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GRN (granulin precursor)

Gene

2896

Granulin precursor

GRN

CLN11, FTD2, GEP, GP88, PCDGF, PEPI, PGRN

17q21.31

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin

Show/Hide all(60)

SNP ID	Visualize variation	Clinical significance	Consequence
rs63749801	CAGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs63749817	G>A,C	Likely-pathogenic, pathogenic, not-provided	Splice donor variant
rs63749877	CACT>-	Pathogenic, not-provided	Frameshift variant, coding sequence variant
rs63749905	->A	Pathogenic, not-provided	Frameshift variant, coding sequence variant
rs63749908	C>T	Pathogenic, not-provided	Stop gained, coding sequence variant
rs63750077	C>T	Pathogenic, not-provided	Stop gained, coding sequence variant
rs63750331	G>A	Pathogenic, not-provided	Initiator codon variant, missense variant
rs63750411	C>T	Pathogenic	Stop gained, coding sequence variant
rs63750412	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, benign	Missense variant, coding sequence variant
rs63750548	A>G	Pathogenic, not-provided	Splice acceptor variant
rs63750707	G>A	Likely-pathogenic, not-provided	Splice donor variant
rs63751006	T>C	Pathogenic, not-provided	Initiator codon variant, missense variant
rs63751020	A>G,T	Likely-pathogenic, not-provided	Intron variant, 5 prime UTR variant, upstream transcript variant, genic upstream transcript variant
rs63751035	TG>-,TGTG	Pathogenic, not-provided	Stop gained, inframe indel, frameshift variant, coding sequence variant
rs63751073	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs63751074	C>T	Conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs63751085	CA>-	Pathogenic	Frameshift variant, coding sequence variant
rs63751100	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs63751166	G>A	Pathogenic, not-provided	Synonymous variant, coding sequence variant
rs63751177	G>A	Pathogenic	Stop gained, coding sequence variant
rs63751180	C>A,G,T	Pathogenic	Synonymous variant, stop gained, missense variant, coding sequence variant
rs63751243	C>A,T	Pathogenic, not-provided	Missense variant, coding sequence variant
rs63751294	C>T	Pathogenic	Stop gained, coding sequence variant
rs63751296	G>C	Pathogenic, not-provided	Splice acceptor variant
rs193026789	C>A,T	Likely-benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs606231220	->CCTG	Pathogenic	Coding sequence variant, frameshift variant
rs606231221	G>A	Pathogenic	Splice donor variant
rs770058074	C>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs778599933	TGAG>-	Uncertain-significance, likely-pathogenic	Splice donor variant, intron variant
rs794729669	G>C	Pathogenic	Splice donor variant
rs794729670	T>C,G	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs794729671	->T	Pathogenic	Coding sequence variant, frameshift variant
rs794729672	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1392550887	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1555610855	G>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1555611136	AG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555611154	G>A	Pathogenic	Splice acceptor variant
rs1555611253	C>T	Pathogenic	Stop gained, coding sequence variant
rs1555611256	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555611293	C>T	Pathogenic	Stop gained, coding sequence variant
rs1555611412	A>G	Pathogenic	Splice acceptor variant
rs1555611439	->AACGT	Pathogenic	Frameshift variant, coding sequence variant
rs1567885658	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1567885728	G>A	Likely-pathogenic	Splice donor variant
rs1567886206	->A	Pathogenic	Frameshift variant, coding sequence variant
rs1567886445	->TGTGAAGACAGGGTGCACTGCTGTC	Pathogenic	Frameshift variant, coding sequence variant
rs1567886478	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1567887004	->CC	Pathogenic	Frameshift variant, coding sequence variant
rs1567887015	->A	Pathogenic	Frameshift variant, coding sequence variant
rs1567887496	C>T	Pathogenic	Coding sequence variant, stop gained
rs1567887567	->AA	Pathogenic	Frameshift variant, coding sequence variant
rs1567887777	G>A	Likely-pathogenic	Synonymous variant, coding sequence variant
rs1567888461	C>A	Pathogenic	Coding sequence variant, stop gained
rs1598362746	G>A	Pathogenic	Coding sequence variant, stop gained
rs1598363083	G>C	Pathogenic	Splice donor variant
rs1598363490	->A	Pathogenic	Frameshift variant, coding sequence variant
rs1598364296	TCAGGCCAC>-	Pathogenic	Coding sequence variant, splice acceptor variant, intron variant
rs1598364358	C>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1598364782	C>A	Pathogenic	Coding sequence variant, stop gained
rs1598364961	AG>-	Likely-pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(236)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004761	hsa-miR-107	Microarray, Western blot	20884628
MIRT004761	hsa-miR-107	Microarray, Western blot	20884628
MIRT004761	hsa-miR-107	Microarray, Western blot	20884628
MIRT000034	hsa-miR-659-3p	Luciferase reporter assay, Western blot	18723524
MIRT000034	hsa-miR-659-3p	Luciferase reporter assay, Western blot	18723524
MIRT005486	hsa-miR-29b-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	20479936
MIRT005486	hsa-miR-29b-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	20479936
MIRT005486	hsa-miR-29b-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	20479936
MIRT005486	hsa-miR-29b-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	20479936
MIRT021404	hsa-miR-9-5p	Reporter assay	20479936
MIRT004761	hsa-miR-107	Reporter assay;Western blot;Microarray	20489155
MIRT005486	hsa-miR-29b-3p	Reporter assay;Western blot;Other	20479936
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT627129	hsa-miR-8485	HITS-CLIP	23824327
MIRT627127	hsa-miR-3939	HITS-CLIP	23824327
MIRT627128	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT627126	hsa-miR-5191	HITS-CLIP	23824327
MIRT627125	hsa-miR-376b-5p	HITS-CLIP	23824327
MIRT627124	hsa-miR-376c-5p	HITS-CLIP	23824327
MIRT627123	hsa-miR-3691-5p	HITS-CLIP	23824327
MIRT627121	hsa-miR-8056	HITS-CLIP	23824327
