HMOX1 (heme oxygenase 1)

Gene

• Entrez ID: 3162
• Gene name: Heme oxygenase 1
• Gene symbol: HMOX1
• Synonyms: HMOX1D, HO-1, HSP32, bK286B10
• Chromosome: 22
• Chromosome location: 22q12.3
• Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its subs

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1601739478	->G	Likely-pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004719	hsa-miR-196a-5p	Luciferase reporter assay, qRT-PCR, Western blot	20127796
MIRT001455	hsa-miR-16-5p	pSILAC	18668040
MIRT017714	hsa-miR-335-5p	Microarray	18185580
MIRT019368	hsa-miR-148b-3p	Microarray	17612493
MIRT021967	hsa-miR-128-3p	Microarray	17612493
MIRT022531	hsa-miR-124-3p	Microarray	18668037
MIRT023272	hsa-miR-122-5p	Western blot;qRT-PCR	20633528
MIRT023272	hsa-miR-122-5p	Microarray	17612493
MIRT023697	hsa-miR-1-3p	Proteomics	18668040
MIRT029307	hsa-miR-26b-5p	Microarray	19088304
MIRT001455	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT054754	hsa-miR-24-3p	Luciferase reporter assay, Western blot	24854275
MIRT462676	hsa-miR-5193	HITS-CLIP	23824327
MIRT462675	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT462674	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT462673	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT650816	hsa-miR-4448	HITS-CLIP	23824327
MIRT462656	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT462655	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT462654	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT462653	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT462652	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650815	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT462650	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT462683	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462682	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462681	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT462680	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT462679	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT021967	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT462678	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT462677	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT462676	hsa-miR-5193	PAR-CLIP	23592263
MIRT462675	hsa-miR-660-3p	PAR-CLIP	23592263
MIRT462674	hsa-miR-6734-3p	PAR-CLIP	23592263
MIRT462673	hsa-miR-3667-3p	PAR-CLIP	23592263
MIRT462672	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT462671	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT462670	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT462669	hsa-miR-4721	PAR-CLIP	23592263
MIRT462668	hsa-miR-7976	PAR-CLIP	23592263
MIRT462667	hsa-miR-3135b	PAR-CLIP	23592263
MIRT462666	hsa-miR-3612	PAR-CLIP	23592263
MIRT462665	hsa-miR-650	PAR-CLIP	23592263
MIRT462664	hsa-miR-1291	PAR-CLIP	23592263
MIRT462663	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT462662	hsa-miR-3652	PAR-CLIP	23592263
MIRT462661	hsa-miR-4430	PAR-CLIP	23592263
MIRT462660	hsa-miR-4492	PAR-CLIP	23592263
MIRT462659	hsa-miR-4498	PAR-CLIP	23592263
MIRT462658	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT462657	hsa-miR-762	PAR-CLIP	23592263
MIRT462656	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT462655	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT462654	hsa-miR-4691-5p	PAR-CLIP	23592263
