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HGFAC (HGF activator)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3083
Gene nameGene Name - the full gene name approved by the HGNC.
HGF activator
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
HGFAC
SynonymsGene synonyms aliases
HGFA
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p16.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that con
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT019046 hsa-miR-335-5p Microarray 18185580
MIRT572586 hsa-miR-3607-3p PAR-CLIP 20371350
MIRT572585 hsa-miR-3686 PAR-CLIP 20371350
MIRT572584 hsa-miR-4273 PAR-CLIP 20371350
MIRT572583 hsa-miR-7156-5p PAR-CLIP 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region NAS 14718574
GO:0005615 Component Extracellular space IBA 21873635
GO:0005791 Component Rough endoplasmic reticulum IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q04756
Protein name Hepatocyte growth factor activator serine protease (HGF activator) (HGFA) (HGFA serine protease) (EC 3.4.21.-) (Serine protease HGFAC) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
Protein function Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.
PDB 1YBW , 1YC0 , 2R0K , 2R0L , 2WUB , 2WUC , 3K2U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00040 fn2
108 → 148
Fibronectin type II domain
 Domain
PF00039 fn1
202 → 237
Fibronectin type I domain
 Domain
PF00008 EGF
245 → 277
EGF-like domain
 Domain
PF00051 Kringle
286 → 367
Kringle domain
 Domain
PF00089 Trypsin
408 → 641
Trypsin
 Domain
Sequence
Sequence length 655
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    MET Receptor Activation
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 29212778
Inflammatory bowel disease Inflammatory Bowel Diseases rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 26192919
Unknown
Disease name Disease term dbSNP ID References
Cardiovascular diseases Cardiovascular Diseases 30595370
Crohn disease Crohn Disease rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438 26192919
Liver carcinoma Liver carcinoma 19363144

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