MIRT627122	hsa-miR-4752	HITS-CLIP	23824327
MIRT1035277	hsa-miR-1321	CLIP-seq
MIRT1035278	hsa-miR-2054	CLIP-seq
MIRT1035279	hsa-miR-3119	CLIP-seq
MIRT1035280	hsa-miR-3140-3p	CLIP-seq
MIRT1035281	hsa-miR-3150a-3p	CLIP-seq
MIRT1035282	hsa-miR-3162-5p	CLIP-seq
MIRT1035283	hsa-miR-3175	CLIP-seq
MIRT1035284	hsa-miR-3670	CLIP-seq
MIRT1035285	hsa-miR-3689d	CLIP-seq
MIRT1035286	hsa-miR-4270	CLIP-seq
MIRT1035287	hsa-miR-4278	CLIP-seq
MIRT1035288	hsa-miR-4300	CLIP-seq
MIRT1035289	hsa-miR-4441	CLIP-seq
MIRT1035290	hsa-miR-4474-3p	CLIP-seq
MIRT1035291	hsa-miR-4685-5p	CLIP-seq
MIRT1035292	hsa-miR-4716-3p	CLIP-seq
MIRT1035293	hsa-miR-4723-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035295	hsa-miR-4739	CLIP-seq
MIRT1035296	hsa-miR-4756-5p	CLIP-seq
MIRT1035297	hsa-miR-615-5p	CLIP-seq
MIRT1035298	hsa-miR-659	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT1035300	hsa-miR-920	CLIP-seq
MIRT1035301	hsa-miR-939	CLIP-seq
MIRT1035277	hsa-miR-1321	CLIP-seq
MIRT2006946	hsa-miR-1470	CLIP-seq
MIRT2006947	hsa-miR-2467-3p	CLIP-seq
MIRT1035282	hsa-miR-3162-5p	CLIP-seq
MIRT2006948	hsa-miR-3616-3p	CLIP-seq
MIRT1035285	hsa-miR-3689d	CLIP-seq
MIRT1035287	hsa-miR-4278	CLIP-seq
MIRT2006949	hsa-miR-4468	CLIP-seq
MIRT2006950	hsa-miR-4481	CLIP-seq
MIRT1035292	hsa-miR-4716-3p	CLIP-seq
MIRT1035293	hsa-miR-4723-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035295	hsa-miR-4739	CLIP-seq
MIRT2006951	hsa-miR-4745-5p	CLIP-seq
MIRT1035296	hsa-miR-4756-5p	CLIP-seq
MIRT1035297	hsa-miR-615-5p	CLIP-seq
MIRT1035298	hsa-miR-659	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT2239479	hsa-miR-4701-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT2437502	hsa-miR-1237	CLIP-seq
MIRT1035278	hsa-miR-2054	CLIP-seq
MIRT2437503	hsa-miR-3064-3p	CLIP-seq
MIRT1035279	hsa-miR-3119	CLIP-seq
MIRT2437504	hsa-miR-3127-3p	CLIP-seq
MIRT1035280	hsa-miR-3140-3p	CLIP-seq
MIRT2437505	hsa-miR-3660	CLIP-seq
MIRT2437506	hsa-miR-4256	CLIP-seq
MIRT1035290	hsa-miR-4474-3p	CLIP-seq
MIRT2437507	hsa-miR-4526	CLIP-seq
MIRT2437508	hsa-miR-4640-3p	CLIP-seq
MIRT2437509	hsa-miR-4715-3p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT2437510	hsa-miR-4776-3p	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT2543202	hsa-miR-1224-3p	CLIP-seq
MIRT2437502	hsa-miR-1237	CLIP-seq
MIRT2543203	hsa-miR-1245b-5p	CLIP-seq
MIRT2543204	hsa-miR-1304	CLIP-seq
MIRT1035277	hsa-miR-1321	CLIP-seq
MIRT2006946	hsa-miR-1470	CLIP-seq
MIRT1035278	hsa-miR-2054	CLIP-seq
MIRT2006947	hsa-miR-2467-3p	CLIP-seq
MIRT2437503	hsa-miR-3064-3p	CLIP-seq
MIRT1035279	hsa-miR-3119	CLIP-seq
MIRT2437504	hsa-miR-3127-3p	CLIP-seq
MIRT1035280	hsa-miR-3140-3p	CLIP-seq
MIRT2543205	hsa-miR-3142	CLIP-seq
MIRT1035281	hsa-miR-3150a-3p	CLIP-seq
MIRT2543206	hsa-miR-3158-5p	CLIP-seq
MIRT1035282	hsa-miR-3162-5p	CLIP-seq
MIRT1035283	hsa-miR-3175	CLIP-seq
MIRT2006948	hsa-miR-3616-3p	CLIP-seq
MIRT2437505	hsa-miR-3660	CLIP-seq
MIRT1035284	hsa-miR-3670	CLIP-seq
MIRT2543207	hsa-miR-3678-3p	CLIP-seq
MIRT1035285	hsa-miR-3689d	CLIP-seq
MIRT2437506	hsa-miR-4256	CLIP-seq
MIRT1035286	hsa-miR-4270	CLIP-seq
MIRT1035287	hsa-miR-4278	CLIP-seq
MIRT2543208	hsa-miR-4281	CLIP-seq
MIRT1035288	hsa-miR-4300	CLIP-seq
MIRT1035289	hsa-miR-4441	CLIP-seq
MIRT2543209	hsa-miR-4446-3p	CLIP-seq
MIRT2006949	hsa-miR-4468	CLIP-seq
MIRT1035290	hsa-miR-4474-3p	CLIP-seq
MIRT2006950	hsa-miR-4481	CLIP-seq
MIRT2543210	hsa-miR-4493	CLIP-seq
MIRT2437507	hsa-miR-4526	CLIP-seq
MIRT2437508	hsa-miR-4640-3p	CLIP-seq
MIRT1035291	hsa-miR-4685-5p	CLIP-seq
MIRT2437509	hsa-miR-4715-3p	CLIP-seq
MIRT1035292	hsa-miR-4716-3p	CLIP-seq
MIRT2543211	hsa-miR-4721	CLIP-seq
MIRT1035293	hsa-miR-4723-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035295	hsa-miR-4739	CLIP-seq
MIRT2543212	hsa-miR-4740-3p	CLIP-seq
MIRT2006951	hsa-miR-4745-5p	CLIP-seq
MIRT2543213	hsa-miR-4747-5p	CLIP-seq
MIRT1035296	hsa-miR-4756-5p	CLIP-seq
MIRT2543214	hsa-miR-4758-3p	CLIP-seq
MIRT2543215	hsa-miR-4760-5p	CLIP-seq
MIRT2437510	hsa-miR-4776-3p	CLIP-seq
MIRT1035297	hsa-miR-615-5p	CLIP-seq
MIRT1035298	hsa-miR-659	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT1035300	hsa-miR-920	CLIP-seq
MIRT1035301	hsa-miR-939	CLIP-seq
MIRT2543202	hsa-miR-1224-3p	CLIP-seq
MIRT2437502	hsa-miR-1237	CLIP-seq
MIRT2543203	hsa-miR-1245b-5p	CLIP-seq
MIRT2543204	hsa-miR-1304	CLIP-seq
MIRT1035277	hsa-miR-1321	CLIP-seq
MIRT2006946	hsa-miR-1470	CLIP-seq
MIRT1035278	hsa-miR-2054	CLIP-seq
MIRT2006947	hsa-miR-2467-3p	CLIP-seq
MIRT2437503	hsa-miR-3064-3p	CLIP-seq
MIRT1035279	hsa-miR-3119	CLIP-seq
MIRT2437504	hsa-miR-3127-3p	CLIP-seq
MIRT1035280	hsa-miR-3140-3p	CLIP-seq
MIRT2543205	hsa-miR-3142	CLIP-seq
MIRT1035281	hsa-miR-3150a-3p	CLIP-seq
MIRT2543206	hsa-miR-3158-5p	CLIP-seq
MIRT1035282	hsa-miR-3162-5p	CLIP-seq
MIRT1035283	hsa-miR-3175	CLIP-seq
MIRT2006948	hsa-miR-3616-3p	CLIP-seq
MIRT2437505	hsa-miR-3660	CLIP-seq
MIRT1035284	hsa-miR-3670	CLIP-seq
MIRT2543207	hsa-miR-3678-3p	CLIP-seq
MIRT1035285	hsa-miR-3689d	CLIP-seq
MIRT2437506	hsa-miR-4256	CLIP-seq
MIRT1035286	hsa-miR-4270	CLIP-seq
MIRT1035287	hsa-miR-4278	CLIP-seq
MIRT2543208	hsa-miR-4281	CLIP-seq
MIRT1035288	hsa-miR-4300	CLIP-seq
MIRT1035289	hsa-miR-4441	CLIP-seq
MIRT2543209	hsa-miR-4446-3p	CLIP-seq
MIRT2006949	hsa-miR-4468	CLIP-seq
MIRT1035290	hsa-miR-4474-3p	CLIP-seq
MIRT2006950	hsa-miR-4481	CLIP-seq
MIRT2543210	hsa-miR-4493	CLIP-seq
MIRT2437507	hsa-miR-4526	CLIP-seq
MIRT2437508	hsa-miR-4640-3p	CLIP-seq
MIRT1035291	hsa-miR-4685-5p	CLIP-seq
MIRT2437509	hsa-miR-4715-3p	CLIP-seq
MIRT1035292	hsa-miR-4716-3p	CLIP-seq
MIRT2543211	hsa-miR-4721	CLIP-seq
MIRT1035293	hsa-miR-4723-5p	CLIP-seq
MIRT1035294	hsa-miR-4728-5p	CLIP-seq
MIRT1035295	hsa-miR-4739	CLIP-seq
MIRT2543212	hsa-miR-4740-3p	CLIP-seq
MIRT2006951	hsa-miR-4745-5p	CLIP-seq
MIRT2543213	hsa-miR-4747-5p	CLIP-seq
MIRT1035296	hsa-miR-4756-5p	CLIP-seq
MIRT2543214	hsa-miR-4758-3p	CLIP-seq
MIRT2543215	hsa-miR-4760-5p	CLIP-seq
MIRT2437510	hsa-miR-4776-3p	CLIP-seq
MIRT1035297	hsa-miR-615-5p	CLIP-seq
MIRT1035298	hsa-miR-659	CLIP-seq
MIRT1035299	hsa-miR-885-3p	CLIP-seq
MIRT1035300	hsa-miR-920	CLIP-seq
MIRT1035301	hsa-miR-939	CLIP-seq

