GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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CXCL1 (C-X-C motif chemokine ligand 1)

Gene

2919

C-X-C motif chemokine ligand 1

CXCL1

FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1

4q13.3

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattra

Show/Hide all(246)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023084	hsa-miR-124-3p	Microarray	18668037
MIRT023999	hsa-miR-1-3p	Microarray	18668037
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT734007	hsa-miR-302e	Luciferase reporter assay, qRT-PCR, Western blotting	34079750
MIRT613684	hsa-miR-27b-5p	Luciferase reporter assay, qRT-PCR	32782028
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT756129	hsa-miR-34c-5p	Luciferase reporter assay, Microarray, qRT-PCR, Immunofluorescence, ELISA	36829591
MIRT756130	hsa-miR-34b-5p	Luciferase reporter assay, Microarray, qRT-PCR, Immunofluorescence, ELISA	36829591
MIRT917939	hsa-miR-371-5p	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436544	hsa-miR-1237	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT2511174	hsa-miR-1197	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT2511175	hsa-miR-1273e	CLIP-seq
MIRT2511176	hsa-miR-128	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT2511177	hsa-miR-1305	CLIP-seq
MIRT2511178	hsa-miR-141	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2511179	hsa-miR-186	CLIP-seq
MIRT2511180	hsa-miR-200a	CLIP-seq
MIRT2511181	hsa-miR-2116	CLIP-seq
MIRT2511182	hsa-miR-2682	CLIP-seq
MIRT2511183	hsa-miR-27a	CLIP-seq
MIRT2511184	hsa-miR-27b	CLIP-seq
MIRT2511185	hsa-miR-3143	CLIP-seq
MIRT2511186	hsa-miR-3145-3p	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT2511187	hsa-miR-3163	CLIP-seq
MIRT2511188	hsa-miR-3168	CLIP-seq
MIRT2511189	hsa-miR-3170	CLIP-seq
MIRT2511190	hsa-miR-3187-3p	CLIP-seq
MIRT2511191	hsa-miR-3194-5p	CLIP-seq
MIRT2511192	hsa-miR-331-3p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT2511193	hsa-miR-3607-3p	CLIP-seq
MIRT2511194	hsa-miR-3613-3p	CLIP-seq
MIRT2511195	hsa-miR-3617	CLIP-seq
MIRT2511196	hsa-miR-3622a-5p	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2511197	hsa-miR-3652	CLIP-seq
MIRT2511198	hsa-miR-3662	CLIP-seq
MIRT2511199	hsa-miR-3665	CLIP-seq
MIRT2511200	hsa-miR-3671	CLIP-seq
MIRT2511201	hsa-miR-369-3p	CLIP-seq
MIRT2511202	hsa-miR-3714	CLIP-seq
MIRT2511203	hsa-miR-374a	CLIP-seq
MIRT2511204	hsa-miR-374b	CLIP-seq
MIRT2511205	hsa-miR-3927	CLIP-seq
MIRT2511206	hsa-miR-3944-5p	CLIP-seq
MIRT2511207	hsa-miR-409-3p	CLIP-seq
MIRT2511208	hsa-miR-421	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2511209	hsa-miR-4297	CLIP-seq
MIRT2511210	hsa-miR-4302	CLIP-seq
MIRT2511211	hsa-miR-4423-3p	CLIP-seq
MIRT2511212	hsa-miR-4424	CLIP-seq
MIRT2511213	hsa-miR-4430	CLIP-seq
MIRT2511214	hsa-miR-4434	CLIP-seq
MIRT2511215	hsa-miR-4435	CLIP-seq
MIRT2511216	hsa-miR-4451	CLIP-seq
MIRT2511217	hsa-miR-449c	CLIP-seq
MIRT2511218	hsa-miR-4505	CLIP-seq
MIRT2511219	hsa-miR-4516	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT2511220	hsa-miR-4529-5p	CLIP-seq
MIRT2511221	hsa-miR-4531	CLIP-seq
MIRT2511222	hsa-miR-4633-5p	CLIP-seq
MIRT2511223	hsa-miR-4637	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2511224	hsa-miR-4695-3p	CLIP-seq
MIRT2511225	hsa-miR-4701-5p	CLIP-seq
MIRT2511226	hsa-miR-4720-5p	CLIP-seq
MIRT2511227	hsa-miR-4724-3p	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT2511228	hsa-miR-4773	CLIP-seq
MIRT2511229	hsa-miR-4799-3p	CLIP-seq
MIRT2511230	hsa-miR-4803	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2511231	hsa-miR-487a	CLIP-seq
MIRT2511232	hsa-miR-489	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2511233	hsa-miR-513b	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT2511234	hsa-miR-520d-5p	CLIP-seq
MIRT2511235	hsa-miR-524-5p	CLIP-seq
MIRT2511236	hsa-miR-532-5p	CLIP-seq
