HDAC2 (histone deacetylase 2)

Gene

• Entrez ID: 3066
• Gene name: Histone deacetylase 2
• Gene symbol: HDAC2
• Synonyms: HD2, KDAC2, RPD3, YAF1
• Chromosome: 6
• Chromosome location: 6q21
• Summary: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007307	hsa-miR-145-5p	Luciferase reporter assay	23499894
MIRT023724	hsa-miR-1-3p	Proteomics	18668040
MIRT045549	hsa-miR-149-5p	CLASH	23622248
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT437990	hsa-let-7f-5p	qRT-PCR	24405266
MIRT733684	hsa-miR-494-3p	Flow cytometry, Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	31465536
MIRT736874	hsa-miR-204-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, Flow cytometry	33614251
MIRT1042307	hsa-let-7a	CLIP-seq
MIRT1042308	hsa-let-7b	CLIP-seq
MIRT1042309	hsa-let-7c	CLIP-seq
MIRT1042310	hsa-let-7d	CLIP-seq
MIRT1042311	hsa-let-7e	CLIP-seq
MIRT1042312	hsa-let-7f	CLIP-seq
MIRT1042313	hsa-let-7g	CLIP-seq
MIRT1042314	hsa-let-7i	CLIP-seq
MIRT1042315	hsa-miR-103a	CLIP-seq
MIRT1042316	hsa-miR-107	CLIP-seq
MIRT1042317	hsa-miR-1205	CLIP-seq
MIRT1042318	hsa-miR-1226	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT1042320	hsa-miR-1254	CLIP-seq
MIRT1042321	hsa-miR-1262	CLIP-seq
MIRT1042322	hsa-miR-1264	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT1042324	hsa-miR-1293	CLIP-seq
MIRT1042325	hsa-miR-1295	CLIP-seq
MIRT1042326	hsa-miR-1304	CLIP-seq
MIRT1042327	hsa-miR-146a	CLIP-seq
MIRT1042328	hsa-miR-146b-5p	CLIP-seq
MIRT1042329	hsa-miR-186	CLIP-seq
MIRT1042330	hsa-miR-188-3p	CLIP-seq
MIRT1042331	hsa-miR-197	CLIP-seq
MIRT1042332	hsa-miR-202	CLIP-seq
MIRT1042333	hsa-miR-24	CLIP-seq
MIRT1042334	hsa-miR-2467-3p	CLIP-seq
MIRT1042335	hsa-miR-300	CLIP-seq
MIRT1042336	hsa-miR-3116	CLIP-seq
MIRT1042337	hsa-miR-3122	CLIP-seq
MIRT1042338	hsa-miR-3124-3p	CLIP-seq
MIRT1042339	hsa-miR-3133	CLIP-seq
MIRT1042340	hsa-miR-3135	CLIP-seq
MIRT1042341	hsa-miR-3145-5p	CLIP-seq
MIRT1042342	hsa-miR-3153	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042344	hsa-miR-3173-3p	CLIP-seq
MIRT1042345	hsa-miR-3177-5p	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT1042349	hsa-miR-338-5p	CLIP-seq
MIRT1042350	hsa-miR-3605-5p	CLIP-seq
MIRT1042351	hsa-miR-3606	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT1042353	hsa-miR-362-5p	CLIP-seq
MIRT1042354	hsa-miR-3647-3p	CLIP-seq
MIRT1042355	hsa-miR-3656	CLIP-seq
MIRT1042356	hsa-miR-3668	CLIP-seq
MIRT1042357	hsa-miR-3671	CLIP-seq
MIRT1042358	hsa-miR-3682-5p	CLIP-seq
MIRT1042359	hsa-miR-3689a-3p	CLIP-seq
MIRT1042360	hsa-miR-3689c	CLIP-seq
MIRT1042361	hsa-miR-3690	CLIP-seq
MIRT1042362	hsa-miR-3691-3p	CLIP-seq
MIRT1042363	hsa-miR-371-5p	CLIP-seq
MIRT1042364	hsa-miR-371b-5p	CLIP-seq
MIRT1042365	hsa-miR-381	CLIP-seq
MIRT1042366	hsa-miR-3913-5p	CLIP-seq
MIRT1042367	hsa-miR-3915	CLIP-seq
MIRT1042368	hsa-miR-3924	CLIP-seq
MIRT1042369	hsa-miR-3926	CLIP-seq
MIRT1042370	hsa-miR-3928	CLIP-seq
MIRT1042371	hsa-miR-3937	CLIP-seq
MIRT1042372	hsa-miR-4252	CLIP-seq
MIRT1042373	hsa-miR-4269	CLIP-seq
MIRT1042374	hsa-miR-4275	CLIP-seq