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002265	Process	Astrocyte activation involved in immune response	ISS
GO:0002282	Process	Microglial cell activation involved in immune response	ISS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	12526812, 16189514, 21078624, 21092856, 21516116, 21988832, 23088713, 23236149, 24070898, 25416956, 25839164, 25910212, 26370502, 27789271, 28453791, 28493053, 28541286, 29892012, 31515488, 32296183, 32814053
GO:0005576	Component	Extracellular region	IBA	21873635
GO:0005576	Component	Extracellular region	IDA	21092856, 26370502
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	20479936
GO:0005764	Component	Lysosome	IDA	26370502, 28073925, 28541286, 28743268
GO:0005765	Component	Lysosomal membrane	IDA	21092856
GO:0005768	Component	Endosome	IDA
GO:0005770	Component	Late endosome	IDA	26370502
GO:0005783	Component	Endoplasmic reticulum	IDA	26370502, 28073925
GO:0005794	Component	Golgi apparatus	IDA	28073925
GO:0005802	Component	Trans-Golgi network	ISS
GO:0005886	Component	Plasma membrane	IDA	21092856
GO:0007040	Process	Lysosome organization	ISS
GO:0007041	Process	Lysosomal transport	IMP	28541286
GO:0007041	Process	Lysosomal transport	ISS
GO:0007042	Process	Lysosomal lumen acidification	IMP	28073925
GO:0007165	Process	Signal transduction	NAS	1542665
GO:0008083	Function	Growth factor activity	TAS	1542665
GO:0010595	Process	Positive regulation of endothelial cell migration	ISS
GO:0016020	Component	Membrane	IDA	28073925
GO:0030335	Process	Positive regulation of cell migration	IMP	27571908
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	18378771
GO:0043525	Process	Positive regulation of neuron apoptotic process	ISS
GO:0045766	Process	Positive regulation of angiogenesis	ISS
GO:0048680	Process	Positive regulation of axon regeneration	ISS
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IDA	12526812
GO:0050727	Process	Regulation of inflammatory response	IBA	21873635
GO:0050821	Process	Protein stabilization	IMP	28453791
GO:0051087	Function	Chaperone binding	IDA	27789271
GO:0060266	Process	Negative regulation of respiratory burst involved in inflammatory response	IDA	12526812
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0106016	Process	Positive regulation of inflammatory response to wounding	ISS
GO:1900426	Process	Positive regulation of defense response to bacterium	ISS
GO:1902564	Process	Negative regulation of neutrophil activation	IDA	12526812
GO:1903334	Process	Positive regulation of protein folding	ISS
GO:1903979	Process	Negative regulation of microglial cell activation	ISS
GO:1905247	Process	Positive regulation of aspartic-type peptidase activity	IMP	28453791
GO:1905247	Process	Positive regulation of aspartic-type peptidase activity	ISS
GO:1905673	Process	Positive regulation of lysosome organization	IDA	28073925

