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HSBP1 (heat shock factor binding protein 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3281
Gene nameGene Name - the full gene name approved by the HGNC.
Heat shock factor binding protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HSBP1
SynonymsGene synonyms aliases
NPC-A-13
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q23.3
SummarySummary of gene provided in NCBI Entrez Gene.
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), i
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT709021 hsa-miR-4687-5p HITS-CLIP 19536157
MIRT709020 hsa-miR-4690-3p HITS-CLIP 19536157
MIRT709019 hsa-miR-5685 HITS-CLIP 19536157
MIRT709018 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT709017 hsa-miR-3157-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 9649501
GO:0003714 Function Transcription corepressor activity IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 28514442, 29892012, 31515488, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O75506
Protein name Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)
Protein function Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
PDB 3CI9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06825 HSBP1
10 60
Heat shock factor binding protein 1
Coiled-coil
Sequence
Sequence length 76
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 26503814

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