PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting)

Gene

• Entrez ID: 342372
• Gene name: Polycystin 1 like 3, transient receptor potential channel interacting
• Gene symbol: PKD1L3
• Synonyms: -
• Chromosome: 16
• Chromosome location: 16q22.2
• Summary: This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may f

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001581	Process	Detection of chemical stimulus involved in sensory perception of sour taste	ISS
GO:0001581	Process	Detection of chemical stimulus involved in sensory perception of sour taste	ISS
GO:0001822	Process	Kidney development	IEA
GO:0005261	Function	Cation channel activity	ISS
GO:0005262	Function	Calcium channel activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	20538909
GO:0005886	Component	Plasma membrane	IDA	20538909
GO:0006812	Process	Cation transport	ISS
GO:0008324	Function	Cation transmembrane transporter activity	ISS
GO:0009986	Component	Cell surface	ISS
GO:0016020	Component	Membrane	IBA	21873635
GO:0030246	Function	Carbohydrate binding	IEA
GO:0033040	Function	Sour taste receptor activity	ISS
GO:0033040	Function	Sour taste receptor activity	ISS
GO:0034703	Component	Cation channel complex	ISS
GO:0043235	Component	Receptor complex	ISS
GO:0050915	Process	Sensory perception of sour taste	IMP	19812697
GO:0050982	Process	Detection of mechanical stimulus	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0071468	Process	Cellular response to acidic pH	ISS
GO:0071468	Process	Cellular response to acidic pH	ISS

Other IDs

• MIM: 607895
• HGNC: 21716
• e!Ensembl: ENSG00000277481

Protein

• UniProt ID: Q7Z443
• Protein name: Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3)
• Protein function: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:19464260, PubMed:23212381). Also shows permeability towards NA(1+), K(+) and Mg(2+) (PubMed:23212381). Heterotetrameric complex channel
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00059	Lectin_C	41 → 139	Lectin C-type domain	Domain
  PF01825	GPS	633 → 673	GPCR proteolysis site, GPS, motif	Motif
  PF01477	PLAT	745 → 860	PLAT/LH2 domain	Domain
  PF08016	PKD_channel	1438 → 1680	Polycystin cation channel	Family

• Sequence:

  MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAH
  IWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFI
  RISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGP
  GHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVS
  VTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKL
  QEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHS
  LNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATL
  LLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDN
  RNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTS
  LEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQ
  HGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILR
  TQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARK
  KDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLC
  DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHF
  LCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQF
  TRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPI
  NLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLL
  SKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVL
  QRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEE
  GKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIF
  ISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAP
  AINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH
  QFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDE
  GQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIM
  RGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKR
  NILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPV
  LLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDY
  RTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGK
  ERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP

• Sequence length: 1732

Pathways

KEGG:

Taste transduction

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25939597

Unknown
Disease name	Disease term	dbSNP ID	References
Stroke	Cerebrovascular accident		23422753