MIM	HGNC	e!Ensembl
138945	4601	ENSG00000030582

Protein

UniProt ID

P28799

Protein name

Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Gr

Protein function

Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regu

PDB

1G26 , 2JYE , 2JYT , 2JYU , 2JYV , 6NUG , 8T8R , 8T8S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00396	Granulin	72 → 113	Granulin	Family
PF00396	Granulin	138 → 179	Granulin	Family
PF00396	Granulin	220 → 261	Granulin	Family
PF00396	Granulin	295 → 336	Granulin	Family
PF00396	Granulin	377 → 417	Granulin	Family
PF00396	Granulin	455 → 496	Granulin	Family
PF00396	Granulin	532 → 573	Granulin	Family

Sequence

MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGP
CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNS
VGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCIT
PTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC
SDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ
SGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQAL
KRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS
EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQH
CCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQG
WACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

Sequence length

593

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (11)

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316
Apraxia	Apraxias	rs121908377, rs121908378, rs1135401820, rs1178491246, rs1584969672
Ceroid lipofuscinosis neuronal	CEROID LIPOFUSCINOSIS, NEURONAL, 11	rs121434286, rs267606737, rs104894483, rs121908079, rs786205065, rs397515352, rs774543080, rs121908080, rs104894486, rs786205067, rs154774633, rs154774634, rs154774636, rs587776892, rs387907043, rs154774640, rs154774639, rs587779408, rs786201028, rs1555438234, rs1451777867, rs762902907, rs756522171, rs1555440188, rs1555440206, rs1555438212, rs1555438229, rs1555438411, rs1555438443, rs1555438614, rs758921701, rs1567095153, rs1381427322, rs1012449574, rs1600887859	23338682, 16950801, 28264768, 27258413, 20142524, 22608501, 17202431, 18183624, 16862116, 22647257, 21482928, 17334266, 17439980
Myasthenic syndrome	Congenital myasthenic syndrome ib	rs606231128, rs606231129, rs606231130, rs606231131, rs606231132, rs118203994, rs118203995, rs863223277, rs606231133, rs121908547, rs121908553, rs121908557, rs104893733, rs104893734, rs121908922, rs769982050, rs759911990, rs121908923, rs121908924, rs1384843815, rs104893735, rs104894299, rs104894300, rs786200904, rs104894301, rs786200905, rs104894294, rs121909254, rs121909255, rs879255561, rs121912821, rs75466054, rs121912822, rs199476396, rs121909510, rs121909511, rs121909514, rs121909512, rs121909513, rs879255562, rs879253722, rs879253723, rs28999110, rs886037628, rs753828284, rs121909515, rs121909516, rs121909517, rs879255563, rs121909502, rs121909503, rs121909504, rs879255564, rs121909505, rs121909508, rs137852810, rs137852811, rs137852798, rs137852800, rs137852801, rs137852802, rs137852804, rs137852805, rs137852806, rs137852807, rs137852808, rs2105350984, rs374391312, rs201322234, rs1671535986, rs1574066341, rs1574058076, rs1574066599, rs387906803, rs387907243, rs376039938, rs397515321, rs387907244, rs387907245, rs377767449, rs193919341, rs398122830, rs397515450, rs587777298, rs587777299, rs587777781, rs730882050, rs730882123, rs730882051, rs786204773, rs786205885, rs794727884, rs761899995, rs797045040, rs797045528, rs200783529, rs551423795, rs756877019, rs864309662, rs864309663, rs756623659, rs773526895, rs763258280, rs762368691, rs1555794286, rs886037842, rs147656110, rs886039767, rs886039768, rs770045897, rs763281993, rs755236236, rs886043239, rs764497513, rs1057517666, rs370019023, rs769114543, rs922548333, rs139574075, rs767507908, rs759226183, rs1057523690, rs55868108, rs755303686, rs1085307792, rs775583136, rs376808313, rs1131691986, rs776927709, rs1279554995, rs1553850100, rs1156634884, rs1553390600, rs1349476281, rs1555546465, rs199875082, rs200761047, rs1553360075, rs971863968, rs369251527, rs372760913, rs1479498379, rs1555547003, rs1423995073, rs1555546315, rs1555546765, rs201033437, rs1430654625, rs1554943789, rs1316112168, rs781689096, rs1553354962, rs753545038, rs1011196447, rs1553389102, rs185829251, rs28929768, rs1555546096, rs932032926, rs1553846331, rs756015202, rs1555142142, rs1436090495, rs1553352792, rs145356495, rs770987150, rs768892432, rs1557700705, rs1172015222, rs1558749457, rs1361739547, rs775517492, rs1558773839, rs1559510978, rs771879602, rs777102590, rs1567635954, rs1407243713, rs1567638401, rs756675414, rs781908532, rs1306593300, rs1559519107, rs199470447, rs1557721600, rs1558762013, rs746220436, rs1565527239, rs1565527137, rs1565527140, rs1567636493, rs1558761046, rs143766249, rs1447564693, rs757060689, rs1309292778, rs1575460231, rs1570193864, rs1570195582, rs1239736447, rs779488471, rs201947904, rs1597612665, rs1597613302, rs781774131, rs760022829, rs1597619440, rs1597621353, rs1187421976, rs977512223, rs1239393228, rs762875734, rs148092524, rs1269227357, rs1208462125, rs1597622118, rs1597749210, rs1570190059, rs1574007436, rs781974501, rs748639083, rs1597613479, rs1597621396, rs1570242061, rs149020371, rs1595903667, rs1597618787, rs1600807788, rs1579484850, rs1577153029, rs779816027, rs1598406692, rs1577153124, rs778172294, rs1590576560, rs753652169, rs1595902947, rs1369980189, rs762345055, rs1675812434, rs375268742, rs1671813157, rs759488854, rs761584017, rs1969834618, rs1969839736, rs1255916068, rs1597618854, rs1969973509, rs1908994498, rs1320610655, rs373710822
