GRM5 (glutamate metabotropic receptor 5)

Gene

• Entrez ID: 2915
• Gene name: Glutamate metabotropic receptor 5
• Gene symbol: GRM5
• Synonyms: GPRC1E, MGLUR5, PPP1R86, mGlu5
• Chromosome: 11
• Chromosome location: 11q14.2-q14.3
• Summary: This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018632	hsa-miR-335-5p	Microarray	18185580
MIRT503738	hsa-miR-548n	PAR-CLIP	23446348
MIRT503737	hsa-miR-548a-5p	PAR-CLIP	23446348
MIRT503736	hsa-miR-548ab	PAR-CLIP	23446348
MIRT503735	hsa-miR-548ad-5p	PAR-CLIP	23446348
MIRT503734	hsa-miR-548ae-5p	PAR-CLIP	23446348
MIRT503733	hsa-miR-548ak	PAR-CLIP	23446348
MIRT503732	hsa-miR-548am-5p	PAR-CLIP	23446348
MIRT503731	hsa-miR-548ap-5p	PAR-CLIP	23446348
MIRT503730	hsa-miR-548aq-5p	PAR-CLIP	23446348
MIRT503729	hsa-miR-548ar-5p	PAR-CLIP	23446348
MIRT503728	hsa-miR-548as-5p	PAR-CLIP	23446348
MIRT503727	hsa-miR-548au-5p	PAR-CLIP	23446348
MIRT503726	hsa-miR-548ay-5p	PAR-CLIP	23446348
MIRT503725	hsa-miR-548b-5p	PAR-CLIP	23446348
MIRT503724	hsa-miR-548bb-5p	PAR-CLIP	23446348
MIRT503723	hsa-miR-548c-5p	PAR-CLIP	23446348
MIRT503722	hsa-miR-548d-5p	PAR-CLIP	23446348
MIRT503721	hsa-miR-548h-5p	PAR-CLIP	23446348
MIRT503720	hsa-miR-548i	PAR-CLIP	23446348
MIRT503719	hsa-miR-548j-5p	PAR-CLIP	23446348
MIRT503718	hsa-miR-548o-5p	PAR-CLIP	23446348
MIRT503717	hsa-miR-548w	PAR-CLIP	23446348
MIRT503716	hsa-miR-548y	PAR-CLIP	23446348
MIRT503715	hsa-miR-559	PAR-CLIP	23446348
MIRT503714	hsa-miR-582-3p	PAR-CLIP	23446348
MIRT503713	hsa-miR-892b	PAR-CLIP	23446348
MIRT503712	hsa-miR-4719	PAR-CLIP	23446348
MIRT503710	hsa-miR-6815-3p	PAR-CLIP	23446348
MIRT503711	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT503709	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT735982	hsa-miR-128-3p	Luciferase reporter assay, Microarray, Immunohistochemistry (IHC)	32958647
MIRT736669	hsa-miR-129-5p	Luciferase reporter assay, qRT-PCR	32552820
MIRT503738	hsa-miR-548n	PAR-CLIP	23446348
MIRT503737	hsa-miR-548a-5p	PAR-CLIP	23446348
MIRT503736	hsa-miR-548ab	PAR-CLIP	23446348
MIRT503735	hsa-miR-548ad-5p	PAR-CLIP	23446348
MIRT503734	hsa-miR-548ae-5p	PAR-CLIP	23446348
MIRT503733	hsa-miR-548ak	PAR-CLIP	23446348
MIRT503732	hsa-miR-548am-5p	PAR-CLIP	23446348
MIRT503731	hsa-miR-548ap-5p	PAR-CLIP	23446348
MIRT503730	hsa-miR-548aq-5p	PAR-CLIP	23446348
MIRT503729	hsa-miR-548ar-5p	PAR-CLIP	23446348
MIRT503728	hsa-miR-548as-5p	PAR-CLIP	23446348
MIRT503727	hsa-miR-548au-5p	PAR-CLIP	23446348
MIRT503726	hsa-miR-548ay-5p	PAR-CLIP	23446348
MIRT503725	hsa-miR-548b-5p	PAR-CLIP	23446348
MIRT503724	hsa-miR-548bb-5p	PAR-CLIP	23446348
MIRT503723	hsa-miR-548c-5p	PAR-CLIP	23446348
MIRT503722	hsa-miR-548d-5p	PAR-CLIP	23446348
