GADL1 (glutamate decarboxylase like 1)

Gene

• Entrez ID: 339896
• Gene name: Glutamate decarboxylase like 1
• Gene symbol: GADL1
• Synonyms: ADC, CSADC, HuADC, HuCSADC
• Chromosome: 3
• Chromosome location: 3p24.1-p23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	24906430
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	23446348
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	23446348
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	23446348
MIRT516104	hsa-miR-3921	PAR-CLIP	23446348
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT516100	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	23446348
MIRT516097	hsa-miR-6089	PAR-CLIP	23446348
MIRT516096	hsa-miR-4320	PAR-CLIP	23446348
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	23446348
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	23446348
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	23446348
MIRT516104	hsa-miR-3921	PAR-CLIP	23446348
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT516100	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	23446348
MIRT516097	hsa-miR-6089	PAR-CLIP	23446348
MIRT516096	hsa-miR-4320	PAR-CLIP	23446348
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT1010249	hsa-miR-125a-3p	CLIP-seq
MIRT1010250	hsa-miR-1915	CLIP-seq
MIRT1010251	hsa-miR-2113	CLIP-seq
MIRT1010252	hsa-miR-218	CLIP-seq
MIRT1010253	hsa-miR-2964a-5p	CLIP-seq
MIRT1010254	hsa-miR-329	CLIP-seq
MIRT1010255	hsa-miR-362-3p	CLIP-seq
MIRT1010256	hsa-miR-4502	CLIP-seq
MIRT1010257	hsa-miR-451b	CLIP-seq
MIRT1010258	hsa-miR-4726-3p	CLIP-seq
MIRT1010259	hsa-miR-4762-3p	CLIP-seq
MIRT1010260	hsa-miR-4766-3p	CLIP-seq
MIRT1999210	hsa-miR-3065-5p	CLIP-seq
MIRT1999211	hsa-miR-3924	CLIP-seq
MIRT1010257	hsa-miR-451b	CLIP-seq
MIRT1999212	hsa-miR-494	CLIP-seq
MIRT1999213	hsa-miR-505	CLIP-seq
MIRT2388348	hsa-miR-4481	CLIP-seq
MIRT2388349	hsa-miR-4745-5p	CLIP-seq
MIRT2388350	hsa-miR-759	CLIP-seq
MIRT2465340	hsa-miR-3121-5p	CLIP-seq
MIRT2465341	hsa-miR-3128	CLIP-seq
MIRT2465342	hsa-miR-4470	CLIP-seq
MIRT2388348	hsa-miR-4481	CLIP-seq
MIRT2388349	hsa-miR-4745-5p	CLIP-seq
MIRT2388350	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000098	Process	Sulfur amino acid catabolic process	TAS
GO:0004068	Function	Aspartate 1-decarboxylase activity	IEA
GO:0004782	Function	Sulfinoalanine decarboxylase activity	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008652	Process	Cellular amino acid biosynthetic process	TAS
GO:0030170	Function	Pyridoxal phosphate binding	IEA

Other IDs

• MIM: 615601
• HGNC: 27949
• e!Ensembl: ENSG00000144644

Protein

• UniProt ID: Q6ZQY3
• Protein name: Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)
• Protein function: May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000269|Pu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00282	Pyridoxal_deC	77 → 445	Pyridoxal-dependent decarboxylase conserved domain	Domain

• Sequence:

  MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEV
  VLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQ
  LYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGG
  SVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKAASFLGIGTENVCFVE
  TDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHV
  DASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAK
  ASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLV
  DEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLM
  LGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM

• Sequence length: 521

Pathways

KEGG:

beta-Alanine metabolism
Taurine and hypotaurine metabolism
Pantothenate and CoA biosynthesis
Metabolic pathways

Reactome:

Degradation of cysteine and homocysteine
Aspartate and asparagine metabolism

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar I disorder		24369049
Liver neoplasms	Liver neoplasms		19233941
Liver cancer	Malignant neoplasm of liver		19233941