HNF4G (hepatocyte nuclear factor 4 gamma)

Gene

• Entrez ID: 3174
• Gene name: Hepatocyte nuclear factor 4 gamma
• Gene symbol: HNF4G
• Synonyms: NR2A2, NR2A3
• Chromosome: 8
• Chromosome location: 8q21.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT709336	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT709335	hsa-miR-4263	HITS-CLIP	19536157
MIRT709334	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT709333	hsa-miR-3149	HITS-CLIP	19536157
MIRT709332	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT709336	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT709335	hsa-miR-4263	HITS-CLIP	19536157
MIRT709334	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT709333	hsa-miR-3149	HITS-CLIP	19536157
MIRT709332	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT1050583	hsa-miR-101	CLIP-seq
MIRT1050584	hsa-miR-1197	CLIP-seq
MIRT1050585	hsa-miR-139-5p	CLIP-seq
MIRT1050586	hsa-miR-140-5p	CLIP-seq
MIRT1050587	hsa-miR-144	CLIP-seq
MIRT1050588	hsa-miR-3121-3p	CLIP-seq
MIRT1050589	hsa-miR-3646	CLIP-seq
MIRT1050590	hsa-miR-3924	CLIP-seq
MIRT1050591	hsa-miR-410	CLIP-seq
MIRT1050592	hsa-miR-4272	CLIP-seq
MIRT1050593	hsa-miR-4738-3p	CLIP-seq
MIRT1050594	hsa-miR-4796-3p	CLIP-seq
MIRT1050595	hsa-miR-485-3p	CLIP-seq
MIRT1050596	hsa-miR-498	CLIP-seq
MIRT1050597	hsa-miR-513a-3p	CLIP-seq
MIRT1050598	hsa-miR-548v	CLIP-seq
MIRT1050599	hsa-miR-568	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT2243779	hsa-miR-1224-3p	CLIP-seq
MIRT2243780	hsa-miR-1260	CLIP-seq
MIRT2243781	hsa-miR-1260b	CLIP-seq
MIRT2243782	hsa-miR-1269	CLIP-seq
MIRT2243783	hsa-miR-1269b	CLIP-seq
MIRT2243784	hsa-miR-128	CLIP-seq
MIRT2243785	hsa-miR-1280	CLIP-seq
MIRT2243786	hsa-miR-188-3p	CLIP-seq
MIRT2243787	hsa-miR-188-5p	CLIP-seq
MIRT2243788	hsa-miR-27a	CLIP-seq
MIRT2243789	hsa-miR-27b	CLIP-seq
MIRT2243790	hsa-miR-3156-3p	CLIP-seq
MIRT2243791	hsa-miR-4279	CLIP-seq
MIRT2243792	hsa-miR-432	CLIP-seq
MIRT2243793	hsa-miR-4446-5p	CLIP-seq
MIRT2243794	hsa-miR-4529-3p	CLIP-seq
MIRT2243795	hsa-miR-4755-5p	CLIP-seq
MIRT2243796	hsa-miR-617	CLIP-seq
MIRT2243797	hsa-miR-642a	CLIP-seq
MIRT2389077	hsa-miR-1208	CLIP-seq
MIRT2389078	hsa-miR-2909	CLIP-seq
MIRT2389079	hsa-miR-452	CLIP-seq
MIRT2389080	hsa-miR-4676-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12220531
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	23896584
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8622695
GO:0004879	Function	Nuclear receptor activity	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	23896584
GO:0048856	Process	Anatomical structure development	IBA	21873635
GO:0072686	Component	Mitotic spindle	IDA

Other IDs

• MIM: 605966
• HGNC: 5026
• e!Ensembl: ENSG00000164749

Protein

• UniProt ID: Q14541
• Protein name: Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)
• Protein function: Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
• PDB: 1LV2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00105	zf-C4	10 → 79	Zinc finger, C4 type (two domains)	Domain
  PF00104	Hormone_recep	124 → 312	Ligand-binding domain of nuclear hormone receptor	Domain

• Sequence:

  MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK
  RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS
  SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL
  LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL
  KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW
  QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS
  TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL

• Sequence length: 408

Pathways

KEGG:

Maturity onset diabetes of the young

Reactome:

Nuclear Receptor transcription pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	23535729
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	25751625, 29059683, 23535729

Unknown
Disease name	Disease term	dbSNP ID	References
Gout	Gout		23263486
Gouty arthritis	Arthritis, Gouty		23263486
Pancreatic carcinoma	Pancreatic carcinoma		29422604