MIRT503721	hsa-miR-548h-5p	PAR-CLIP	23446348
MIRT503720	hsa-miR-548i	PAR-CLIP	23446348
MIRT503719	hsa-miR-548j-5p	PAR-CLIP	23446348
MIRT503718	hsa-miR-548o-5p	PAR-CLIP	23446348
MIRT503717	hsa-miR-548w	PAR-CLIP	23446348
MIRT503716	hsa-miR-548y	PAR-CLIP	23446348
MIRT503715	hsa-miR-559	PAR-CLIP	23446348
MIRT503714	hsa-miR-582-3p	PAR-CLIP	23446348
MIRT503713	hsa-miR-892b	PAR-CLIP	23446348
MIRT503712	hsa-miR-4719	PAR-CLIP	23446348
MIRT503710	hsa-miR-6815-3p	PAR-CLIP	23446348
MIRT503711	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT503709	hsa-miR-510-3p	PAR-CLIP	23446348
MIRT1035111	hsa-miR-1	CLIP-seq
MIRT1035112	hsa-miR-1236	CLIP-seq
MIRT1035113	hsa-miR-1261	CLIP-seq
MIRT1035114	hsa-miR-1279	CLIP-seq
MIRT1035115	hsa-miR-128	CLIP-seq
MIRT1035116	hsa-miR-1305	CLIP-seq
MIRT1035117	hsa-miR-132	CLIP-seq
MIRT1035118	hsa-miR-144	CLIP-seq
MIRT1035119	hsa-miR-145	CLIP-seq
MIRT1035120	hsa-miR-1825	CLIP-seq
MIRT1035121	hsa-miR-199a-5p	CLIP-seq
MIRT1035122	hsa-miR-199b-5p	CLIP-seq
MIRT1035123	hsa-miR-2053	CLIP-seq
MIRT1035124	hsa-miR-206	CLIP-seq
MIRT1035125	hsa-miR-212	CLIP-seq
MIRT1035126	hsa-miR-27a	CLIP-seq
MIRT1035127	hsa-miR-27b	CLIP-seq
MIRT1035128	hsa-miR-3064-3p	CLIP-seq
MIRT1035129	hsa-miR-3065-5p	CLIP-seq
MIRT1035130	hsa-miR-3133	CLIP-seq
MIRT1035131	hsa-miR-3152-3p	CLIP-seq
MIRT1035132	hsa-miR-3152-5p	CLIP-seq
MIRT1035133	hsa-miR-3163	CLIP-seq
MIRT1035134	hsa-miR-3199	CLIP-seq
MIRT1035135	hsa-miR-3609	CLIP-seq
MIRT1035136	hsa-miR-3616-5p	CLIP-seq
MIRT1035137	hsa-miR-3646	CLIP-seq
MIRT1035138	hsa-miR-3647-3p	CLIP-seq
MIRT1035139	hsa-miR-3647-5p	CLIP-seq
MIRT1035140	hsa-miR-3662	CLIP-seq
MIRT1035141	hsa-miR-3673	CLIP-seq
MIRT1035142	hsa-miR-3919	CLIP-seq
MIRT1035143	hsa-miR-3973	CLIP-seq
MIRT1035144	hsa-miR-421	CLIP-seq
MIRT1035145	hsa-miR-4282	CLIP-seq
MIRT1035146	hsa-miR-4452	CLIP-seq
MIRT1035147	hsa-miR-4528	CLIP-seq
MIRT1035148	hsa-miR-4645-3p	CLIP-seq
MIRT1035149	hsa-miR-4648	CLIP-seq
MIRT1035150	hsa-miR-4709-5p	CLIP-seq
MIRT1035151	hsa-miR-4742-3p	CLIP-seq
MIRT1035152	hsa-miR-4773	CLIP-seq
MIRT1035153	hsa-miR-4774-3p	CLIP-seq
MIRT1035154	hsa-miR-4795-3p	CLIP-seq
MIRT1035155	hsa-miR-4795-5p	CLIP-seq
MIRT1035156	hsa-miR-500a	CLIP-seq
MIRT1035157	hsa-miR-501-5p	CLIP-seq
MIRT1035158	hsa-miR-5096	CLIP-seq
MIRT1035159	hsa-miR-513a-5p	CLIP-seq
MIRT1035160	hsa-miR-519a	CLIP-seq
MIRT1035161	hsa-miR-519b-3p	CLIP-seq
MIRT1035162	hsa-miR-519c-3p	CLIP-seq
MIRT1035163	hsa-miR-520g	CLIP-seq
MIRT1035164	hsa-miR-520h	CLIP-seq
MIRT1035165	hsa-miR-541	CLIP-seq
MIRT1035166	hsa-miR-548ah	CLIP-seq
MIRT1035167	hsa-miR-569	CLIP-seq
MIRT1035168	hsa-miR-573	CLIP-seq
MIRT1035169	hsa-miR-580	CLIP-seq
MIRT1035170	hsa-miR-613	CLIP-seq
MIRT1035171	hsa-miR-654-5p	CLIP-seq
