GIT1 (GIT ArfGAP 1)

Gene

• Entrez ID: 28964
• Gene name: GIT ArfGAP 1
• Gene symbol: GIT1
• Synonyms: p95-APP1
• Chromosome: 17
• Chromosome location: 17q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025756	hsa-miR-7-5p	Microarray	19073608
MIRT042200	hsa-miR-484	CLASH	23622248
MIRT054625	hsa-miR-149-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24608434
MIRT054625	hsa-miR-149-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24608434
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT438167	hsa-miR-491-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24335959
MIRT731825	hsa-miR-34c-5p	Immunohistochemistry, Luciferase reporter assay, Western blot	27698902
MIRT731825	hsa-miR-34c-5p	Immunohistochemistry, Luciferase reporter assay, Western blot	27698902
MIRT732112	hsa-miR-125a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28101188
MIRT732112	hsa-miR-125a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28101188
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT1019449	hsa-miR-3173-3p	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT1019451	hsa-miR-3688-5p	CLIP-seq
MIRT1019452	hsa-miR-3943	CLIP-seq
MIRT1019453	hsa-miR-4313	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019455	hsa-miR-4492	CLIP-seq
MIRT1019456	hsa-miR-4498	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT1019458	hsa-miR-4779	CLIP-seq
MIRT1019459	hsa-miR-520d-5p	CLIP-seq
MIRT1019460	hsa-miR-524-5p	CLIP-seq
MIRT1019461	hsa-miR-548v	CLIP-seq
MIRT1019462	hsa-miR-644	CLIP-seq
MIRT1019463	hsa-miR-762	CLIP-seq
MIRT1019464	hsa-miR-885-3p	CLIP-seq
MIRT1019465	hsa-miR-1207-3p	CLIP-seq
MIRT1019466	hsa-miR-1207-5p	CLIP-seq
MIRT1019467	hsa-miR-1286	CLIP-seq
MIRT1019468	hsa-miR-1321	CLIP-seq
MIRT1019469	hsa-miR-1827	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT1019471	hsa-miR-3612	CLIP-seq
MIRT1019472	hsa-miR-4270	CLIP-seq
MIRT1019473	hsa-miR-4441	CLIP-seq
MIRT1019474	hsa-miR-4462	CLIP-seq
MIRT1019475	hsa-miR-4652-5p	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT1019476	hsa-miR-4691-3p	CLIP-seq
MIRT1019477	hsa-miR-4728-5p	CLIP-seq
MIRT1019478	hsa-miR-4736	CLIP-seq
MIRT1019479	hsa-miR-4739	CLIP-seq
MIRT1019480	hsa-miR-4756-5p	CLIP-seq
MIRT1019481	hsa-miR-4763-3p	CLIP-seq
MIRT1019482	hsa-miR-4772-5p	CLIP-seq
MIRT1019483	hsa-miR-512-5p	CLIP-seq
MIRT1019484	hsa-miR-650	CLIP-seq
MIRT2001896	hsa-miR-122	CLIP-seq
MIRT2001897	hsa-miR-1245	CLIP-seq
MIRT2001898	hsa-miR-1294	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001900	hsa-miR-140-3p	CLIP-seq
MIRT2001901	hsa-miR-1910	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT2001903	hsa-miR-196a	CLIP-seq
MIRT2001904	hsa-miR-196b	CLIP-seq
MIRT2001905	hsa-miR-214	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT2001907	hsa-miR-2467-3p	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2001909	hsa-miR-3136-3p	CLIP-seq
MIRT2001910	hsa-miR-3176	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2001912	hsa-miR-3202	CLIP-seq
MIRT2001913	hsa-miR-346	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2001914	hsa-miR-3614-3p	CLIP-seq
MIRT2001915	hsa-miR-3619-5p	CLIP-seq
MIRT2001916	hsa-miR-3649	CLIP-seq
MIRT2001917	hsa-miR-3665	CLIP-seq
MIRT2001918	hsa-miR-3677-5p	CLIP-seq
MIRT2001919	hsa-miR-3678-3p	CLIP-seq
MIRT2001920	hsa-miR-3679-3p	CLIP-seq
MIRT2001921	hsa-miR-371b-5p	CLIP-seq
MIRT2001922	hsa-miR-3922-3p	CLIP-seq
MIRT2001923	hsa-miR-3925-3p	CLIP-seq
MIRT2001924	hsa-miR-4264	CLIP-seq
MIRT2001925	hsa-miR-4267	CLIP-seq
MIRT2001926	hsa-miR-4297	CLIP-seq
MIRT2001927	hsa-miR-4435	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019455	hsa-miR-4492	CLIP-seq
MIRT1019456	hsa-miR-4498	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2001929	hsa-miR-455-3p	CLIP-seq
MIRT2001930	hsa-miR-4632	CLIP-seq
MIRT2001931	hsa-miR-4648	CLIP-seq
MIRT2001932	hsa-miR-4651	CLIP-seq
MIRT2001933	hsa-miR-4676-5p	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT2001934	hsa-miR-4691-5p	CLIP-seq
MIRT2001935	hsa-miR-4726-3p	CLIP-seq
