KCNIP3 (potassium voltage-gated channel interacting protein 3)

Gene

• Entrez ID: 30818
• Gene name: Potassium voltage-gated channel interacting protein 3
• Gene symbol: KCNIP3
• Synonyms: CSEN, DREAM, KCHIP3
• Chromosome: 2
• Chromosome location: 2q11.1
• Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domai

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT608434	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT608433	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT608432	hsa-miR-3908	HITS-CLIP	23824327
MIRT667780	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT608428	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608427	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT667779	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT667778	hsa-miR-507	HITS-CLIP	23824327
MIRT667777	hsa-miR-557	HITS-CLIP	23824327
MIRT667776	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT667775	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT608426	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT608434	hsa-miR-3942-5p	HITS-CLIP	24906430
MIRT608433	hsa-miR-4703-5p	HITS-CLIP	24906430
MIRT608432	hsa-miR-3908	HITS-CLIP	24906430
MIRT608431	hsa-miR-889-5p	HITS-CLIP	24906430
MIRT608430	hsa-miR-7974	HITS-CLIP	24906430
MIRT608429	hsa-miR-4687-3p	HITS-CLIP	24906430
MIRT608428	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608427	hsa-miR-4766-3p	HITS-CLIP	24906430
MIRT608426	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608432	hsa-miR-3908	HITS-CLIP	27418678
MIRT608434	hsa-miR-3942-5p	HITS-CLIP	27418678
MIRT608433	hsa-miR-4703-5p	HITS-CLIP	27418678
MIRT608427	hsa-miR-4766-3p	HITS-CLIP	27418678
MIRT608426	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608428	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608434	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT608433	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT608432	hsa-miR-3908	HITS-CLIP	23824327
MIRT667780	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT608428	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608427	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT667779	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT667778	hsa-miR-507	HITS-CLIP	23824327
MIRT667777	hsa-miR-557	HITS-CLIP	23824327
MIRT667776	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT667775	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT608426	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1081145	hsa-miR-1200	CLIP-seq
MIRT1081146	hsa-miR-1245b-5p	CLIP-seq
MIRT1081147	hsa-miR-1827	CLIP-seq
MIRT1081148	hsa-miR-1976	CLIP-seq
MIRT1081149	hsa-miR-3142	CLIP-seq
MIRT1081150	hsa-miR-4324	CLIP-seq
MIRT1081151	hsa-miR-4649-3p	CLIP-seq
MIRT1081152	hsa-miR-544b	CLIP-seq
MIRT1081153	hsa-miR-877	CLIP-seq
MIRT1081154	hsa-miR-1275	CLIP-seq
MIRT1081155	hsa-miR-3689d	CLIP-seq
MIRT1081156	hsa-miR-371b-3p	CLIP-seq
MIRT1081157	hsa-miR-4290	CLIP-seq
MIRT1081158	hsa-miR-4330	CLIP-seq
MIRT1081159	hsa-miR-4487	CLIP-seq
MIRT1081160	hsa-miR-4651	CLIP-seq
MIRT1081161	hsa-miR-4665-5p	CLIP-seq
MIRT1081162	hsa-miR-4693-3p	CLIP-seq
MIRT1081163	hsa-miR-578	CLIP-seq
MIRT1081164	hsa-miR-608	CLIP-seq
MIRT1081165	hsa-miR-635	CLIP-seq
MIRT1081166	hsa-miR-663b	CLIP-seq
MIRT2020109	hsa-miR-1205	CLIP-seq
MIRT2020110	hsa-miR-136	CLIP-seq
MIRT2020111	hsa-miR-19a	CLIP-seq
