GRHL1 (grainyhead like transcription factor 1)

Gene

• Entrez ID: 29841
• Gene name: Grainyhead like transcription factor 1
• Gene symbol: GRHL1
• Synonyms: LBP32, MGR, NH32, TFCP2L2
• Chromosome: 2
• Chromosome location: 2p25.1
• Summary: This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026212	hsa-miR-192-5p	Microarray	19074876
MIRT437584	hsa-miR-125a-5p	Microarray, qRT-PCR	22815788
MIRT437754	hsa-miR-99a-5p	Microarray, qRT-PCR	22815788
MIRT437755	hsa-miR-99b-5p	Microarray, qRT-PCR	22815788
MIRT437756	hsa-miR-100-5p	Microarray, qRT-PCR	22815788
MIRT721325	hsa-miR-1183	HITS-CLIP	19536157
MIRT721324	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT721323	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT721322	hsa-miR-1-5p	HITS-CLIP	19536157
MIRT721321	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721320	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT721319	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT721325	hsa-miR-1183	HITS-CLIP	19536157
MIRT721324	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT721323	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT721322	hsa-miR-1-5p	HITS-CLIP	19536157
MIRT721321	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721320	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT721319	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT1033767	hsa-miR-100	CLIP-seq
MIRT1033768	hsa-miR-125a-3p	CLIP-seq
MIRT1033769	hsa-miR-125b	CLIP-seq
MIRT1033770	hsa-miR-1273d	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033772	hsa-miR-144	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033776	hsa-miR-1827	CLIP-seq
MIRT1033777	hsa-miR-190	CLIP-seq
MIRT1033778	hsa-miR-190b	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT1033784	hsa-miR-25	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033786	hsa-miR-297	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033788	hsa-miR-299-5p	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033796	hsa-miR-3136-5p	CLIP-seq
MIRT1033797	hsa-miR-3148	CLIP-seq
MIRT1033798	hsa-miR-3163	CLIP-seq
MIRT1033799	hsa-miR-3164	CLIP-seq
MIRT1033800	hsa-miR-32	CLIP-seq
MIRT1033801	hsa-miR-340	CLIP-seq
MIRT1033802	hsa-miR-345	CLIP-seq
MIRT1033803	hsa-miR-34a	CLIP-seq
MIRT1033804	hsa-miR-34c-5p	CLIP-seq
MIRT1033805	hsa-miR-3613-3p	CLIP-seq
MIRT1033806	hsa-miR-3613-5p	CLIP-seq
MIRT1033807	hsa-miR-3617	CLIP-seq
MIRT1033808	hsa-miR-363	CLIP-seq
MIRT1033809	hsa-miR-3664-5p	CLIP-seq
MIRT1033810	hsa-miR-367	CLIP-seq
MIRT1033811	hsa-miR-3673	CLIP-seq
MIRT1033812	hsa-miR-3682-5p	CLIP-seq
MIRT1033813	hsa-miR-3714	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT1033817	hsa-miR-3919	CLIP-seq
MIRT1033818	hsa-miR-3934	CLIP-seq
MIRT1033819	hsa-miR-3978	CLIP-seq
MIRT1033820	hsa-miR-410	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033823	hsa-miR-4282	CLIP-seq
MIRT1033824	hsa-miR-4316	CLIP-seq
MIRT1033825	hsa-miR-4319	CLIP-seq
MIRT1033826	hsa-miR-432	CLIP-seq
MIRT1033827	hsa-miR-4321	CLIP-seq
MIRT1033828	hsa-miR-4325	CLIP-seq
MIRT1033829	hsa-miR-433	CLIP-seq
MIRT1033830	hsa-miR-4436b-5p	CLIP-seq
MIRT1033831	hsa-miR-4439	CLIP-seq
MIRT1033832	hsa-miR-4452	CLIP-seq
MIRT1033833	hsa-miR-449a	CLIP-seq
MIRT1033834	hsa-miR-449b	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033836	hsa-miR-4513	CLIP-seq
MIRT1033837	hsa-miR-4522	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033840	hsa-miR-4643	CLIP-seq
MIRT1033841	hsa-miR-4653-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033844	hsa-miR-466	CLIP-seq
MIRT1033845	hsa-miR-4661-5p	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT1033847	hsa-miR-4680-3p	CLIP-seq
MIRT1033848	hsa-miR-4686	CLIP-seq
MIRT1033849	hsa-miR-4724-5p	CLIP-seq
MIRT1033850	hsa-miR-4732-3p	CLIP-seq
MIRT1033851	hsa-miR-4744	CLIP-seq
MIRT1033852	hsa-miR-4764-3p	CLIP-seq
MIRT1033853	hsa-miR-4781-5p	CLIP-seq
MIRT1033854	hsa-miR-4789-3p	CLIP-seq
MIRT1033855	hsa-miR-495	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT1033864	hsa-miR-539	CLIP-seq
MIRT1033865	hsa-miR-548aa	CLIP-seq
MIRT1033866	hsa-miR-548an	CLIP-seq
MIRT1033867	hsa-miR-567	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT1033869	hsa-miR-582-5p	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT1033871	hsa-miR-618	CLIP-seq
MIRT1033872	hsa-miR-630	CLIP-seq
MIRT1033873	hsa-miR-634	CLIP-seq
MIRT1033874	hsa-miR-641	CLIP-seq
