APBA2 (amyloid beta precursor protein binding family A member 2)

Gene

• Entrez ID: 321
• Gene name: Amyloid beta precursor protein binding family A member 2
• Gene symbol: APBA2
• Synonyms: D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
• Chromosome: 15
• Chromosome location: 15q13.1
• Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer`s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019347	hsa-miR-148b-3p	Microarray	17612493
MIRT039930	hsa-miR-615-3p	CLASH	23622248
MIRT788736	hsa-miR-1253	CLIP-seq
MIRT788737	hsa-miR-1909	CLIP-seq
MIRT788738	hsa-miR-198	CLIP-seq
MIRT788739	hsa-miR-3613-3p	CLIP-seq
MIRT788740	hsa-miR-3922-5p	CLIP-seq
MIRT788741	hsa-miR-3926	CLIP-seq
MIRT788742	hsa-miR-3944-5p	CLIP-seq
MIRT788743	hsa-miR-4270	CLIP-seq
MIRT788744	hsa-miR-4434	CLIP-seq
MIRT788745	hsa-miR-4441	CLIP-seq
MIRT788746	hsa-miR-4516	CLIP-seq
MIRT788747	hsa-miR-455-3p	CLIP-seq
MIRT788748	hsa-miR-4640-5p	CLIP-seq
MIRT788749	hsa-miR-4726-5p	CLIP-seq
MIRT788750	hsa-miR-661	CLIP-seq
MIRT2172904	hsa-miR-1264	CLIP-seq
MIRT2172905	hsa-miR-134	CLIP-seq
MIRT2172906	hsa-miR-1827	CLIP-seq
MIRT2172907	hsa-miR-22	CLIP-seq
MIRT2172908	hsa-miR-2467-3p	CLIP-seq
MIRT2172909	hsa-miR-3118	CLIP-seq
MIRT2172910	hsa-miR-3121-5p	CLIP-seq
MIRT2172911	hsa-miR-3161	CLIP-seq
MIRT2172912	hsa-miR-3164	CLIP-seq
MIRT2172913	hsa-miR-320a	CLIP-seq
MIRT2172914	hsa-miR-320b	CLIP-seq
MIRT2172915	hsa-miR-320c	CLIP-seq
MIRT2172916	hsa-miR-320d	CLIP-seq
MIRT2172917	hsa-miR-3617	CLIP-seq
MIRT2172918	hsa-miR-3657	CLIP-seq
MIRT2172919	hsa-miR-3685	CLIP-seq
MIRT2172920	hsa-miR-4429	CLIP-seq
MIRT2172921	hsa-miR-4522	CLIP-seq
MIRT2172922	hsa-miR-4677-3p	CLIP-seq
MIRT2172923	hsa-miR-4679	CLIP-seq
MIRT2172924	hsa-miR-4697-3p	CLIP-seq
MIRT2172925	hsa-miR-4793-5p	CLIP-seq
MIRT2172926	hsa-miR-483-3p	CLIP-seq
MIRT2172927	hsa-miR-495	CLIP-seq
MIRT2172928	hsa-miR-520d-5p	CLIP-seq
MIRT2172929	hsa-miR-524-5p	CLIP-seq
MIRT2172930	hsa-miR-548u	CLIP-seq
MIRT2172931	hsa-miR-641	CLIP-seq
MIRT2172932	hsa-miR-890	CLIP-seq
MIRT2172906	hsa-miR-1827	CLIP-seq
MIRT2384303	hsa-miR-3665	CLIP-seq
MIRT2384304	hsa-miR-3934	CLIP-seq
MIRT2384305	hsa-miR-4736	CLIP-seq
MIRT2384306	hsa-miR-940	CLIP-seq
MIRT2675129	hsa-miR-3688-5p	CLIP-seq
MIRT2675130	hsa-miR-4470	CLIP-seq
MIRT2172932	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10833507, 17332754, 29578633, 31413325
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	9890987
GO:0008021	Component	Synaptic vesicle	IEA
GO:0015031	Process	Protein transport	IEA
GO:0042802	Function	Identical protein binding	IPI	29578633
GO:0043197	Component	Dendritic spine	IBA	21873635

Other IDs

• MIM: 602712
• HGNC: 579
• e!Ensembl: ENSG00000034053

Protein

• UniProt ID: Q99767
• Protein name: Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2)
• Protein function: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	372 → 530	Phosphotyrosine interaction domain (PTB/PID)	Domain
  PF00595	PDZ	568 → 652	PDZ domain	Domain
  PF00595	PDZ	659 → 732	PDZ domain	Domain

• Sequence:

  MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
  QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
  YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
  EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
  SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
  KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
  CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
  GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
  QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
  KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
  MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
  LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
  SNSVGEIHMKTMPAAMFRLLTGQETPLYI

• Sequence length: 749

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	17989066

Unknown
Disease name	Disease term	dbSNP ID	References
Dermatologic disorders	Dermatologic disorders		28720099