MIRT1042375	hsa-miR-4282	CLIP-seq
MIRT1042376	hsa-miR-4284	CLIP-seq
MIRT1042377	hsa-miR-4328	CLIP-seq
MIRT1042378	hsa-miR-4428	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042380	hsa-miR-4458	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT1042382	hsa-miR-4476	CLIP-seq
MIRT1042383	hsa-miR-4480	CLIP-seq
MIRT1042384	hsa-miR-4483	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT1042386	hsa-miR-4500	CLIP-seq
MIRT1042387	hsa-miR-4511	CLIP-seq
MIRT1042388	hsa-miR-451b	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT1042390	hsa-miR-4638-3p	CLIP-seq
MIRT1042391	hsa-miR-4646-5p	CLIP-seq
MIRT1042392	hsa-miR-4666-3p	CLIP-seq
MIRT1042393	hsa-miR-4668-5p	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT1042395	hsa-miR-4699-3p	CLIP-seq
MIRT1042396	hsa-miR-4701-3p	CLIP-seq
MIRT1042397	hsa-miR-4710	CLIP-seq
MIRT1042398	hsa-miR-4719	CLIP-seq
MIRT1042399	hsa-miR-4728-5p	CLIP-seq
MIRT1042400	hsa-miR-4744	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT1042402	hsa-miR-4755-3p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT1042405	hsa-miR-4792	CLIP-seq
MIRT1042406	hsa-miR-4793-3p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT1042408	hsa-miR-495	CLIP-seq
MIRT1042409	hsa-miR-500b	CLIP-seq
MIRT1042410	hsa-miR-501-5p	CLIP-seq
MIRT1042411	hsa-miR-502-5p	CLIP-seq
MIRT1042412	hsa-miR-511	CLIP-seq
MIRT1042413	hsa-miR-520d-5p	CLIP-seq
MIRT1042414	hsa-miR-524-5p	CLIP-seq
MIRT1042415	hsa-miR-526b	CLIP-seq
MIRT1042416	hsa-miR-548a-3p	CLIP-seq
MIRT1042417	hsa-miR-548b-3p	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT1042419	hsa-miR-548e	CLIP-seq
MIRT1042420	hsa-miR-548f	CLIP-seq
MIRT1042421	hsa-miR-548k	CLIP-seq
MIRT1042422	hsa-miR-548n	CLIP-seq
MIRT1042423	hsa-miR-548p	CLIP-seq
MIRT1042424	hsa-miR-548s	CLIP-seq
MIRT1042425	hsa-miR-556-3p	CLIP-seq
MIRT1042426	hsa-miR-558	CLIP-seq
MIRT1042427	hsa-miR-579	CLIP-seq
MIRT1042428	hsa-miR-587	CLIP-seq
MIRT1042429	hsa-miR-589	CLIP-seq
MIRT1042430	hsa-miR-607	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT1042432	hsa-miR-633	CLIP-seq
MIRT1042433	hsa-miR-661	CLIP-seq
MIRT1042434	hsa-miR-98	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042369	hsa-miR-3926	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT1042424	hsa-miR-548s	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT1042307	hsa-let-7a	CLIP-seq
MIRT1042308	hsa-let-7b	CLIP-seq
MIRT1042309	hsa-let-7c	CLIP-seq
MIRT1042310	hsa-let-7d	CLIP-seq
MIRT1042311	hsa-let-7e	CLIP-seq
MIRT1042312	hsa-let-7f	CLIP-seq
MIRT1042313	hsa-let-7g	CLIP-seq
MIRT1042314	hsa-let-7i	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT1042320	hsa-miR-1254	CLIP-seq
MIRT1042321	hsa-miR-1262	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT1042324	hsa-miR-1293	CLIP-seq
MIRT1042326	hsa-miR-1304	CLIP-seq
MIRT2008921	hsa-miR-135a	CLIP-seq
MIRT2008922	hsa-miR-135b	CLIP-seq
MIRT2008923	hsa-miR-1827	CLIP-seq
MIRT1042332	hsa-miR-202	CLIP-seq
MIRT2008924	hsa-miR-2054	CLIP-seq
MIRT2008925	hsa-miR-2114	CLIP-seq
MIRT2008926	hsa-miR-223	CLIP-seq
MIRT1042333	hsa-miR-24	CLIP-seq
