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HMGB1 (high mobility group box 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3146
Gene nameGene Name - the full gene name approved by the HGNC.
High mobility group box 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HMGB1
SynonymsGene synonyms aliases
HMG-1, HMG1, HMG3, SBP-1
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular proces
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007157 hsa-miR-22-3p Luciferase reporter assay, qRT-PCR, Western blot 23303785
MIRT016305 hsa-miR-193b-3p Microarray 20304954
MIRT052166 hsa-let-7b-5p CLASH 23622248
MIRT051522 hsa-let-7e-5p CLASH 23622248
MIRT050047 hsa-miR-26b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NFIC Activation 11245470
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IGI 19158276
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19158276
GO:0000400 Function Four-way junction DNA binding ISS
GO:0000405 Function Bubble DNA binding ISS
GO:0000793 Component Condensed chromosome IDA 12925773
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P09429
Protein name High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Protein function Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chrom
PDB 2LY4 , 2RTU , 2YRQ , 6CG0 , 6CIJ , 6CIK , 6CIL , 6CIM , 6OEM , 6OEN , 6OEO , 8I9M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2
6 78
HMG-box domain
Domain
PF00505 HMG_box
95 163
HMG (high mobility group) box
Domain
Sequence
Sequence length 215
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Base excision repair
Autophagy - animal
Necroptosis
Neutrophil extracellular trap formation
  Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Myocardial infarction Myocardial Infarction rs12316150, rs41303970, rs909253, rs7291467, rs2234693 21113057
Neuropathy Neuropathy, Painful rs121913593, rs121913595, rs751050956, rs878853221, rs768554986, rs1553259568, rs1567973091, rs1560046845, rs1567969825, rs1567973088, rs756896276 27474498
Unknown
Disease name Disease term dbSNP ID References
Alveolitis Alveolitis, Fibrosing 27616297
Leukostasis Leukostasis 28294475
Myocardial ischemia Myocardial Ischemia 16214533
Septicemia Septicemia 23146691, 19265175

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