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HSPA2 (heat shock protein family A (Hsp70) member 2)

Gene

3306

Heat shock protein family A (Hsp70) member 2

HSPA2

HSP70-2, HSP70-3

14q23.3

Show/Hide all(94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024730	hsa-miR-215-5p	Microarray	19074876
MIRT026895	hsa-miR-192-5p	Microarray	19074876
MIRT036912	hsa-miR-877-3p	CLASH	23622248
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT632863	hsa-miR-3929	HITS-CLIP	23824327
MIRT632862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT632861	hsa-miR-4478	HITS-CLIP	23824327
MIRT632860	hsa-miR-5690	HITS-CLIP	23824327
MIRT632859	hsa-miR-8088	HITS-CLIP	23824327
MIRT632858	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632857	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632856	hsa-miR-7977	HITS-CLIP	23824327
MIRT632855	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	22012620
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT632863	hsa-miR-3929	HITS-CLIP	23824327
MIRT632862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT632861	hsa-miR-4478	HITS-CLIP	23824327
MIRT632860	hsa-miR-5690	HITS-CLIP	23824327
MIRT632859	hsa-miR-8088	HITS-CLIP	23824327
MIRT632858	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632857	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632856	hsa-miR-7977	HITS-CLIP	23824327
MIRT632855	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	22012620
MIRT1056135	hsa-miR-3143	CLIP-seq
MIRT1056136	hsa-miR-3144-3p	CLIP-seq
MIRT1056137	hsa-miR-33a	CLIP-seq
MIRT1056138	hsa-miR-33b	CLIP-seq
MIRT1056139	hsa-miR-450b-5p	CLIP-seq
MIRT1056140	hsa-miR-4729	CLIP-seq
MIRT1056141	hsa-miR-491-3p	CLIP-seq
MIRT1056142	hsa-miR-518a-5p	CLIP-seq
MIRT1056143	hsa-miR-527	CLIP-seq
MIRT1056144	hsa-miR-548an	CLIP-seq
MIRT1056145	hsa-miR-548l	CLIP-seq
MIRT1056146	hsa-miR-548n	CLIP-seq
MIRT1056147	hsa-miR-583	CLIP-seq
MIRT1056148	hsa-miR-586	CLIP-seq
MIRT1056149	hsa-miR-875-5p	CLIP-seq
MIRT2682473	hsa-miR-3613-3p	CLIP-seq
MIRT2682474	hsa-miR-4457	CLIP-seq
MIRT2682475	hsa-miR-495	CLIP-seq
MIRT2682476	hsa-miR-607	CLIP-seq

Show/Hide all(45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000795	Component	Synaptonemal complex	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 25036637, 25416956, 28514442, 31515488, 32296183, 32814053
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006986	Process	Response to unfolded protein	TAS	7829106
GO:0007140	Process	Male meiotic nuclear division	TAS	8622925
GO:0007141	Process	Male meiosis I	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007286	Process	Spermatid development	IEA
GO:0009408	Process	Response to heat	ISS
GO:0009409	Process	Response to cold	ISS
GO:0009986	Component	Cell surface	IEA
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016192	Process	Vesicle-mediated transport	IBA	21873635
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0019899	Function	Enzyme binding	IPI	23921388
GO:0031072	Function	Heat shock protein binding	IBA	21873635
GO:0032781	Process	Positive regulation of ATPase activity	IEA
GO:0034620	Process	Cellular response to unfolded protein	IBA	21873635
GO:0036128	Component	CatSper complex	ISS
GO:0042026	Process	Protein refolding	IBA	21873635
GO:0042026	Process	Protein refolding	IDA	21231916
GO:0044183	Function	Protein folding chaperone	IBA	21873635
GO:0048156	Function	Tau protein binding	IEA
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0051082	Function	Unfolded protein binding	IDA	21231916
GO:0051085	Process	Chaperone cofactor-dependent protein refolding	IBA	21873635
GO:0051087	Function	Chaperone binding	IEA
GO:0051787	Function	Misfolded protein binding	IBA	21873635
GO:0051861	Function	Glycolipid binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070194	Process	Synaptonemal complex disassembly	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0072687	Component	Meiotic spindle	ISS
GO:0090084	Process	Negative regulation of inclusion body assembly	IDA	21231916
GO:0097718	Function	Disordered domain specific binding	IPI	15914229
GO:1901896	Process	Positive regulation of ATPase-coupled calcium transmembrane transporter activity	IEA

MIM	HGNC	e!Ensembl
140560	5235	ENSG00000126803

Protein

UniProt ID

P54652

Protein name

Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2)

Protein function

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation

PDB

3I33 , 4FSV , 5FPD , 5FPE , 5FPM , 5FPN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00012	HSP70	7 → 615	Hsp70 protein	Family

Sequence

MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQV
AMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEI
SSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAA
AIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRM
VSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSI
TRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGK
ELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRN
TTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVT
FDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVA
AKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQK
ELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD

Sequence length

639

Interactions

View interactions

	KEGG		Reactome
	Antigen processing and presentation Lipid and atherosclerosis		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	15059925

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533

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