HCAR2 (hydroxycarboxylic acid receptor 2)

Gene

• Entrez ID: 338442
• Gene name: Hydroxycarboxylic acid receptor 2
• Gene symbol: HCAR2
• Synonyms: GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
• Chromosome: 12
• Chromosome location: 12q24.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1041686	hsa-miR-204	CLIP-seq
MIRT1041687	hsa-miR-211	CLIP-seq
MIRT1041688	hsa-miR-3153	CLIP-seq
MIRT1041689	hsa-miR-4257	CLIP-seq
MIRT1041690	hsa-miR-4261	CLIP-seq
MIRT1041691	hsa-miR-4668-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001781	Process	Neutrophil apoptotic process	IDA	17932499
GO:0005886	Component	Plasma membrane	IDA	17932499
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IDA	17932499
GO:0050995	Process	Negative regulation of lipid catabolic process	ISS
GO:0070165	Process	Positive regulation of adiponectin secretion	ISS
GO:0070553	Function	Nicotinic acid receptor activity	ISS

Other IDs

• MIM: 609163
• HGNC: 24827
• e!Ensembl: ENSG00000182782

Protein

• UniProt ID: Q8TDS4
• Protein name: Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
• Protein function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This
• PDB: 7XK2, 7ZL9, 7ZLY, 8H2G, 8I7V, 8I7W, 8IHB, 8IHF, 8IHH, 8IHI, 8IJ3, 8IJA, 8IJB, 8IJD, 8IY9, 8IYH, 8IYW, 8J6I, 8J6J, 8J6L, 8J6P, 8J6Q, 8J6R, 8JER, 8JHN, 8JHY, 8JII, 8JIL, 8JIM, 8JZ7, 8K5B, 8K5C, 8K5D, 8UTD, 9IQT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	44 → 294	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
  SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
  VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
  SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
  VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
  FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
  TSP

• Sequence length: 363

Pathways

KEGG:

cAMP signaling pathway

Reactome:

Hydroxycarboxylic acid-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21655214
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	18722346
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18639743

Unknown
Disease name	Disease term	dbSNP ID	References
Palmoplantar pustules	Pustulosis of Palms and Soles		18722346
Skin cancer	Malignant neoplasm of skin		21655214
Skin neoplasms	Skin Neoplasms		21655214