MIRT462653	hsa-miR-6792-3p	PAR-CLIP	23592263
MIRT462652	hsa-miR-6749-3p	PAR-CLIP	23592263
MIRT462651	hsa-miR-4443	PAR-CLIP	23592263
MIRT462650	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT733875	hsa-miR-183-5p	Luciferase reporter assay, qRT-PCR, Western blotting	32602850
MIRT735144	hsa-miR-135a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32762552
MIRT735145	hsa-miR-135b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32762552
MIRT462676	hsa-miR-5193	HITS-CLIP	23824327
MIRT462675	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT462674	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT462673	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT650816	hsa-miR-4448	HITS-CLIP	23824327
MIRT462656	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT462655	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT462654	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT462653	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT462652	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650815	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT462650	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT462683	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462682	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462681	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT462680	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT462679	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT021967	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT462678	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT462677	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT462676	hsa-miR-5193	PAR-CLIP	23592263
MIRT462675	hsa-miR-660-3p	PAR-CLIP	23592263
MIRT462674	hsa-miR-6734-3p	PAR-CLIP	23592263
MIRT462673	hsa-miR-3667-3p	PAR-CLIP	23592263
MIRT462672	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT462671	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT462670	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT462669	hsa-miR-4721	PAR-CLIP	23592263
MIRT462668	hsa-miR-7976	PAR-CLIP	23592263
MIRT462667	hsa-miR-3135b	PAR-CLIP	23592263
MIRT462666	hsa-miR-3612	PAR-CLIP	23592263
MIRT462665	hsa-miR-650	PAR-CLIP	23592263
MIRT462664	hsa-miR-1291	PAR-CLIP	23592263
MIRT462663	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT462662	hsa-miR-3652	PAR-CLIP	23592263
MIRT462661	hsa-miR-4430	PAR-CLIP	23592263
MIRT462660	hsa-miR-4492	PAR-CLIP	23592263
MIRT462659	hsa-miR-4498	PAR-CLIP	23592263
MIRT462658	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT462657	hsa-miR-762	PAR-CLIP	23592263
MIRT462656	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT462655	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT462654	hsa-miR-4691-5p	PAR-CLIP	23592263
MIRT462653	hsa-miR-6792-3p	PAR-CLIP	23592263
MIRT462652	hsa-miR-6749-3p	PAR-CLIP	23592263
MIRT462651	hsa-miR-4443	PAR-CLIP	23592263
MIRT462650	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT1050128	hsa-miR-1185	CLIP-seq
MIRT1050129	hsa-miR-1245b-5p	CLIP-seq
MIRT1050130	hsa-miR-128	CLIP-seq
MIRT1050131	hsa-miR-1295	CLIP-seq
MIRT1050132	hsa-miR-1304	CLIP-seq
MIRT1050133	hsa-miR-200b	CLIP-seq
MIRT1050134	hsa-miR-200c	CLIP-seq
MIRT1050135	hsa-miR-217	CLIP-seq