MIRT2511237	hsa-miR-539	CLIP-seq
MIRT2511238	hsa-miR-543	CLIP-seq
MIRT2511239	hsa-miR-548a-3p	CLIP-seq
MIRT2511240	hsa-miR-548e	CLIP-seq
MIRT2511241	hsa-miR-548f	CLIP-seq
MIRT2511242	hsa-miR-548s	CLIP-seq
MIRT2511243	hsa-miR-561	CLIP-seq
MIRT2511244	hsa-miR-563	CLIP-seq
MIRT2511245	hsa-miR-570	CLIP-seq
MIRT2511246	hsa-miR-576-3p	CLIP-seq
MIRT2511247	hsa-miR-588	CLIP-seq
MIRT2511248	hsa-miR-607	CLIP-seq
MIRT2511249	hsa-miR-641	CLIP-seq
MIRT2511250	hsa-miR-648	CLIP-seq
MIRT2511251	hsa-miR-657	CLIP-seq
MIRT2511252	hsa-miR-935	CLIP-seq
MIRT2511253	hsa-miR-944	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT2511174	hsa-miR-1197	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT2436544	hsa-miR-1237	CLIP-seq
MIRT2678849	hsa-miR-1238	CLIP-seq
MIRT2511175	hsa-miR-1273e	CLIP-seq
MIRT2511176	hsa-miR-128	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT2511177	hsa-miR-1305	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2511179	hsa-miR-186	CLIP-seq
MIRT2678850	hsa-miR-205	CLIP-seq
MIRT2511181	hsa-miR-2116	CLIP-seq
MIRT2511183	hsa-miR-27a	CLIP-seq
MIRT2511184	hsa-miR-27b	CLIP-seq
MIRT2678851	hsa-miR-3124-3p	CLIP-seq
MIRT2511185	hsa-miR-3143	CLIP-seq
MIRT2511186	hsa-miR-3145-3p	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT2511187	hsa-miR-3163	CLIP-seq
MIRT2511188	hsa-miR-3168	CLIP-seq
MIRT2511189	hsa-miR-3170	CLIP-seq
MIRT2511190	hsa-miR-3187-3p	CLIP-seq
MIRT2511191	hsa-miR-3194-5p	CLIP-seq
MIRT2511192	hsa-miR-331-3p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT2511194	hsa-miR-3613-3p	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2511197	hsa-miR-3652	CLIP-seq
MIRT2511198	hsa-miR-3662	CLIP-seq
MIRT2511199	hsa-miR-3665	CLIP-seq
MIRT2511200	hsa-miR-3671	CLIP-seq
MIRT2511201	hsa-miR-369-3p	CLIP-seq
MIRT2511203	hsa-miR-374a	CLIP-seq
MIRT2511204	hsa-miR-374b	CLIP-seq
MIRT2678852	hsa-miR-3918	CLIP-seq
MIRT2511205	hsa-miR-3927	CLIP-seq
MIRT2511206	hsa-miR-3944-5p	CLIP-seq
MIRT2511207	hsa-miR-409-3p	CLIP-seq
MIRT2511208	hsa-miR-421	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2511209	hsa-miR-4297	CLIP-seq
MIRT2511210	hsa-miR-4302	CLIP-seq
MIRT2511212	hsa-miR-4424	CLIP-seq
MIRT2511213	hsa-miR-4430	CLIP-seq
MIRT2511214	hsa-miR-4434	CLIP-seq
MIRT2511215	hsa-miR-4435	CLIP-seq
MIRT2511216	hsa-miR-4451	CLIP-seq
MIRT2511218	hsa-miR-4505	CLIP-seq
MIRT2678853	hsa-miR-4512	CLIP-seq
MIRT2511219	hsa-miR-4516	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT2511220	hsa-miR-4529-5p	CLIP-seq
MIRT2511221	hsa-miR-4531	CLIP-seq
MIRT2511223	hsa-miR-4637	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2678854	hsa-miR-4691-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2511224	hsa-miR-4695-3p	CLIP-seq
MIRT2511225	hsa-miR-4701-5p	CLIP-seq
MIRT2678855	hsa-miR-4711-3p	CLIP-seq
MIRT2511226	hsa-miR-4720-5p	CLIP-seq
MIRT2511227	hsa-miR-4724-3p	CLIP-seq
MIRT2678856	hsa-miR-4753-3p	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT2511228	hsa-miR-4773	CLIP-seq
MIRT2511229	hsa-miR-4799-3p	CLIP-seq
MIRT2511230	hsa-miR-4803	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2511231	hsa-miR-487a	CLIP-seq
MIRT2511232	hsa-miR-489	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2511233	hsa-miR-513b	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT2511234	hsa-miR-520d-5p	CLIP-seq
MIRT2511235	hsa-miR-524-5p	CLIP-seq
MIRT2511237	hsa-miR-539	CLIP-seq
MIRT2511238	hsa-miR-543	CLIP-seq
MIRT2511242	hsa-miR-548s	CLIP-seq
MIRT2511243	hsa-miR-561	CLIP-seq
MIRT2511244	hsa-miR-563	CLIP-seq
MIRT2511245	hsa-miR-570	CLIP-seq
MIRT2511246	hsa-miR-576-3p	CLIP-seq
MIRT2511247	hsa-miR-588	CLIP-seq
MIRT2678857	hsa-miR-593	CLIP-seq
MIRT2678858	hsa-miR-603	CLIP-seq
MIRT2511248	hsa-miR-607	CLIP-seq
MIRT2511250	hsa-miR-648	CLIP-seq
MIRT2511251	hsa-miR-657	CLIP-seq
MIRT2678859	hsa-miR-873	CLIP-seq
MIRT2511252	hsa-miR-935	CLIP-seq

