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HOXA9 (homeobox A9)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3205
Gene nameGene Name - the full gene name approved by the HGNC.
Homeobox A9
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HOXA9
SynonymsGene synonyms aliases
ABD-B, HOX1, HOX1.7, HOX1G
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.2
SummarySummary of gene provided in NCBI Entrez Gene.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic develo
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001918 hsa-miR-126-3p GFP reporter assay, qRT-PCR, Western blot 18474618
MIRT001917 hsa-miR-145-5p GFP reporter assay, qRT-PCR, Western blot 18474618
MIRT001917 hsa-miR-145-5p GFP reporter assay, qRT-PCR, Western blot 18474618
MIRT001918 hsa-miR-126-3p Luciferase reporter assay 18474618
MIRT000149 hsa-miR-210-3p Luciferase reporter assay 19782034
Transcription factors
Transcription factor Regulation Reference
CREBBP Activation 16849538
KAT6A Activation 22713874;23994619
NFKB1 Repression 18068911
SALL4 Activation 24051379
SUZ12 Unknown 15225548
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
GO:0003700 Function DNA-binding transcription factor activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P31269
Protein name Homeobox protein Hox-A9 (Homeobox protein Hox-1G)
Protein function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothel
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04617 Hox9_act
1 193
Family
PF00046 Homeodomain
207 263
Homeodomain
Domain
Sequence
Sequence length 272
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Transcriptional misregulation in cancer  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 22541086
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 16778180
Unknown
Disease name Disease term dbSNP ID References
Urinary bladder cancer Malignant neoplasm of urinary bladder 26332997
Bladder neoplasm Bladder Neoplasm 26332997
Myeloid leukemia Acute Myeloid Leukemia, M1 22541086

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