MIRT1042336	hsa-miR-3116	CLIP-seq
MIRT1042341	hsa-miR-3145-5p	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042344	hsa-miR-3173-3p	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT2008927	hsa-miR-3194-3p	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT2008928	hsa-miR-325	CLIP-seq
MIRT2008929	hsa-miR-3607-3p	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT2008930	hsa-miR-3663-5p	CLIP-seq
MIRT2008931	hsa-miR-3686	CLIP-seq
MIRT1042359	hsa-miR-3689a-3p	CLIP-seq
MIRT1042360	hsa-miR-3689c	CLIP-seq
MIRT1042361	hsa-miR-3690	CLIP-seq
MIRT2008932	hsa-miR-374c	CLIP-seq
MIRT2008933	hsa-miR-377	CLIP-seq
MIRT2008934	hsa-miR-3923	CLIP-seq
MIRT2008935	hsa-miR-3929	CLIP-seq
MIRT1042372	hsa-miR-4252	CLIP-seq
MIRT1042376	hsa-miR-4284	CLIP-seq
MIRT1042377	hsa-miR-4328	CLIP-seq
MIRT2008936	hsa-miR-4419b	CLIP-seq
MIRT1042378	hsa-miR-4428	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042380	hsa-miR-4458	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT2008937	hsa-miR-4478	CLIP-seq
MIRT1042384	hsa-miR-4483	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT1042386	hsa-miR-4500	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT1042390	hsa-miR-4638-3p	CLIP-seq
MIRT2008938	hsa-miR-4649-3p	CLIP-seq
MIRT2008939	hsa-miR-4659a-3p	CLIP-seq
MIRT2008940	hsa-miR-4659b-3p	CLIP-seq
MIRT2008941	hsa-miR-4666-5p	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT1042396	hsa-miR-4701-3p	CLIP-seq
MIRT2008942	hsa-miR-4704-5p	CLIP-seq
MIRT1042398	hsa-miR-4719	CLIP-seq
MIRT2008943	hsa-miR-4722-5p	CLIP-seq
MIRT1042399	hsa-miR-4728-5p	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT2008944	hsa-miR-4778-3p	CLIP-seq
MIRT1042406	hsa-miR-4793-3p	CLIP-seq
MIRT2008945	hsa-miR-4797-5p	CLIP-seq
MIRT2008946	hsa-miR-485-5p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT1042412	hsa-miR-511	CLIP-seq
MIRT1042415	hsa-miR-526b	CLIP-seq
MIRT1042416	hsa-miR-548a-3p	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT1042419	hsa-miR-548e	CLIP-seq
MIRT1042420	hsa-miR-548f	CLIP-seq
MIRT2008947	hsa-miR-578	CLIP-seq
MIRT1042427	hsa-miR-579	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT2008948	hsa-miR-616	CLIP-seq
MIRT2008949	hsa-miR-655	CLIP-seq
MIRT2008950	hsa-miR-890	CLIP-seq
MIRT2008951	hsa-miR-940	CLIP-seq
MIRT1042434	hsa-miR-98	CLIP-seq
MIRT2241267	hsa-miR-1206	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT1042324	hsa-miR-1293	CLIP-seq
MIRT2241268	hsa-miR-1321	CLIP-seq
MIRT2241269	hsa-miR-15a	CLIP-seq
MIRT2241270	hsa-miR-15b	CLIP-seq
MIRT2241271	hsa-miR-16	CLIP-seq
MIRT2008923	hsa-miR-1827	CLIP-seq
MIRT1042329	hsa-miR-186	CLIP-seq
MIRT2241272	hsa-miR-195	CLIP-seq
MIRT1042331	hsa-miR-197	CLIP-seq
MIRT2008924	hsa-miR-2054	CLIP-seq
MIRT2008925	hsa-miR-2114	CLIP-seq
MIRT1042333	hsa-miR-24	CLIP-seq
MIRT1042337	hsa-miR-3122	CLIP-seq
MIRT1042339	hsa-miR-3133	CLIP-seq
MIRT1042341	hsa-miR-3145-5p	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT2241273	hsa-miR-323-5p	CLIP-seq
MIRT2241274	hsa-miR-342-3p	CLIP-seq
MIRT2241275	hsa-miR-3529	CLIP-seq