Transcription factors

Show/Hide all(10)

Transcription factor	Regulation	Reference
BRCA1	Repression	22120723
CEBPD	Activation	23028973
GATA3	Repression	22120723
HMGA1	Unknown	11112786;7479086
NFKB1	Activation	10530453;15958549
NFKB1	Unknown	11112786;16040075;7479086
PARP1	Unknown	11112786
RELA	Activation	10530453;15958549
RELA	Unknown	11112786;16040075
SP1	Unknown	11112786;7479086

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	TAS	9079638, 10820279
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006935	Process	Chemotaxis	TAS	10820279
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	9725262, 10820279
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007399	Process	Nervous system development	TAS	9058825
GO:0008009	Function	Chemokine activity	IBA	21873635
GO:0008047	Function	Enzyme activator activity	TAS	9079638
GO:0008083	Function	Growth factor activity	TAS	8380167
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9551928
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030036	Process	Actin cytoskeleton organization	TAS	9725262
GO:0030593	Process	Neutrophil chemotaxis	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	TAS	9551928
GO:0035580	Component	Specific granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045236	Function	CXCR chemokine receptor binding	IBA	21873635
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA	21873635
GO:1904724	Component	Tertiary granule lumen	TAS

MIM	HGNC	e!Ensembl
155730	4602	ENSG00000163739

Protein

UniProt ID

P09341

Protein name

Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]

Protein function

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold high

PDB

1MGS , 1MSG , 1MSH , 1ROD , 8K4O , 8XWA , 8XWV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00048	IL8	41 → 100	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

Sequence

MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQCLQTLQGIHPKNIQSV
NVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN

Sequence length

107

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Legionellosis Amoebiasis Kaposi sarcoma-associated herpesvirus infection Rheumatoid arthritis Lipid and atherosclerosis		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	23099361

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Bronchial hyperreactivity	Bronchial Hyperreactivity		12388339
Autoimmune hepatitis	Autoimmune Chronic Hepatitis		21227906
Juvenile arthritis	Juvenile psoriatic arthritis		19565504
Seronegative polyarthritis	Polyarthritis, Juvenile, Rheumatoid Factor Negative		19565504
Polyarthritis, rheumatoid factor positive	Polyarthritis, Juvenile, Rheumatoid Factor Positive		19565504
Still disease	Juvenile-Onset Still Disease		19565504

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