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APOH (apolipoprotein H)

Gene

350

Apolipoprotein H

APOH

B2G1, B2GP1, BG

17q24.2

Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphos

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs398124629	T>C	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017373	hsa-miR-335-5p	Microarray	18185580
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650871	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT650870	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650871	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT650870	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT634105	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT634104	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT634103	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT634102	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT634101	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT634100	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT634099	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT634098	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT634097	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT634096	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT634095	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT634094	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT634093	hsa-miR-302e	HITS-CLIP	23824327
MIRT634092	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT634091	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT634090	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT634089	hsa-miR-520b	HITS-CLIP	23824327
MIRT634088	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT634087	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT634086	hsa-miR-520e	HITS-CLIP	23824327
MIRT634085	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT634084	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT634083	hsa-miR-520h	HITS-CLIP	23824327
MIRT634082	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT634081	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634080	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634079	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT634078	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT634077	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650871	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT650870	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650871	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT650870	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT634105	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT634104	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT634103	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT634102	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT634101	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT634100	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT634099	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT634098	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT634097	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT634096	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT634095	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT634094	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT634093	hsa-miR-302e	HITS-CLIP	23824327
MIRT634092	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT634091	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT634090	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT634089	hsa-miR-520b	HITS-CLIP	23824327
MIRT634088	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT634087	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT634086	hsa-miR-520e	HITS-CLIP	23824327
MIRT634085	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT634084	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT634083	hsa-miR-520h	HITS-CLIP	23824327
MIRT634082	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT634081	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634080	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634079	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT634078	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT634077	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT621471	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT621470	hsa-miR-764	HITS-CLIP	23824327
MIRT621469	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT621468	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT621467	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT621466	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT621465	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT621464	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621463	hsa-miR-640	HITS-CLIP	23824327
MIRT621462	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT790067	hsa-miR-4504	CLIP-seq
MIRT790068	hsa-miR-542-3p	CLIP-seq
MIRT790069	hsa-miR-595	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IDA	17872974
GO:0002576	Process	Platelet degranulation	TAS
GO:0005515	Function	Protein binding	IPI	9269765, 16480936, 19805618, 20223219, 32814053
GO:0005543	Function	Phospholipid binding	IDA	15486070
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 20551380
GO:0005615	Component	Extracellular space	IDA	15486070
GO:0006641	Process	Triglyceride metabolic process	IDA	7417307
GO:0007597	Process	Blood coagulation, intrinsic pathway	IDA	4052628
GO:0008201	Function	Heparin binding	IEA
GO:0008289	Function	Lipid binding	IDA	222615
GO:0009986	Component	Cell surface	IDA	16480936
GO:0010596	Process	Negative regulation of endothelial cell migration	IDA	17872974
GO:0016525	Process	Negative regulation of angiogenesis	IDA	17872974
GO:0030194	Process	Positive regulation of blood coagulation	TAS	16480936
GO:0030195	Process	Negative regulation of blood coagulation	IDA	4052628
GO:0031089	Component	Platelet dense granule lumen	TAS
GO:0031639	Process	Plasminogen activation	IDA	16480936
GO:0033033	Process	Negative regulation of myeloid cell apoptotic process	IDA	15534879
GO:0034197	Process	Triglyceride transport	ISS	7078428
GO:0034361	Component	Very-low-density lipoprotein particle	IDA	222615
GO:0034364	Component	High-density lipoprotein particle	IDA	222615
GO:0034392	Process	Negative regulation of smooth muscle cell apoptotic process	IDA	15534879
GO:0042627	Component	Chylomicron	IDA	222615
GO:0042802	Function	Identical protein binding	IPI	18822289
GO:0051006	Process	Positive regulation of lipoprotein lipase activity	IDA	7417307
GO:0051917	Process	Regulation of fibrinolysis	IDA	16480936
GO:0051918	Process	Negative regulation of fibrinolysis	IDA	14726399
GO:0060230	Function	Lipoprotein lipase activator activity	IDA	7417307
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	20551380
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
138700	616	ENSG00000091583

Protein

UniProt ID

P02749

Protein name

Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)

Protein function

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

PDB

1C1Z , 1G4F , 1G4G , 1QUB , 2KRI , 3OP8 , 4JHS , 6V06 , 6V08 , 6V09 , 6XSD , 6XST , 7JIK , 7KG4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00084	Sushi	23 → 79	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	81 → 137	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	142 → 200	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	205 → 260	Sushi repeat (SCR repeat)	Domain
PF09014	Sushi_2	261 → 345	Beta-2-glycoprotein-1 fifth domain	Domain

Sequence

MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD
SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM
FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL
DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC
KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Sequence length

345

Interactions

View interactions

	KEGG		Reactome
	Cholesterol metabolism		Platelet degranulation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24482440

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Antiphospholipid syndrome	Antiphospholipid Syndrome		10446865

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