IGF2R (insulin like growth factor 2 receptor)

Gene

• Entrez ID: 3482
• Gene name: Insulin like growth factor 2 receptor
• Gene symbol: IGF2R
• Synonyms: CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI
• Chromosome: 6
• Chromosome location: 6q25.3
• Summary: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121434587	G>T	Pathogenic	Missense variant, coding sequence variant
rs121434588	G>A	Pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001451	hsa-miR-16-5p	pSILAC	18668040
MIRT016136	hsa-miR-657	Reporter assay	18602895
MIRT020747	hsa-miR-155-5p	Proteomics	18668040
MIRT021356	hsa-miR-9-5p	Microarray	17612493
MIRT029460	hsa-miR-26b-5p	Microarray	19088304
MIRT001451	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT045878	hsa-miR-128-3p	CLASH	23622248
MIRT042556	hsa-miR-423-3p	CLASH	23622248
MIRT036067	hsa-miR-1271-5p	CLASH	23622248
MIRT054454	hsa-miR-211-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24039954
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT713918	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713917	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713916	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713915	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT713914	hsa-miR-4512	HITS-CLIP	19536157
MIRT713913	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713912	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713911	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713910	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713909	hsa-miR-3666	HITS-CLIP	19536157
MIRT713908	hsa-miR-4295	HITS-CLIP	19536157
MIRT713907	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713906	hsa-miR-3146	HITS-CLIP	19536157
MIRT713905	hsa-miR-5008-5p	HITS-CLIP	19536157
MIRT679245	hsa-miR-6089	HITS-CLIP	19536157
MIRT713904	hsa-miR-4480	HITS-CLIP	19536157
MIRT713903	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT713902	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT713901	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713897	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT607437	hsa-miR-8485	HITS-CLIP	22927820
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	22927820
MIRT672625	hsa-miR-342-3p	HITS-CLIP	22927820
MIRT440462	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT679245	hsa-miR-6089	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672623	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT672622	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT672621	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT672620	hsa-miR-612	HITS-CLIP	23824327
MIRT672619	hsa-miR-6860	HITS-CLIP	23824327
MIRT672618	hsa-miR-564	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	24906430
MIRT457094	hsa-miR-548m	PAR-CLIP	23592263
MIRT457093	hsa-miR-2681-3p	PAR-CLIP	23592263
MIRT457092	hsa-miR-96-3p	PAR-CLIP	23592263
MIRT316722	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT440463	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440462	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440461	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440463	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440462	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440461	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT607437	hsa-miR-8485	HITS-CLIP	27418678
MIRT607437	hsa-miR-8485	HITS-CLIP	27418678
MIRT735290	hsa-miR-28-3p	qRT-PCR	32425976
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT713918	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713917	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713916	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713915	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT713914	hsa-miR-4512	HITS-CLIP	19536157
MIRT713913	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713912	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713911	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713910	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713909	hsa-miR-3666	HITS-CLIP	19536157
MIRT713908	hsa-miR-4295	HITS-CLIP	19536157
MIRT713907	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713906	hsa-miR-3146	HITS-CLIP	19536157
MIRT713905	hsa-miR-5008-5p	HITS-CLIP	19536157
MIRT679245	hsa-miR-6089	HITS-CLIP	19536157
MIRT713904	hsa-miR-4480	HITS-CLIP	19536157
MIRT713903	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT713902	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT713901	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713897	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT607437	hsa-miR-8485	HITS-CLIP	22927820
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	22927820
MIRT672625	hsa-miR-342-3p	HITS-CLIP	22927820
MIRT440462	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT679245	hsa-miR-6089	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672623	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT672622	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT672621	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT672620	hsa-miR-612	HITS-CLIP	23824327
MIRT672619	hsa-miR-6860	HITS-CLIP	23824327
MIRT672618	hsa-miR-564	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT457094	hsa-miR-548m	PAR-CLIP	23592263
MIRT457093	hsa-miR-2681-3p	PAR-CLIP	23592263
MIRT457092	hsa-miR-96-3p	PAR-CLIP	23592263
MIRT316722	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT1062022	hsa-miR-1205	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT1062025	hsa-miR-1266	CLIP-seq
MIRT1062026	hsa-miR-1296	CLIP-seq
MIRT1062027	hsa-miR-130a	CLIP-seq
MIRT1062028	hsa-miR-130b	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT1062030	hsa-miR-1471	CLIP-seq
MIRT1062031	hsa-miR-15a	CLIP-seq
MIRT1062032	hsa-miR-15b	CLIP-seq
MIRT1062033	hsa-miR-16	CLIP-seq
MIRT1062034	hsa-miR-1909	CLIP-seq
MIRT1062035	hsa-miR-1913	CLIP-seq
MIRT1062036	hsa-miR-195	CLIP-seq
MIRT1062037	hsa-miR-1973	CLIP-seq
MIRT1062038	hsa-miR-19a	CLIP-seq
MIRT1062039	hsa-miR-19b	CLIP-seq
MIRT1062040	hsa-miR-22	CLIP-seq
MIRT1062041	hsa-miR-224	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT1062045	hsa-miR-301a	CLIP-seq
MIRT1062046	hsa-miR-301b	CLIP-seq
MIRT1062047	hsa-miR-3141	CLIP-seq
