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HLF (HLF transcription factor, PAR bZIP family member)

Gene

HLF transcription factor, PAR bZIP family member

HLF

17q22

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to

Show/Hide all(274)

miRTarBase ID	miRNA	Experiments	Reference
MIRT715185	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT612902	hsa-miR-8485	HITS-CLIP	23313552
MIRT612901	hsa-miR-603	HITS-CLIP	23313552
MIRT702941	hsa-miR-374c-3p	HITS-CLIP	23313552
MIRT612900	hsa-miR-600	HITS-CLIP	23313552
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT614624	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614623	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT614621	hsa-miR-4643	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT614620	hsa-miR-3941	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT614624	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614623	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT614622	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614621	hsa-miR-4643	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT614620	hsa-miR-3941	HITS-CLIP	23824327
MIRT614619	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT443770	hsa-miR-5692a	PAR-CLIP	22100165
MIRT443768	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT443769	hsa-miR-664a-3p	PAR-CLIP	22100165
MIRT443767	hsa-miR-4289	PAR-CLIP	22100165
MIRT443766	hsa-miR-4320	PAR-CLIP	22100165
MIRT443765	hsa-miR-3926	PAR-CLIP	22100165
MIRT443764	hsa-miR-569	PAR-CLIP	22100165
MIRT443763	hsa-miR-548s	PAR-CLIP	22100165
MIRT443762	hsa-miR-2053	PAR-CLIP	22100165
MIRT443761	hsa-miR-5004-3p	PAR-CLIP	22100165
MIRT612900	hsa-miR-600	HITS-CLIP	27418678
MIRT612901	hsa-miR-603	HITS-CLIP	27418678
MIRT612902	hsa-miR-8485	HITS-CLIP	27418678
MIRT733884	hsa-miR-98-5p	Luciferase reporter assay, Western blotting, ChIP-seq, qRT-PCR	32637414
MIRT715185	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT612902	hsa-miR-8485	HITS-CLIP	23313552
MIRT612901	hsa-miR-603	HITS-CLIP	23313552
MIRT702941	hsa-miR-374c-3p	HITS-CLIP	23313552
MIRT612900	hsa-miR-600	HITS-CLIP	23313552
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT614624	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614623	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT614621	hsa-miR-4643	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT614620	hsa-miR-3941	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT614624	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614623	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT614622	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614621	hsa-miR-4643	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT614620	hsa-miR-3941	HITS-CLIP	23824327
MIRT614619	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612902	hsa-miR-8485	HITS-CLIP	23824327
MIRT612901	hsa-miR-603	HITS-CLIP	23824327
MIRT612900	hsa-miR-600	HITS-CLIP	23824327
MIRT443770	hsa-miR-5692a	PAR-CLIP	22100165
MIRT443768	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT443769	hsa-miR-664a-3p	PAR-CLIP	22100165
MIRT443767	hsa-miR-4289	PAR-CLIP	22100165
MIRT443766	hsa-miR-4320	PAR-CLIP	22100165
MIRT443765	hsa-miR-3926	PAR-CLIP	22100165
MIRT443764	hsa-miR-569	PAR-CLIP	22100165
MIRT443763	hsa-miR-548s	PAR-CLIP	22100165
MIRT443762	hsa-miR-2053	PAR-CLIP	22100165
MIRT443761	hsa-miR-5004-3p	PAR-CLIP	22100165
MIRT1048663	hsa-miR-1193	CLIP-seq
MIRT1048664	hsa-miR-1227	CLIP-seq
MIRT1048665	hsa-miR-181a	CLIP-seq
MIRT1048666	hsa-miR-181b	CLIP-seq
MIRT1048667	hsa-miR-181c	CLIP-seq
MIRT1048668	hsa-miR-181d	CLIP-seq
MIRT1048669	hsa-miR-223	CLIP-seq
MIRT1048670	hsa-miR-2964a-5p	CLIP-seq
MIRT1048671	hsa-miR-29a	CLIP-seq
MIRT1048672	hsa-miR-29b	CLIP-seq
MIRT1048673	hsa-miR-29c	CLIP-seq
MIRT1048674	hsa-miR-325	CLIP-seq
MIRT1048675	hsa-miR-329	CLIP-seq
MIRT1048676	hsa-miR-3667-3p	CLIP-seq
MIRT1048677	hsa-miR-377	CLIP-seq
MIRT1048678	hsa-miR-3942-3p	CLIP-seq
MIRT1048679	hsa-miR-4252	CLIP-seq
MIRT1048680	hsa-miR-4262	CLIP-seq
MIRT1048681	hsa-miR-4264	CLIP-seq
