CCN1 (cellular communication network factor 1)

Gene

• Entrez ID: 3491
• Gene name: Cellular communication network factor 1
• Gene symbol: CCN1
• Synonyms: CYR61, GIG1, IGFBP10
• Chromosome: 1
• Chromosome location: 1p22.3
• Summary: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell prolife

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	20675382
GO:0002041	Process	Intussusceptive angiogenesis	IEA
GO:0003181	Process	Atrioventricular valve morphogenesis	IEA
GO:0003278	Process	Apoptotic process involved in heart morphogenesis	IEA
GO:0003281	Process	Ventricular septum development	IEA
GO:0005178	Function	Integrin binding	IBA	21873635
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005520	Function	Insulin-like growth factor binding	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006935	Process	Chemotaxis	IEA
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0008201	Function	Heparin binding	IBA	21873635
GO:0010518	Process	Positive regulation of phospholipase activity	IEA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	20675382
GO:0030501	Process	Positive regulation of bone mineralization	IDA	20675382
GO:0030513	Process	Positive regulation of BMP signaling pathway	IGI	20675382
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0033690	Process	Positive regulation of osteoblast proliferation	IDA	20675382
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043280	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0044319	Process	Wound healing, spreading of cells	IDA	20675382
GO:0045669	Process	Positive regulation of osteoblast differentiation	IDA	20675382
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	20675382
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20675382
GO:0050840	Function	Extracellular matrix binding	IEA
GO:0060413	Process	Atrial septum morphogenesis	IEA
GO:0060548	Process	Negative regulation of cell death	IBA	21873635
GO:0060591	Process	Chondroblast differentiation	IEA
GO:0060710	Process	Chorio-allantoic fusion	IEA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:0061036	Process	Positive regulation of cartilage development	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023, 28327460
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IDA	20675382
GO:0072593	Process	Reactive oxygen species metabolic process	IEA
GO:2000304	Process	Positive regulation of ceramide biosynthetic process	IEA

Other IDs

• MIM: 602369
• HGNC: 2654
• e!Ensembl: ENSG00000142871

Protein

• UniProt ID: O00622
• Protein name: CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)
• Protein function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodel
• PDB: 4D0Z, 4D11
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00219	IGFBP	26 → 78	Insulin-like growth factor binding protein	Domain
  PF00093	VWC	100 → 163	von Willebrand factor type C domain	Family
  PF19035	TSP1_CCN	229 → 272	CCN3 Nov like TSP1 domain	Domain
  PF00007	Cys_knot	283 → 375	Cystine-knot domain	Domain

• Sequence:

  MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
  NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
  CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
  KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
  KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
  AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
  HANEAAFPFYRLFNDIHKFRD

• Sequence length: 381

Pathways

Reactome:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27935865
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19192274

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		17699798
Lung neoplasms	Lung Neoplasms		27935865
Scleroderma	Systemic Scleroderma		27482699