MIRT1062048	hsa-miR-3189-5p	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062050	hsa-miR-324-3p	CLIP-seq
MIRT1062051	hsa-miR-331-3p	CLIP-seq
MIRT1062052	hsa-miR-338-3p	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT1062054	hsa-miR-3605-3p	CLIP-seq
MIRT1062055	hsa-miR-3660	CLIP-seq
MIRT1062056	hsa-miR-3662	CLIP-seq
MIRT1062057	hsa-miR-3671	CLIP-seq
MIRT1062058	hsa-miR-3689d	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062063	hsa-miR-3977	CLIP-seq
MIRT1062064	hsa-miR-421	CLIP-seq
MIRT1062065	hsa-miR-424	CLIP-seq
MIRT1062066	hsa-miR-4258	CLIP-seq
MIRT1062067	hsa-miR-4269	CLIP-seq
MIRT1062068	hsa-miR-4422	CLIP-seq
MIRT1062069	hsa-miR-4443	CLIP-seq
MIRT1062070	hsa-miR-4449	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT1062072	hsa-miR-4518	CLIP-seq
MIRT1062073	hsa-miR-4526	CLIP-seq
MIRT1062074	hsa-miR-4530	CLIP-seq
MIRT1062075	hsa-miR-454	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT1062077	hsa-miR-4659a-3p	CLIP-seq
MIRT1062078	hsa-miR-4659b-3p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT1062085	hsa-miR-4718	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062087	hsa-miR-4758-3p	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062091	hsa-miR-497	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT1062094	hsa-miR-510	CLIP-seq
MIRT1062095	hsa-miR-519a	CLIP-seq
MIRT1062096	hsa-miR-545	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062099	hsa-miR-603	CLIP-seq
MIRT1062100	hsa-miR-636	CLIP-seq
MIRT1062101	hsa-miR-642b	CLIP-seq
MIRT1062102	hsa-miR-647	CLIP-seq
MIRT1062103	hsa-miR-659	CLIP-seq
MIRT1062104	hsa-miR-766	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT2014652	hsa-miR-203	CLIP-seq
MIRT2014653	hsa-miR-205	CLIP-seq
MIRT1062052	hsa-miR-338-3p	CLIP-seq
MIRT2014654	hsa-miR-3607-3p	CLIP-seq
MIRT2014655	hsa-miR-361-3p	CLIP-seq
MIRT2014656	hsa-miR-3620	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2014657	hsa-miR-412	CLIP-seq
MIRT2014658	hsa-miR-4311	CLIP-seq
MIRT2014659	hsa-miR-4452	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT1062074	hsa-miR-4530	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT2014662	hsa-miR-548p	CLIP-seq
MIRT2014663	hsa-miR-653	CLIP-seq
MIRT1062104	hsa-miR-766	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT1062022	hsa-miR-1205	CLIP-seq
MIRT2246599	hsa-miR-1273f	CLIP-seq
MIRT2246600	hsa-miR-1283	CLIP-seq
MIRT2246601	hsa-miR-143	CLIP-seq
MIRT1062031	hsa-miR-15a	CLIP-seq
MIRT1062032	hsa-miR-15b	CLIP-seq
MIRT1062033	hsa-miR-16	CLIP-seq
MIRT1062034	hsa-miR-1909	CLIP-seq
MIRT1062036	hsa-miR-195	CLIP-seq
MIRT1062038	hsa-miR-19a	CLIP-seq
MIRT1062039	hsa-miR-19b	CLIP-seq
MIRT2014653	hsa-miR-205	CLIP-seq
MIRT1062041	hsa-miR-224	CLIP-seq
MIRT2246602	hsa-miR-2861	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT2246603	hsa-miR-3126-5p	CLIP-seq
MIRT1062047	hsa-miR-3141	CLIP-seq
MIRT2246604	hsa-miR-3151	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT2014654	hsa-miR-3607-3p	CLIP-seq
MIRT2014656	hsa-miR-3620	CLIP-seq
MIRT1062057	hsa-miR-3671	CLIP-seq
MIRT2246605	hsa-miR-3686	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT2246606	hsa-miR-3929	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062063	hsa-miR-3977	CLIP-seq
MIRT2014657	hsa-miR-412	CLIP-seq
MIRT1062065	hsa-miR-424	CLIP-seq
MIRT2014658	hsa-miR-4311	CLIP-seq
MIRT2246607	hsa-miR-4419a	CLIP-seq
MIRT2246608	hsa-miR-4419b	CLIP-seq
MIRT1062068	hsa-miR-4422	CLIP-seq
MIRT2246609	hsa-miR-4476	CLIP-seq
MIRT2246610	hsa-miR-4478	CLIP-seq
MIRT2246611	hsa-miR-4481	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT2246612	hsa-miR-4510	CLIP-seq
MIRT2246613	hsa-miR-4533	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2246614	hsa-miR-4652-3p	CLIP-seq
MIRT1062077	hsa-miR-4659a-3p	CLIP-seq
MIRT1062078	hsa-miR-4659b-3p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT2246615	hsa-miR-4708-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2246616	hsa-miR-4745-5p	CLIP-seq
MIRT2246617	hsa-miR-4770	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT2246618	hsa-miR-4790-3p	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062091	hsa-miR-497	CLIP-seq
MIRT1062096	hsa-miR-545	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT2014662	hsa-miR-548p	CLIP-seq
MIRT1062099	hsa-miR-603	CLIP-seq
MIRT2246619	hsa-miR-873	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2550512	hsa-miR-1200	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT2550513	hsa-miR-1226	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT2550514	hsa-miR-18a	CLIP-seq
MIRT2550515	hsa-miR-18b	CLIP-seq
MIRT2550516	hsa-miR-197	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2550517	hsa-miR-3944-5p	CLIP-seq
MIRT2550518	hsa-miR-4426	CLIP-seq
MIRT2014659	hsa-miR-4452	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2550519	hsa-miR-4647	CLIP-seq
MIRT2550520	hsa-miR-4662b	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT2550521	hsa-miR-4733-3p	CLIP-seq
MIRT2550522	hsa-miR-4735-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT2550523	hsa-miR-513c	CLIP-seq
MIRT2550524	hsa-miR-514b-5p	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT2550512	hsa-miR-1200	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT2550514	hsa-miR-18a	CLIP-seq
MIRT2550515	hsa-miR-18b	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT2682668	hsa-miR-3144-5p	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT2682669	hsa-miR-3622a-5p	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT2682670	hsa-miR-3910	CLIP-seq
MIRT2550517	hsa-miR-3944-5p	CLIP-seq
MIRT2682671	hsa-miR-4423-3p	CLIP-seq
MIRT2550518	hsa-miR-4426	CLIP-seq
MIRT2682672	hsa-miR-4470	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT2682673	hsa-miR-4509	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2550519	hsa-miR-4647	CLIP-seq
MIRT2550520	hsa-miR-4662b	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT2550522	hsa-miR-4735-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2682674	hsa-miR-4742-5p	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT2550523	hsa-miR-513c	CLIP-seq
MIRT2550524	hsa-miR-514b-5p	CLIP-seq
MIRT2682675	hsa-miR-515-5p	CLIP-seq
MIRT2682676	hsa-miR-542-5p	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
USF2	Activation	12857727