MIRT1048682	hsa-miR-4268	CLIP-seq
MIRT1048683	hsa-miR-4697-3p	CLIP-seq
MIRT1048684	hsa-miR-4714-3p	CLIP-seq
MIRT1048685	hsa-miR-4716-5p	CLIP-seq
MIRT1048686	hsa-miR-4721	CLIP-seq
MIRT1048687	hsa-miR-4728-5p	CLIP-seq
MIRT1048688	hsa-miR-4777-5p	CLIP-seq
MIRT1048689	hsa-miR-4789-5p	CLIP-seq
MIRT1048690	hsa-miR-500a	CLIP-seq
MIRT1048691	hsa-miR-579	CLIP-seq
MIRT1048692	hsa-miR-622	CLIP-seq
MIRT1048693	hsa-miR-628-3p	CLIP-seq
MIRT1048694	hsa-miR-664	CLIP-seq
MIRT2011047	hsa-miR-2052	CLIP-seq
MIRT1048669	hsa-miR-223	CLIP-seq
MIRT2011048	hsa-miR-24	CLIP-seq
MIRT2011049	hsa-miR-3200-5p	CLIP-seq
MIRT2011050	hsa-miR-335	CLIP-seq
MIRT2011051	hsa-miR-4284	CLIP-seq
MIRT2011052	hsa-miR-4436b-5p	CLIP-seq
MIRT2011053	hsa-miR-452	CLIP-seq
MIRT2011054	hsa-miR-4676-3p	CLIP-seq
MIRT1048683	hsa-miR-4697-3p	CLIP-seq
MIRT2011055	hsa-miR-4766-5p	CLIP-seq
MIRT2243345	hsa-miR-106a	CLIP-seq
MIRT2243346	hsa-miR-106b	CLIP-seq
MIRT2243347	hsa-miR-17	CLIP-seq
MIRT2243348	hsa-miR-20a	CLIP-seq
MIRT2243349	hsa-miR-20b	CLIP-seq
MIRT1048670	hsa-miR-2964a-5p	CLIP-seq
MIRT2243350	hsa-miR-302a	CLIP-seq
MIRT2243351	hsa-miR-302b	CLIP-seq
MIRT2243352	hsa-miR-302c	CLIP-seq
MIRT2243353	hsa-miR-302d	CLIP-seq
MIRT2243354	hsa-miR-302e	CLIP-seq
MIRT1048675	hsa-miR-329	CLIP-seq
MIRT2243355	hsa-miR-3609	CLIP-seq
MIRT2243356	hsa-miR-372	CLIP-seq
MIRT2243357	hsa-miR-373	CLIP-seq
MIRT1048677	hsa-miR-377	CLIP-seq
MIRT2243358	hsa-miR-4286	CLIP-seq
MIRT2243359	hsa-miR-4318	CLIP-seq
MIRT2243360	hsa-miR-4490	CLIP-seq
MIRT2243361	hsa-miR-4796-3p	CLIP-seq
MIRT2243362	hsa-miR-512-3p	CLIP-seq
MIRT2243363	hsa-miR-519d	CLIP-seq
MIRT2243364	hsa-miR-520a-3p	CLIP-seq
MIRT2243365	hsa-miR-520b	CLIP-seq
MIRT2243366	hsa-miR-520c-3p	CLIP-seq
MIRT2243367	hsa-miR-520d-3p	CLIP-seq
MIRT2243368	hsa-miR-520e	CLIP-seq
MIRT2243369	hsa-miR-548ah	CLIP-seq
MIRT2243370	hsa-miR-93	CLIP-seq
MIRT2389028	hsa-miR-1205	CLIP-seq
MIRT2389029	hsa-miR-1324	CLIP-seq
MIRT2389030	hsa-miR-4536	CLIP-seq
MIRT2389031	hsa-miR-4790-3p	CLIP-seq
MIRT2451241	hsa-miR-128	CLIP-seq
MIRT2451242	hsa-miR-27a	CLIP-seq
MIRT2451243	hsa-miR-27b	CLIP-seq
MIRT2451244	hsa-miR-431	CLIP-seq
MIRT2451245	hsa-miR-4774-3p	CLIP-seq
MIRT2546523	hsa-miR-1184	CLIP-seq
MIRT2389028	hsa-miR-1205	CLIP-seq
MIRT2546524	hsa-miR-298	CLIP-seq
MIRT2546525	hsa-miR-3158-5p	CLIP-seq
MIRT2546526	hsa-miR-544	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	8065331
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	8065331
GO:0003677	Function	DNA binding	TAS	8639829
GO:0003690	Function	Double-stranded DNA binding	TAS	1386162
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007275	Process	Multicellular organism development	TAS	1386162
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IMP	8065331
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	8065331
GO:0048511	Process	Rhythmic process	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142385	4977	ENSG00000108924

Protein

UniProt ID

Q16534

Protein name

Hepatic leukemia factor

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07716	bZIP_2	224 → 277	Basic region leucine zipper	Coiled-coil

Sequence

MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP
QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA
PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA
DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAK
RSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL

Sequence length

295

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Burkitt`s lymphoma	Burkitt Lymphoma	rs28933407, rs121918683, rs121918684	20519628
Lymphoblastic leukemia	Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor B-cell lymphoblastic leukemia, Precursor B-cell acute lymphoblastic leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	26214592, 20519628

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		31043756
Gout	Gout		23263486
Gouty arthritis	Arthritis, Gouty		23263486
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	25880836

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