Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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29 |
Gene nameGene Name - the full gene name approved by the HGNC.
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ABR activator of RhoGEF and GTPase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ABR |
SynonymsGene synonyms aliases
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MDB |
ChromosomeChromosome number
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17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17p13.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q12979 |
Protein name |
Active breakpoint cluster region-related protein |
Protein function |
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00621 |
RhoGEF |
95 → 282 |
RhoGEF domain |
Domain |
PF00169 |
PH |
302 → 459 |
PH domain |
Domain |
PF00168 |
C2 |
504 → 610 |
C2 domain |
Domain |
PF00620 |
RhoGAP |
661 → 813 |
RhoGAP domain |
Domain |
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Sequence |
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Sequence length |
859 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
24763052 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Prostatic neoplasms |
Prostatic Neoplasms |
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24763052 |
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