MIRT1035172	hsa-miR-103a	CLIP-seq
MIRT1035173	hsa-miR-103b	CLIP-seq
MIRT1035174	hsa-miR-107	CLIP-seq
MIRT1035175	hsa-miR-1184	CLIP-seq
MIRT1035176	hsa-miR-1255a	CLIP-seq
MIRT1035177	hsa-miR-1255b	CLIP-seq
MIRT1035178	hsa-miR-1269	CLIP-seq
MIRT1035179	hsa-miR-1269b	CLIP-seq
MIRT1035115	hsa-miR-128	CLIP-seq
MIRT1035180	hsa-miR-1288	CLIP-seq
MIRT1035118	hsa-miR-144	CLIP-seq
MIRT1035181	hsa-miR-146b-3p	CLIP-seq
MIRT1035182	hsa-miR-22	CLIP-seq
MIRT1035183	hsa-miR-224	CLIP-seq
MIRT1035126	hsa-miR-27a	CLIP-seq
MIRT1035127	hsa-miR-27b	CLIP-seq
MIRT1035133	hsa-miR-3163	CLIP-seq
MIRT1035184	hsa-miR-3173-5p	CLIP-seq
MIRT1035185	hsa-miR-3202	CLIP-seq
MIRT1035186	hsa-miR-376a	CLIP-seq
MIRT1035187	hsa-miR-376b	CLIP-seq
MIRT1035145	hsa-miR-4282	CLIP-seq
MIRT1035188	hsa-miR-4418	CLIP-seq
MIRT1035189	hsa-miR-4481	CLIP-seq
MIRT1035190	hsa-miR-4515	CLIP-seq
MIRT1035191	hsa-miR-4533	CLIP-seq
MIRT1035192	hsa-miR-4694-3p	CLIP-seq
MIRT1035193	hsa-miR-4698	CLIP-seq
MIRT1035194	hsa-miR-4740-5p	CLIP-seq
MIRT1035151	hsa-miR-4742-3p	CLIP-seq
MIRT1035195	hsa-miR-4745-5p	CLIP-seq
MIRT1035196	hsa-miR-4758-5p	CLIP-seq
MIRT1035197	hsa-miR-509-3-5p	CLIP-seq
MIRT1035198	hsa-miR-509-5p	CLIP-seq
MIRT1035158	hsa-miR-5096	CLIP-seq
MIRT1035159	hsa-miR-513a-5p	CLIP-seq
MIRT1035199	hsa-miR-874	CLIP-seq
MIRT1035200	hsa-miR-922	CLIP-seq
MIRT1035182	hsa-miR-22	CLIP-seq
MIRT1035128	hsa-miR-3064-3p	CLIP-seq
MIRT1035130	hsa-miR-3133	CLIP-seq
MIRT1035142	hsa-miR-3919	CLIP-seq
MIRT2006905	hsa-miR-4670-3p	CLIP-seq
MIRT2006906	hsa-miR-4769-3p	CLIP-seq
MIRT2006907	hsa-miR-518d-5p	CLIP-seq
MIRT2006908	hsa-miR-519b-5p	CLIP-seq
MIRT2006909	hsa-miR-519c-5p	CLIP-seq
MIRT2006910	hsa-miR-520c-5p	CLIP-seq
MIRT2006911	hsa-miR-526a	CLIP-seq
MIRT1035115	hsa-miR-128	CLIP-seq
MIRT1035118	hsa-miR-144	CLIP-seq
MIRT1035182	hsa-miR-22	CLIP-seq
MIRT1035183	hsa-miR-224	CLIP-seq
MIRT1035126	hsa-miR-27a	CLIP-seq
MIRT1035127	hsa-miR-27b	CLIP-seq
MIRT1035128	hsa-miR-3064-3p	CLIP-seq
MIRT1035130	hsa-miR-3133	CLIP-seq
MIRT2239437	hsa-miR-3135b	CLIP-seq
MIRT2239438	hsa-miR-3180-5p	CLIP-seq
MIRT2239439	hsa-miR-3652	CLIP-seq
MIRT2239440	hsa-miR-3670	CLIP-seq
MIRT1035142	hsa-miR-3919	CLIP-seq
MIRT2239441	hsa-miR-4263	CLIP-seq
MIRT2239442	hsa-miR-4307	CLIP-seq
MIRT2239443	hsa-miR-4430	CLIP-seq
MIRT2239444	hsa-miR-4633-3p	CLIP-seq
MIRT2239445	hsa-miR-4676-5p	CLIP-seq
MIRT1035151	hsa-miR-4742-3p	CLIP-seq
MIRT2239446	hsa-miR-4755-3p	CLIP-seq
MIRT2239447	hsa-miR-4762-5p	CLIP-seq
MIRT1035158	hsa-miR-5096	CLIP-seq
MIRT1035159	hsa-miR-513a-5p	CLIP-seq
MIRT2239448	hsa-miR-520a-5p	CLIP-seq
MIRT2239449	hsa-miR-520d-5p	CLIP-seq
MIRT2239450	hsa-miR-524-5p	CLIP-seq
MIRT2239451	hsa-miR-525-5p	CLIP-seq
