APBA1 (amyloid beta precursor protein binding family A member 1)

Gene

• Entrez ID: 320
• Gene name: Amyloid beta precursor protein binding family A member 1
• Gene symbol: APBA1
• Synonyms: D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA
• Chromosome: 9
• Chromosome location: 9q21.12
• Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer`s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT719460	hsa-miR-132-3p	HITS-CLIP	19536157
MIRT719459	hsa-miR-212-3p	HITS-CLIP	19536157
MIRT719458	hsa-miR-2114-5p	HITS-CLIP	19536157
MIRT719457	hsa-miR-1470	HITS-CLIP	19536157
MIRT719456	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT719455	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT719454	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT719453	hsa-miR-635	HITS-CLIP	19536157
MIRT719452	hsa-miR-6774-5p	HITS-CLIP	19536157
MIRT719451	hsa-miR-1292-5p	HITS-CLIP	19536157
MIRT719450	hsa-miR-4471	HITS-CLIP	19536157
MIRT719449	hsa-miR-8059	HITS-CLIP	19536157
MIRT719448	hsa-miR-7977	HITS-CLIP	19536157
MIRT719447	hsa-miR-450a-1-3p	HITS-CLIP	19536157
MIRT719460	hsa-miR-132-3p	HITS-CLIP	19536157
MIRT719459	hsa-miR-212-3p	HITS-CLIP	19536157
MIRT719458	hsa-miR-2114-5p	HITS-CLIP	19536157
MIRT719457	hsa-miR-1470	HITS-CLIP	19536157
MIRT719456	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT719455	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT719454	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT719453	hsa-miR-635	HITS-CLIP	19536157
MIRT719452	hsa-miR-6774-5p	HITS-CLIP	19536157
MIRT719451	hsa-miR-1292-5p	HITS-CLIP	19536157
MIRT719450	hsa-miR-4471	HITS-CLIP	19536157
MIRT719449	hsa-miR-8059	HITS-CLIP	19536157
MIRT719448	hsa-miR-7977	HITS-CLIP	19536157
MIRT719447	hsa-miR-450a-1-3p	HITS-CLIP	19536157
MIRT788692	hsa-miR-1226	CLIP-seq
MIRT788693	hsa-miR-1228	CLIP-seq
MIRT788694	hsa-miR-128	CLIP-seq
MIRT788695	hsa-miR-139-3p	CLIP-seq
MIRT788696	hsa-miR-146b-3p	CLIP-seq
MIRT788697	hsa-miR-1827	CLIP-seq
MIRT788698	hsa-miR-194	CLIP-seq
MIRT788699	hsa-miR-3122	CLIP-seq
MIRT788700	hsa-miR-3145-3p	CLIP-seq
MIRT788701	hsa-miR-3173-5p	CLIP-seq
MIRT788702	hsa-miR-320a	CLIP-seq
MIRT788703	hsa-miR-320b	CLIP-seq
MIRT788704	hsa-miR-320c	CLIP-seq
MIRT788705	hsa-miR-320d	CLIP-seq
MIRT788706	hsa-miR-3619-3p	CLIP-seq
MIRT788707	hsa-miR-3620	CLIP-seq
MIRT788708	hsa-miR-3622a-3p	CLIP-seq
MIRT788709	hsa-miR-3622b-3p	CLIP-seq
MIRT788710	hsa-miR-3913-5p	CLIP-seq
MIRT788711	hsa-miR-4428	CLIP-seq
MIRT788712	hsa-miR-4429	CLIP-seq
MIRT788713	hsa-miR-4502	CLIP-seq
MIRT788714	hsa-miR-4517	CLIP-seq
MIRT788715	hsa-miR-4520b-3p	CLIP-seq
MIRT788716	hsa-miR-4529-3p	CLIP-seq
MIRT788717	hsa-miR-4533	CLIP-seq
MIRT788718	hsa-miR-4535	CLIP-seq
MIRT788719	hsa-miR-4643	CLIP-seq
MIRT788720	hsa-miR-4663	CLIP-seq
MIRT788721	hsa-miR-4666-5p	CLIP-seq
MIRT788722	hsa-miR-4693-3p	CLIP-seq
MIRT788723	hsa-miR-4698	CLIP-seq
MIRT788724	hsa-miR-4699-3p	CLIP-seq
MIRT788725	hsa-miR-4717-5p	CLIP-seq
MIRT788726	hsa-miR-4738-3p	CLIP-seq
MIRT788727	hsa-miR-4747-5p	CLIP-seq
MIRT788728	hsa-miR-4776-5p	CLIP-seq
MIRT788729	hsa-miR-486-5p	CLIP-seq
MIRT788730	hsa-miR-568	CLIP-seq
MIRT788731	hsa-miR-570	CLIP-seq
MIRT788732	hsa-miR-634	CLIP-seq
MIRT788733	hsa-miR-642b	CLIP-seq
MIRT788734	hsa-miR-874	CLIP-seq
