CARD10 (caspase recruitment domain family member 10)

Gene

• Entrez ID: 29775
• Gene name: Caspase recruitment domain family member 10
• Gene symbol: CARD10
• Synonyms: BIMP1, CARMA3, IMD89
• Chromosome: 22
• Chromosome location: 22q13.1
• Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs139006752	G>A	Risk-factor	Coding sequence variant, missense variant
rs200148764	C>T	Risk-factor	Coding sequence variant, missense variant
rs201794655	G>A	Risk-factor	Coding sequence variant, missense variant
rs750643216	G>A	Risk-factor	Coding sequence variant, missense variant
rs1057519378	C>A,T	Risk-factor	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020696	hsa-miR-155-5p	Other	20584899
MIRT027101	hsa-miR-103a-3p	Sequencing	20371350
MIRT030440	hsa-miR-24-3p	Microarray	19748357
MIRT031650	hsa-miR-16-5p	Sequencing	20371350
MIRT053495	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT053495	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT053495	hsa-miR-146a-5p	Luciferase reporter assay, QRTPCR, Western blot	24985472
MIRT479989	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT479988	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT479987	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT479986	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT479985	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT031650	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT479984	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT479983	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT479982	hsa-miR-2278	PAR-CLIP	23592263
MIRT479981	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT479980	hsa-miR-5697	PAR-CLIP	23592263
MIRT479979	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT479978	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT479977	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT479976	hsa-miR-4532	PAR-CLIP	23592263
MIRT479975	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT479974	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT479973	hsa-miR-4481	PAR-CLIP	23592263
MIRT479972	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT479971	hsa-miR-3175	PAR-CLIP	23592263
MIRT479970	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT479969	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT479968	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT479967	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479966	hsa-miR-4449	PAR-CLIP	23592263
MIRT479965	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479964	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT479963	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT030440	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR, Western blot	26252200
MIRT030440	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR, Western blot	26252200
MIRT479989	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT479988	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT479987	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT479986	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT479985	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT031650	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT479984	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT479983	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT479982	hsa-miR-2278	PAR-CLIP	23592263
MIRT479981	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT479980	hsa-miR-5697	PAR-CLIP	23592263
MIRT479979	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT479978	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT479977	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT479976	hsa-miR-4532	PAR-CLIP	23592263
MIRT479975	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT479974	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT479973	hsa-miR-4481	PAR-CLIP	23592263
MIRT479972	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT479971	hsa-miR-3175	PAR-CLIP	23592263
MIRT479970	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT479969	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT479968	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT479967	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479966	hsa-miR-4449	PAR-CLIP	23592263
MIRT479965	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479964	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT479963	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT862760	hsa-miR-1207-5p	CLIP-seq
MIRT862761	hsa-miR-1275	CLIP-seq
MIRT862762	hsa-miR-1301	CLIP-seq
MIRT862763	hsa-miR-155	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT862765	hsa-miR-3189-3p	CLIP-seq
MIRT862766	hsa-miR-3918	CLIP-seq
MIRT862767	hsa-miR-3944-5p	CLIP-seq
MIRT862768	hsa-miR-425	CLIP-seq
MIRT862769	hsa-miR-4263	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862771	hsa-miR-4640-5p	CLIP-seq
MIRT862772	hsa-miR-4660	CLIP-seq
MIRT862773	hsa-miR-4665-5p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862775	hsa-miR-4726-5p	CLIP-seq
MIRT862776	hsa-miR-4763-3p	CLIP-seq
MIRT862777	hsa-miR-5047	CLIP-seq
MIRT862778	hsa-miR-548t	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862760	hsa-miR-1207-5p	CLIP-seq
MIRT2193468	hsa-miR-125a-3p	CLIP-seq
MIRT2193469	hsa-miR-146a	CLIP-seq
MIRT2193470	hsa-miR-146b-5p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862771	hsa-miR-4640-5p	CLIP-seq
MIRT2193471	hsa-miR-4649-5p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862775	hsa-miR-4726-5p	CLIP-seq
MIRT862776	hsa-miR-4763-3p	CLIP-seq
MIRT2193472	hsa-miR-4773	CLIP-seq
MIRT2193473	hsa-miR-508-5p	CLIP-seq
MIRT2193474	hsa-miR-552	CLIP-seq
MIRT2193475	hsa-miR-589	CLIP-seq
MIRT2193476	hsa-miR-591	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT2446155	hsa-miR-1	CLIP-seq
MIRT2446156	hsa-miR-206	CLIP-seq
MIRT2446157	hsa-miR-4301	CLIP-seq
MIRT2446158	hsa-miR-4491	CLIP-seq
MIRT2446159	hsa-miR-4657	CLIP-seq
MIRT2446160	hsa-miR-4727-3p	CLIP-seq
MIRT2446161	hsa-miR-613	CLIP-seq
MIRT2496631	hsa-miR-1294	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT2496632	hsa-miR-3150b-3p	CLIP-seq
MIRT2496633	hsa-miR-3184	CLIP-seq
MIRT2496634	hsa-miR-3607-5p	CLIP-seq
MIRT2496635	hsa-miR-423-5p	CLIP-seq
MIRT2496636	hsa-miR-4316	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT2496637	hsa-miR-4689	CLIP-seq
MIRT2496638	hsa-miR-4784	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11259443, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	NAS	11259443
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IDA	11259443
GO:0030159	Function	Signaling receptor complex adaptor activity	NAS	11259443
GO:0032449	Component	CBM complex	NAS	15125833
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0050700	Function	CARD domain binding	IBA	21873635
GO:0065003	Process	Protein-containing complex assembly	NAS	11259443
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IMP	24863965
GO:1900182	Process	Positive regulation of protein localization to nucleus	IMP	24863965

Other IDs

• MIM: 607209
• HGNC: 16422
• e!Ensembl: ENSG00000100065

Protein

• UniProt ID: Q9BWT7
• Protein name: Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3)
• Protein function: Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00619	CARD	28 → 114	Caspase recruitment domain	Domain

• Sequence:

  MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ
  DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC
  SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ
  AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK
  VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG
  LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM
  EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR
  KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS
  EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP
  APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI
  RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA
  CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD
  PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL
  PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL
  LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA
  TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR
  PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC
  GSSRGCPSSSEA

• Sequence length: 1032

Pathways

KEGG:

NF-kappa B signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma, Primary Open Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	27896285