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HLA-E (major histocompatibility complex, class I, E)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3133
Gene nameGene Name - the full gene name approved by the HGNC.
Major histocompatibility complex, class I, E
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HLA-E
SynonymsGene synonyms aliases
HLA-6.2, QA1
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.1
SummarySummary of gene provided in NCBI Entrez Gene.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049514 hsa-miR-92a-3p CLASH 23622248
MIRT038407 hsa-miR-296-3p CLASH 23622248
MIRT722051 hsa-miR-124-3p HITS-CLIP 19536157
MIRT722049 hsa-miR-5582-5p HITS-CLIP 19536157
MIRT722048 hsa-miR-605-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
HIVEP2 Unknown 1409593
MYC Activation 8206526
MYCN Unknown 8895520
STAT1 Unknown 11137213
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0001815 Process Positive regulation of antibody-dependent cellular cytotoxicity IDA 30134159
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity IBA 21873635
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity IDA 25631937
GO:0002250 Process Adaptive immune response IDA 25631937
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P13747
Protein name HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Protein function Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (V
PDB 1KPR , 1KTL , 1MHE , 2ESV , 3AM8 , 3BZE , 3BZF , 3CDG , 3CII , 5W1V , 5W1W , 6GGM , 6GH1 , 6GH4 , 6GHN , 6GL1 , 6ZKW , 6ZKX , 6ZKY , 6ZKZ , 7BH8 , 7NDQ , 7NDT , 7NDU , 7P49 , 7P4B , 8QFY , 8RLT , 8RLU , 8RLV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I
22 200
Class I Histocompatibility antigen, domains alpha 1 and 2
Domain
PF07654 C1-set
207 287
Immunoglobulin C1-set domain
Domain
PF06623 MHC_I_C
334 355
MHC_I C-terminus
Family
Sequence
Sequence length 358
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Endocytosis
Phagosome
Cellular senescence
Cell adhesion molecules
Antigen processing and presentation
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Viral carcinogenesis
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Viral myocarditis
  ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 signaling
Interferon gamma signaling
Interferon alpha/beta signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 23177929, 22433715, 22187495, 24888570, 24365204
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 21037240
Erythroderma Erythroderma, Maculopapular 16538176
Nonorganic psychosis Nonorganic psychosis 24888570
Parakeratosis variegata Parakeratosis Variegata 16538176

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