MIRT1042350	hsa-miR-3605-5p	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT2241276	hsa-miR-3622b-5p	CLIP-seq
MIRT2241277	hsa-miR-3646	CLIP-seq
MIRT2241278	hsa-miR-3662	CLIP-seq
MIRT2241279	hsa-miR-3664-3p	CLIP-seq
MIRT2241280	hsa-miR-3672	CLIP-seq
MIRT1042359	hsa-miR-3689a-3p	CLIP-seq
MIRT1042360	hsa-miR-3689c	CLIP-seq
MIRT2241281	hsa-miR-379	CLIP-seq
MIRT1042366	hsa-miR-3913-5p	CLIP-seq
MIRT1042369	hsa-miR-3926	CLIP-seq
MIRT2008935	hsa-miR-3929	CLIP-seq
MIRT2241282	hsa-miR-3934	CLIP-seq
MIRT2241283	hsa-miR-3973	CLIP-seq
MIRT2241284	hsa-miR-424	CLIP-seq
MIRT1042372	hsa-miR-4252	CLIP-seq
MIRT2241285	hsa-miR-4270	CLIP-seq
MIRT1042376	hsa-miR-4284	CLIP-seq
MIRT2008936	hsa-miR-4419b	CLIP-seq
MIRT2241286	hsa-miR-4422	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT2241287	hsa-miR-4441	CLIP-seq
MIRT2241288	hsa-miR-4451	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT2241289	hsa-miR-4477a	CLIP-seq
MIRT2008937	hsa-miR-4478	CLIP-seq
MIRT1042384	hsa-miR-4483	CLIP-seq
MIRT2241290	hsa-miR-4488	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT1042387	hsa-miR-4511	CLIP-seq
MIRT2241291	hsa-miR-4524	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT2241292	hsa-miR-4537	CLIP-seq
MIRT2008938	hsa-miR-4649-3p	CLIP-seq
MIRT2241293	hsa-miR-4649-5p	CLIP-seq
MIRT2241294	hsa-miR-4650-3p	CLIP-seq
MIRT2241295	hsa-miR-4676-5p	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT2241296	hsa-miR-4695-5p	CLIP-seq
MIRT2241297	hsa-miR-4697-5p	CLIP-seq
MIRT1042397	hsa-miR-4710	CLIP-seq
MIRT2241298	hsa-miR-4718	CLIP-seq
MIRT1042398	hsa-miR-4719	CLIP-seq
MIRT2008943	hsa-miR-4722-5p	CLIP-seq
MIRT1042399	hsa-miR-4728-5p	CLIP-seq
MIRT2241299	hsa-miR-4739	CLIP-seq
MIRT1042400	hsa-miR-4744	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT2241300	hsa-miR-4756-5p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT2241301	hsa-miR-4766-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT1042405	hsa-miR-4792	CLIP-seq
MIRT1042406	hsa-miR-4793-3p	CLIP-seq
MIRT2008945	hsa-miR-4797-5p	CLIP-seq
MIRT2008946	hsa-miR-485-5p	CLIP-seq
MIRT2241302	hsa-miR-486-5p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT2241303	hsa-miR-497	CLIP-seq
MIRT2241304	hsa-miR-500a	CLIP-seq
MIRT2241305	hsa-miR-503	CLIP-seq
MIRT2241306	hsa-miR-510	CLIP-seq
MIRT2241307	hsa-miR-512-5p	CLIP-seq
MIRT1042413	hsa-miR-520d-5p	CLIP-seq
MIRT1042414	hsa-miR-524-5p	CLIP-seq
MIRT2241308	hsa-miR-541	CLIP-seq
MIRT1042424	hsa-miR-548s	CLIP-seq
MIRT2241309	hsa-miR-575	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT2241310	hsa-miR-646	CLIP-seq
MIRT2241311	hsa-miR-654-5p	CLIP-seq
MIRT2241312	hsa-miR-758	CLIP-seq
MIRT2241313	hsa-miR-759	CLIP-seq
MIRT2241314	hsa-miR-876-3p	CLIP-seq
MIRT2008950	hsa-miR-890	CLIP-seq
MIRT2008951	hsa-miR-940	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT2008924	hsa-miR-2054	CLIP-seq
MIRT1042333	hsa-miR-24	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT1042347	hsa-miR-3194-5p	CLIP-seq
