HLA-C (major histocompatibility complex, class I, C)

Gene

• Entrez ID: 3107
• Gene name: Major histocompatibility complex, class I, C
• Gene symbol: HLA-C
• Synonyms: D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051644	hsa-let-7e-5p	CLASH	23622248
MIRT042611	hsa-miR-423-3p	CLASH	23622248
MIRT041720	hsa-miR-484	CLASH	23622248
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT487936	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT487934	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT487933	hsa-miR-4660	PAR-CLIP	23592263
MIRT487931	hsa-miR-3672	PAR-CLIP	23592263
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	26701625
MIRT487936	hsa-miR-152-3p	PAR-CLIP	26701625
MIRT487931	hsa-miR-3672	PAR-CLIP	26701625
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT487933	hsa-miR-4660	PAR-CLIP	26701625
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	26701625
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	26701625
MIRT487934	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT487938	hsa-miR-148a-3p	RNA-seq, qRT-PCR	31578687
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT487936	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT487934	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT487933	hsa-miR-4660	PAR-CLIP	23592263
MIRT487931	hsa-miR-3672	PAR-CLIP	23592263
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT1048293	hsa-miR-4323	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT1048295	hsa-miR-4758-3p	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243221	hsa-miR-103b	CLIP-seq
MIRT2243222	hsa-miR-1301	CLIP-seq
MIRT2243223	hsa-miR-146a	CLIP-seq
MIRT2243224	hsa-miR-146b-5p	CLIP-seq
MIRT2243225	hsa-miR-148a	CLIP-seq
MIRT2243226	hsa-miR-148b	CLIP-seq
MIRT2243227	hsa-miR-152	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2243229	hsa-miR-224	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT2243230	hsa-miR-3162-5p	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2243231	hsa-miR-3616-5p	CLIP-seq
MIRT2243232	hsa-miR-3647-5p	CLIP-seq
MIRT2243233	hsa-miR-3653	CLIP-seq
MIRT2243234	hsa-miR-376a	CLIP-seq
MIRT2243235	hsa-miR-376b	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT2243237	hsa-miR-4428	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243240	hsa-miR-4635	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT2243244	hsa-miR-4719	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243247	hsa-miR-5047	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2243249	hsa-miR-548p	CLIP-seq
MIRT2243250	hsa-miR-573	CLIP-seq
MIRT2243251	hsa-miR-580	CLIP-seq
MIRT2243252	hsa-miR-589	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT2389011	hsa-miR-3185	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2389012	hsa-miR-3611	CLIP-seq
MIRT2243231	hsa-miR-3616-5p	CLIP-seq
MIRT2243232	hsa-miR-3647-5p	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243240	hsa-miR-4635	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243250	hsa-miR-573	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT2435125	hsa-miR-873	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT2435125	hsa-miR-873	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Activation	11053628
HIVEP2	Unknown	1409593
MYC	Activation	8206526
MYCN	Unknown	8895520

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0002480	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IDA	22031944
GO:0005515	Function	Protein binding	IPI	18322206, 18624290, 19858347, 27649529, 28546555, 28685972
GO:0005783	Component	Endoplasmic reticulum	IDA	20946353
GO:0005794	Component	Golgi apparatus	IDA	20946353
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	NAS	1384166, 2708822, 2787363, 2843461
GO:0006955	Process	Immune response	NAS	1384166, 2708822, 2787363, 2843461
GO:0009986	Component	Cell surface	IDA	9754572, 22031944
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031901	Component	Early endosome membrane	TAS
GO:0042605	Function	Peptide antigen binding	IDA	22031944
GO:0042612	Component	MHC class I protein complex	IDA	22031944
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046977	Function	TAP binding	IDA	8617941, 8805302
GO:0050776	Process	Regulation of immune response	TAS
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	TAS

Other IDs

• MIM: 142840
• HGNC: 4933
• e!Ensembl: ENSG00000204525

Protein

• UniProt ID: P10321
• Protein name: HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)
• Protein function: Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:11172028, PubMed:20104487, PubMed:20439706, PubMed:20972337, PubMed:24091323, PubMed:28649982, PubM
• PDB: 1EFX, 1IM9, 1QQD, 3BZF, 4NT6, 5VGD, 5VGE, 5W67, 5W69, 5W6A, 6JTO, 6PA1, 6PAG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00129	MHC_I	25 → 203	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
  PF07654	C1-set	211 → 290	Immunoglobulin C1-set domain	Domain
  PF06623	MHC_I_C	338 → 365	MHC_I C-terminus	Family

• Sequence:

  MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF
  DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ
  RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL
  RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT
  WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP
  SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES
  LITCKA

• Sequence length: 366

Pathways

KEGG:

Endocytosis
Phagosome
Cellular senescence
Cell adhesion molecules
Antigen processing and presentation
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Viral carcinogenesis
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Viral myocarditis

Reactome:

ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
Neutrophil degranulation
Interferon gamma signaling
Interferon alpha/beta signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Burkitt`s lymphoma	Burkitt Lymphoma	rs28933407, rs121918683, rs121918684	25163702
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	14511464
Lymphoblastic leukemia	Precursor B-cell lymphoblastic leukemia, Precursor B-cell acute lymphoblastic leukemia	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	25163702
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	19169254, 20953190
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	21156761
Sarcoidosis	Sarcoidosis	rs2076530	22952805
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24365204, 22883433

Unknown
Disease name	Disease term	dbSNP ID	References
Palmoplantar pustules	Pustulosis of Palms and Soles		19169254, 20953190
Psoriasiform eczema	Psoriasiform eczema
Psoriatic arthritis	Arthritis, Psoriatic		20953186
Stevens-johnson syndrome	Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome, Drug-Induced Stevens Johnson Syndrome, Mycoplasma-Induced Stevens-Johnson Syndrome, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum		19629158