MIRT1033875	hsa-miR-660	CLIP-seq
MIRT1033876	hsa-miR-670	CLIP-seq
MIRT1033877	hsa-miR-764	CLIP-seq
MIRT1033878	hsa-miR-92a	CLIP-seq
MIRT1033879	hsa-miR-92b	CLIP-seq
MIRT1033880	hsa-miR-99a	CLIP-seq
MIRT1033881	hsa-miR-99b	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT2006602	hsa-miR-3074-3p	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033823	hsa-miR-4282	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT2006603	hsa-miR-4672	CLIP-seq
MIRT2006604	hsa-miR-4803	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT1033865	hsa-miR-548aa	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT1033869	hsa-miR-582-5p	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT1033873	hsa-miR-634	CLIP-seq
MIRT2006605	hsa-miR-873	CLIP-seq
MIRT2239008	hsa-miR-1253	CLIP-seq
MIRT2239009	hsa-miR-1263	CLIP-seq
MIRT1033770	hsa-miR-1273d	CLIP-seq
MIRT2239010	hsa-miR-1281	CLIP-seq
MIRT2239011	hsa-miR-1301	CLIP-seq
MIRT1033776	hsa-miR-1827	CLIP-seq
MIRT2239012	hsa-miR-185	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT2239013	hsa-miR-217	CLIP-seq
MIRT2239014	hsa-miR-2276	CLIP-seq
MIRT1033784	hsa-miR-25	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033786	hsa-miR-297	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT1033796	hsa-miR-3136-5p	CLIP-seq
MIRT2239015	hsa-miR-3165	CLIP-seq
MIRT1033800	hsa-miR-32	CLIP-seq
MIRT1033802	hsa-miR-345	CLIP-seq
MIRT1033803	hsa-miR-34a	CLIP-seq
MIRT2239016	hsa-miR-34c-3p	CLIP-seq
MIRT1033804	hsa-miR-34c-5p	CLIP-seq
MIRT1033805	hsa-miR-3613-3p	CLIP-seq
MIRT1033806	hsa-miR-3613-5p	CLIP-seq
MIRT2239017	hsa-miR-3614-5p	CLIP-seq
MIRT1033807	hsa-miR-3617	CLIP-seq
MIRT2239018	hsa-miR-3622a-5p	CLIP-seq
MIRT1033808	hsa-miR-363	CLIP-seq
MIRT1033810	hsa-miR-367	CLIP-seq
MIRT1033813	hsa-miR-3714	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT2239019	hsa-miR-3914	CLIP-seq
MIRT2239020	hsa-miR-3938	CLIP-seq
MIRT1033820	hsa-miR-410	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT2239021	hsa-miR-4256	CLIP-seq
MIRT2239022	hsa-miR-4269	CLIP-seq
MIRT2239023	hsa-miR-4306	CLIP-seq
MIRT1033824	hsa-miR-4316	CLIP-seq
MIRT1033828	hsa-miR-4325	CLIP-seq
MIRT2239024	hsa-miR-4418	CLIP-seq
MIRT2239025	hsa-miR-4423-3p	CLIP-seq
MIRT2239026	hsa-miR-4432	CLIP-seq
MIRT1033831	hsa-miR-4439	CLIP-seq
MIRT2239027	hsa-miR-4444	CLIP-seq
MIRT1033832	hsa-miR-4452	CLIP-seq
MIRT2239028	hsa-miR-4456	CLIP-seq
MIRT2239029	hsa-miR-4457	CLIP-seq
MIRT2239030	hsa-miR-448	CLIP-seq
MIRT1033833	hsa-miR-449a	CLIP-seq
MIRT1033834	hsa-miR-449b	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033836	hsa-miR-4513	CLIP-seq
MIRT2239031	hsa-miR-4514	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033840	hsa-miR-4643	CLIP-seq
MIRT2239032	hsa-miR-4644	CLIP-seq
MIRT1033841	hsa-miR-4653-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033844	hsa-miR-466	CLIP-seq
MIRT2239033	hsa-miR-4660	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT2006603	hsa-miR-4672	CLIP-seq
MIRT1033847	hsa-miR-4680-3p	CLIP-seq
MIRT2239034	hsa-miR-4692	CLIP-seq
MIRT2239035	hsa-miR-4693-3p	CLIP-seq
MIRT2239036	hsa-miR-4708-3p	CLIP-seq
MIRT1033849	hsa-miR-4724-5p	CLIP-seq
MIRT2239037	hsa-miR-4733-5p	CLIP-seq
MIRT2239038	hsa-miR-4742-5p	CLIP-seq
MIRT2239039	hsa-miR-4756-3p	CLIP-seq
MIRT2239040	hsa-miR-4762-3p	CLIP-seq
MIRT1033854	hsa-miR-4789-3p	CLIP-seq
MIRT2006604	hsa-miR-4803	CLIP-seq
MIRT2239041	hsa-miR-499-5p	CLIP-seq
MIRT2239042	hsa-miR-5047	CLIP-seq
MIRT2239043	hsa-miR-509-3-5p	CLIP-seq
MIRT2239044	hsa-miR-509-5p	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT2239045	hsa-miR-550b	CLIP-seq
MIRT1033867	hsa-miR-567	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT2239046	hsa-miR-580	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT2239047	hsa-miR-616	CLIP-seq
MIRT2239048	hsa-miR-617	CLIP-seq
MIRT1033874	hsa-miR-641	CLIP-seq
MIRT1033875	hsa-miR-660	CLIP-seq
MIRT1033878	hsa-miR-92a	CLIP-seq
MIRT1033879	hsa-miR-92b	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033812	hsa-miR-3682-5p	CLIP-seq
MIRT2543027	hsa-miR-421	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033845	hsa-miR-4661-5p	CLIP-seq
MIRT2543028	hsa-miR-4709-5p	CLIP-seq
MIRT1033855	hsa-miR-495	CLIP-seq
MIRT2543029	hsa-miR-513c	CLIP-seq
MIRT2543030	hsa-miR-514b-5p	CLIP-seq
MIRT2543031	hsa-miR-543	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC3	Repression	24419085
MYCN	Repression	24419085

