GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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LRP12 (LDL receptor related protein 12)

Gene

29967

LDL receptor related protein 12

LRP12

ALS28, MIG13A, ST7

8q22.3

This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variant

Show/Hide all(179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040084	hsa-miR-615-3p	CLASH	23622248
MIRT566890	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT566889	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT566888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT566887	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT566886	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT566885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT566884	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT566883	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT566882	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT566881	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT566880	hsa-miR-3609	PAR-CLIP	20371350
MIRT566879	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT566878	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT566877	hsa-miR-5692a	PAR-CLIP	20371350
MIRT566876	hsa-miR-548p	PAR-CLIP	20371350
MIRT566875	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT566874	hsa-miR-636	PAR-CLIP	20371350
MIRT566873	hsa-miR-633	PAR-CLIP	20371350
MIRT566872	hsa-miR-4473	PAR-CLIP	20371350
MIRT321819	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT566871	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT566870	hsa-miR-5093	PAR-CLIP	20371350
MIRT566890	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT566889	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT566888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT566887	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT566886	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT566885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT566884	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT566883	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT566882	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT566881	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT566880	hsa-miR-3609	PAR-CLIP	20371350
MIRT566879	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT566878	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT566877	hsa-miR-5692a	PAR-CLIP	20371350
MIRT566876	hsa-miR-548p	PAR-CLIP	20371350
MIRT566875	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT566874	hsa-miR-636	PAR-CLIP	20371350
MIRT566873	hsa-miR-633	PAR-CLIP	20371350
MIRT566872	hsa-miR-4473	PAR-CLIP	20371350
MIRT321819	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT566871	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT566870	hsa-miR-5093	PAR-CLIP	20371350
MIRT1117819	hsa-miR-377	CLIP-seq
MIRT1117820	hsa-miR-450b-5p	CLIP-seq
MIRT1117821	hsa-miR-507	CLIP-seq
MIRT1117822	hsa-miR-557	CLIP-seq
MIRT1117823	hsa-miR-629	CLIP-seq
MIRT1117824	hsa-miR-300	CLIP-seq
MIRT1117825	hsa-miR-381	CLIP-seq
MIRT1117826	hsa-miR-4287	CLIP-seq
MIRT1117827	hsa-miR-4469	CLIP-seq
MIRT1117828	hsa-miR-4501	CLIP-seq
MIRT1117829	hsa-miR-4666-3p	CLIP-seq
MIRT1117830	hsa-miR-4685-3p	CLIP-seq
MIRT1117831	hsa-miR-568	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2033326	hsa-miR-137	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562939	hsa-miR-10a	CLIP-seq
MIRT2562940	hsa-miR-10b	CLIP-seq
MIRT2562941	hsa-miR-1182	CLIP-seq
MIRT2562942	hsa-miR-125a-3p	CLIP-seq
MIRT2562943	hsa-miR-1297	CLIP-seq
MIRT2562944	hsa-miR-130a	CLIP-seq
MIRT2562945	hsa-miR-130b	CLIP-seq
MIRT2562946	hsa-miR-19a	CLIP-seq
MIRT2562947	hsa-miR-19b	CLIP-seq
MIRT2562948	hsa-miR-2054	CLIP-seq
MIRT2562949	hsa-miR-2277-3p	CLIP-seq
MIRT2562950	hsa-miR-26a	CLIP-seq
MIRT2562951	hsa-miR-26b	CLIP-seq
MIRT2562952	hsa-miR-301a	CLIP-seq
MIRT2562953	hsa-miR-301b	CLIP-seq
MIRT2562954	hsa-miR-3147	CLIP-seq
MIRT2562955	hsa-miR-3153	CLIP-seq
MIRT2562956	hsa-miR-3162-5p	CLIP-seq
MIRT2562957	hsa-miR-323-3p	CLIP-seq