MIRT1042376	hsa-miR-4284	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT2388925	hsa-miR-4651	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT2388926	hsa-miR-608	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT1042433	hsa-miR-661	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT2451037	hsa-miR-192	CLIP-seq
MIRT2008924	hsa-miR-2054	CLIP-seq
MIRT2451038	hsa-miR-215	CLIP-seq
MIRT2451039	hsa-miR-28-3p	CLIP-seq
MIRT1042337	hsa-miR-3122	CLIP-seq
MIRT1042340	hsa-miR-3135	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT2451040	hsa-miR-3591-3p	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT1042359	hsa-miR-3689a-3p	CLIP-seq
MIRT1042360	hsa-miR-3689c	CLIP-seq
MIRT1042363	hsa-miR-371-5p	CLIP-seq
MIRT1042364	hsa-miR-371b-5p	CLIP-seq
MIRT1042366	hsa-miR-3913-5p	CLIP-seq
MIRT2451041	hsa-miR-4305	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT1042399	hsa-miR-4728-5p	CLIP-seq
MIRT2451042	hsa-miR-4731-3p	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT2451043	hsa-miR-4801	CLIP-seq
MIRT1042417	hsa-miR-548b-3p	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT2451039	hsa-miR-28-3p	CLIP-seq
MIRT2465436	hsa-miR-3659	CLIP-seq
MIRT2465437	hsa-miR-3921	CLIP-seq
MIRT2465438	hsa-miR-4653-5p	CLIP-seq
MIRT2465439	hsa-miR-4658	CLIP-seq
MIRT2465440	hsa-miR-4682	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT2465441	hsa-miR-574-5p	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT1042322	hsa-miR-1264	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT1042324	hsa-miR-1293	CLIP-seq
MIRT1042327	hsa-miR-146a	CLIP-seq
MIRT1042328	hsa-miR-146b-5p	CLIP-seq
MIRT2008923	hsa-miR-1827	CLIP-seq
MIRT2008924	hsa-miR-2054	CLIP-seq
MIRT1042335	hsa-miR-300	CLIP-seq
MIRT1042337	hsa-miR-3122	CLIP-seq
MIRT1042340	hsa-miR-3135	CLIP-seq
MIRT1042341	hsa-miR-3145-5p	CLIP-seq
MIRT2545012	hsa-miR-3163	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT1042351	hsa-miR-3606	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT2241277	hsa-miR-3646	CLIP-seq
MIRT1042354	hsa-miR-3647-3p	CLIP-seq
MIRT2241278	hsa-miR-3662	CLIP-seq
MIRT2241279	hsa-miR-3664-3p	CLIP-seq
MIRT2241280	hsa-miR-3672	CLIP-seq
MIRT1042359	hsa-miR-3689a-3p	CLIP-seq
MIRT1042360	hsa-miR-3689c	CLIP-seq
MIRT1042363	hsa-miR-371-5p	CLIP-seq
MIRT1042364	hsa-miR-371b-5p	CLIP-seq
MIRT1042365	hsa-miR-381	CLIP-seq
MIRT1042366	hsa-miR-3913-5p	CLIP-seq
MIRT2008935	hsa-miR-3929	CLIP-seq
MIRT2241283	hsa-miR-3973	CLIP-seq
MIRT1042372	hsa-miR-4252	CLIP-seq
MIRT2008936	hsa-miR-4419b	CLIP-seq
MIRT2241286	hsa-miR-4422	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT2545013	hsa-miR-4434	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT2008937	hsa-miR-4478	CLIP-seq
MIRT1042383	hsa-miR-4480	CLIP-seq
MIRT1042384	hsa-miR-4483	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT2545014	hsa-miR-4516	CLIP-seq
MIRT2545015	hsa-miR-4531	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT2008938	hsa-miR-4649-3p	CLIP-seq
MIRT2545016	hsa-miR-4662a-5p	CLIP-seq
MIRT1042392	hsa-miR-4666-3p	CLIP-seq