MIRT1050136	hsa-miR-2467-5p	CLIP-seq
MIRT1050137	hsa-miR-3065-5p	CLIP-seq
MIRT1050138	hsa-miR-3142	CLIP-seq
MIRT1050139	hsa-miR-3163	CLIP-seq
MIRT1050140	hsa-miR-3188	CLIP-seq
MIRT1050141	hsa-miR-3687	CLIP-seq
MIRT1050142	hsa-miR-371-3p	CLIP-seq
MIRT1050143	hsa-miR-3922-5p	CLIP-seq
MIRT1050144	hsa-miR-3929	CLIP-seq
MIRT1050145	hsa-miR-3975	CLIP-seq
MIRT1050146	hsa-miR-429	CLIP-seq
MIRT1050147	hsa-miR-4297	CLIP-seq
MIRT1050148	hsa-miR-4313	CLIP-seq
MIRT1050149	hsa-miR-4418	CLIP-seq
MIRT1050150	hsa-miR-4419b	CLIP-seq
MIRT1050151	hsa-miR-4442	CLIP-seq
MIRT1050152	hsa-miR-4478	CLIP-seq
MIRT1050153	hsa-miR-4493	CLIP-seq
MIRT1050154	hsa-miR-4663	CLIP-seq
MIRT1050155	hsa-miR-4670-3p	CLIP-seq
MIRT1050156	hsa-miR-4717-5p	CLIP-seq
MIRT1050157	hsa-miR-4753-5p	CLIP-seq
MIRT1050158	hsa-miR-485-5p	CLIP-seq
MIRT1050159	hsa-miR-509-3-5p	CLIP-seq
MIRT1050160	hsa-miR-509-5p	CLIP-seq
MIRT1050161	hsa-miR-548ac	CLIP-seq
MIRT1050162	hsa-miR-548ae	CLIP-seq
MIRT1050163	hsa-miR-548aj	CLIP-seq
MIRT1050164	hsa-miR-548am	CLIP-seq
MIRT1050165	hsa-miR-548d-3p	CLIP-seq
MIRT1050166	hsa-miR-548x	CLIP-seq
MIRT1050167	hsa-miR-548z	CLIP-seq
MIRT1050168	hsa-miR-873	CLIP-seq
MIRT1050128	hsa-miR-1185	CLIP-seq
MIRT2437630	hsa-miR-3155	CLIP-seq
MIRT1050148	hsa-miR-4313	CLIP-seq
MIRT1050155	hsa-miR-4670-3p	CLIP-seq
MIRT1050168	hsa-miR-873	CLIP-seq
MIRT1050128	hsa-miR-1185	CLIP-seq
MIRT2546899	hsa-miR-1206	CLIP-seq
MIRT1050129	hsa-miR-1245b-5p	CLIP-seq
MIRT2546900	hsa-miR-1251	CLIP-seq
MIRT2546901	hsa-miR-1254	CLIP-seq
MIRT1050130	hsa-miR-128	CLIP-seq
MIRT1050131	hsa-miR-1295	CLIP-seq
MIRT2546902	hsa-miR-1306	CLIP-seq
MIRT2546903	hsa-miR-148a	CLIP-seq
MIRT2546904	hsa-miR-148b	CLIP-seq
MIRT2546905	hsa-miR-152	CLIP-seq
MIRT2546906	hsa-miR-2110	CLIP-seq
MIRT2546907	hsa-miR-218	CLIP-seq
MIRT2546908	hsa-miR-3116	CLIP-seq
MIRT2546909	hsa-miR-3123	CLIP-seq
MIRT2546910	hsa-miR-3140-3p	CLIP-seq
MIRT1050138	hsa-miR-3142	CLIP-seq
MIRT2546911	hsa-miR-3150a-3p	CLIP-seq
MIRT2437630	hsa-miR-3155	CLIP-seq
MIRT2546912	hsa-miR-3183	CLIP-seq
MIRT2546913	hsa-miR-3192	CLIP-seq
MIRT2546914	hsa-miR-3194-5p	CLIP-seq
MIRT2546915	hsa-miR-328	CLIP-seq
MIRT2546916	hsa-miR-3614-3p	CLIP-seq
MIRT1050141	hsa-miR-3687	CLIP-seq
MIRT2546917	hsa-miR-371b-3p	CLIP-seq
MIRT2546918	hsa-miR-3938	CLIP-seq
MIRT2546919	hsa-miR-4271	CLIP-seq
MIRT2546920	hsa-miR-4276	CLIP-seq
MIRT2546921	hsa-miR-4292	CLIP-seq
MIRT1050147	hsa-miR-4297	CLIP-seq
MIRT2546922	hsa-miR-4300	CLIP-seq
MIRT1050148	hsa-miR-4313	CLIP-seq
MIRT2546923	hsa-miR-4317	CLIP-seq
MIRT1050151	hsa-miR-4442	CLIP-seq
MIRT1050153	hsa-miR-4493	CLIP-seq
MIRT1050155	hsa-miR-4670-3p	CLIP-seq
MIRT1050156	hsa-miR-4717-5p	CLIP-seq
MIRT2546924	hsa-miR-4723-3p	CLIP-seq
MIRT2546925	hsa-miR-4725-3p	CLIP-seq
MIRT2546926	hsa-miR-4764-5p	CLIP-seq
MIRT2546927	hsa-miR-4766-5p	CLIP-seq
MIRT2546928	hsa-miR-4786-3p	CLIP-seq
MIRT2546929	hsa-miR-636	CLIP-seq
MIRT2546930	hsa-miR-642a	CLIP-seq
MIRT2546931	hsa-miR-661	CLIP-seq
MIRT2546932	hsa-miR-671-5p	CLIP-seq
MIRT1050168	hsa-miR-873	CLIP-seq
MIRT2546933	hsa-miR-920	CLIP-seq
MIRT1050128	hsa-miR-1185	CLIP-seq
MIRT2546899	hsa-miR-1206	CLIP-seq
MIRT1050129	hsa-miR-1245b-5p	CLIP-seq
MIRT2546900	hsa-miR-1251	CLIP-seq
MIRT2546901	hsa-miR-1254	CLIP-seq
MIRT1050130	hsa-miR-128	CLIP-seq
MIRT1050131	hsa-miR-1295	CLIP-seq
