GRM4 (glutamate metabotropic receptor 4)

Gene

• Entrez ID: 2914
• Gene name: Glutamate metabotropic receptor 4
• Gene symbol: GRM4
• Synonyms: GPRC1D, MGLUR4, mGlu4
• Chromosome: 6
• Chromosome location: 6p21.31
• Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT054785	hsa-miR-1202	Immunocytochemistry, qRT-PCR, /Western blot	24908571
MIRT1035091	hsa-miR-1224-5p	CLIP-seq
MIRT1035092	hsa-miR-1321	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT1035094	hsa-miR-185	CLIP-seq
MIRT1035095	hsa-miR-28-5p	CLIP-seq
MIRT1035096	hsa-miR-3139	CLIP-seq
MIRT1035097	hsa-miR-3160-3p	CLIP-seq
MIRT1035098	hsa-miR-3605-5p	CLIP-seq
MIRT1035099	hsa-miR-4306	CLIP-seq
MIRT1035100	hsa-miR-4419a	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT1035102	hsa-miR-4510	CLIP-seq
MIRT1035103	hsa-miR-4644	CLIP-seq
MIRT1035104	hsa-miR-4728-5p	CLIP-seq
MIRT1035105	hsa-miR-4739	CLIP-seq
MIRT1035106	hsa-miR-4751	CLIP-seq
MIRT1035107	hsa-miR-4756-5p	CLIP-seq
MIRT1035108	hsa-miR-583	CLIP-seq
MIRT1035109	hsa-miR-708	CLIP-seq
MIRT1035110	hsa-miR-765	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT2006900	hsa-miR-31	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT2006901	hsa-miR-4539	CLIP-seq
MIRT2006902	hsa-miR-4680-5p	CLIP-seq
MIRT2006903	hsa-miR-4696	CLIP-seq
MIRT2006904	hsa-miR-4724-5p	CLIP-seq
MIRT1035091	hsa-miR-1224-5p	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT2239423	hsa-miR-182	CLIP-seq
MIRT1035095	hsa-miR-28-5p	CLIP-seq
MIRT2239424	hsa-miR-3117-5p	CLIP-seq
MIRT1035096	hsa-miR-3139	CLIP-seq
MIRT1035097	hsa-miR-3160-3p	CLIP-seq
MIRT2239425	hsa-miR-3614-5p	CLIP-seq
MIRT2239426	hsa-miR-3649	CLIP-seq
MIRT2239427	hsa-miR-4456	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT2239428	hsa-miR-4648	CLIP-seq
MIRT2239429	hsa-miR-4717-5p	CLIP-seq
MIRT2239430	hsa-miR-4722-5p	CLIP-seq
MIRT2239431	hsa-miR-4733-3p	CLIP-seq
MIRT1035106	hsa-miR-4751	CLIP-seq
MIRT2239432	hsa-miR-541	CLIP-seq
MIRT1035108	hsa-miR-583	CLIP-seq
MIRT2239433	hsa-miR-603	CLIP-seq
MIRT2239434	hsa-miR-654-5p	CLIP-seq
MIRT2239435	hsa-miR-665	CLIP-seq
MIRT1035109	hsa-miR-708	CLIP-seq
MIRT2239436	hsa-miR-711	CLIP-seq
MIRT1035110	hsa-miR-765	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IDA	15102938
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IMP	8738157, 9473604
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	15102938
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IMP	15102938
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS	8738157
GO:0007269	Process	Neurotransmitter secretion	TAS	15102938
GO:0008066	Function	Glutamate receptor activity	IMP	8738157, 9473604
GO:0031410	Component	Cytoplasmic vesicle	IDA	15102938
GO:0043410	Process	Positive regulation of MAPK cascade	IEP	15102938
GO:0043523	Process	Regulation of neuron apoptotic process	TAS	15102938
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 604100
• HGNC: 4596
• e!Ensembl: ENSG00000124493

Protein

• UniProt ID: Q14833
• Protein name: Metabotropic glutamate receptor 4 (mGluR4)
• Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate
• PDB: 7E9H, 8JD4, 8JD5, 8JD6, 8WG9, 8WGB, 8WGC, 8WGD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	77 → 484	Receptor family ligand binding region	Family
  PF07562	NCD3G	516 → 566	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	599 → 844	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Sequence:

  MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
  GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
  TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
  STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
  KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
  NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
  WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
  HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
  QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
  HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
  ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
  LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
  DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
  FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
  KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
  KQTYVTYTNHAI

• Sequence length: 912

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	15694259
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	11525421, 23714430, 19351574

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		17239033, 16380905
Osteosarcoma	Osteosarcoma		23727862