Frontotemporal dementia	Frontotemporal dementia, Frontotemporal Lobar Degeneration	rs63751273, rs63750376, rs63750424, rs63750972, rs1568327531, rs63750570, rs63750756, rs63751165, rs63750512, rs63751438, rs63750912, rs63750711, rs63750635, rs63750349, rs63750092, rs63749801, rs63751399, rs199476352, rs63751035, rs63749974, rs63750568, rs63750013, rs63751394, rs63750308, rs63751011, rs63750095, rs794729672, rs794729669, rs63749817, rs794729670, rs193026789, rs794729671, rs1085307051, rs1566630811, rs1566630884, rs1567885658, rs1567886206, rs1567886445, rs1567886478, rs1567887015, rs1567887777, rs1567888461, rs1566630791, rs1598408073, rs1570725499, rs1598408336	21454553, 17923627, 22028881, 20154673
Neuronal ceroid lipofuscinosis	CLN11 disease	rs118203975, rs118203976, rs118203977, rs267607235, rs140948465, rs1740291234, rs386833969, rs104894385, rs104894386, rs121908292, rs267606738, rs1555274312, rs119455953, rs119455954, rs119455955, rs56144125, rs119455956, rs28940573, rs119455957, rs119455958, rs104894064, rs28940569, rs104894060, rs137852883, rs1555468634, rs121434286, rs267606737, rs104894483, rs397515352, rs774543080, rs121908080, rs786205067, rs137852695, rs137852696, rs137852697, rs137852698, rs137852699, rs137852700, rs137852701, rs137852702, rs63749877, rs121912789, rs121912790, rs786205105, rs154774634, rs587776892, rs387907246, rs386833624, rs386833626, rs386833625, rs386833627, rs386833628, rs386833629, rs386833630, rs386833632, rs386833633, rs386833634, rs386833635, rs386833636, rs386833637, rs386833638, rs386833641, rs386833642, rs386833643, rs386833644, rs386833645, rs386833646, rs386833647, rs386833648, rs386833649, rs386833650, rs386833651, rs386833652, rs386833653, rs148412181, rs386833654, rs386833655, rs386833656, rs386833657, rs386833658, rs386833659, rs386833660, rs386833661, rs386833663, rs386833664, rs386833665, rs386833666, rs386833667, rs386833668, rs386833669, rs386833671, rs386833694, rs386833695, rs386833696, rs386833697, rs386833698, rs386833699, rs386833700, rs386833701, rs386833702, rs386833703, rs386833704, rs386833705, rs386833706, rs386833707, rs386833708, rs386833709, rs386833710, rs386833712, rs386833713, rs386833714, rs386833715, rs386833717, rs386833720, rs386833721, rs386833722, rs386833724, rs386833725, rs386833726, rs386833728, rs386833729, rs386833730, rs386833731, rs386833732, rs386833735, rs386833736, rs386833737, rs386833739, rs386833740, rs386833741, rs386833742, rs386833743, rs386833744, rs386833963, rs386833964, rs386833965, rs386833966, rs386833967, rs386833970, rs386833971, rs386833972, rs386833973, rs386833974, rs386833975, rs386833978, rs386833979, rs386833980, rs386833981, rs386833982, rs386833983, rs386834123, rs386834124, rs386834125, rs386834126, rs386834128, rs386834130, rs386834132, rs386834133, rs386834135, rs34238807, rs386834138, rs386834139, rs397514731, rs397514732, rs753084727, rs587778809, rs154774640, rs154774639, rs121908197, rs121908198, rs121908199, rs121908200, rs121908201, rs121908203, rs121908202, rs121908195, rs121908204, rs121908205, rs121908209, rs121908207, rs104895127, rs63750411, rs587779397, rs587780315, rs724159970, rs727502800, rs727502801, rs724159971, rs746645358, rs786204553, rs786204753, rs778232650, rs786204644, rs794727955, rs794729218, rs796052925, rs796052923, rs796052927, rs558274487, rs796052752, rs144495588, rs1554901472, rs750428882, rs796053439, rs763162812, rs756564767, rs202189057, rs759080581, rs746085696, rs546989392, rs143781303, rs796052356, rs796052351, rs796052335, rs797045136, rs797045137, rs765097897, rs864309505, rs869025274, rs869312751, rs1085307087, rs878853322, rs878853325, rs878853929, rs878855053, rs878855331, rs553522118, rs748710466, rs886041568, rs886041487, rs886041546, rs1057516575, rs1057516889, rs1057517401, rs1057516447, rs1057517049, rs1057517192, rs1057517368, rs1057517112, rs747204624, rs1057516867, rs1057516582, rs756267448, rs1057516579, rs1057516511, rs1057516264, rs1057516319, rs113019349, rs1057517313, rs1057516945, rs752164603, rs1057516366, rs1057516667, rs1057516814, rs780198002, rs1057517134, rs1057516390, rs764495616, rs750935331, rs1057516677, rs1057516267, rs771788391, rs1057517350, rs1057516335, rs1057517287, rs1057517215, rs1057516343, rs777625354, rs764051026, rs559155109, rs1064796787, rs139842473, rs1064794233, rs181995380, rs1064795153, rs752612332, rs1131691676, rs1131691539, rs1555438255, rs1555058286, rs1555274005, rs1555468632, rs200348035, rs1265044710, rs1439582451, rs751696703, rs761621368, rs143730802, rs1554901580, rs1554902052, rs1553950197, rs200319160, rs143657539, rs1554901523, rs1555274338, rs1555273604, rs1555273881, rs1216139602, rs762226836, rs1553167863, rs1553166135, rs1553166147, rs1553167430, rs1349528345, rs1553166499, rs1553166337, rs1553167415, rs1553167474, rs1553167479, rs1554451504, rs746397087, rs1554449028, rs759830733, rs1554449124, rs554042394, rs1554451484, rs1554448874, rs1554448924, rs1554449047, rs1554449136, rs1554901463, rs1184563885, rs1554902043, rs763961289, rs1407106889, rs1554901576, rs1554901731, rs1424116749, rs1554901784, rs1554902216, rs779615685, rs1554902085, rs764790770, rs1555274343, rs1555274369, rs1555273567, rs1555274365, rs1555273609, rs1555274344, rs1555274373, rs1555274387, rs1451777867, rs762902907, rs756522171, rs1555438212, rs1555438443, rs1555468374, rs1555469452, rs1555467473, rs1418997146, rs1555273