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EHD3 (EH domain containing 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
30845
Gene nameGene Name - the full gene name approved by the HGNC.
EH domain containing 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EHD3
SynonymsGene synonyms aliases
PAST3
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p23.1
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025667 hsa-miR-7-5p Microarray 19073608
MIRT607977 hsa-miR-3664-5p HITS-CLIP 19536157
MIRT607976 hsa-miR-4522 HITS-CLIP 19536157
MIRT450028 hsa-miR-4524a-3p HITS-CLIP 19536157
MIRT504484 hsa-miR-6867-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001881 Process Receptor recycling IMP 21791287
GO:0003676 Function Nucleic acid binding TAS 10673336
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 17233914, 19864458, 20489164, 26226295, 27189942, 32296183
GO:0005524 Function ATP binding IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NZN3
Protein name EH domain-containing protein 3 (PAST homolog 3)
Protein function ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16880 EHD_N
24 56
N-terminal EH-domain containing protein
Family
PF00350 Dynamin_N
61 221
Dynamin family
Domain
PF18150 DUF5600
288 394
Domain of unknown function (DUF5600)
Domain
PF12763 EF-hand_4
439 535
Cytoskeletal-regulatory complex EF hand
Family
Sequence
Sequence length 535
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Endocytosis   Factors involved in megakaryocyte development and platelet production
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 17330099
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560
Mental depression Unipolar Depression, Major Depressive Disorder rs587778876, rs587778877 22337703, 24607927, 24607927, 22337703
Myeloid leukemia Acute Myeloid Leukemia, M1 17330099

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