MIRT2001936	hsa-miR-516b	CLIP-seq
MIRT2001937	hsa-miR-520a-5p	CLIP-seq
MIRT2001938	hsa-miR-525-5p	CLIP-seq
MIRT2001939	hsa-miR-541	CLIP-seq
MIRT2001940	hsa-miR-575	CLIP-seq
MIRT2001941	hsa-miR-603	CLIP-seq
MIRT2001942	hsa-miR-608	CLIP-seq
MIRT2001943	hsa-miR-654-5p	CLIP-seq
MIRT2001944	hsa-miR-657	CLIP-seq
MIRT2001945	hsa-miR-663b	CLIP-seq
MIRT2001946	hsa-miR-761	CLIP-seq
MIRT1019463	hsa-miR-762	CLIP-seq
MIRT2001947	hsa-miR-764	CLIP-seq
MIRT2001948	hsa-miR-766	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019466	hsa-miR-1207-5p	CLIP-seq
MIRT2001896	hsa-miR-122	CLIP-seq
MIRT2234964	hsa-miR-1224-3p	CLIP-seq
MIRT2234965	hsa-miR-1227	CLIP-seq
MIRT2234966	hsa-miR-1231	CLIP-seq
MIRT2234967	hsa-miR-1267	CLIP-seq
MIRT2001898	hsa-miR-1294	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2001900	hsa-miR-140-3p	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT2001906	hsa-miR-24	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2001909	hsa-miR-3136-3p	CLIP-seq
MIRT2234968	hsa-miR-3147	CLIP-seq
MIRT2234969	hsa-miR-3151	CLIP-seq
MIRT2234970	hsa-miR-3170	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2234971	hsa-miR-342-5p	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2001918	hsa-miR-3677-5p	CLIP-seq
MIRT2001925	hsa-miR-4267	CLIP-seq
MIRT2234972	hsa-miR-4284	CLIP-seq
MIRT2234973	hsa-miR-4425	CLIP-seq
MIRT2001927	hsa-miR-4435	CLIP-seq
MIRT2234974	hsa-miR-4436b-3p	CLIP-seq
MIRT2234975	hsa-miR-4450	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2001932	hsa-miR-4651	CLIP-seq
MIRT2234976	hsa-miR-4664-5p	CLIP-seq
MIRT1019481	hsa-miR-4763-3p	CLIP-seq
MIRT2001936	hsa-miR-516b	CLIP-seq
MIRT1019461	hsa-miR-548v	CLIP-seq
MIRT2001942	hsa-miR-608	CLIP-seq
MIRT2234977	hsa-miR-654-3p	CLIP-seq
MIRT2001945	hsa-miR-663b	CLIP-seq
MIRT2234978	hsa-miR-760	CLIP-seq
MIRT2001947	hsa-miR-764	CLIP-seq
MIRT2234979	hsa-miR-892b	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq
MIRT2234964	hsa-miR-1224-3p	CLIP-seq
MIRT2538765	hsa-miR-1260	CLIP-seq
MIRT2538766	hsa-miR-1260b	CLIP-seq
MIRT2538767	hsa-miR-1280	CLIP-seq
MIRT2001899	hsa-miR-1296	CLIP-seq
MIRT1019448	hsa-miR-138	CLIP-seq
MIRT2538768	hsa-miR-185	CLIP-seq
MIRT2001902	hsa-miR-1915	CLIP-seq
MIRT1019470	hsa-miR-2277-3p	CLIP-seq
MIRT2001908	hsa-miR-2861	CLIP-seq
MIRT2538769	hsa-miR-3150a-3p	CLIP-seq
MIRT2538770	hsa-miR-3175	CLIP-seq
MIRT2001911	hsa-miR-3185	CLIP-seq
MIRT2001913	hsa-miR-346	CLIP-seq
MIRT1019450	hsa-miR-361-3p	CLIP-seq
MIRT2538771	hsa-miR-4306	CLIP-seq
MIRT1019454	hsa-miR-4456	CLIP-seq
MIRT1019474	hsa-miR-4462	CLIP-seq
MIRT2538772	hsa-miR-4487	CLIP-seq
MIRT2001928	hsa-miR-4512	CLIP-seq
MIRT2538773	hsa-miR-4644	CLIP-seq
MIRT1019457	hsa-miR-4690-3p	CLIP-seq
MIRT2001939	hsa-miR-541	CLIP-seq
MIRT2001943	hsa-miR-654-5p	CLIP-seq
MIRT2001949	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001957	Process	Intramembranous ossification	ISS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	15182672, 15383276, 16628223, 16717130, 16787945, 18369319, 19041750, 21295525, 21706016, 21900206, 23108400, 23455922, 25852190, 31980649
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA
GO:0007420	Process	Brain development	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	9826657
GO:0016020	Component	Membrane	HDA	19946888
GO:0032465	Process	Regulation of cytokinesis	IDA	23108400
GO:0032691	Process	Negative regulation of interleukin-1 beta production	ISS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0044305	Component	Calyx of Held	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045454	Process	Cell redox homeostasis	ISS
GO:0045820	Process	Negative regulation of glycolytic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0048666	Process	Neuron development	IEA
GO:0061743	Process	Motor learning	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0106015	Process	Negative regulation of inflammatory response to wounding	ISS
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 608434
• HGNC: 4272
• e!Ensembl: ENSG00000108262