MIRT2546902	hsa-miR-1306	CLIP-seq
MIRT2546903	hsa-miR-148a	CLIP-seq
MIRT2546904	hsa-miR-148b	CLIP-seq
MIRT2546905	hsa-miR-152	CLIP-seq
MIRT2546906	hsa-miR-2110	CLIP-seq
MIRT2546907	hsa-miR-218	CLIP-seq
MIRT2546908	hsa-miR-3116	CLIP-seq
MIRT2546909	hsa-miR-3123	CLIP-seq
MIRT2546910	hsa-miR-3140-3p	CLIP-seq
MIRT1050138	hsa-miR-3142	CLIP-seq
MIRT2546911	hsa-miR-3150a-3p	CLIP-seq
MIRT2437630	hsa-miR-3155	CLIP-seq
MIRT2546912	hsa-miR-3183	CLIP-seq
MIRT2546913	hsa-miR-3192	CLIP-seq
MIRT2546914	hsa-miR-3194-5p	CLIP-seq
MIRT2546915	hsa-miR-328	CLIP-seq
MIRT2546916	hsa-miR-3614-3p	CLIP-seq
MIRT1050141	hsa-miR-3687	CLIP-seq
MIRT2546917	hsa-miR-371b-3p	CLIP-seq
MIRT2546918	hsa-miR-3938	CLIP-seq
MIRT2546919	hsa-miR-4271	CLIP-seq
MIRT2546920	hsa-miR-4276	CLIP-seq
MIRT2546921	hsa-miR-4292	CLIP-seq
MIRT1050147	hsa-miR-4297	CLIP-seq
MIRT2546922	hsa-miR-4300	CLIP-seq
MIRT1050148	hsa-miR-4313	CLIP-seq
MIRT2546923	hsa-miR-4317	CLIP-seq
MIRT1050151	hsa-miR-4442	CLIP-seq
MIRT1050153	hsa-miR-4493	CLIP-seq
MIRT1050155	hsa-miR-4670-3p	CLIP-seq
MIRT1050156	hsa-miR-4717-5p	CLIP-seq
MIRT2546924	hsa-miR-4723-3p	CLIP-seq
MIRT2546925	hsa-miR-4725-3p	CLIP-seq
MIRT2546926	hsa-miR-4764-5p	CLIP-seq
MIRT2546927	hsa-miR-4766-5p	CLIP-seq
MIRT2546928	hsa-miR-4786-3p	CLIP-seq
MIRT2546929	hsa-miR-636	CLIP-seq
MIRT2546930	hsa-miR-642a	CLIP-seq
MIRT2546931	hsa-miR-661	CLIP-seq
MIRT2546932	hsa-miR-671-5p	CLIP-seq
MIRT1050168	hsa-miR-873	CLIP-seq
MIRT2546933	hsa-miR-920	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Activation	11965035
BACH1	Activation	17942419
BACH1	Repression	17409198;18550526;21982894
CREB1	Repression	14523007
ERG	Unknown	10022513
ETS1	Unknown	10022513
FLI1	Unknown	10022513
NFE2L2	Activation	16551619;21982894;22484158
NFE2L2	Repression	22459801
NFE2L2	Unknown	17942419;24035498
NFKB1	Unknown	8016102
PPARA	Unknown	17413033
PPARG	Unknown	17413033
RELA	Unknown	8016102
SMAD7	Unknown	11018038
SREBF1	Unknown	17452746
STAT1	Activation	19129475
STAT3	Activation	19129475
TFAP2A	Unknown	8016102
USF1	Activation	15242350
USF2	Activation	15242350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	TAS	12239590
GO:0001935	Process	Endothelial cell proliferation	TAS	12239590
GO:0002246	Process	Wound healing involved in inflammatory response	IMP	9884342
GO:0002686	Process	Negative regulation of leukocyte migration	TAS	14525760
GO:0004392	Function	Heme oxygenase (decyclizing) activity	IBA	21873635
GO:0004392	Function	Heme oxygenase (decyclizing) activity	IDA	17915953
GO:0004392	Function	Heme oxygenase (decyclizing) activity	IMP	19556236
GO:0004630	Function	Phospholipase D activity	IEA
GO:0005198	Function	Structural molecule activity	IMP	19556236
GO:0005515	Function	Protein binding	IPI	21044950, 21597468, 32296183
GO:0005615	Component	Extracellular space	TAS	18307065
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	19556236, 22503972
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	IEA
GO:0005901	Component	Caveola	IEA
GO:0006788	Process	Heme oxidation	IBA	21873635
GO:0006788	Process	Heme oxidation	IDA	17915953
GO:0006879	Process	Cellular iron ion homeostasis	IMP	22989377
GO:0006879	Process	Cellular iron ion homeostasis	TAS
GO:0006979	Process	Response to oxidative stress	IBA	21873635
