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GSK3B (glycogen synthase kinase 3 beta)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2932
Gene nameGene Name - the full gene name approved by the HGNC.
Glycogen synthase kinase 3 beta
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GSK3B
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.33
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction,
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004676 hsa-miR-26a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20525681
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT021044 hsa-miR-155-5p Proteomics 19289835
MIRT049345 hsa-miR-92a-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
CDX2 Unknown 24501326
CREB1 Unknown 11579131
NFKB1 Unknown 11579131
TFCP2 Unknown 16973241
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001085 Function RNA polymerase II transcription factor binding IPI 20864106
GO:0001837 Process Epithelial to mesenchymal transition IMP 15448698
GO:0001954 Process Positive regulation of cell-matrix adhesion IMP 18156211
GO:0002020 Function Protease binding IPI 25118933
GO:0002039 Function P53 binding IDA 14744935
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P49841
Protein name Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Protein function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase
PDB 1GNG , 1H8F , 1I09 , 1J1B , 1J1C , 1O6K , 1O6L , 1O9U , 1PYX , 1Q3D , 1Q3W , 1Q41 , 1Q4L , 1Q5K , 1R0E , 1UV5 , 2JDO , 2JDR , 2JLD , 2O5K , 2OW3 , 2UW9 , 2X39 , 2XH5 , 3CQU , 3CQW , 3DU8 , 3E87 , 3E88 , 3E8D , 3F7Z , 3F88 , 3GB2 , 3I4B , 3L1S , 3M1S , 3MV5 , 3OW4 , 3PUP , 3Q3B , 3QKK , 3QKL , 3SAY , 3SD0 , 3ZDI , 3ZRK , 3ZRL , 3ZRM , 4ACC , 4ACD , 4ACG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
56 340
Protein kinase domain
Domain
Sequence
Sequence length 420
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
mTOR signaling pathway
PI3K-Akt signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
IL-17 signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
Cushing syndrome
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Alzheimer disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Shigellosis
Yersinia infection
Hepatitis C
Measles
Human cytomegalovirus infection
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
  Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Alzheimer disease Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 22944069, 17409235, 17409235, 22944069, 22944069, 29274321, 17409235
Hypertension Hypertensive disease rs13306026, rs13333226 22982863
Multiple congenital anomalies Multiple congenital anomalies rs1057517732 22975441
Myocardial infarction Myocardial Infarction, Myocardial Failure rs12316150, rs41303970, rs909253, rs7291467, rs2234693 16716347, 17901358
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder, Depression, Bipolar 24677591, 23440732, 24929537, 24992082, 20357757, 22990942, 20357757
Cognitive disorder Cognition Disorders 24634145
Congestive heart failure Congestive heart failure rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569 17901358
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741 17901358

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