ZDHHC8 (zDHHC palmitoyltransferase 8)

Gene

• Entrez ID: 29801
• Gene name: ZDHHC palmitoyltransferase 8
• Gene symbol: ZDHHC8
• Synonyms: DHHC8, ZDHHCL1, ZNF378
• Chromosome: 22
• Chromosome location: 22q11.21
• Summary: This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050261	hsa-miR-25-3p	CLASH	23622248
MIRT718261	hsa-miR-3929	HITS-CLIP	19536157
MIRT718260	hsa-miR-4419b	HITS-CLIP	19536157
MIRT718259	hsa-miR-4478	HITS-CLIP	19536157
MIRT718258	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT718257	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718256	hsa-miR-1913	HITS-CLIP	19536157
MIRT718255	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718254	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718253	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718252	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT300511	hsa-miR-4313	HITS-CLIP	19536157
MIRT718251	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT718250	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT718249	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT529802	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT529801	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT529800	hsa-miR-5685	PAR-CLIP	22012620
MIRT529799	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT529798	hsa-miR-4786-5p	PAR-CLIP	22012620
MIRT529797	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT718261	hsa-miR-3929	HITS-CLIP	19536157
MIRT718260	hsa-miR-4419b	HITS-CLIP	19536157
MIRT718259	hsa-miR-4478	HITS-CLIP	19536157
MIRT718258	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT718257	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718256	hsa-miR-1913	HITS-CLIP	19536157
MIRT718255	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718254	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718253	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718252	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT300511	hsa-miR-4313	HITS-CLIP	19536157
MIRT718251	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT718250	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT718249	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT529802	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT529801	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT529800	hsa-miR-5685	PAR-CLIP	22012620
MIRT529799	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT529798	hsa-miR-4786-5p	PAR-CLIP	22012620
MIRT529797	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT1509043	hsa-miR-1206	CLIP-seq
MIRT1509044	hsa-miR-1225-5p	CLIP-seq
MIRT1509045	hsa-miR-124	CLIP-seq
MIRT1509046	hsa-miR-1285	CLIP-seq
MIRT1509047	hsa-miR-1321	CLIP-seq
MIRT1509048	hsa-miR-3132	CLIP-seq
MIRT1509049	hsa-miR-3151	CLIP-seq
MIRT1509050	hsa-miR-3162-5p	CLIP-seq
MIRT1509051	hsa-miR-3187-5p	CLIP-seq
MIRT1509052	hsa-miR-3607-5p	CLIP-seq
MIRT1509053	hsa-miR-3714	CLIP-seq
MIRT1509054	hsa-miR-3910	CLIP-seq
MIRT1509055	hsa-miR-3937	CLIP-seq
MIRT1509056	hsa-miR-4271	CLIP-seq
MIRT1509057	hsa-miR-4323	CLIP-seq
MIRT1509058	hsa-miR-4456	CLIP-seq
MIRT1509059	hsa-miR-4487	CLIP-seq
MIRT1509060	hsa-miR-4505	CLIP-seq
MIRT1509061	hsa-miR-4670-3p	CLIP-seq
MIRT1509062	hsa-miR-4725-3p	CLIP-seq
MIRT1509063	hsa-miR-4739	CLIP-seq
MIRT1509064	hsa-miR-4747-5p	CLIP-seq
MIRT1509065	hsa-miR-4756-5p	CLIP-seq
MIRT1509066	hsa-miR-485-5p	CLIP-seq
MIRT1509067	hsa-miR-506	CLIP-seq
MIRT1509068	hsa-miR-592	CLIP-seq
MIRT1509069	hsa-miR-597	CLIP-seq
MIRT1509070	hsa-miR-612	CLIP-seq
MIRT1509071	hsa-miR-665	CLIP-seq
MIRT1509072	hsa-miR-125a-5p	CLIP-seq
MIRT1509073	hsa-miR-125b	CLIP-seq
MIRT1509074	hsa-miR-1262	CLIP-seq
MIRT1509075	hsa-miR-342-5p	CLIP-seq
MIRT1509076	hsa-miR-365	CLIP-seq
MIRT1509077	hsa-miR-3914	CLIP-seq
MIRT1509078	hsa-miR-3915	CLIP-seq
MIRT1509079	hsa-miR-3928	CLIP-seq
MIRT1509080	hsa-miR-4319	CLIP-seq
MIRT1509081	hsa-miR-4651	CLIP-seq
MIRT1509082	hsa-miR-4664-5p	CLIP-seq
MIRT1509083	hsa-miR-4667-5p	CLIP-seq
MIRT1509084	hsa-miR-4700-5p	CLIP-seq
MIRT1509085	hsa-miR-4701-3p	CLIP-seq
MIRT1509086	hsa-miR-4731-5p	CLIP-seq
MIRT1509087	hsa-miR-4749-3p	CLIP-seq
MIRT1509088	hsa-miR-544b	CLIP-seq
MIRT1509089	hsa-miR-608	CLIP-seq
MIRT1509090	hsa-miR-637	CLIP-seq
MIRT2153302	hsa-miR-1245b-3p	CLIP-seq
MIRT2153303	hsa-miR-1260	CLIP-seq
MIRT2153304	hsa-miR-1260b	CLIP-seq