MIRT2562958	hsa-miR-323b-3p	CLIP-seq
MIRT2562959	hsa-miR-330-3p	CLIP-seq
MIRT2562960	hsa-miR-3591-5p	CLIP-seq
MIRT2562961	hsa-miR-361-3p	CLIP-seq
MIRT2562962	hsa-miR-3617	CLIP-seq
MIRT2562963	hsa-miR-3646	CLIP-seq
MIRT2562964	hsa-miR-3665	CLIP-seq
MIRT2562965	hsa-miR-3666	CLIP-seq
MIRT1117819	hsa-miR-377	CLIP-seq
MIRT2562966	hsa-miR-382	CLIP-seq
MIRT2562967	hsa-miR-3940-5p	CLIP-seq
MIRT2562968	hsa-miR-4280	CLIP-seq
MIRT2562969	hsa-miR-4295	CLIP-seq
MIRT2562970	hsa-miR-4310	CLIP-seq
MIRT2562971	hsa-miR-4425	CLIP-seq
MIRT2562972	hsa-miR-4427	CLIP-seq
MIRT2562973	hsa-miR-4465	CLIP-seq
MIRT2562974	hsa-miR-4507	CLIP-seq
MIRT1117820	hsa-miR-450b-5p	CLIP-seq
MIRT2562975	hsa-miR-4525	CLIP-seq
MIRT2562976	hsa-miR-454	CLIP-seq
MIRT2562977	hsa-miR-4645-3p	CLIP-seq
MIRT2562978	hsa-miR-4671-3p	CLIP-seq
MIRT2562979	hsa-miR-4680-3p	CLIP-seq
MIRT2562980	hsa-miR-4693-3p	CLIP-seq
MIRT2562981	hsa-miR-4731-3p	CLIP-seq
MIRT2562982	hsa-miR-4742-3p	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562983	hsa-miR-4781-3p	CLIP-seq
MIRT2562984	hsa-miR-4786-5p	CLIP-seq
MIRT2562985	hsa-miR-4801	CLIP-seq
MIRT2562986	hsa-miR-496	CLIP-seq
MIRT2562987	hsa-miR-498	CLIP-seq
MIRT1117821	hsa-miR-507	CLIP-seq
MIRT2562988	hsa-miR-545	CLIP-seq
MIRT2562989	hsa-miR-548c-3p	CLIP-seq
MIRT1117822	hsa-miR-557	CLIP-seq
MIRT2562990	hsa-miR-570	CLIP-seq
MIRT2562991	hsa-miR-590-3p	CLIP-seq
MIRT2562992	hsa-miR-605	CLIP-seq
MIRT1117823	hsa-miR-629	CLIP-seq
MIRT2562993	hsa-miR-634	CLIP-seq
MIRT2562994	hsa-miR-641	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2562995	hsa-miR-769-5p	CLIP-seq
MIRT2562939	hsa-miR-10a	CLIP-seq
MIRT2562940	hsa-miR-10b	CLIP-seq
MIRT2562941	hsa-miR-1182	CLIP-seq
MIRT2562943	hsa-miR-1297	CLIP-seq
MIRT2562944	hsa-miR-130a	CLIP-seq
MIRT2562945	hsa-miR-130b	CLIP-seq
MIRT2684152	hsa-miR-181a	CLIP-seq
MIRT2684153	hsa-miR-181b	CLIP-seq
MIRT2684154	hsa-miR-181c	CLIP-seq
MIRT2684155	hsa-miR-181d	CLIP-seq
MIRT2562946	hsa-miR-19a	CLIP-seq
MIRT2562947	hsa-miR-19b	CLIP-seq
MIRT2562948	hsa-miR-2054	CLIP-seq
MIRT2562949	hsa-miR-2277-3p	CLIP-seq
MIRT2562950	hsa-miR-26a	CLIP-seq
MIRT2562951	hsa-miR-26b	CLIP-seq
MIRT2562952	hsa-miR-301a	CLIP-seq
MIRT2562953	hsa-miR-301b	CLIP-seq
MIRT2562955	hsa-miR-3153	CLIP-seq
MIRT2562956	hsa-miR-3162-5p	CLIP-seq
MIRT2562957	hsa-miR-323-3p	CLIP-seq
MIRT2562958	hsa-miR-323b-3p	CLIP-seq
MIRT2562959	hsa-miR-330-3p	CLIP-seq
MIRT2562960	hsa-miR-3591-5p	CLIP-seq
MIRT2562961	hsa-miR-361-3p	CLIP-seq
MIRT2562962	hsa-miR-3617	CLIP-seq
MIRT2562963	hsa-miR-3646	CLIP-seq
MIRT2684156	hsa-miR-3662	CLIP-seq
MIRT2562965	hsa-miR-3666	CLIP-seq
MIRT2562966	hsa-miR-382	CLIP-seq
MIRT2684157	hsa-miR-3973	CLIP-seq
MIRT2684158	hsa-miR-4262	CLIP-seq
MIRT2684159	hsa-miR-4291	CLIP-seq
MIRT2562969	hsa-miR-4295	CLIP-seq
MIRT2562970	hsa-miR-4310	CLIP-seq
MIRT2562973	hsa-miR-4465	CLIP-seq
MIRT2562976	hsa-miR-454	CLIP-seq
MIRT2562978	hsa-miR-4671-3p	CLIP-seq
MIRT2562981	hsa-miR-4731-3p	CLIP-seq
MIRT2562982	hsa-miR-4742-3p	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562984	hsa-miR-4786-5p	CLIP-seq
MIRT2562985	hsa-miR-4801	CLIP-seq
MIRT2562987	hsa-miR-498	CLIP-seq
MIRT2562988	hsa-miR-545	CLIP-seq
MIRT2562989	hsa-miR-548c-3p	CLIP-seq
MIRT2684160	hsa-miR-548k	CLIP-seq
MIRT2562990	hsa-miR-570	CLIP-seq
MIRT2562991	hsa-miR-590-3p	CLIP-seq
MIRT2562992	hsa-miR-605	CLIP-seq
MIRT2562993	hsa-miR-634	CLIP-seq
MIRT2562994	hsa-miR-641	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2562995	hsa-miR-769-5p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IDA	26639854
GO:0005041	Function	Low-density lipoprotein particle receptor activity	NAS	12809483
GO:0005515	Function	Protein binding	IPI	12809483
GO:0005887	Component	Integral component of plasma membrane	IDA	12809483
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	NAS	12809483
GO:0007165	Process	Signal transduction	NAS	12809483
GO:0016021	Component	Integral component of membrane	NAS	9927190
GO:0031175	Process	Neuron projection development	IDA	26639854
GO:0040008	Process	Regulation of growth	NAS	9927190