MIRT788735	hsa-miR-9	CLIP-seq
MIRT1932621	hsa-miR-125a-5p	CLIP-seq
MIRT1932622	hsa-miR-125b	CLIP-seq
MIRT1932623	hsa-miR-1275	CLIP-seq
MIRT1932624	hsa-miR-1343	CLIP-seq
MIRT1932625	hsa-miR-3133	CLIP-seq
MIRT1932626	hsa-miR-4260	CLIP-seq
MIRT1932627	hsa-miR-4319	CLIP-seq
MIRT1932628	hsa-miR-4493	CLIP-seq
MIRT1932629	hsa-miR-4659a-3p	CLIP-seq
MIRT1932630	hsa-miR-4659b-3p	CLIP-seq
MIRT1932631	hsa-miR-4665-5p	CLIP-seq
MIRT1932632	hsa-miR-4732-3p	CLIP-seq
MIRT1932633	hsa-miR-670	CLIP-seq
MIRT788735	hsa-miR-9	CLIP-seq
MIRT2172885	hsa-miR-103a	CLIP-seq
MIRT2172886	hsa-miR-107	CLIP-seq
MIRT1932623	hsa-miR-1275	CLIP-seq
MIRT2172887	hsa-miR-1301	CLIP-seq
MIRT2172888	hsa-miR-1321	CLIP-seq
MIRT2172889	hsa-miR-24	CLIP-seq
MIRT2172890	hsa-miR-3192	CLIP-seq
MIRT2172891	hsa-miR-3688-5p	CLIP-seq
MIRT2172892	hsa-miR-3919	CLIP-seq
MIRT1932626	hsa-miR-4260	CLIP-seq
MIRT2172893	hsa-miR-4284	CLIP-seq
MIRT2172894	hsa-miR-4314	CLIP-seq
MIRT2172895	hsa-miR-4646-5p	CLIP-seq
MIRT1932629	hsa-miR-4659a-3p	CLIP-seq
MIRT1932630	hsa-miR-4659b-3p	CLIP-seq
MIRT788720	hsa-miR-4663	CLIP-seq
MIRT1932631	hsa-miR-4665-5p	CLIP-seq
MIRT2172896	hsa-miR-4684-3p	CLIP-seq
MIRT2172897	hsa-miR-4714-3p	CLIP-seq
MIRT788725	hsa-miR-4717-5p	CLIP-seq
MIRT2172898	hsa-miR-4728-5p	CLIP-seq
MIRT2172899	hsa-miR-4739	CLIP-seq
MIRT788727	hsa-miR-4747-5p	CLIP-seq
MIRT2172900	hsa-miR-4756-3p	CLIP-seq
MIRT2172901	hsa-miR-4756-5p	CLIP-seq
MIRT2172902	hsa-miR-5047	CLIP-seq
MIRT2172903	hsa-miR-665	CLIP-seq
MIRT788735	hsa-miR-9	CLIP-seq
MIRT1932623	hsa-miR-1275	CLIP-seq
MIRT2384290	hsa-miR-136	CLIP-seq
MIRT2384291	hsa-miR-181a	CLIP-seq
MIRT2384292	hsa-miR-181b	CLIP-seq
MIRT2384293	hsa-miR-181c	CLIP-seq
MIRT2384294	hsa-miR-181d	CLIP-seq
MIRT2384295	hsa-miR-3064-5p	CLIP-seq
MIRT1932626	hsa-miR-4260	CLIP-seq
MIRT2384296	hsa-miR-4262	CLIP-seq
MIRT2384297	hsa-miR-4276	CLIP-seq
MIRT2384298	hsa-miR-4492	CLIP-seq
MIRT2384299	hsa-miR-4498	CLIP-seq
MIRT1932629	hsa-miR-4659a-3p	CLIP-seq
MIRT1932630	hsa-miR-4659b-3p	CLIP-seq
MIRT1932631	hsa-miR-4665-5p	CLIP-seq
MIRT2384300	hsa-miR-604	CLIP-seq
MIRT2384301	hsa-miR-647	CLIP-seq
MIRT2384302	hsa-miR-762	CLIP-seq
MIRT788735	hsa-miR-9	CLIP-seq
MIRT2476058	hsa-miR-1253	CLIP-seq
MIRT2476059	hsa-miR-1254	CLIP-seq
MIRT1932624	hsa-miR-1343	CLIP-seq
MIRT2476060	hsa-miR-147b	CLIP-seq
MIRT2384291	hsa-miR-181a	CLIP-seq
MIRT2384292	hsa-miR-181b	CLIP-seq
MIRT2384293	hsa-miR-181c	CLIP-seq
MIRT2384294	hsa-miR-181d	CLIP-seq
MIRT2476061	hsa-miR-2392	CLIP-seq
MIRT2476062	hsa-miR-2682	CLIP-seq
MIRT2476063	hsa-miR-3116	CLIP-seq
MIRT2476064	hsa-miR-3117-5p	CLIP-seq
MIRT2476065	hsa-miR-3127-3p	CLIP-seq
MIRT2476066	hsa-miR-3130-3p	CLIP-seq
MIRT2476067	hsa-miR-342-5p	CLIP-seq
MIRT788706	hsa-miR-3619-3p	CLIP-seq
MIRT2476068	hsa-miR-3653	CLIP-seq
MIRT2476069	hsa-miR-3658	CLIP-seq
MIRT2476070	hsa-miR-3679-3p	CLIP-seq
MIRT2476071	hsa-miR-3714	CLIP-seq
MIRT2384296	hsa-miR-4262	CLIP-seq
MIRT2384297	hsa-miR-4276	CLIP-seq
MIRT2172893	hsa-miR-4284	CLIP-seq
MIRT2476072	hsa-miR-4299	CLIP-seq
MIRT2476073	hsa-miR-4434	CLIP-seq
MIRT2476074	hsa-miR-4448	CLIP-seq
MIRT2476075	hsa-miR-4455	CLIP-seq
MIRT2476076	hsa-miR-4456	CLIP-seq
MIRT2476077	hsa-miR-449c	CLIP-seq
MIRT2476078	hsa-miR-4516	CLIP-seq
MIRT2476079	hsa-miR-4531	CLIP-seq
MIRT2476080	hsa-miR-4651	CLIP-seq