MIRT2241295	hsa-miR-4676-5p	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT2241296	hsa-miR-4695-5p	CLIP-seq
MIRT1042397	hsa-miR-4710	CLIP-seq
MIRT2008943	hsa-miR-4722-5p	CLIP-seq
MIRT1042399	hsa-miR-4728-5p	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT2545017	hsa-miR-4786-3p	CLIP-seq
MIRT1042405	hsa-miR-4792	CLIP-seq
MIRT1042406	hsa-miR-4793-3p	CLIP-seq
MIRT2008945	hsa-miR-4797-5p	CLIP-seq
MIRT2008946	hsa-miR-485-5p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT2241306	hsa-miR-510	CLIP-seq
MIRT2241307	hsa-miR-512-5p	CLIP-seq
MIRT1042416	hsa-miR-548a-3p	CLIP-seq
MIRT2545018	hsa-miR-548ad	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT1042419	hsa-miR-548e	CLIP-seq
MIRT1042420	hsa-miR-548f	CLIP-seq
MIRT2545019	hsa-miR-566	CLIP-seq
MIRT2545020	hsa-miR-570	CLIP-seq
MIRT2241309	hsa-miR-575	CLIP-seq
MIRT1042429	hsa-miR-589	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT2241313	hsa-miR-759	CLIP-seq
MIRT2008951	hsa-miR-940	CLIP-seq
MIRT1042319	hsa-miR-1228	CLIP-seq
MIRT1042322	hsa-miR-1264	CLIP-seq
MIRT1042323	hsa-miR-1285	CLIP-seq
MIRT1042324	hsa-miR-1293	CLIP-seq
MIRT1042327	hsa-miR-146a	CLIP-seq
MIRT1042328	hsa-miR-146b-5p	CLIP-seq
MIRT1042335	hsa-miR-300	CLIP-seq
MIRT1042340	hsa-miR-3135	CLIP-seq
MIRT1042341	hsa-miR-3145-5p	CLIP-seq
MIRT2545012	hsa-miR-3163	CLIP-seq
MIRT1042343	hsa-miR-3165	CLIP-seq
MIRT1042346	hsa-miR-3187-5p	CLIP-seq
MIRT1042348	hsa-miR-3202	CLIP-seq
MIRT1042351	hsa-miR-3606	CLIP-seq
MIRT1042352	hsa-miR-3613-3p	CLIP-seq
MIRT2241277	hsa-miR-3646	CLIP-seq
MIRT1042354	hsa-miR-3647-3p	CLIP-seq
MIRT2241278	hsa-miR-3662	CLIP-seq
MIRT1042363	hsa-miR-371-5p	CLIP-seq
MIRT1042364	hsa-miR-371b-5p	CLIP-seq
MIRT1042365	hsa-miR-381	CLIP-seq
MIRT2241282	hsa-miR-3934	CLIP-seq
MIRT2241283	hsa-miR-3973	CLIP-seq
MIRT1042372	hsa-miR-4252	CLIP-seq
MIRT2241286	hsa-miR-4422	CLIP-seq
MIRT1042379	hsa-miR-4433	CLIP-seq
MIRT2545013	hsa-miR-4434	CLIP-seq
MIRT1042381	hsa-miR-4459	CLIP-seq
MIRT1042383	hsa-miR-4480	CLIP-seq
MIRT1042384	hsa-miR-4483	CLIP-seq
MIRT1042385	hsa-miR-4493	CLIP-seq
MIRT2545014	hsa-miR-4516	CLIP-seq
MIRT2545015	hsa-miR-4531	CLIP-seq
MIRT1042389	hsa-miR-4533	CLIP-seq
MIRT2545016	hsa-miR-4662a-5p	CLIP-seq
MIRT1042392	hsa-miR-4666-3p	CLIP-seq
MIRT2241295	hsa-miR-4676-5p	CLIP-seq
MIRT1042394	hsa-miR-4684-5p	CLIP-seq
MIRT1042397	hsa-miR-4710	CLIP-seq
MIRT1042401	hsa-miR-4753-5p	CLIP-seq
MIRT1042403	hsa-miR-4761-5p	CLIP-seq
MIRT1042404	hsa-miR-4768-3p	CLIP-seq
MIRT2545017	hsa-miR-4786-3p	CLIP-seq
MIRT1042405	hsa-miR-4792	CLIP-seq
MIRT1042406	hsa-miR-4793-3p	CLIP-seq
MIRT2008945	hsa-miR-4797-5p	CLIP-seq
MIRT1042407	hsa-miR-490-3p	CLIP-seq
MIRT1042416	hsa-miR-548a-3p	CLIP-seq
MIRT2545018	hsa-miR-548ad	CLIP-seq
MIRT1042418	hsa-miR-548c-3p	CLIP-seq
MIRT1042419	hsa-miR-548e	CLIP-seq
MIRT1042420	hsa-miR-548f	CLIP-seq
MIRT2241309	hsa-miR-575	CLIP-seq
MIRT1042429	hsa-miR-589	CLIP-seq
MIRT1042431	hsa-miR-612	CLIP-seq
MIRT2241313	hsa-miR-759	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Activation	20697349
MYCN	Activation	20697349
RFX5	Unknown	16464847
YY1	Unknown	11532945

