369470	hsa-miR-4769-3p	CLIP-seq
MIRT1369471	hsa-miR-4774-3p	CLIP-seq
MIRT1369472	hsa-miR-4775	CLIP-seq
MIRT1369473	hsa-miR-4777-5p	CLIP-seq
MIRT1369474	hsa-miR-4803	CLIP-seq
MIRT1369475	hsa-miR-518d-5p	CLIP-seq
MIRT1369476	hsa-miR-519b-5p	CLIP-seq
MIRT1369477	hsa-miR-519c-5p	CLIP-seq
MIRT1369478	hsa-miR-520c-5p	CLIP-seq
MIRT1369479	hsa-miR-520d-5p	CLIP-seq
MIRT1369480	hsa-miR-521	CLIP-seq
MIRT1369481	hsa-miR-522	CLIP-seq
MIRT1369482	hsa-miR-524-5p	CLIP-seq
MIRT1369483	hsa-miR-526a	CLIP-seq
MIRT1369484	hsa-miR-590-3p	CLIP-seq
MIRT1369485	hsa-miR-630	CLIP-seq
MIRT1369486	hsa-miR-670	CLIP-seq
MIRT1369436	hsa-miR-1288	CLIP-seq
MIRT2109684	hsa-miR-2110	CLIP-seq
MIRT2109685	hsa-miR-3124-3p	CLIP-seq
MIRT2109686	hsa-miR-3144-5p	CLIP-seq
MIRT2109687	hsa-miR-3150a-3p	CLIP-seq
MIRT2109688	hsa-miR-3191	CLIP-seq
MIRT1369446	hsa-miR-3199	CLIP-seq
MIRT1369457	hsa-miR-4424	CLIP-seq
MIRT1369462	hsa-miR-4652-5p	CLIP-seq
MIRT1369463	hsa-miR-4663	CLIP-seq
MIRT1369466	hsa-miR-4682	CLIP-seq
MIRT2109689	hsa-miR-582-5p	CLIP-seq
MIRT1369436	hsa-miR-1288	CLIP-seq
MIRT2332959	hsa-miR-153	CLIP-seq
MIRT2109684	hsa-miR-2110	CLIP-seq
MIRT2109686	hsa-miR-3144-5p	CLIP-seq
MIRT2109687	hsa-miR-3150a-3p	CLIP-seq
MIRT2109688	hsa-miR-3191	CLIP-seq
MIRT1369446	hsa-miR-3199	CLIP-seq
MIRT2332960	hsa-miR-323b-3p	CLIP-seq
MIRT2332961	hsa-miR-338-5p	CLIP-seq
MIRT2332962	hsa-miR-4268	CLIP-seq
MIRT1369457	hsa-miR-4424	CLIP-seq
MIRT2332963	hsa-miR-448	CLIP-seq
MIRT2332964	hsa-miR-450b-5p	CLIP-seq
MIRT1369458	hsa-miR-4527	CLIP-seq
MIRT1369462	hsa-miR-4652-5p	CLIP-seq
MIRT1369463	hsa-miR-4663	CLIP-seq
MIRT1369466	hsa-miR-4682	CLIP-seq
MIRT2332965	hsa-miR-4708-3p	CLIP-seq
MIRT2332966	hsa-miR-507	CLIP-seq
MIRT2332967	hsa-miR-557	CLIP-seq
MIRT2332968	hsa-miR-580	CLIP-seq
MIRT2459943	hsa-miR-1237	CLIP-seq
MIRT2459944	hsa-miR-1248	CLIP-seq
MIRT2459945	hsa-miR-4279	CLIP-seq
MIRT2459946	hsa-miR-4452	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA3	Unknown	23874392

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	IBA	21873635
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	TAS
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0043252	Process	Sodium-independent organic anion transport	IBA	21873635
GO:0043252	Process	Sodium-independent organic anion transport	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0055085	Process	Transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 609013
• HGNC: 23612
• e!Ensembl: ENSG00000173930

Protein

• UniProt ID: Q6ZQN7
• Protein name: Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20)
• Protein function: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:2061
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03137	OATP	106 → 664	Organic Anion Transporter Polypeptide (OATP) family	Family
  PF07648	Kazal_2	502 → 547	Kazal-type serine protease inhibitor domain	Domain

• Sequence:

  MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPE
  PSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGI
  VVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAF
  MIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLG
  AGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGES
  TDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNA
  DVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFA
  ATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEP
  FAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPK
  VYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITV
  SILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYD
  NIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKI
  VKEG

• Sequence length: 724

Pathways

Reactome:

Neutrophil degranulation
Transport of organic anions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28566273