MIRT2239452	hsa-miR-548c-3p	CLIP-seq
MIRT2239453	hsa-miR-575	CLIP-seq
MIRT2239454	hsa-miR-576-5p	CLIP-seq
MIRT2388791	hsa-miR-371-5p	CLIP-seq
MIRT2388792	hsa-miR-371b-5p	CLIP-seq
MIRT2450806	hsa-miR-143	CLIP-seq
MIRT2450807	hsa-miR-3689a-3p	CLIP-seq
MIRT2450808	hsa-miR-3689c	CLIP-seq
MIRT2450809	hsa-miR-4311	CLIP-seq
MIRT1035148	hsa-miR-4645-3p	CLIP-seq
MIRT2450810	hsa-miR-4728-5p	CLIP-seq
MIRT2450811	hsa-miR-4770	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0001932	Process	Regulation of protein phosphorylation	IGI	24012003
GO:0004930	Function	G protein-coupled receptor activity	IMP	7908515
GO:0005515	Function	Protein binding	IPI	19694902, 24012003, 28130356
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IMP	7908515
GO:0006417	Process	Regulation of translation	TAS	24012003
GO:0006448	Process	Regulation of translational elongation	IGI	24012003
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007206	Process	Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	TAS	7908515
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IMP	7908515
GO:0007268	Process	Chemical synaptic transmission	TAS	7908515
GO:0007611	Process	Learning or memory	ISS
GO:0007612	Process	Learning	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008066	Function	Glutamate receptor activity	IDA	7908515
GO:0030296	Function	Protein tyrosine kinase activator activity	TAS	24012003
GO:0035584	Process	Calcium-mediated signaling using intracellular calcium source	IGI	24012003
GO:0042802	Function	Identical protein binding	IPI	30675062
GO:0043005	Component	Neuron projection	IEA
GO:0048169	Process	Regulation of long-term neuronal synaptic plasticity	IEA
GO:0050808	Process	Synapse organization	ISS
GO:0050890	Process	Cognition	IMP	23227193
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0061098	Process	Positive regulation of protein tyrosine kinase activity	ISS
GO:0090647	Process	Modulation of age-related behavioral decline	ISS
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA	21873635
GO:0099170	Process	Postsynaptic modulation of chemical synaptic transmission	IEA
GO:0099530	Function	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA	21873635
GO:0099553	Process	Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IBA	21873635
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0099583	Function	Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA	21873635
GO:1902938	Process	Regulation of intracellular calcium activated chloride channel activity	IGI	24012003
GO:1904646	Process	Cellular response to amyloid-beta	IGI	24012003
GO:1904646	Process	Cellular response to amyloid-beta	ISS
GO:1990782	Function	Protein tyrosine kinase binding	ISS

