GRM8 (glutamate metabotropic receptor 8)

Gene

• Entrez ID: 2918
• Gene name: Glutamate metabotropic receptor 8
• Gene symbol: GRM8
• Synonyms: GLUR8, GPRC1H, MGLUR8, mGlu8
• Chromosome: 7
• Chromosome location: 7q31.33
• Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028921	hsa-miR-26b-5p	Microarray	19088304
MIRT717828	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT717827	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT717826	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT717825	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT717824	hsa-miR-491-3p	HITS-CLIP	19536157
MIRT717828	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT717827	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT717826	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT717825	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT717824	hsa-miR-491-3p	HITS-CLIP	19536157
MIRT1035271	hsa-miR-2113	CLIP-seq
MIRT1035272	hsa-miR-3157-5p	CLIP-seq
MIRT1035273	hsa-miR-3663-5p	CLIP-seq
MIRT1035274	hsa-miR-4691-3p	CLIP-seq
MIRT1035275	hsa-miR-758	CLIP-seq
MIRT1035276	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0001642	Function	Group III metabotropic glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IMP	9473604
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	11166323
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IMP	9473604
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007601	Process	Visual perception	TAS	9473604
GO:0008066	Function	Glutamate receptor activity	IMP	9473604
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635

Other IDs

• MIM: 601116
• HGNC: 4600
• e!Ensembl: ENSG00000179603

Protein

• UniProt ID: O00222
• Protein name: Metabotropic glutamate receptor 8 (mGluR8)
• Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Si
• PDB: 6BSZ, 6BT5, 6E5V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	74 → 480	Receptor family ligand binding region	Family
  PF07562	NCD3G	512 → 562	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	595 → 840	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Sequence:

  MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
  GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
  QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
  PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
  EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
  GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
  EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
  KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
  KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
  CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
  VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
  FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
  IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
  KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
  IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
  ISYSNHSI

• Sequence length: 908

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention Deficit Disorder, Attention deficit hyperactivity disorder	rs120074176, rs786205019	22138692
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	12676915
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22941189
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	15211621, 17434465, 11163549

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety Disorders, Anxiety States, Neurotic		17434465
Gastroesophageal reflux disease	Gastroesophageal reflux disease		31527586
Minimal brain dysfunction	Minimal Brain Dysfunction		22138692