GO:0006979	Process	Response to oxidative stress	IMP	9884342
GO:0007264	Process	Small GTPase mediated signal transduction	IEA
GO:0007588	Process	Excretion	IC	17915953
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0008219	Process	Cell death	ISS
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:0010656	Process	Negative regulation of muscle cell apoptotic process	IEA
GO:0014806	Process	Smooth muscle hyperplasia	TAS	18289072
GO:0016020	Component	Membrane	TAS	3345742
GO:0016239	Process	Positive regulation of macroautophagy	IEA
GO:0016242	Process	Negative regulation of macroautophagy	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019899	Function	Enzyme binding	ISS	15516695
GO:0020037	Function	Heme binding	IBA	21873635
GO:0020037	Function	Heme binding	IDA	17915953
GO:0031670	Process	Cellular response to nutrient	IEA
GO:0032722	Process	Positive regulation of chemokine production	TAS	17652371
GO:0032764	Process	Negative regulation of mast cell cytokine production	IEA
GO:0034101	Process	Erythrocyte homeostasis	IMP	9884342
GO:0034383	Process	Low-density lipoprotein particle clearance	TAS	9884342
GO:0034395	Process	Regulation of transcription from RNA polymerase II promoter in response to iron	IEA
GO:0034605	Process	Cellular response to heat	IMP	21597468
GO:0035094	Process	Response to nicotine	IDA	18205746
GO:0035556	Process	Intracellular signal transduction	TAS	17652371
GO:0042167	Process	Heme catabolic process	IBA	21873635
GO:0042167	Process	Heme catabolic process	IDA	17915953
GO:0042167	Process	Heme catabolic process	TAS
GO:0042493	Process	Response to drug	IEA
GO:0042542	Process	Response to hydrogen peroxide	ISS
GO:0042802	Function	Identical protein binding	IPI	19556236
GO:0042803	Function	Protein homodimerization activity	IDA	19556236
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP	12761501
GO:0043305	Process	Negative regulation of mast cell degranulation	IEA
GO:0043392	Process	Negative regulation of DNA binding	IEA
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043619	Process	Regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISS
GO:0043627	Process	Response to estrogen	IEA
GO:0045765	Process	Regulation of angiogenesis	TAS	17652371
GO:0045766	Process	Positive regulation of angiogenesis	IDA	21788589
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	22503972
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IDA	17600318
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	17600318
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	ISS
GO:0055072	Process	Iron ion homeostasis	IBA	21873635
GO:0055072	Process	Iron ion homeostasis	IDA	17915953
GO:0055072	Process	Iron ion homeostasis	IMP	9884342
GO:0071243	Process	Cellular response to arsenic-containing substance	IEA
GO:0071276	Process	Cellular response to cadmium ion	IEA
GO:0071456	Process	Cellular response to hypoxia	IEP	12511571
GO:0072719	Process	Cellular response to cisplatin	IEA
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	24844779
GO:0097421	Process	Liver regeneration	IEA
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP	18202225
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	24844779
GO:1904036	Process	Negative regulation of epithelial cell apoptotic process	IEA
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IEA