MIRT2020112	hsa-miR-19b	CLIP-seq
MIRT2020113	hsa-miR-2113	CLIP-seq
MIRT2020114	hsa-miR-218	CLIP-seq
MIRT2020115	hsa-miR-3074-5p	CLIP-seq
MIRT2020116	hsa-miR-3140-3p	CLIP-seq
MIRT2020117	hsa-miR-3667-3p	CLIP-seq
MIRT2020118	hsa-miR-4297	CLIP-seq
MIRT2020119	hsa-miR-4419a	CLIP-seq
MIRT2020120	hsa-miR-4510	CLIP-seq
MIRT2020121	hsa-miR-4659a-5p	CLIP-seq
MIRT2020122	hsa-miR-4659b-5p	CLIP-seq
MIRT2020123	hsa-miR-4708-3p	CLIP-seq
MIRT2020124	hsa-miR-4722-3p	CLIP-seq
MIRT2020125	hsa-miR-4757-5p	CLIP-seq
MIRT2020126	hsa-miR-4769-3p	CLIP-seq
MIRT2020127	hsa-miR-4802-5p	CLIP-seq
MIRT2020128	hsa-miR-636	CLIP-seq
MIRT2020129	hsa-miR-885-5p	CLIP-seq
MIRT2020110	hsa-miR-136	CLIP-seq
MIRT2020130	hsa-miR-4326	CLIP-seq
MIRT2020129	hsa-miR-885-5p	CLIP-seq
MIRT2251932	hsa-miR-1	CLIP-seq
MIRT2251933	hsa-miR-103a	CLIP-seq
MIRT2251934	hsa-miR-107	CLIP-seq
MIRT2251935	hsa-miR-1207-3p	CLIP-seq
MIRT2251936	hsa-miR-1207-5p	CLIP-seq
MIRT2251937	hsa-miR-1343	CLIP-seq
MIRT2020110	hsa-miR-136	CLIP-seq
MIRT2251938	hsa-miR-1909	CLIP-seq
MIRT2020111	hsa-miR-19a	CLIP-seq
MIRT2020112	hsa-miR-19b	CLIP-seq
MIRT2251939	hsa-miR-206	CLIP-seq
MIRT2020113	hsa-miR-2113	CLIP-seq
MIRT2020114	hsa-miR-218	CLIP-seq
MIRT2251940	hsa-miR-2392	CLIP-seq
MIRT2020116	hsa-miR-3140-3p	CLIP-seq
MIRT2251941	hsa-miR-3184	CLIP-seq
MIRT2251942	hsa-miR-323-5p	CLIP-seq
MIRT2251943	hsa-miR-338-3p	CLIP-seq
MIRT1081155	hsa-miR-3689d	CLIP-seq
MIRT2251944	hsa-miR-3690	CLIP-seq
MIRT2251945	hsa-miR-3913-3p	CLIP-seq
MIRT2251946	hsa-miR-423-5p	CLIP-seq
MIRT2251947	hsa-miR-4254	CLIP-seq
MIRT2020130	hsa-miR-4326	CLIP-seq
MIRT2251948	hsa-miR-4455	CLIP-seq
MIRT2251949	hsa-miR-4530	CLIP-seq
MIRT2251950	hsa-miR-4534	CLIP-seq
MIRT2251951	hsa-miR-4640-3p	CLIP-seq
MIRT2251952	hsa-miR-4736	CLIP-seq
MIRT2251953	hsa-miR-4763-3p	CLIP-seq
MIRT2020127	hsa-miR-4802-5p	CLIP-seq
MIRT2251954	hsa-miR-489	CLIP-seq
MIRT2251955	hsa-miR-613	CLIP-seq
MIRT2020128	hsa-miR-636	CLIP-seq
MIRT2251956	hsa-miR-646	CLIP-seq
MIRT2251957	hsa-miR-876-3p	CLIP-seq
MIRT2020129	hsa-miR-885-5p	CLIP-seq
MIRT2020109	hsa-miR-1205	CLIP-seq
MIRT2251936	hsa-miR-1207-5p	CLIP-seq
MIRT2251938	hsa-miR-1909	CLIP-seq
MIRT2020111	hsa-miR-19a	CLIP-seq
MIRT2020112	hsa-miR-19b	CLIP-seq
MIRT2020113	hsa-miR-2113	CLIP-seq
MIRT2020114	hsa-miR-218	CLIP-seq
MIRT2251940	hsa-miR-2392	CLIP-seq
MIRT2020116	hsa-miR-3140-3p	CLIP-seq
MIRT1081155	hsa-miR-3689d	CLIP-seq
MIRT2389635	hsa-miR-4268	CLIP-seq
MIRT2389636	hsa-miR-4448	CLIP-seq
MIRT2251950	hsa-miR-4534	CLIP-seq
MIRT2251952	hsa-miR-4736	CLIP-seq
MIRT2389637	hsa-miR-4758-3p	CLIP-seq
MIRT2251953	hsa-miR-4763-3p	CLIP-seq
MIRT2020127	hsa-miR-4802-5p	CLIP-seq
MIRT2389638	hsa-miR-485-5p	CLIP-seq
MIRT2020128	hsa-miR-636	CLIP-seq
MIRT2020129	hsa-miR-885-5p	CLIP-seq
MIRT2020109	hsa-miR-1205	CLIP-seq
MIRT2020110	hsa-miR-136	CLIP-seq
MIRT2020125	hsa-miR-4757-5p	CLIP-seq
MIRT2020129	hsa-miR-885-5p	CLIP-seq
MIRT2555222	hsa-miR-3064-5p	CLIP-seq
MIRT2555223	hsa-miR-3652	CLIP-seq
MIRT2251944	hsa-miR-3690	CLIP-seq
MIRT2555224	hsa-miR-378	CLIP-seq
MIRT2555225	hsa-miR-378b	CLIP-seq
MIRT2555226	hsa-miR-378c	CLIP-seq
MIRT2555227	hsa-miR-378d	CLIP-seq
MIRT2555228	hsa-miR-378e	CLIP-seq
MIRT2555229	hsa-miR-378f	CLIP-seq
MIRT2555230	hsa-miR-378h	CLIP-seq
MIRT2555231	hsa-miR-378i	CLIP-seq
MIRT2555232	hsa-miR-422a	CLIP-seq
MIRT2251947	hsa-miR-4254	CLIP-seq
MIRT2555233	hsa-miR-4283	CLIP-seq