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	IDA	18288204
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12175488
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	21873635
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12175488
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	29309642
GO:0002934	Process	Desmosome organization	IEA
GO:0005515	Function	Protein binding	IPI	29309642
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	18288204, 21081122
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008544	Process	Epidermis development	ISS
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0031490	Function	Chromatin DNA binding	IDA	21081122
GO:0042803	Function	Protein homodimerization activity	IPI	29309642
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043565	Function	Sequence-specific DNA binding	IDA	18288204
GO:0045616	Process	Regulation of keratinocyte differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12175488
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	29309642
GO:0061436	Process	Establishment of skin barrier	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 609786
• HGNC: 17923
• e!Ensembl: ENSG00000134317

Protein

• UniProt ID: Q9NZI5
• Protein name: Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)
• Protein function: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal
• PDB: 5MPF, 5MPH, 5MPI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04516	CP2	231 → 442	CP2 transcription factor	Family

• Sequence:

  MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAA
  LGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPF
  NIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPT
  ERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSE
  DYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKV
  RSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAIS
  FTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVF
  CDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFA
  NLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESE
  EVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTF
  QLQIEEAGGSYKLTLTEI

• Sequence length: 618

Pathways

Reactome:

PPARA activates gene expression

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	27790247
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683
Diabetes	Diabetes	rs80356611	27790247
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	27790247
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	23535732, 29892016, 23535732

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	27790247
Heart failure	Heart failure	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	27790247
Malignant neoplasm	Malignant Neoplasms		27790247
Stroke	Cerebrovascular accident		27790247