Other IDs

• MIM: 141250
• HGNC: 5013
• e!Ensembl: ENSG00000100292

Protein

• UniProt ID: P09601
• Protein name: Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form]
• Protein function: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, Pu
• PDB: 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ, 6EHA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01126	Heme_oxygenase	11 → 216	Heme oxygenase	Domain

• Sequence:

  MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
  LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
  VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
  LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
  SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

• Sequence length: 288

Pathways

KEGG:

Porphyrin metabolism
Metabolic pathways
HIF-1 signaling pathway
Ferroptosis
Mineral absorption
Pathways in cancer
MicroRNAs in cancer
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis

Reactome:

Heme degradation
Interleukin-4 and Interleukin-13 signaling
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adrenoleukodystrophy	Adrenoleukodystrophy	rs128624213, rs128624214, rs1569541109, rs128624215, rs128624216, rs128624217, rs128624218, rs128624219, rs128624220, rs128624221, rs387906494, rs128624222, rs128624223, rs387906495, rs128624224, rs1569541096, rs2147483647, rs128624225, rs11146842, rs4010613, rs387906496, rs1569541198, rs1569540743, rs387906497, rs193922093, rs193922097, rs193922098, rs398123100, rs398123102, rs398123105, rs398123106, rs398123107, rs398123108, rs398123110, rs398123111, rs398123112, rs713993050, rs201568579, rs150346282, rs797044610, rs797044625, rs797044726, rs864309520, rs886044777, rs1057516052, rs1057517954, rs1064793877, rs1131691916, rs1131691743, rs1557054318, rs1557054153, rs1557052302, rs1557052362, rs1557054873, rs1557055340, rs1557052530, rs1557055392, rs1557052171, rs1557054875, rs1557052294, rs1557052390, rs1557052397, rs1557054210, rs1170974058, rs727503786, rs1557055405, rs1557055311, rs1557052555, rs1557052133, rs1159943880, rs1557054776, rs1557052351, rs1557055253, rs1557055398, rs1557052573, rs1557055260, rs1292006620, rs1569540693, rs782266592, rs1557055316, rs1569540676, rs1569541115, rs1569541000, rs1569541088, rs1569541203, rs1569540688, rs1569540883, rs1569541009, rs1569540665, rs1569540695, rs1569540704, rs1569541006, rs781862879, rs1557055337, rs1569541207, rs1603235321, rs1603231653, rs1603231784, rs1603231897, rs1603232111, rs1603232195, rs1603232243, rs1603233089, rs1603233113, rs1603234451, rs1603234759, rs1603235901, rs1603236012, rs1603235263, rs1603235389, rs1603231911, rs1603233120, rs1603234501, rs1603236020, rs1603231848, rs1603232237, rs1603234466, rs1603235267, rs1603235421, rs1603235941, rs1603234574, rs1603236013, rs2091702389, rs2091711094, rs2091711370, rs782509393, rs2091726671, rs2091726809, rs1557054173, rs2091749146, rs2091762383, rs2091763089, rs2091764526, rs2091764754, rs2091774046, rs2091775068, rs2091727061, rs2091708827, rs2091774163, rs2091726242	16319717
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	11144356
Amyloidosis	Amyloidosis	rs63750567, rs63750560, rs387906821, rs387906822, rs387906823, rs1561123748, rs140352180, rs770211260, rs763065333, rs1554300664, rs747723062, rs773435101	21088618
Anemia	Anemia, Hemolytic, Anemia, Hemolytic, Acquired, Anemia, Microangiopathic	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	9884342
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	18048809
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	16298037
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	16298037
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	12136229
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	16959961, 12136229, 16123366
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	22490514, 14647439