Other IDs

• MIM: 604102
• HGNC: 4597
• e!Ensembl: ENSG00000168959

Protein

• UniProt ID: P41594
• Protein name: Metabotropic glutamate receptor 5 (mGluR5)
• Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phospha
• PDB: 3LMK, 4OO9, 5CGC, 5CGD, 6N4X, 6N4Y, 6N50, 6N51, 6N52, 7FD8, 7FD9, 8T6J, 8T7H, 8T8M, 8TAO, 8X0B, 8X0C, 8X0D, 8X0E, 8X0F, 8X0G, 8X0H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	67 → 475	Receptor family ligand binding region	Family
  PF07562	NCD3G	507 → 558	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	591 → 824	7 transmembrane sweet-taste receptor of 3 GCPR	Family
  PF10606	GluR_Homer-bdg	1162 → 1212	Homer-binding domain of metabotropic glutamate receptor	Domain

• Sequence:

  MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
  REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
  EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
  DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
  CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
  LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
  HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
  GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
  YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
  EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
  FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
  ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
  HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
  TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
  TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
  NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
  LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
  PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
  STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
  RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
  IIRDYTQSSSSL

• Sequence length: 1212

Pathways

KEGG:

Calcium signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Alzheimer disease
Huntington disease
Pathways of neurodegeneration - multiple diseases

Reactome:

G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Neurexins and neuroligins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention Deficit Disorder, Attention deficit hyperactivity disorder	rs120074176, rs786205019	19546859, 22138692, 22138692, 22012869, 19546859
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	15694259
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23149219, 24472577, 24365204

Unknown
Disease name	Disease term	dbSNP ID	References
Asymmetric diabetic proximal motor neuropathy	Asymmetric Diabetic Proximal Motor Neuropathy		19840219
Bipolar disorder	Bipolar Disorder		23778581
Diabetic amyotrophy	Diabetic Amyotrophy		19840219
Diabetic asymmetric polyneuropathy	Diabetic Asymmetric Polyneuropathy		19840219
Diabetic autonomic neuropathy	Diabetic Autonomic Neuropathy		19840219
Diabetic mononeuropathy	Diabetic Mononeuropathy		19840219
Diabetic nephropathy	Diabetic Neuropathies		19840219
Diabetic neuralgia	Diabetic Neuralgia		19840219
Diabetic polyneuropathy	Diabetic Polyneuropathies		19840219
Grand mal status epilepticus	Grand Mal Status Epilepticus		18774262, 17634364
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	24472577, 20600666, 21635931, 21635931, 29662059, 29942085, 30718901, 24472577, 20600666
Minimal brain dysfunction	Minimal Brain Dysfunction		19546859, 22138692
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		18774262, 17634364
Petit mal status	Petit mal status		18774262, 17634364
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		17634364, 18774262, 18774262, 17634364
Symmetric diabetic proximal motor neuropathy	Symmetric Diabetic Proximal Motor Neuropathy		19840219