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DCPS (decapping enzyme, scavenger)
Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
28960
Gene nameGene Name - the full gene name approved by the HGNC.
Decapping enzyme, scavenger
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DCPS
SynonymsGene synonyms aliases
ARS, DCS1, HINT-5, HINT5, HSL1, HSPC015
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosom
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs138737928 C>T Pathogenic Coding sequence variant, missense variant
rs147935593 G>T Conflicting-interpretations-of-pathogenicity Missense variant, coding sequence variant
rs556401323 C>T Likely-pathogenic Missense variant, coding sequence variant
rs770528538 G>A,T Pathogenic Splice donor variant
rs1057519083 T>C Pathogenic Missense variant, coding sequence variant, splice donor variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT041500 hsa-miR-193b-3p CLASH 23622248
MIRT461052 hsa-miR-4695-5p HITS-CLIP 23706177
MIRT461051 hsa-miR-1910-3p HITS-CLIP 23706177
MIRT461050 hsa-miR-6511a-5p HITS-CLIP 23706177
MIRT461049 hsa-miR-3174 HITS-CLIP 23706177
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS 12198172, 15383679, 22985415
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IBA 21873635
GO:0000340 Function RNA 7-methylguanosine cap binding IBA 21873635
GO:0000340 Function RNA 7-methylguanosine cap binding IDA 12198172, 15383679, 18426921, 18441014, 22985415
GO:0000932 Component P-body IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96C86
Protein name m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)
Protein function Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosph
PDB 1ST0 , 1ST4 , 1XML , 1XMM , 3BL7 , 3BL9 , 3BLA , 4QDE , 4QDV , 4QEB , 5OSY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05652 DcpS
43 → 146
Scavenger mRNA decapping enzyme (DcpS) N-terminal
 Family
PF11969 DcpS_C
174 → 294
Family
Sequence
Sequence length 337
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  RNA degradation   mRNA decay by 3' to 5' exoribonuclease
Associated diseases
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Al-raqad syndrome AL-RAQAD SYNDROME rs1057519083, rs770528538, rs138737928 25712129, 25701870
Autism Autistic behavior rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634
Brachydactyly Brachydactyly rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852, rs121917853, rs121917854, rs121917855, rs121917859, rs121917861, rs267606873, rs267606872, rs267606985, rs267606986, rs267606987, rs267606988, rs28933082, rs397514519, rs869025613, rs869025614, rs886039878, rs1553540620, rs1057518333, rs1948841937, rs1948868228, rs1948842030, rs1948842142
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Unknown
Disease name Disease term dbSNP ID References
Absence of septum pellucidum Absence of septum pellucidum
Central visual impairment Central visual impairment
Cerebral atrophy Cerebral atrophy
Cortical dysplasia Cortical Dysplasia

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