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ANXA2 (annexin A2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
302
Gene nameGene Name - the full gene name approved by the HGNC.
Annexin A2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ANXA2
SynonymsGene synonyms aliases
ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV
ChromosomeChromosome number
15
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor whi
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001388 hsa-miR-1-3p pSILAC 18668040
MIRT020897 hsa-miR-155-5p Proteomics 18668040
MIRT001388 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001388 hsa-miR-1-3p Proteomics 18668040
MIRT045844 hsa-miR-132-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEP 11866539
GO:0001765 Process Membrane raft assembly IMP 23861394
GO:0001786 Function Phosphatidylserine binding IBA 21873635
GO:0001921 Process Positive regulation of receptor recycling IDA 22848640
GO:0002020 Function Protease binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P07355
Protein name Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation,
PDB 1W7B , 1XJL , 2HYU , 2HYV , 2HYW , 4DRW , 4FTG , 4HRH , 5LPU , 5LPX , 5LQ0 , 5LQ2 , 5N7D , 5N7F , 5N7G , 6TWQ , 6TWU , 6TWX , 6TWY , 7DTO , 7EQ7 , 7NMI , 7P70 , 7P71 , 7P72 , 7P73 , 7P74 , 7PC3 , 7PC4 , 7PC5 , 7PC7 , 7PC8 , 7PC9 , 7PCB , 7QQL , 7QQM , 7QQN , 7ZVN , 7ZVX , 8AEL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin
37 102
Annexin
Family
PF00191 Annexin
109 174
Annexin
Family
PF00191 Annexin
193 259
Annexin
Family
PF00191 Annexin
269 334
Annexin
Family
Sequence
Sequence length 339
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Salmonella infection   Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 15274141
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 17330099
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 20682992
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease name Disease term dbSNP ID References
Liver neoplasms Liver neoplasms 19233941
Liver cancer Malignant neoplasm of liver 19233941
Lung neoplasms Lung Neoplasms 20682992
Malignant mesothelioma Malignant mesothelioma 20682992

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