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	IBA	21873635
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19041327, 19276356
GO:0000785	Component	Chromatin	HDA	16217013
GO:0001103	Function	RNA polymerase II repressing transcription factor binding	IPI	22926524
GO:0001975	Process	Response to amphetamine	IEA
GO:0003300	Process	Cardiac muscle hypertrophy	IEA
GO:0003682	Function	Chromatin binding	ISS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0004407	Function	Histone deacetylase activity	IBA	21873635
GO:0004407	Function	Histone deacetylase activity	IDA	16642021
GO:0005515	Function	Protein binding	IPI	9150135, 11062478, 11259576, 11641274, 11739383, 12140263, 12176973, 12670868, 12711603, 14752048, 16254079, 16464847, 16919237, 17245431, 17314511, 17318229, 17827154, 17956988, 17984088, 18451879, 19182791, 19343227, 19433865, 19497860, 19505873, 19703393, 19729656, 19805145, 2019
GO:0005634	Component	Nucleus	IDA	18347167, 24970816
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24970816
GO:0005737	Component	Cytoplasm	TAS	12711221
GO:0006338	Process	Chromatin remodeling	IC	17827154
GO:0007596	Process	Blood coagulation	TAS
GO:0008134	Function	Transcription factor binding	IPI	17827154
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18347167
GO:0009913	Process	Epidermal cell differentiation	ISS	21093383
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IEA
GO:0010977	Process	Negative regulation of neuron projection development	ISS	18754010
GO:0016358	Process	Dendrite development	ISS
GO:0016575	Process	Histone deacetylation	IMP	19372552
GO:0016580	Component	Sin3 complex	IDA	14966270, 17827154
GO:0016581	Component	NuRD complex	IDA	17827154, 19644445, 22926524
GO:0019213	Function	Deacetylase activity	ISS
GO:0019899	Function	Enzyme binding	IPI	11062478, 11641274
GO:0031000	Process	Response to caffeine	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031492	Function	Nucleosomal DNA binding	HDA	16217013
GO:0032041	Function	NAD-dependent histone deacetylase activity (H3-K14 specific)	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032732	Process	Positive regulation of interleukin-1 production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IC	19041327
GO:0032991	Component	Protein-containing complex	HDA	16217013
GO:0032991	Component	Protein-containing complex	IDA	28046085
GO:0033558	Function	Protein deacetylase activity	IMP	19041327
GO:0034605	Process	Cellular response to heat	IEA
GO:0035094	Process	Response to nicotine	IEA
GO:0035098	Component	ESC/E(Z) complex	IDA	20075857
GO:0042220	Process	Response to cocaine	IEA
GO:0042475	Process	Odontogenesis of dentin-containing tooth	ISS	21093383
GO:0042493	Process	Response to drug	IEA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IEA
GO:0042733	Process	Embryonic digit morphogenesis	ISS	21093383
GO:0042826	Function	Histone deacetylase binding	IPI	28046085
GO:0043044	Process	ATP-dependent chromatin remodeling	HDA	16217013
GO:0043066	Process	Negative regulation of apoptotic process	ISS	21093383
GO:0043392	Process	Negative regulation of DNA binding	IEA
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	IMP	19041327
GO:0043565	Function	Sequence-specific DNA binding	IDA	19276356
GO:0045347	Process	Negative regulation of MHC class II biosynthetic process	IC	19041327
GO:0045862	Process	Positive regulation of proteolysis	IMP	19041327
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IC	19041327
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	19276356
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IC	19041327
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	19041327, 19372552
GO:0048149	Process	Behavioral response to ethanol	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA
GO:0051059	Function	NF-kappaB binding	IPI	17785205
GO:0055093	Process	Response to hyperoxia	IEA
GO:0060789	Process	Hair follicle placode formation	ISS	21093383
GO:0061000	Process	Negative regulation of dendritic spine development	IEA
GO:0061029	Process	Eyelid development in camera-type eye	ISS	21093383
GO:0061198	Process	Fungiform papilla formation	ISS	21093383
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0070829	Process	Heterochromatin maintenance	IMP	19372552
GO:0070932	Process	Histone H3 deacetylation	IBA	21873635
GO:0070932	Process	Histone H3 deacetylation	ISS
GO:0070933	Process	Histone H4 deacetylation	IBA	21873635
GO:0070933	Process	Histone H4 deacetylation	ISS
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0071560	Process	Cellular response to transforming growth factor beta stimulus	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1902437	Process	Positive regulation of male mating behavior	IEA
GO:1903351	Process	Cellular response to dopamine	IEA
GO:1990841	Function	Promoter-specific chromatin binding	IEA
GO:2000273	Process	Positive regulation of signaling receptor activity	IMP	18316616
GO:2000757	Process	Negative regulation of peptidyl-lysine acetylation	IEA