MIRT2476081	hsa-miR-4664-5p	CLIP-seq
MIRT2476082	hsa-miR-4746-3p	CLIP-seq
MIRT788728	hsa-miR-4776-5p	CLIP-seq
MIRT2476083	hsa-miR-4793-3p	CLIP-seq
MIRT2476084	hsa-miR-502-5p	CLIP-seq
MIRT2476085	hsa-miR-548an	CLIP-seq
MIRT2476086	hsa-miR-548q	CLIP-seq
MIRT2476087	hsa-miR-608	CLIP-seq
MIRT2476088	hsa-miR-609	CLIP-seq
MIRT2476089	hsa-miR-661	CLIP-seq
MIRT2476090	hsa-miR-940	CLIP-seq
MIRT2675127	hsa-miR-296-5p	CLIP-seq
MIRT2476065	hsa-miR-3127-3p	CLIP-seq
MIRT2476066	hsa-miR-3130-3p	CLIP-seq
MIRT2675128	hsa-miR-3622b-5p	CLIP-seq
MIRT2476068	hsa-miR-3653	CLIP-seq
MIRT2476069	hsa-miR-3658	CLIP-seq
MIRT2476070	hsa-miR-3679-3p	CLIP-seq
MIRT2476071	hsa-miR-3714	CLIP-seq
MIRT2476074	hsa-miR-4448	CLIP-seq
MIRT2476083	hsa-miR-4793-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IBA	21873635
GO:0001701	Process	In utero embryonic development	IEA
GO:0005515	Function	Protein binding	IPI	8887653, 11083918, 16007100, 20531236, 31413325
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006886	Process	Intracellular protein transport	IEA
GO:0007155	Process	Cell adhesion	TAS	9753324
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007269	Process	Neurotransmitter secretion	TAS
GO:0007399	Process	Nervous system development	TAS	9753324
GO:0007626	Process	Locomotory behavior	IEA
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008088	Process	Axo-dendritic transport	TAS	9822620
GO:0010468	Process	Regulation of gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0014051	Process	Gamma-aminobutyric acid secretion	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0043197	Component	Dendritic spine	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048787	Component	Presynaptic active zone membrane	IEA
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 602414
• HGNC: 578
• e!Ensembl: ENSG00000107282

Protein

• UniProt ID: Q02410
• Protein name: Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)
• Protein function: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Co
• PDB: 1AQC, 1U37, 1U38, 1U39, 1U3B, 1X11, 1X45, 1Y7N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	461 → 618	Phosphotyrosine interaction domain (PTB/PID)	Domain
  PF00595	PDZ	656 → 740	PDZ domain	Domain
  PF00595	PDZ	747 → 820	PDZ domain	Domain

• Sequence:

  MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL
  RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV
  QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED
  EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE
  RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL
  ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV
  KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH
  PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN
  VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH
  PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI
  AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE
  KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS
  TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG
  GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI

• Sequence length: 837

Pathways

Reactome:

Dopamine Neurotransmitter Release Cycle

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203