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001889	Process	Liver development	IEA
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0001972	Function	Retinoic acid binding	IEA
GO:0005010	Function	Insulin-like growth factor-activated receptor activity	TAS	10799489
GO:0005515	Function	Protein binding	IDA	10900005
GO:0005515	Function	Protein binding	IPI	10900005, 11387475, 11390366, 16977309, 17850746, 18046459
GO:0005520	Function	Insulin-like growth factor binding	IBA	21873635
GO:0005537	Function	Mannose binding	IEA
GO:0005641	Component	Nuclear envelope lumen	IEA
GO:0005768	Component	Endosome	IDA	15078902
GO:0005769	Component	Early endosome	IMP	17959629
GO:0005770	Component	Late endosome	IBA	21873635
GO:0005770	Component	Late endosome	IDA	22456507
GO:0005794	Component	Golgi apparatus	IDA	18817523
GO:0005802	Component	Trans-Golgi network	IBA	21873635
GO:0005802	Component	Trans-Golgi network	IMP	17959629
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10799489
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006898	Process	Receptor-mediated endocytosis	TAS	10799489
GO:0007041	Process	Lysosomal transport	IEA
GO:0007165	Process	Signal transduction	TAS	7753549
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0009986	Component	Cell surface	IDA	10900005
GO:0010008	Component	Endosome membrane	IDA	18817523
GO:0016020	Component	Membrane	HDA	19946888
GO:0019899	Function	Enzyme binding	IEA
GO:0030118	Component	Clathrin coat	IEA
GO:0030133	Component	Transport vesicle	TAS
GO:0030139	Component	Endocytic vesicle	IDA	10900005
GO:0030140	Component	Trans-Golgi network transport vesicle	IDA	15078902
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031995	Function	Insulin-like growth factor II binding	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0038023	Function	Signaling receptor activity	TAS	7753549
GO:0042802	Function	Identical protein binding	IPI	22681933
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044794	Process	Positive regulation by host of viral process	IMP	20889566
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051219	Function	Phosphoprotein binding	IDA	10900005
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1904772	Process	Response to tetrachloromethane	IEA
GO:1905394	Function	Retromer complex binding	IDA	18817523

