HLA-E (major histocompatibility complex, class I, E)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3133 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Major histocompatibility complex, class I, E |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
HLA-E |
SynonymsGene synonyms aliases
|
HLA-6.2, QA1 |
ChromosomeChromosome number
|
6 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6p22.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000139 |
Component |
Golgi membrane |
TAS |
|
GO:0001815 |
Process |
Positive regulation of antibody-dependent cellular cytotoxicity |
IDA |
30134159 |
GO:0001916 |
Process |
Positive regulation of T cell mediated cytotoxicity |
IBA |
21873635 |
GO:0001916 |
Process |
Positive regulation of T cell mediated cytotoxicity |
IDA |
25631937 |
GO:0002250 |
Process |
Adaptive immune response |
IDA |
25631937 |
GO:0002474 |
Process |
Antigen processing and presentation of peptide antigen via MHC class I |
TAS |
|
GO:0002476 |
Process |
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
IBA |
21873635 |
GO:0002476 |
Process |
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
IDA |
9754572 |
GO:0002477 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
IDA |
30087334 |
GO:0002479 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS |
|
GO:0002480 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
TAS |
|
GO:0002486 |
Process |
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
IBA |
21873635 |
GO:0002519 |
Process |
Natural killer cell tolerance induction |
IDA |
9486650 |
GO:0002639 |
Process |
Positive regulation of immunoglobulin production |
IDA |
25631937 |
GO:0002715 |
Process |
Regulation of natural killer cell mediated immunity |
IDA |
18448674 |
GO:0002717 |
Process |
Positive regulation of natural killer cell mediated immunity |
IDA |
9754572 |
GO:0002729 |
Process |
Positive regulation of natural killer cell cytokine production |
IDA |
30134159 |
GO:0005102 |
Function |
Signaling receptor binding |
IBA |
21873635 |
GO:0005102 |
Function |
Signaling receptor binding |
IPI |
18448674 |
GO:0005515 |
Function |
Protein binding |
IPI |
9427624, 18083576, 20483783 |
GO:0005615 |
Component |
Extracellular space |
IBA |
21873635 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
9427624, 17179229 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0006955 |
Process |
Immune response |
IBA |
21873635 |
GO:0009897 |
Component |
External side of plasma membrane |
IBA |
21873635 |
GO:0009986 |
Component |
Cell surface |
IDA |
9754572, 12411439, 25631937 |
GO:0012507 |
Component |
ER to Golgi transport vesicle membrane |
TAS |
|
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0019731 |
Process |
Antibacterial humoral response |
IDA |
25631937 |
GO:0030670 |
Component |
Phagocytic vesicle membrane |
TAS |
|
GO:0030881 |
Function |
Beta-2-microglobulin binding |
IDA |
16474394, 18339401, 18448674, 25631937, 30087334 |
GO:0030881 |
Function |
Beta-2-microglobulin binding |
IMP |
12411439 |
GO:0031901 |
Component |
Early endosome membrane |
TAS |
|
GO:0032398 |
Component |
MHC class Ib protein complex |
IDA |
9427624, 23335510, 25631937, 30087334 |
GO:0032736 |
Process |
Positive regulation of interleukin-13 production |
IDA |
25631937 |
GO:0032753 |
Process |
Positive regulation of interleukin-4 production |
IDA |
25631937 |
GO:0032759 |
Process |
Positive regulation of TRAIL production |
IDA |
25631937 |
GO:0032760 |
Process |
Positive regulation of tumor necrosis factor production |
IDA |
25631937 |
GO:0032819 |
Process |
Positive regulation of natural killer cell proliferation |
IDA |
30134159 |
GO:0036037 |
Process |
CD8-positive, alpha-beta T cell activation |
IDA |
25631937 |
GO:0042270 |
Process |
Protection from natural killer cell mediated cytotoxicity |
IDA |
9754572, 25631937 |
GO:0042288 |
Function |
MHC class I protein binding |
IDA |
9754572 |
GO:0042605 |
Function |
Peptide antigen binding |
IBA |
21873635 |
GO:0042605 |
Function |
Peptide antigen binding |
IDA |
9427624, 9486650, 9754572, 10799855, 16474394, 18083576, 18339401, 18448674, 23335510, 25631937, 30087334 |
GO:0042605 |
Function |
Peptide antigen binding |
IMP |
12411439 |
GO:0042608 |
Function |
T cell receptor binding |
IDA |
16474394 |
GO:0042612 |
Component |
MHC class I protein complex |
IDA |
12411439, 16474394, 18448674 |
GO:0045087 |
Process |
Innate immune response |
TAS |
|
GO:0045953 |
Process |
Negative regulation of natural killer cell mediated cytotoxicity |
IDA |
9486650, 10799855, 17179229, 23335510 |
GO:0045954 |
Process |
Positive regulation of natural killer cell mediated cytotoxicity |
IDA |
23335510 |
GO:0046703 |
Function |
Natural killer cell lectin-like receptor binding |
IPI |
25631937 |
GO:0050776 |
Process |
Regulation of immune response |
TAS |
|
GO:0050830 |
Process |
Defense response to Gram-positive bacterium |
IDA |
25631937 |
GO:0055038 |
Component |
Recycling endosome membrane |
TAS |
|
GO:0060333 |
Process |
Interferon-gamma-mediated signaling pathway |
TAS |
|
GO:0060337 |
Process |
Type I interferon signaling pathway |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
20458337 |
GO:0071556 |
Component |
Integral component of lumenal side of endoplasmic reticulum membrane |
TAS |
|
GO:2000566 |
Process |
Positive regulation of CD8-positive, alpha-beta T cell proliferation |
IDA |
25631937 |
GO:2001187 |
Process |
Positive regulation of CD8-positive, alpha-beta T cell activation |
IDA |
28676677 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P13747 |
Protein name |
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] |
Protein function |
Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (V |
PDB |
1KPR
,
1KTL
,
1MHE
,
2ESV
,
3AM8
,
3BZE
,
3BZF
,
3CDG
,
3CII
,
5W1V
,
5W1W
,
6GGM
,
6GH1
,
6GH4
,
6GHN
,
6GL1
,
6ZKW
,
6ZKX
,
6ZKY
,
6ZKZ
,
7BH8
,
7NDQ
,
7NDT
,
7NDU
,
7P49
,
7P4B
,
8QFY
,
8RLT
,
8RLU
,
8RLV
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00129 |
MHC_I |
22 → 200 |
Class I Histocompatibility antigen, domains alpha 1 and 2 |
Domain |
PF07654 |
C1-set |
207 → 287 |
Immunoglobulin C1-set domain |
Domain |
PF06623 |
MHC_I_C |
334 → 355 |
MHC_I C-terminus |
Family |
|
Sequence |
|
Sequence length |
358 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
23177929, 22433715, 22187495, 24888570, 24365204 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Bipolar disorder |
Bipolar Disorder |
|
21037240 |
Erythroderma |
Erythroderma, Maculopapular |
|
16538176 |
Nonorganic psychosis |
Nonorganic psychosis |
|
24888570 |
Parakeratosis variegata |
Parakeratosis Variegata |
|
16538176 |
Parapsoriasis |
Parapsoriasis |
|
16538176 |
Parapsoriasis en plaques |
Parapsoriasis en Plaques |
|
16538176 |
Psychosis |
Psychotic Disorders |
|
24888570 |
|
|
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