NR4A1 (nuclear receptor subfamily 4 group A member 1)

Gene

• Entrez ID: 3164
• Gene name: Nuclear receptor subfamily 4 group A member 1
• Gene symbol: NR4A1
• Synonyms: GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
• Chromosome: 12
• Chromosome location: 12q13.13
• Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018925	hsa-miR-335-5p	Microarray	18185580
MIRT023110	hsa-miR-124-3p	Microarray	18668037
MIRT026031	hsa-miR-196a-5p	Sequencing	20371350
MIRT032110	hsa-let-7d-5p	Sequencing	20371350
MIRT048853	hsa-miR-93-5p	CLASH	23622248
MIRT1192779	hsa-miR-15a	CLIP-seq
MIRT1192780	hsa-miR-15b	CLIP-seq
MIRT1192781	hsa-miR-16	CLIP-seq
MIRT1192782	hsa-miR-195	CLIP-seq
MIRT1192783	hsa-miR-214	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT1192785	hsa-miR-3152-3p	CLIP-seq
MIRT1192786	hsa-miR-3173-3p	CLIP-seq
MIRT1192787	hsa-miR-3177-3p	CLIP-seq
MIRT1192788	hsa-miR-3190	CLIP-seq
MIRT1192789	hsa-miR-3202	CLIP-seq
MIRT1192790	hsa-miR-3619-5p	CLIP-seq
MIRT1192791	hsa-miR-3652	CLIP-seq
MIRT1192792	hsa-miR-378g	CLIP-seq
MIRT1192793	hsa-miR-384	CLIP-seq
MIRT1192794	hsa-miR-3924	CLIP-seq
MIRT1192795	hsa-miR-3978	CLIP-seq
MIRT1192796	hsa-miR-424	CLIP-seq
MIRT1192797	hsa-miR-4430	CLIP-seq
MIRT1192798	hsa-miR-4459	CLIP-seq
MIRT1192799	hsa-miR-4476	CLIP-seq
MIRT1192800	hsa-miR-4491	CLIP-seq
MIRT1192801	hsa-miR-4530	CLIP-seq
MIRT1192802	hsa-miR-4533	CLIP-seq
MIRT1192803	hsa-miR-4645-3p	CLIP-seq
MIRT1192804	hsa-miR-4657	CLIP-seq
MIRT1192805	hsa-miR-4666-5p	CLIP-seq
MIRT1192806	hsa-miR-4695-5p	CLIP-seq
MIRT1192807	hsa-miR-4699-3p	CLIP-seq
MIRT1192808	hsa-miR-4722-5p	CLIP-seq
MIRT1192809	hsa-miR-4778-3p	CLIP-seq
MIRT1192810	hsa-miR-4779	CLIP-seq
MIRT1192811	hsa-miR-485-5p	CLIP-seq
MIRT1192812	hsa-miR-497	CLIP-seq
MIRT1192813	hsa-miR-511	CLIP-seq
MIRT1192814	hsa-miR-542-3p	CLIP-seq
MIRT1192815	hsa-miR-579	CLIP-seq
MIRT1192816	hsa-miR-616	CLIP-seq
MIRT1192817	hsa-miR-761	CLIP-seq
MIRT1192818	hsa-miR-875-3p	CLIP-seq
MIRT1192819	hsa-miR-124	CLIP-seq
MIRT1192779	hsa-miR-15a	CLIP-seq
MIRT1192780	hsa-miR-15b	CLIP-seq
MIRT1192781	hsa-miR-16	CLIP-seq
MIRT1192782	hsa-miR-195	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT1192788	hsa-miR-3190	CLIP-seq
MIRT1192820	hsa-miR-342-5p	CLIP-seq
MIRT1192792	hsa-miR-378g	CLIP-seq
MIRT1192793	hsa-miR-384	CLIP-seq
MIRT1192794	hsa-miR-3924	CLIP-seq
MIRT1192796	hsa-miR-424	CLIP-seq
MIRT1192821	hsa-miR-4484	CLIP-seq
MIRT1192800	hsa-miR-4491	CLIP-seq
MIRT1192822	hsa-miR-4509	CLIP-seq
MIRT1192803	hsa-miR-4645-3p	CLIP-seq
MIRT1192823	hsa-miR-4651	CLIP-seq
MIRT1192804	hsa-miR-4657	CLIP-seq
MIRT1192824	hsa-miR-4664-5p	CLIP-seq
MIRT1192805	hsa-miR-4666-5p	CLIP-seq
MIRT1192825	hsa-miR-4693-3p	CLIP-seq
MIRT1192807	hsa-miR-4699-3p	CLIP-seq
MIRT1192826	hsa-miR-4712-3p	CLIP-seq
MIRT1192827	hsa-miR-4717-3p	CLIP-seq
MIRT1192828	hsa-miR-4719	CLIP-seq
MIRT1192829	hsa-miR-4731-3p	CLIP-seq
MIRT1192830	hsa-miR-4742-3p	CLIP-seq
MIRT1192809	hsa-miR-4778-3p	CLIP-seq
MIRT1192831	hsa-miR-4801	CLIP-seq
MIRT1192812	hsa-miR-497	CLIP-seq
MIRT1192832	hsa-miR-506	CLIP-seq
MIRT1192813	hsa-miR-511	CLIP-seq
MIRT1192814	hsa-miR-542-3p	CLIP-seq
MIRT1192833	hsa-miR-548an	CLIP-seq
MIRT1192815	hsa-miR-579	CLIP-seq
MIRT1192834	hsa-miR-608	CLIP-seq
MIRT1192835	hsa-miR-615-5p	CLIP-seq
MIRT1192816	hsa-miR-616	CLIP-seq
MIRT1192836	hsa-miR-933	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT1192833	hsa-miR-548an	CLIP-seq
MIRT2055991	hsa-miR-637	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT1192787	hsa-miR-3177-3p	CLIP-seq
MIRT1192807	hsa-miR-4699-3p	CLIP-seq
MIRT1192788	hsa-miR-3190	CLIP-seq
MIRT1192789	hsa-miR-3202	CLIP-seq
MIRT1192791	hsa-miR-3652	CLIP-seq
MIRT1192793	hsa-miR-384	CLIP-seq
MIRT1192794	hsa-miR-3924	CLIP-seq
MIRT1192795	hsa-miR-3978	CLIP-seq
MIRT1192797	hsa-miR-4430	CLIP-seq
MIRT1192799	hsa-miR-4476	CLIP-seq
MIRT1192800	hsa-miR-4491	CLIP-seq
MIRT1192802	hsa-miR-4533	CLIP-seq
MIRT1192803	hsa-miR-4645-3p	CLIP-seq
MIRT1192804	hsa-miR-4657	CLIP-seq
MIRT1192805	hsa-miR-4666-5p	CLIP-seq
MIRT1192809	hsa-miR-4778-3p	CLIP-seq
MIRT1192813	hsa-miR-511	CLIP-seq
MIRT1192814	hsa-miR-542-3p	CLIP-seq
MIRT1192815	hsa-miR-579	CLIP-seq
MIRT1192816	hsa-miR-616	CLIP-seq
MIRT1192818	hsa-miR-875-3p	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT1192800	hsa-miR-4491	CLIP-seq
MIRT1192804	hsa-miR-4657	CLIP-seq
MIRT1192805	hsa-miR-4666-5p	CLIP-seq
MIRT1192784	hsa-miR-3120-3p	CLIP-seq
MIRT2582513	hsa-miR-1908	CLIP-seq
MIRT1192799	hsa-miR-4476	CLIP-seq
MIRT2582514	hsa-miR-663	CLIP-seq
MIRT2582515	hsa-miR-744	CLIP-seq
MIRT2582513	hsa-miR-1908	CLIP-seq
MIRT1192799	hsa-miR-4476	CLIP-seq
MIRT2582514	hsa-miR-663	CLIP-seq
MIRT2582515	hsa-miR-744	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC7	Unknown	15623513
HIF1A	Activation	14729605
MEF2C	Repression	18079734
PML	Repression	12032831
SP1	Unknown	8961265