MIRT2555234	hsa-miR-4430	CLIP-seq
MIRT2555235	hsa-miR-4489	CLIP-seq
MIRT2555236	hsa-miR-4505	CLIP-seq
MIRT2555237	hsa-miR-4731-5p	CLIP-seq
MIRT2251935	hsa-miR-1207-3p	CLIP-seq
MIRT2683209	hsa-miR-1226	CLIP-seq
MIRT2683210	hsa-miR-1253	CLIP-seq
MIRT2683211	hsa-miR-1285	CLIP-seq
MIRT2555222	hsa-miR-3064-5p	CLIP-seq
MIRT2251941	hsa-miR-3184	CLIP-seq
MIRT2683212	hsa-miR-3187-5p	CLIP-seq
MIRT2683213	hsa-miR-3192	CLIP-seq
MIRT2555223	hsa-miR-3652	CLIP-seq
MIRT2683214	hsa-miR-3656	CLIP-seq
MIRT2683215	hsa-miR-3689a-3p	CLIP-seq
MIRT2683216	hsa-miR-3689c	CLIP-seq
MIRT2251944	hsa-miR-3690	CLIP-seq
MIRT2555224	hsa-miR-378	CLIP-seq
MIRT2555225	hsa-miR-378b	CLIP-seq
MIRT2555226	hsa-miR-378c	CLIP-seq
MIRT2555227	hsa-miR-378d	CLIP-seq
MIRT2555228	hsa-miR-378e	CLIP-seq
MIRT2555229	hsa-miR-378f	CLIP-seq
MIRT2555230	hsa-miR-378h	CLIP-seq
MIRT2555231	hsa-miR-378i	CLIP-seq
MIRT2555232	hsa-miR-422a	CLIP-seq
MIRT2251946	hsa-miR-423-5p	CLIP-seq
MIRT2251947	hsa-miR-4254	CLIP-seq
MIRT2555233	hsa-miR-4283	CLIP-seq
MIRT2020119	hsa-miR-4419a	CLIP-seq
MIRT2555234	hsa-miR-4430	CLIP-seq
MIRT2683217	hsa-miR-4434	CLIP-seq
MIRT2683218	hsa-miR-4446-3p	CLIP-seq
MIRT2555235	hsa-miR-4489	CLIP-seq
MIRT2683219	hsa-miR-4492	CLIP-seq
MIRT2683220	hsa-miR-4498	CLIP-seq
MIRT2555236	hsa-miR-4505	CLIP-seq
MIRT2020120	hsa-miR-4510	CLIP-seq
MIRT2683221	hsa-miR-4516	CLIP-seq
MIRT2683222	hsa-miR-4721	CLIP-seq
MIRT2683223	hsa-miR-4728-5p	CLIP-seq
MIRT2555237	hsa-miR-4731-5p	CLIP-seq
MIRT2683224	hsa-miR-612	CLIP-seq
MIRT2683225	hsa-miR-762	CLIP-seq
MIRT2683226	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	10078534
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10078534
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	10078534
GO:0005244	Function	Voltage-gated ion channel activity	IEA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 17189291, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	TAS	10900016
GO:0008076	Component	Voltage-gated potassium channel complex	ISS
GO:0015459	Function	Potassium channel regulator activity	ISS
GO:0030425	Component	Dendrite	IEA
GO:0032993	Component	Protein-DNA complex	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0044325	Function	Ion channel binding	IEA
GO:0061337	Process	Cardiac conduction	TAS
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:0072659	Process	Protein localization to plasma membrane	ISS
GO:1901379	Process	Regulation of potassium ion transmembrane transport	ISS

Other IDs

• MIM: 604662
• HGNC: 15523
• e!Ensembl: ENSG00000115041

Protein

• UniProt ID: Q9Y2W7
• Protein name: Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)
• Protein function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similari
• PDB: 2E6W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13833	EF-hand_8	105 → 158	EF-hand domain pair	Domain
  PF13499	EF-hand_7	164 → 240	EF-hand domain pair	Domain
  PF00036	EF-hand_1	166 → 194	EF hand	Domain

• Sequence:

  MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGS
  DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQ
  FFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDG
  YITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ
  KDENIMSSMQLFENVI

• Sequence length: 256

Pathways

Reactome:

Phase 1 - inactivation of fast Na+ channels

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959