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NANOS1 (nanos C2HC-type zinc finger 1)
Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
340719
Gene nameGene Name - the full gene name approved by the HGNC.
Nanos C2HC-type zinc finger 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NANOS1
SynonymsGene synonyms aliases
EC_Rep1a, NOS-1, NOS1, SPGF12, ZC2HC12A
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.11
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repr
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs538539239 GCCGCCGCCGCC>-,GCC,GCCGCC,GCCGCCGCC,GCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCCGCCGCC Pathogenic, benign Inframe deletion, coding sequence variant, inframe insertion
rs587777031 CTCCTCCTC>-,CTCCTC,CTCCTCCTCCTC Conflicting-interpretations-of-pathogenicity Coding sequence variant, inframe deletion, inframe insertion
rs587777767 G>A Pathogenic Coding sequence variant, missense variant
rs587777768 CG>TA Pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT037712 hsa-miR-744-5p CLASH 23622248
MIRT611330 hsa-miR-1182 HITS-CLIP 19536157
MIRT611328 hsa-miR-140-3p HITS-CLIP 19536157
MIRT614332 hsa-miR-3119 HITS-CLIP 19536157
MIRT611319 hsa-miR-3692-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth IEA
GO:0001894 Process Tissue homeostasis IEA
GO:0003729 Function MRNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 17047063, 19168546, 21800163, 24736845
GO:0005737 Component Cytoplasm IDA 12690449, 17047063
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8WY41
Protein name Nanos homolog 1 (NOS-1) (EC_Rep1a)
Protein function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadhe
PDB 4CQO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05741 zf-nanos
214 → 267
Nanos RNA binding domain
 Family
Sequence 
MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGE
PRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRG
RYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEAT
PREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVL
CPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR
Sequence length 292
Interactions View interactions
Associated diseases
Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Causal
Disease name Disease term dbSNP ID References
Azoospermia Azoospermia rs200969445, rs144567652, rs765353898
Male infertility Male infertility with azoospermia or oligozoospermia due to single gene mutation rs554675432, rs9332971, rs397507505, rs797045116, rs748618094, rs781431741, rs1555979575, rs377581367
Non-obstructive azoospermia Non-obstructive azoospermia rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Obstructive azoospermia Obstructive azoospermia rs121909016, rs121908805, rs144055758, rs397508761
Unknown
Disease name Disease term dbSNP ID References
Male infertility with teratozoospermia Male infertility with teratozoospermia due to single gene mutation 23315541
Malignant mesothelioma Malignant mesothelioma 25756049

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