HAGH (hydroxyacylglutathione hydrolase)

Gene

• Entrez ID: 3029
• Gene name: Hydroxyacylglutathione hydrolase
• Gene symbol: HAGH
• Synonyms: GLO2, GLO2D, GLX2, GLXII, HAGH1
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029772	hsa-miR-26b-5p	Microarray	19088304
MIRT047796	hsa-miR-30d-5p	CLASH	23622248
MIRT040597	hsa-miR-92b-3p	CLASH	23622248
MIRT1040553	hsa-miR-340	CLIP-seq
MIRT1040554	hsa-miR-3607-3p	CLIP-seq
MIRT1040555	hsa-miR-4282	CLIP-seq
MIRT1040556	hsa-miR-4446-3p	CLIP-seq
MIRT1040557	hsa-miR-4675	CLIP-seq
MIRT1040558	hsa-miR-4731-3p	CLIP-seq
MIRT1040559	hsa-miR-4741	CLIP-seq
MIRT1040560	hsa-miR-4753-3p	CLIP-seq
MIRT1040561	hsa-miR-4801	CLIP-seq
MIRT1040562	hsa-miR-586	CLIP-seq
MIRT1040563	hsa-miR-942	CLIP-seq
MIRT2008492	hsa-miR-4499	CLIP-seq
MIRT2008493	hsa-miR-4680-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004416	Function	Hydroxyacylglutathione hydrolase activity	IDA	8550579
GO:0005515	Function	Protein binding	IPI	21044950
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006090	Process	Pyruvate metabolic process	TAS
GO:0006750	Process	Glutathione biosynthetic process	IDA	8550579
GO:0019243	Process	Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 138760
• HGNC: 4805
• e!Ensembl: ENSG00000063854

Protein

• UniProt ID: Q16775
• Protein name: Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)
• Protein function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
• PDB: 1QH3, 1QH5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00753	Lactamase_B	57 → 139	Metallo-beta-lactamase superfamily	Domain
  PF16123	HAGH_C	222 → 303	Hydroxyacylglutathione hydrolase C-terminus	Family

• Sequence:

  MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
  YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
  LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
  GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
  IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
  DQFKMPRD

• Sequence length: 308

Pathways

KEGG:

Pyruvate metabolism
Metabolic pathways

Reactome:

Pyruvate metabolism

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25645869