882, rs1478660606, rs1555273992, rs1555274014, rs1555274337, rs142456044, rs1555469159, rs758921701, rs1555469089, rs1555469477, rs1554901898, rs1554902217, rs1564855860, rs1564854729, rs1460276679, rs1560776422, rs556661896, rs868732642, rs1564855725, rs1566219136, rs1381427322, rs1557714302, rs1593914689, rs1302326945, rs1570470281, rs1570476221, rs775699005, rs1578912362, rs750162094, rs759664259, rs1589947644, rs1012449574, rs1570467252, rs778875017, rs1578794927, rs1578912759, rs1314967038, rs1465284719, rs1595816465, rs1595816474, rs1596563048, rs1565311875, rs2046113301, rs1578889355, rs776253867, rs1649597261, rs1649901192, rs749315686, rs1801297484, rs764256845, rs1242337070, rs2034349431, rs1380684360, rs1648444864, rs1739594685, rs1736369601, rs1739482158, rs1471253353, rs2046243804, rs1845791308, rs1397197980, rs2046158549
Optic atrophy	Optic Atrophy	rs121434508, rs267607017, rs80356524, rs80356525, rs879255560, rs104893753, rs80356529, rs397515360, rs104893620, rs199476104, rs199476112, rs199476118, rs398124298, rs770066665, rs398124299, rs61750185, rs672601379, rs727504060, rs786204830, rs794727804, rs199946797, rs863224127, rs863224131, rs863224134, rs863224906, rs372054380, rs886037828, rs764791523, rs145639028, rs1057519312, rs1064794257, rs1064794656, rs1064797303, rs774265764, rs760337383, rs1553784985, rs72653786, rs1555229948, rs1555119216, rs761743852, rs1553785338, rs1020764190, rs782581701, rs1560408865, rs761460379, rs773022324, rs782740998, rs1560327427, rs80356528, rs1734162973, rs1716524583, rs1057368575
Parkinson disease	Parkinsonian Disorders	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106
Retinal dystrophy	Retinal Dystrophies	rs267606794, rs200691042, rs397704718, rs202193201, rs794728002, rs121965036, rs121965057, rs121918129, rs137853190, rs386834252, rs121918165, rs137853113, rs137853114, rs121918328, rs587777803, rs121908282, rs549625604, rs137852837, rs281865192, rs80044281, rs75895925, rs121918244, rs750962965, rs104893678, rs104893680, rs28940313, rs386834261, rs28940314, rs104894471, rs104894474, rs104894475, rs28940315, rs121434337, rs202126574, rs111033578, rs119103283, rs199476183, rs267607017, rs80338903, rs111033367, rs121912599, rs80338902, rs111033364, rs121912600, rs121909398, rs119103286, rs587777809, rs606231137, rs28940274, rs28941468, rs28941469, rs121918283, rs28940276, rs28940570, rs28940278, rs281865528, rs121918284, rs121918286, rs121918288, rs121918289, rs80100937, rs119466001, rs121434241, rs121434242, rs121434236, rs121434238, rs121907899, rs267606876, rs267606875, rs121434286, rs387906312, rs587776590, rs111033258, rs587776595, rs587776596, rs1362648752, rs74315205, rs121908175, rs121908177, rs121908178, rs138043021, rs121908180, rs111033270, rs1131690770, rs28937883, rs80356530, rs121908375, rs1480243085, rs397515359, rs267606739, rs397515360, rs74315396, rs730880273, rs119489105, rs371956016, rs104894492, rs104894493, rs28937873, rs121912631, rs62637014, rs137853005, rs137853006, rs62635656, rs62635654, rs28939720, rs137853137, rs62636291, rs62636275, rs62638214, rs62638624, rs104894082, rs869320726, rs80358322, rs80358312, rs28939709, rs72664233, rs796051866, rs121918358, rs141659620, rs111033570, rs121909074, rs121909076, rs1581742970, rs104894672, rs61748436, rs104894673, rs2123743692, rs61750415, rs201578674, rs61751408, rs61749438, rs61750061, rs61750064, rs61751374, rs61748548, rs61750200, rs121909205, rs61750130, rs61752410, rs387906387, rs61751383, rs121909206, rs61753033, rs267607077, rs62638191, rs62638193, rs111033593, rs104894374, rs121434491, rs796051871, rs397515379, rs121917851, rs104893967, rs121434631, rs61750172, rs61750173, rs104893612, rs104893613, rs104893614, rs104893615, rs104893616, rs104893617, rs137852608, rs104893619, rs104893620, rs104893621, rs199476104, rs199476112, rs61752063, rs61752067, rs104894928, rs104894933, rs104894930, rs61752068, rs62638634, rs606231180, rs606231181, rs28933687, rs104894927, rs104894878, rs104894880, rs132630264, rs587776746, rs132630266, rs122456134, rs28934610, rs104895317, rs113624356, rs137853300, rs587776778, rs777094000, rs104893768, rs29001566, rs29001637, rs28933394, rs104893769, rs104893771, rs104893772, rs104893773, rs104893779, rs104893776, rs104893777, rs28933993, rs104893775, rs104893778, rs104893780, rs104893787, rs104893783, rs104893786, rs104893782, rs104893790, rs104893791, rs104893793, rs104893794, rs104893795, rs137853290, rs28933990, rs137853291, rs121918579, rs730880317, rs121918581, rs61752895, rs61752871, rs121917745, rs61755806, rs121918563, rs61755793, rs61755792, rs61748429, rs61755816, rs61755798, rs121918565, rs61755769, rs61755786, rs61755771, rs121918567, rs61755783, rs121912550, rs121912552, rs62625014, rs121912884, rs80356555, rs121434542, rs80359870, rs193302848, rs193302849, rs387906646, rs121909835, rs61749433, rs61751399, rs387906836, rs387906837, rs374390376, rs786200928, rs201391050, rs373909351, rs140287375, rs148374859, rs483352908, rs140511594, rs387907136, rs770066665, rs376586707, rs387907268, rs142968179, rs150726175, rs387907294, rs200311463, rs149648640, rs747425652, rs387907314, rs199476198, rs199476187, rs199476189, rs199476190, rs207482233, rs199476197, rs62645748, rs786205121, rs140256288, rs201153410, rs397516281, rs111033180, rs397516295, rs111033233, rs199897298, rs111033214, rs111033178, rs111033403, rs111033181, rs397516308, rs111033182, rs111033276, rs397516317, rs111033215, rs397