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HMGB2 (high mobility group box 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3148
Gene nameGene Name - the full gene name approved by the HGNC.
High mobility group box 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HMGB2
SynonymsGene synonyms aliases
HMG2
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q34.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated t
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025152 hsa-miR-181a-5p Microarray 17612493
MIRT028203 hsa-miR-33a-5p Sequencing 20371350
MIRT030580 hsa-miR-24-3p Microarray 19748357
MIRT044016 hsa-miR-374a-5p CLASH 23622248
MIRT438692 hsa-miR-23a-3p Luciferase reporter assay, qRT-PCR, Western blot 23986579
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000400 Function Four-way junction DNA binding ISS
GO:0000785 Component Chromatin ISS
GO:0000793 Component Condensed chromosome IDA 12925773
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 19965638
GO:0000987 Function Cis-regulatory region sequence-specific DNA binding ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P26583
Protein name High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Protein function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2
6 79
HMG-box domain
Domain
PF00505 HMG_box
95 163
HMG (high mobility group) box
Domain
Sequence
Sequence length 209
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Apoptosis induced DNA fragmentation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382 24366584, 27602772
Obesity Obesity rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 20882379
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29877212
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 20851854
Prostatic neoplasms Prostatic Neoplasms 29877212

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