GRM2 (glutamate metabotropic receptor 2)

Gene

• Entrez ID: 2912
• Gene name: Glutamate metabotropic receptor 2
• Gene symbol: GRM2
• Synonyms: GLUR2, GPRC1B, MGLUR2, mGlu2
• Chromosome: 3
• Chromosome location: 3p21.2
• Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2388783	hsa-miR-140-3p	CLIP-seq
MIRT2388784	hsa-miR-3944-5p	CLIP-seq
MIRT2388785	hsa-miR-4318	CLIP-seq
MIRT2388786	hsa-miR-4436a	CLIP-seq
MIRT2388787	hsa-miR-4693-5p	CLIP-seq
MIRT2388788	hsa-miR-4700-3p	CLIP-seq
MIRT2388789	hsa-miR-606	CLIP-seq
MIRT2388790	hsa-miR-892a	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2682094	hsa-miR-3926	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2682095	hsa-miR-548s	CLIP-seq
MIRT2682096	hsa-miR-617	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC2	Unknown	22864611

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	TAS	7620613
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	18297054, 25416956, 32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007194	Process	Negative regulation of adenylate cyclase activity	TAS	7620613
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0008066	Function	Glutamate receptor activity	TAS	7620613
GO:0010467	Process	Gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0051896	Process	Regulation of protein kinase B signaling	ISS
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0090461	Process	Glutamate homeostasis	IEA
GO:0097110	Function	Scaffold protein binding	ISS
GO:0097449	Component	Astrocyte projection	ISS
GO:0099055	Component	Integral component of postsynaptic membrane	IEA

Other IDs

• MIM: 604099
• HGNC: 4594
• e!Ensembl: ENSG00000164082

Protein

• UniProt ID: Q14416
• Protein name: Metabotropic glutamate receptor 2 (mGluR2)
• Protein function: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits pr
• PDB: 4XAQ, 4XAS, 5CNI, 5CNJ, 5KZN, 5KZQ, 7E9G, 7EPA, 7EPB, 7EPD, 7MTQ, 7MTR, 7MTS, 8JCU, 8JCV, 8JCW, 8JCX, 8JCY, 8JCZ, 8JD0, 8JD1, 8JD2, 8JD3, 8JD4, 8JD5, 8WG9, 8WGB, 8WGC, 8WGD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	60 → 462	Receptor family ligand binding region	Family
  PF07562	NCD3G	496 → 546	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	579 → 816	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Sequence:

  MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
  RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
  CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
  FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
  VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
  ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
  DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
  DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
  DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
  GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
  SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
  FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
  CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
  YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
  RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

• Sequence length: 872

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	18804094
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18923069