Other IDs

• MIM: 147280
• HGNC: 5467
• e!Ensembl: ENSG00000197081

Protein

• UniProt ID: P11717
• Protein name: Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (
• Protein function: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate re
• PDB: 1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2L29, 2L2A, 2M68, 2M6T, 2V5N, 2V5O, 2V5P, 5IEI, 6N5X, 6N5Y, 6P8I, 6V02, 6Z30, 6Z31, 6Z32, 8AFZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00878	CIMR	123 → 270	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	277 → 421	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	423 → 573	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	575 → 716	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	720 → 876	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	882 → 1026	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1031 → 1178	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1179 → 1320	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1322 → 1462	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1465 → 1599	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1603 → 1750	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	1755 → 1894	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00040	fn2	1903 → 1942	Fibronectin type II domain	Domain
  PF00878	CIMR	1946 → 2083	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	2085 → 2233	Cation-independent mannose-6-phosphate receptor repeat	Family
  PF00878	CIMR	2237 → 2290	Cation-independent mannose-6-phosphate receptor repeat	Family

• Sequence:

  MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKN
  NVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQ
  GTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEE
  LRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGH
  QAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKL
  TAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYL
  FYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDEC
  SSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDG
  KKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAV
  DKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTS
  GEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFY
  INVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERH
  TPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDL
  SSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGS
  FTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNS
  HPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSG
  IGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFIT
  LTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPS
  PVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVG
  SCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQ
  LQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFR
  VCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCH
  KVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFD
  LSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRV
  RDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAW
  PTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCP
  PGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARP
  TNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESE
  DDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEI
  YLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVR
  MDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSG
  TKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIE
  SRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFE
  WKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCS
  ERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTV
  GRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRA
  SGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDG
  DLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPL
  GVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLT
  TCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALS
  SLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKAR
  KGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI

• Sequence length: 2491

Pathways

KEGG:

Virion - Herpesvirus
Lysosome
Endocytosis

Reactome:

Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	15750215
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	rs121908602, rs121908604, rs864309713, rs780263938, rs756636036, rs775394591	21433279, 20620343
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	29545352
Parkinson disease	Parkinson Disease	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	19276553
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Posterolateral diaphragmatic hernia	Congenital hernia of foramen of Bochdalek		21433279, 20620343
Morgagni diaphragmatic hernia	Congenital hernia of foramen of Morgagni		21433279, 20620343
Kidney failure	Kidney Failure, Chronic		29545352
Lewy body disease	Lewy Body Disease		19276553
Liver carcinoma	Liver carcinoma		15057872
Lung diseases	Lung diseases		21433279, 20620343
Micronodular cirrhosis	Micronodular cirrhosis
Prostatic neoplasms	Prostatic Neoplasms		29610475
Senile dementia	Presenile dementia, Acute Confusional Senile Dementia		15750215