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ZC3H12D (zinc finger CCCH-type containing 12D)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
340152
Gene nameGene Name - the full gene name approved by the HGNC.
Zinc finger CCCH-type containing 12D
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ZC3H12D
SynonymsGene synonyms aliases
C6orf95, MCPIP4, TFL, dJ281H8.1, p34
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.1
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1505515 hsa-miR-106a CLIP-seq
MIRT1505516 hsa-miR-106b CLIP-seq
MIRT1505517 hsa-miR-1200 CLIP-seq
MIRT1505518 hsa-miR-1207-5p CLIP-seq
MIRT1505519 hsa-miR-1245 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IDA 24415781, 26134560
GO:0003729 Function MRNA binding IBA 21873635
GO:0004521 Function Endoribonuclease activity IBA 21873635
GO:0005515 Function Protein binding IPI 26134560
GO:0005634 Component Nucleus IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID A2A288
Protein name Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34)
Protein function May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18039 UBA_6
3 44
UBA-like domain
Domain
PF11977 RNase_Zc3h12a
88 244
Zc3h12a-like Ribonuclease NYN domain
Domain
Sequence
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVP
RGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDW
FRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDD
RYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGP
SLSN
FLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPG
AGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGP
PLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPR
DLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARAR
ARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP
Sequence length 527
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 21666691
Unknown
Disease name Disease term dbSNP ID References
Dupuytren contracture Dupuytren Contracture 28886342

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