MIRT2153305	hsa-miR-1291	CLIP-seq
MIRT2153306	hsa-miR-1324	CLIP-seq
MIRT2153307	hsa-miR-188-3p	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq
MIRT2153309	hsa-miR-1972	CLIP-seq
MIRT2153310	hsa-miR-199a-5p	CLIP-seq
MIRT2153311	hsa-miR-199b-5p	CLIP-seq
MIRT2153312	hsa-miR-218	CLIP-seq
MIRT2153313	hsa-miR-2278	CLIP-seq
MIRT2153314	hsa-miR-2355-5p	CLIP-seq
MIRT2153315	hsa-miR-3064-5p	CLIP-seq
MIRT2153316	hsa-miR-3156-3p	CLIP-seq
MIRT2153317	hsa-miR-3160-5p	CLIP-seq
MIRT2153318	hsa-miR-3202	CLIP-seq
MIRT2153319	hsa-miR-34a	CLIP-seq
MIRT2153320	hsa-miR-34c-5p	CLIP-seq
MIRT1509052	hsa-miR-3607-5p	CLIP-seq
MIRT2153321	hsa-miR-3612	CLIP-seq
MIRT2153322	hsa-miR-3622b-5p	CLIP-seq
MIRT2153323	hsa-miR-3652	CLIP-seq
MIRT2153324	hsa-miR-4260	CLIP-seq
MIRT1509056	hsa-miR-4271	CLIP-seq
MIRT2153325	hsa-miR-4302	CLIP-seq
MIRT2153326	hsa-miR-4430	CLIP-seq
MIRT2153327	hsa-miR-4436b-3p	CLIP-seq
MIRT2153328	hsa-miR-4443	CLIP-seq
MIRT2153329	hsa-miR-4462	CLIP-seq
MIRT2153330	hsa-miR-4479	CLIP-seq
MIRT2153331	hsa-miR-449a	CLIP-seq
MIRT2153332	hsa-miR-449b	CLIP-seq
MIRT1509060	hsa-miR-4505	CLIP-seq
MIRT2153333	hsa-miR-4508	CLIP-seq
MIRT2153334	hsa-miR-4514	CLIP-seq
MIRT2153335	hsa-miR-4634	CLIP-seq
MIRT2153336	hsa-miR-4643	CLIP-seq
MIRT1509083	hsa-miR-4667-5p	CLIP-seq
MIRT2153337	hsa-miR-4692	CLIP-seq
MIRT1509084	hsa-miR-4700-5p	CLIP-seq
MIRT2153338	hsa-miR-4717-3p	CLIP-seq
MIRT1509062	hsa-miR-4725-3p	CLIP-seq
MIRT1509086	hsa-miR-4731-5p	CLIP-seq
MIRT1509064	hsa-miR-4747-5p	CLIP-seq
MIRT2153339	hsa-miR-4754	CLIP-seq
MIRT2153340	hsa-miR-4755-3p	CLIP-seq
MIRT2153341	hsa-miR-4802-3p	CLIP-seq
MIRT1509066	hsa-miR-485-5p	CLIP-seq
MIRT2153342	hsa-miR-486-3p	CLIP-seq
MIRT1509068	hsa-miR-592	CLIP-seq
MIRT1509069	hsa-miR-597	CLIP-seq
MIRT2153343	hsa-miR-602	CLIP-seq
MIRT2153344	hsa-miR-604	CLIP-seq
MIRT2153345	hsa-miR-636	CLIP-seq
MIRT2153346	hsa-miR-642b	CLIP-seq
MIRT2153347	hsa-miR-648	CLIP-seq
MIRT2153348	hsa-miR-650	CLIP-seq
MIRT2153349	hsa-miR-662	CLIP-seq
MIRT2373619	hsa-miR-711	CLIP-seq
MIRT2153329	hsa-miR-4462	CLIP-seq
MIRT2153346	hsa-miR-642b	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	16647879
GO:0005829	Component	Cytosol	TAS
GO:0007626	Process	Locomotory behavior	IEA
GO:0010875	Process	Positive regulation of cholesterol efflux	IDA	19556522
GO:0016021	Component	Integral component of membrane	IEA
GO:0016409	Function	Palmitoyltransferase activity	IBA	21873635
GO:0016409	Function	Palmitoyltransferase activity	IDA	23034182
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IDA	19556522
GO:0018345	Process	Protein palmitoylation	IBA	21873635
GO:0018345	Process	Protein palmitoylation	IDA	23034182
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IC	19556522
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	TAS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0034380	Process	High-density lipoprotein particle assembly	TAS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IC	19556522

Other IDs

• MIM: 608784
• HGNC: 18474
• e!Ensembl: ENSG00000099904

Protein

• UniProt ID: Q9ULC8
• Protein name: Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)
• Protein function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the tra
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01529	DHHC	99 → 224	DHHC palmitoyltransferase	Family

• Sequence:

  MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLA
  NFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHC
  SVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLVYVLNHAEGLGA
  AHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCCGNV
  EHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSK
  GSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPA
  FPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPL
  SASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYD
  SLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGATGDPPRPLPRSFSPVLGPRPREPSPVR
  YDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGP
  ALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRP
  SSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFIHTDLPEPPPSLTVQRDHPQLKTPPSK
  LNGQSPGLARLGPATGPPGPSASPTRHTLVKKVSGVGGTTYEISV

• Sequence length: 765

Pathways

Reactome:

HDL assembly

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20661937, 20468065, 23403413, 16860541, 18075473