Hyperinsulinism	Hyperinsulinism	rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180	19171794
Hypertension	Hypertensive disease	rs13306026, rs13333226	16959961, 22352330, 22349312
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	15688187, 18508827
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	16298037
Moyamoya disease	Arterial Diseases, Common Carotid	rs121434527, rs121434528, rs387906592, rs397514563, rs797045187, rs1555675538, rs1568149971, rs1599150380, rs2079443410	17095719
Myocardial infarction	Myocardial Failure	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	22352330
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	19171794, 18334666, 18375438
Parkinson disease	Parkinson Disease	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	21318773
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25246272
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	15814490
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22875919
Spinocerebellar ataxia	SPINOCEREBELLAR ATAXIA 17	rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926, rs104894393, rs587776685, rs121908216, rs121908215, rs121908217, rs121909326, rs121918511, rs121918512, rs121918513, rs121918514, rs121918515, rs121918516, rs121918517, rs121918518, rs1555808841, rs104894699, rs104894700, rs121912425, rs121913123, rs267606939, rs201486601, rs387906679, rs151344514, rs151344515, rs151344517, rs387907033, rs387907089, rs794726680, rs761213683, rs794726681, rs1555779353, rs151344513, rs151344518, rs151344522, rs397514535, rs397514536, rs318240735, rs386134171, rs386134158, rs386134159, rs386134160, rs386134161, rs386134162, rs386134163, rs386134164, rs386134165, rs386134166, rs386134168, rs386134170, rs386134169, rs146859515, rs373728971, rs397515475, rs397515476, rs587777052, rs121908247, rs121908200, rs398122959, rs587777127, rs587777128, rs587777235, rs587777340, rs587777341, rs587777342, rs587777344, rs587777345, rs587777346, rs587777347, rs587780326, rs587777670, rs587777671, rs606231451, rs606231452, rs540331226, rs144272231, rs690016544, rs727502823, rs372250159, rs793888526, rs876657385, rs869320748, rs876657386, rs786205229, rs876657387, rs774694340, rs786205867, rs794727411, rs797044955, rs797044872, rs797045634, rs797045240, rs765592794, rs797045900, rs748445058, rs863223919, rs765987297, rs863224882, rs753611141, rs869025292, rs869025293, rs755221106, rs869312685, rs751181600, rs886037832, rs875989881, rs372245668, rs879255601, rs876657414, rs752281590, rs879253883, rs1114167316, rs879255651, rs879255653, rs879255654, rs886039392, rs540839115, rs886039762, rs201128942, rs886041279, rs531656357, rs1057519453, rs1057519454, rs573267388, rs1057519561, rs200277996, rs1064795856, rs749320057, rs750331613, rs1131692265, rs761564262, rs1555768154, rs1210764379, rs758937084, rs1555475283, rs1555475375, rs760424025, rs1555806333, rs1554308513, rs1554274719, rs1554317158, rs201920319, rs1553724533, rs1554985851, rs768831597, rs1554986345, rs1555755878, rs1554902760, rs368143665, rs1555370787, rs1322796318, rs1553756062, rs772345347, rs149905705, rs1555475794, rs760752847, rs1555781806, rs1555738369, rs1554986337, rs1184563885, rs1553758021, rs1559718601, rs1206950481, rs1568523843, rs748984540, rs1557539450, rs1557541619, rs771145682, rs1564808324, rs1567283195, rs752352896, rs1557794465, rs547792505, rs193922929, rs1571636501, rs1571636508, rs1571939827, rs1571939905, rs1559603328, rs1562374476, rs1599651549, rs1590020571, rs1598832526, rs1575415900, rs779142717, rs781016340, rs1366090807, rs1579319300, rs1311909367, rs1589625941, rs749656742, rs1317590341, rs1599943097, rs1590955348, rs749679347, rs1590911156, rs1395191127, rs1405576707, rs541484241, rs1598820860, rs1598832568, rs1589611043, rs758809498, rs754446573	24413982