Protein

• UniProt ID: Q9Y2X7
• Protein name: ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
• Protein function: GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, f
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	1 → 120	Putative GTPase activating protein for Arf	Domain
  PF12796	Ank_2	137 → 229	Ankyrin repeats (3 copies)	Repeat
  PF08518	GIT_SHD	264 → 292	Spa2 homology domain (SHD) of GIT	Family
  PF08518	GIT_SHD	328 → 356	Spa2 homology domain (SHD) of GIT	Family
  PF16559	GIT_CC	409 → 474	GIT coiled-coil Rho guanine nucleotide exchange factor	Coiled-coil
  PF12205	GIT1_C	638 → 754	G protein-coupled receptor kinase-interacting protein 1 C term	Domain

• Sequence:

  MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
  LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
  PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
  LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
  HKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQ
  NHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSL
  SSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGA
  VTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPT
  PPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELE
  DDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYEN
  TQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELL
  RAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTV
  PPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ

• Sequence length: 761

Pathways

KEGG:

Endocytosis
Regulation of actin cytoskeleton
Epithelial cell signaling in Helicobacter pylori infection

Reactome:

Ephrin signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention Deficit Disorder, Attention deficit hyperactivity disorder	rs120074176, rs786205019	21499268

Unknown
Disease name	Disease term	dbSNP ID	References
Memory disorders	Memory Disorders		21499268
Age-related memory disorders	Age-Related Memory Disorders		21499268
Minimal brain dysfunction	Minimal Brain Dysfunction		21499268