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	18059339
GO:0002042	Process	Cell migration involved in sprouting angiogenesis	IDA	18059339
GO:0003677	Function	DNA binding	ISS
GO:0004879	Function	Nuclear receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	17139261, 18305892, 18835031, 18985028, 19095693, 20195357, 21988832, 22761572, 24139859, 25416956, 31515488
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0007165	Process	Signal transduction	TAS	2626032
GO:0008270	Function	Zinc ion binding	IEA
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0035259	Function	Glucocorticoid receptor binding	IBA	21873635
GO:0035767	Process	Endothelial cell chemotaxis	IMP	18059339
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IMP	18059339
GO:0044344	Process	Cellular response to fibroblast growth factor stimulus	IMP	18059339
GO:0045444	Process	Fat cell differentiation	ISS
GO:0045786	Process	Negative regulation of cell cycle	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	22427340
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0061469	Process	Regulation of type B pancreatic cell proliferation	ISS
GO:0071376	Process	Cellular response to corticotropin-releasing hormone stimulus	IBA	21873635
GO:0071376	Process	Cellular response to corticotropin-releasing hormone stimulus	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 139139
• HGNC: 7980
• e!Ensembl: ENSG00000123358

Protein

• UniProt ID: P22736
• Protein name: Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
• Protein function: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy
• PDB: 2QW4, 3V3E, 3V3Q, 4JGV, 4KZI, 4KZJ, 4KZM, 4RE8, 4REE, 4REF, 4RZE, 4RZF, 4RZG, 4WHF, 4WHG, 6KZ5, 6LC1, 8WUY, 8Y7L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00105	zf-C4	265 → 334	Zinc finger, C4 type (two domains)	Domain
  PF00104	Hormone_recep	394 → 579	Ligand-binding domain of nuclear hormone receptor	Domain

• Sequence:

  MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
  TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
  DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
  SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
  EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
  YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
  PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
  AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
  DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
  AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

• Sequence length: 598

Pathways

KEGG:

MAPK signaling pathway
PI3K-Akt signaling pathway
Aldosterone synthesis and secretion
Cortisol synthesis and secretion
Cushing syndrome

Reactome:

AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Kidney disease	Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	24722447
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497	20660371

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		22138541
Endometriosis	Endometriosis	rs1800629, rs1143634	22138541
Involutional depression	Involutional Depression		29175309
Involutional paraphrenia	Involutional paraphrenia		29175309
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29175309
Myocardial ischemia	Myocardial Ischemia		16214533
Pancreatic neoplasm	Pancreatic Neoplasm		20660371
Psychosis	Psychosis, Involutional		29175309