Other IDs

• MIM: 605164
• HGNC: 4853
• e!Ensembl: ENSG00000196591

Protein

• UniProt ID: Q92769
• Protein name: Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
• Protein function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role
• PDB: 3MAX, 4LXZ, 4LY1, 5IWG, 5IX0, 6G3O, 6WBW, 6WBZ, 6WHN, 6WHO, 6WHQ, 6WHZ, 6WI3, 6XDM, 6XEB, 6XEC, 7JS8, 7KBG, 7KBH, 7LTG, 7LTK, 7LTL, 7MOS, 7MOT, 7MOX, 7MOY, 7MOZ, 7ZZO, 7ZZP, 7ZZR, 7ZZS, 7ZZT, 7ZZU, 7ZZW, 8A0B, 8BPA, 8BPB, 8BPC, 8C60, 9DTQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00850	Hist_deacetyl	29 → 320	Histone deacetylase domain	Domain

• Sequence:

  MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
  TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
  GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
  GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
  IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
  GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
  EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
  FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
  KSEQLSNP

• Sequence length: 488

Pathways

KEGG:

ATP-dependent chromatin remodeling
Polycomb repressive complex
Cell cycle
Longevity regulating pathway - multiple species
Notch signaling pathway
TGF-beta signaling pathway
Neutrophil extracellular trap formation
Thyroid hormone signaling pathway
Huntington disease
Amphetamine addiction
Alcoholism
Human papillomavirus infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
MicroRNAs in cancer
Chronic myeloid leukemia

Reactome:

Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Factors involved in megakaryocyte development and platelet production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21527555
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	15337792, 18421014
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22864611

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		22138541
Endometriosis	Endometriosis	rs1800629, rs1143634	22138541
Liver cirrhosis	Liver Cirrhosis		27396813
Liver fibrosis	Fibrosis, Liver		27396813
Mental depression	Mental Depression	rs587778876, rs587778877	19767015
Monocytic leukemia	Leukemia, Monocytic, Chronic		21535412
Mood disorder	Mood Disorders		23967191, 19767015
Myeloid leukemia	Myeloid Leukemia		21535412
Nonorganic psychosis	Nonorganic psychosis		22864611
Prostate adenocarcinoma	Adenocarcinoma of prostate
Psychosis	Psychotic Disorders		22864611