MIM	HGNC	e!Ensembl
618299	31708	ENSG00000147650

Protein

UniProt ID

Q9Y561

Protein name

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Protein function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00431	CUB	47 → 156	CUB domain	Domain
PF00057	Ldl_recept_a	164 → 200	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	213 → 254	Low-density lipoprotein receptor domain class A	Repeat
PF00431	CUB	259 → 369	CUB domain	Domain
PF00057	Ldl_recept_a	411 → 448	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	450 → 485	Low-density lipoprotein receptor domain class A	Repeat

Sequence

MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI
ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR
ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP
EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD
GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR
FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN
AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC
SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS
DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL
LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS
NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE
RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS
PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS
DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT
CLEVTLKNETSDDEALLLC

Sequence length

859

Interactions

View interactions

	Reactome
			Retinoid metabolism and transport

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28566273
External ophthalmoplegia	External Ophthalmoplegia	rs1569484022
Oculopharyngeal muscular dystrophy	Muscular Dystrophy, Oculopharyngeal	rs193922941, rs1594987281	31332380

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Distal amyotrophy	Distal amyotrophy	rs1457770815
Dysarthria	Dysarthria
Dysphagia	Deglutition Disorders
Facial paralysis	Facial paralysis
High palate	Byzanthine arch palate
Ptosis	Blepharoptosis, Ptosis	rs139920573

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