Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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334 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Amyloid beta precursor like protein 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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APLP2 |
SynonymsGene synonyms aliases
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APLP-2, APPH, APPL2, CDEBP |
ChromosomeChromosome number
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11 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q24.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q06481 |
Protein name |
Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) |
Protein function |
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin |
PDB |
5JBT
,
5TPT
,
8RQ6
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02177 |
APP_N |
49 → 147 |
Amyloid A4 N-terminal heparin-binding |
Domain |
PF12924 |
APP_Cu_bd |
148 → 204 |
Copper-binding of amyloid precursor, CuBD |
Domain |
PF00014 |
Kunitz_BPTI |
309 → 361 |
Kunitz/Bovine pancreatic trypsin inhibitor domain |
Domain |
PF12925 |
APP_E2 |
365 → 547 |
E2 domain of amyloid precursor protein |
Domain |
PF10515 |
APP_amyloid |
709 → 759 |
Beta-amyloid precursor protein C-terminus |
Family |
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Sequence |
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Sequence length |
763 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
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16214533 |
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