516323, rs111033192, rs397516326, rs111033486, rs111033284, rs111033285, rs367928692, rs370983472, rs371981035, rs397517964, rs369522997, rs111033379, rs111033264, rs202175091, rs111033265, rs397517973, rs397517976, rs397517978, rs151148854, rs111033518, rs397517983, rs397517984, rs111033417, rs397517990, rs397517994, rs111033273, rs397518011, rs397518014, rs375668376, rs397518021, rs397518022, rs111033386, rs111033280, rs397518036, rs397518039, rs397518041, rs397518043, rs397518048, rs73090721, rs111033263, rs386833612, rs386833697, rs386833728, rs386833749, rs386834148, rs386834153, rs786200944, rs398122391, rs386834239, rs199469697, rs267598278, rs267601099, rs398122960, rs398122525, rs398122991, rs369037463, rs61750120, rs61752435, rs1800728, rs398123339, rs398123538, rs398123575, rs398123576, rs372504780, rs398124544, rs398124618, rs398124619, rs431905521, rs104895298, rs104895316, rs61749679, rs61750161, rs61750168, rs61750183, rs61750185, rs61749669, rs61755778, rs61755780, rs61755781, rs61755784, rs61755785, rs61755787, rs62645929, rs62645931, rs281865372, rs61755800, rs61755801, rs61755803, rs61755805, rs61755810, rs61755814, rs61755815, rs62645935, rs61755766, rs281865373, rs61748430, rs61748433, rs281865301, rs62635001, rs62635002, rs62653029, rs62635009, rs62638627, rs62638626, rs62638642, rs281865297, rs62638648, rs62650218, rs62640583, rs62640592, rs281865295, rs61751276, rs61751281, rs62636295, rs62636299, rs61752873, rs281865285, rs62642584, rs61752877, rs62642582, rs61751279, rs61752906, rs62645885, rs62645889, rs61750457, rs61752062, rs61752065, rs61752071, rs61752072, rs61752145, rs281865335, rs62645879, rs61752156, rs61752158, rs61752159, rs61753164, rs281865348, rs61753170, rs61753171, rs61753174, rs281865352, rs281865354, rs281865355, rs281865356, rs281865357, rs281865358, rs281865359, rs281865361, rs281865362, rs281865365, rs281865364, rs281865367, rs281865368, rs281865369, rs61748547, rs63749083, rs62642569, rs61748550, rs61751410, rs61752391, rs61748552, rs61748523, rs61748556, rs150774447, rs61748558, rs61748559, rs61751385, rs61751393, rs55732384, rs61749409, rs61749410, rs61749412, rs61751394, rs61749414, rs61749415, rs61749418, rs61752401, rs61751263, rs62654395, rs61749420, rs201738997, rs61749422, rs62654397, rs61749423, rs61749425, rs61751412, rs61748526, rs61749428, rs61751395, rs61750202, rs61749436, rs61752406, rs61749444, rs61749446, rs61748529, rs61749448, rs61749449, rs61749450, rs61749451, rs61749453, rs61752411, rs62645948, rs61748530, rs61751413, rs61749456, rs61751262, rs61749459, rs61751397, rs61750062, rs61752415, rs61750065, rs61748531, rs61751398, rs61752416, rs61752417, rs62645946, rs61752419, rs61750121, rs1801269, rs61752421, rs61752423, rs61752425, rs281865514, rs61751400, rs61752427, rs61752428, rs62642573, rs61750137, rs61750139, rs61754044, rs61750138, rs61750140, rs61750141, rs61750142, rs61752434, rs61750145, rs61750146, rs61750147, rs61751402, rs281865377, rs62646861, rs61750152, rs62642574, rs62645957, rs61750153, rs61750155, rs61752438, rs61752439, rs61751403, rs61750562, rs62646872, rs61750564, rs61753021, rs61750566, rs61750567, rs61751377, rs61751405, rs61750569, rs61753028, rs61750571, rs61750573, rs61751406, rs61750574, rs61753029, rs61753030, rs62642562, rs62642576, rs61750633, rs62642579, rs61748534, rs61751407, rs61753032, rs61751389, rs61753036, rs61750639, rs61753037, rs61748517, rs61750641, rs61750643, rs61753038, rs61750644, rs61750645, rs281865382, rs61750648, rs62642565, rs61750649, rs61748520, rs61750651, rs61753043, rs61750652, rs61750653, rs61750654, rs61751384, rs63749058, rs61748538, rs61751409, rs61753045, rs61753046, rs63749055, rs61750659, rs62645958, rs62646864, rs62645944, rs61748545, rs61751418, rs62636512, rs281865516, rs62636511, rs281865168, rs281865171, rs281865529, rs281865204, rs281865221, rs281865224, rs281865206, rs281865227, rs281865228, rs281865230, rs281865209, rs281865236, rs200277476, rs281865238, rs281865239, rs281865244, rs281865246, rs281865247, rs137853905, rs281865213, rs281865214, rs281865215, rs281865216, rs281865250, rs281865253, rs281865255, rs1805143, rs281865257, rs281865258, rs281865218, rs1805144, rs281865259, rs281865261, rs281865262, rs281865265, rs281865269, rs281865271, rs281865277, rs62637025, rs281865194, rs62640580, rs62640570, rs62636266, rs62636271, rs62636273, rs62636276, rs281865174, rs62645752, rs137853907, rs137853923, rs377177061, rs202210819, rs587777377, rs199882533, rs587777599, rs527236091, rs527236088, rs527236090, rs527236097, rs527236098, rs527236129, rs148460146, rs527236048, rs527236101, rs527236100, rs527236062, rs527236056, rs527236092, rs527236065, rs527236068, rs527236069, rs527236066, rs527236076, rs527236067, rs527236082, rs372989281, rs527236116, rs201493928, rs527236105, rs527236083, rs527236113, rs527236086, rs199867882, rs527236099, rs114342808, rs527236139, rs527236137, rs527236127, rs527236124, rs527236126, rs527236123, rs55958016, rs587777694, rs587783009, rs587783017, rs713993049, rs727504551, rs727505116, rs727503731, rs146733615, rs727503715, rs727505343, rs727503723, rs376764423, rs727504075, rs782252317, rs797044513, rs797044516, rs150232843, rs730882143, rs730882261, rs142422525, rs746523071, rs786204428, rs61750423, rs372006750, rs786204762, rs373862340, rs773372519, rs786204444, rs786204701, rs786204761, rs750228923, rs749909863, rs786205148, rs748902766, rs786205445, rs2723341, rs786205493, rs368098126, rs786