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ANXA1 (annexin A1)

Gene

301

Annexin A1

ANXA1

ANX1, LPC1

9q21.13

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec

Show/Hide all(65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000709	hsa-miR-196a-5p	real time qRT-PCR, Luciferase reporter assay, Western blot	18663355
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay	18663355
MIRT018638	hsa-miR-335-5p	Microarray	18185580
MIRT000709	hsa-miR-196a-5p	Reporter assay;Other	18663355
MIRT028650	hsa-miR-30a-5p	Proteomics	18668040
MIRT030065	hsa-miR-26b-5p	Microarray	19088304
MIRT054354	hsa-miR-221-3p	Luciferase reporter assay, QRTPCR, Western blot	23630541
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25523631
MIRT737187	hsa-miR-196a-3p	qRT-PCR	31777500
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT2426342	hsa-miR-2110	CLIP-seq
MIRT2426343	hsa-miR-221	CLIP-seq
MIRT2426344	hsa-miR-222	CLIP-seq
MIRT2426345	hsa-miR-28-3p	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2426346	hsa-miR-3150a-3p	CLIP-seq
MIRT2426347	hsa-miR-3163	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT2426348	hsa-miR-3662	CLIP-seq
MIRT2426349	hsa-miR-3675-3p	CLIP-seq
MIRT2426350	hsa-miR-369-3p	CLIP-seq
MIRT2426351	hsa-miR-374a	CLIP-seq
MIRT2426352	hsa-miR-374b	CLIP-seq
MIRT2426353	hsa-miR-376c	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT2426354	hsa-miR-4260	CLIP-seq
MIRT2426355	hsa-miR-4271	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT2426356	hsa-miR-4484	CLIP-seq
MIRT2426357	hsa-miR-4668-5p	CLIP-seq
MIRT2426358	hsa-miR-4694-3p	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT2426359	hsa-miR-4725-3p	CLIP-seq
MIRT2426360	hsa-miR-4773	CLIP-seq
MIRT2426361	hsa-miR-4789-5p	CLIP-seq
MIRT2426362	hsa-miR-4797-5p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT2426363	hsa-miR-548an	CLIP-seq
MIRT2426364	hsa-miR-548c-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2426365	hsa-miR-570	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq

Show/Hide all(131)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	10908733
GO:0001780	Process	Neutrophil homeostasis	IMP	21957127
GO:0001891	Component	Phagocytic cup	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002548	Process	Monocyte chemotaxis	IDA	15187149
GO:0002685	Process	Regulation of leukocyte migration	IBA	21873635
GO:0002685	Process	Regulation of leukocyte migration	ISS
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	10882119
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	20029029, 21383699, 24189400, 31980649, 32296183, 32814053
GO:0005543	Function	Phospholipid binding	TAS	2967291
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	17008549, 19625660, 25664854
GO:0005634	Component	Nucleus	IDA	22056994
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17008549, 19625660, 22056994
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005768	Component	Endosome	IDA	18767904
GO:0005829	Component	Cytosol	IDA
GO:0005884	Component	Actin filament	IDA	22773844
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006909	Process	Phagocytosis	ISS
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006954	Process	Inflammatory response	ISS
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	25664854
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP	15187149
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IDA	15187149
GO:0009986	Component	Cell surface	IDA	22056994
GO:0010165	Process	Response to X-ray	IBA	21873635
GO:0014839	Process	Myoblast migration involved in skeletal muscle regeneration	IBA	21873635
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0018149	Process	Peptide cross-linking	IDA	10908733
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019834	Function	Phospholipase A2 inhibitor activity	IBA	21873635
GO:0019834	Function	Phospholipase A2 inhibitor activity	IDA	2936963, 3013422
GO:0019898	Component	Extrinsic component of membrane	IDA	17008549
GO:0030073	Process	Insulin secretion	IBA	21873635
GO:0030216	Process	Keratinocyte differentiation	IBA	21873635
GO:0030216	Process	Keratinocyte differentiation	IDA	10908733
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030850	Process	Prostate gland development	IBA	21873635
GO:0031018	Process	Endocrine pancreas development	IBA	21873635
GO:0031232	Component	Extrinsic component of external side of plasma membrane	IDA	19625660
GO:0031313	Component	Extrinsic component of endosome membrane	ISS
GO:0031340	Process	Positive regulation of vesicle fusion	IBA	21873635
GO:0031340	Process	Positive regulation of vesicle fusion	IDA	2138016
GO:0031394	Process	Positive regulation of prostaglandin biosynthetic process	IBA	21873635
GO:0031514	Component	Motile cilium	ISS
GO:0031532	Process	Actin cytoskeleton reorganization	IBA	21873635
GO:0031532	Process	Actin cytoskeleton reorganization	IDA	15187149
GO:0031901	Component	Early endosome membrane	ISS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032355	Process	Response to estradiol	IBA	21873635
GO:0032508	Process	DNA duplex unwinding	IBA	21873635
GO:0032652	Process	Regulation of interleukin-1 production	IBA	21873635
GO:0032652	Process	Regulation of interleukin-1 production	ISS
GO:0032717	Process	Negative regulation of interleukin-8 production	IMP	22056994
GO:0032743	Process	Positive regulation of interleukin-2 production	IBA	21873635
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	17008549
GO:0032991	Component	Protein-containing complex	IEA
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IBA	21873635
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IBA	21873635
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	22773844
GO:0036121	Function	Double-stranded DNA helicase activity	IEA
GO:0042063	Process	Gliogenesis	IBA	21873635
GO:0042102	Process	Positive regulation of T cell proliferation	IBA	21873635
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	17008549
GO:0042383	Component	Sarcolemma	IEA
GO:0042493	Process	Response to drug	IBA	21873635
GO:0042629	Component	Mast cell granule	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0043434	Process	Response to peptide hormone	IBA	21873635
GO:0044849	Process	Estrous cycle	IBA	21873635
GO:0045087	Process	Innate immune response	IEA
GO:0045627	Process	Positive regulation of T-helper 1 cell differentiation	IBA	21873635
GO:0045627	Process	Positive regulation of T-helper 1 cell differentiation	IDA	17008549
GO:0045629	Process	Negative regulation of T-helper 2 cell differentiation	IBA	21873635
GO:0045629	Process	Negative regulation of T-helper 2 cell differentiation	IDA	17008549
GO:0045920	Process	Negative regulation of exocytosis	IBA	21873635
GO:0045920	Process	Negative regulation of exocytosis	IMP	19625660
GO:0046632	Process	Alpha-beta T cell differentiation	IBA	21873635
GO:0046632	Process	Alpha-beta T cell differentiation	ISS
GO:0046883	Process	Regulation of hormone secretion	IBA	21873635
GO:0046883	Process	Regulation of hormone secretion	IMP	19625660
GO:0048306	Function	Calcium-dependent protein binding	IPI	15226301
GO:0050482	Process	Arachidonic acid secretion	IBA	21873635
GO:0050709	Process	Negative regulation of protein secretion	IEA
GO:0050727	Process	Regulation of inflammatory response	IBA	21873635
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28344315, 28675934
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 21362503, 23533145
GO:0070062	Component	Extracellular exosome	IDA	25664854
GO:0070301	Process	Cellular response to hydrogen peroxide	IBA	21873635
GO:0070365	Process	Hepatocyte differentiation	IBA	21873635
GO:0070459	Process	Prolactin secretion	IBA	21873635
GO:0070555	Process	Response to interleukin-1	IBA	21873635
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IBA	21873635
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IDA	2936963
GO:0071621	Process	Granulocyte chemotaxis	IBA	21873635
GO:0071621	Process	Granulocyte chemotaxis	IDA	15187149
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IBA	21873635
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	22773844
GO:0090303	Process	Positive regulation of wound healing	IBA	21873635
GO:0090303	Process	Positive regulation of wound healing	IDA	25664854
GO:0097060	Component	Synaptic membrane	IEA
GO:0097350	Process	Neutrophil clearance	IBA	21873635
GO:0097350	Process	Neutrophil clearance	IMP	21957127
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IBA	21873635
GO:1900138	Process	Negative regulation of phospholipase A2 activity	IBA	21873635
GO:1990814	Function	DNA/DNA annealing activity	IEA

MIM	HGNC	e!Ensembl
151690	533	ENSG00000135046

Protein

UniProt ID

P04083

Protein name

Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]

Protein function

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulat

PDB

1AIN , 1BO9 , 1QLS , 5VFW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00191	Annexin	46 → 111	Annexin	Family
PF00191	Annexin	118 → 183	Annexin	Family
PF00191	Annexin	201 → 267	Annexin	Family
PF00191	Annexin	277 → 342	Annexin	Family

Sequence

MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV
DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA
DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL
LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY
TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

Sequence length

346

Interactions

View interactions

	Reactome
			G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-4 and Interleukin-13 signaling

Associated diseases

Show/Hide Causal Diseases (6)

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Squamous cell carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462, 16316942, 15274141, 16316942, 12376462
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21517111
Hypertension	Hypertensive disease	rs13306026, rs13333226	22228705
Kidney disease	Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	20484890
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	19381893
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17566973

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		12376462, 16316942
Lymphatic metastasis	Lymphatic Metastasis		19381893
Mouth neoplasms	Mouth Neoplasms		15274141
Malignant neoplasm of mouth	Malignant neoplasm of mouth		15274141
Prostatic neoplasms	Prostatic Neoplasms		17566973
Stomach diseases	Stomach Diseases		15472012

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