Unknown
Disease name	Disease term	dbSNP ID	References
Adrenomyeloneuropathy	Adrenomyeloneuropathy		16319717
Alveolitis	Alveolitis, Fibrosing		15814490
Blood coagulation disorders	Blood Coagulation Disorders		9884342
Mammary neoplasms	Mammary Neoplasms, Human, Mammary Neoplasms		16298037
Carotid artery disease	Carotid Artery Diseases, External Carotid Artery Diseases, Internal Carotid Artery Diseases		17095719
Carotid atherosclerosis	Carotid Atherosclerosis		17095719
Cirrhosis	Cirrhosis	rs119465999, rs144369314, rs8056684, rs112053857, rs75998507	18784349
Colitis	Colitis		21444764, 16365149
Compensatory hyperinsulinemia	Compensatory Hyperinsulinemia		19171794
Congestive heart failure	Congestive heart failure	rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569	22352330
Coronary arteriosclerosis	Coronary Arteriosclerosis		12136229
Degenerative diseases, central nervous system	Degenerative Diseases, Central Nervous System, Degenerative Diseases, Spinal Cord		15964507, 10942521, 12709579, 10942521, 15964507, 12709579
Diabetic cardiomyopathy	Diabetic Angiopathies, Microangiopathy, Diabetic		16959961
Emphysema	Focal Emphysema		10631150
Endogenous hyperinsulinism	Endogenous Hyperinsulinism		19171794
Exogenous hyperinsulinism	Exogenous Hyperinsulinism		19171794
Gastroparesis	Gastroparesis		20378827
Grand mal status epilepticus	Grand Mal Status Epilepticus		20971094
Heart failure	Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	22352330
Heme oxygenase 1 deficiency	Heme Oxygenase 1 Deficiency, Heme oxygenase-1 deficiency
Hepatorenal syndrome	Hepatorenal Syndrome		21253390
Indolent systemic mastocytosis	Indolent Systemic Mastocytosis		17420286
Intravascular hemolysis	Intravascular hemolysis		25247420
Iron metabolism disorders	Iron Metabolism Disorders		9884342
Kidney failure	Kidney Failure, Acute, Kidney Failure, Chronic		21048024, 22622455
Learning disorders	Learning Disorders, Adult Learning Disorders, Learning Disturbance, Learning Disabilities		11718997
Liver neoplasms	Liver neoplasms		17002867
Liver cancer	Malignant neoplasm of liver		17002867
Lung neoplasms	Lung Neoplasms		15688187, 18508827
Mastocytosis	Mastocytosis, Systemic		17420286
Microangiopathic hemolytic anemia	Microangiopathic hemolytic anemia		9884342
Myocardial ischemia	Myocardial Ischemia		16214533
Neurodegenerative disorders	Neurodegenerative Disorders		12709579, 15964507, 10942521
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		20971094
Panacinar emphysema	Panacinar Emphysema		10631150
Pancreatic diseases	Pancreatic Diseases		18784349
Petit mal status	Petit mal status		20971094
Prostatic neoplasms	Prostatic Neoplasms		25246272
Pulmonary emphysema	Pulmonary Emphysema, Centriacinar Emphysema		10631150
Acute kidney insufficiency	Acute Kidney Insufficiency		21048024
Retinal diseases	Retinal Diseases		23075401
Senile dementia	Presenile dementia, Acute Confusional Senile Dementia		11144356
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		20971094
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		22490514, 14647439
Systemic mastocytosis	Aggressive Systemic Mastocytosis		17420286