205579, rs786205626, rs786205652, rs750542962, rs863223339, rs779007169, rs201422368, rs786205664, rs786205663, rs746559651, rs786205665, rs786205662, rs786205661, rs794726979, rs794727001, rs794727006, rs794727120, rs794727139, rs794727197, rs797044676, rs754012367, rs373441420, rs761238771, rs775557680, rs794727579, rs377311148, rs794727631, rs794727640, rs201657446, rs372347027, rs758329611, rs797044761, rs148660051, rs779791079, rs753330544, rs796065331, rs199946797, rs794729650, rs373273223, rs781192528, rs534542684, rs386833744, rs886041039, rs746174328, rs797045089, rs752683070, rs774122562, rs376306240, rs368049814, rs797045228, rs770558150, rs772624348, rs200692438, rs772136379, rs863224941, rs759781200, rs771214648, rs370483961, rs869025207, rs777668842, rs753874898, rs371525247, rs749439750, rs780624853, rs727503855, rs863225212, rs201541131, rs80358295, rs80358284, rs869312182, rs869312180, rs869312186, rs869312184, rs869312188, rs869312183, rs869312181, rs869312187, rs869312185, rs200460601, rs768933093, rs879255593, rs869320709, rs749012133, rs762951570, rs869320785, rs760225886, rs766590491, rs876657731, rs397517963, rs876657718, rs876661298, rs775177930, rs886044764, rs886044761, rs886044759, rs886044758, rs752147871, rs886044756, rs142253670, rs886044754, rs886044753, rs886044752, rs760549861, rs886044750, rs886044749, rs886044747, rs886044732, rs886044746, rs759672616, rs886044745, rs568792949, rs886044742, rs200967229, rs886044741, rs886044740, rs746541266, rs886044738, rs886044737, rs886044736, rs768278935, rs1047376, rs756840095, rs886044731, rs886044735, rs201471607, rs61749441, rs746566873, rs61749427, rs766570903, rs886044730, rs61752398, rs886044728, rs886044727, rs886044726, rs886044725, rs765707028, rs61752390, rs886044722, rs886044721, rs886044720, rs886044719, rs778908435, rs878853366, rs878853364, rs767648174, rs878853371, rs878853367, rs878853369, rs746837034, rs368675850, rs878853407, rs878853413, rs878853414, rs878853411, rs878853405, rs758705873, rs878853404, rs878853408, rs765293412, rs878853410, rs878853372, rs878853397, rs878853396, rs878853355, rs878853354, rs878853353, rs750151209, rs201186440, rs761440783, rs757470958, rs878853359, rs878853357, rs878853358, rs768660614, rs878853379, rs878853352, rs878853351, rs878853400, rs762078182, rs372513650, rs199584830, rs878853348, rs878853350, rs878853349, rs143994166, rs878853382, rs746359399, rs557432569, rs769156393, rs878853327, rs878853329, rs878853328, rs878853326, rs751788879, rs878853337, rs878853347, rs878853378, rs878853376, rs781112960, rs878853361, rs878853362, rs747835249, rs371496675, rs878853360, rs878853363, rs878853392, rs878853391, rs878853390, rs577932201, rs878853389, rs878853341, rs878853338, rs878853339, rs878853385, rs377031435, rs760430056, rs878853394, rs878853387, rs878853342, rs878853383, rs878853331, rs878853335, rs878853334, rs868538598, rs878853374, rs878853381, rs867451420, rs764256655, rs751130485, rs886039450, rs886039449, rs145961131, rs757557272, rs552069173, rs139027297, rs765998048, rs886039311, rs748810737, rs886039867, rs748706582, rs886041040, rs886041502, rs886041951, rs748394238, rs886041233, rs367877017, rs886041141, rs780225183, rs886041142, rs769035379, rs753353134, rs886041176, rs886041179, rs886041177, rs886041376, rs886041178, rs758109813, rs760165634, rs750396156, rs749526785, rs371777049, rs886043023, rs776256380, rs773539640, rs776740276, rs575453437, rs201855602, rs886044148, rs886044302, rs770748359, rs753018563, rs779426136, rs200094982, rs141563823, rs770218590, rs752953889, rs886063161, rs199877211, rs749199721, rs1057517533, rs536593247, rs758921360, rs1057517251, rs1057516451, rs376894444, rs746875134, rs147030232, rs1057517692, rs1057517844, rs374536346, rs116471343, rs865990202, rs61752902, rs387906385, rs1057517869, rs1057517700, rs543698823, rs752179149, rs1057517857, rs1057517982, rs62645894, rs1057517715, rs1057518922, rs1057518955, rs775796581, rs1057518793, rs368088025, rs1057519165, rs1057519193, rs556788423, rs1057519342, rs1057520152, rs759898765, rs397517979, rs199840367, rs61750638, rs779466403, rs760790294, rs1057520213, rs371489809, rs1057521112, rs763797356, rs1057521475, rs766246531, rs1060499783, rs747656448, rs745340459, rs1166022838, rs775950661, rs375413604, rs1064793289, rs200712760, rs137954284, rs1064793014, rs762150575, rs141823837, rs1064793006, rs769317780, rs559155109, rs753925314, rs769671323, rs199740930, rs1064794848, rs771898125, rs775283269, rs1064794012, rs763762899, rs139842473, rs777849213, rs112005636, rs1064797133, rs1064797134, rs770011113, rs1064797247, rs777497868, rs773065850, rs1064797365, rs1064797368, rs752159903, rs866978361, rs1085307968, rs1375507464, rs772725807, rs201320564, rs776896038, rs764742792, rs1554612159, rs62645747, rs753886165, rs753614067, rs140451304, rs555164150, rs539192853, rs766379510, rs281865531, rs369523378, rs1553192715, rs72664214, rs72653787, rs1473611414, rs1455470131, rs752762669, rs369775002, rs145282040, rs773914330, rs1553263218, rs1003869920, rs1553252388, rs762159022, rs751111524, rs746551311, rs780308389, rs199683808, rs1553186896, rs1297857869, rs776757706, rs778234759, rs1435203678, rs1553188588, rs1553188682, rs1553189507, rs1553190559, rs1553190664, rs1553192432, rs1553192682, rs1553192726, rs1553193813, rs764759172, rs1356104318, rs541717028, rs111733491, rs1553512879, rs1553513437, rs569826109, rs367658438, rs750987123, rs1553403585, rs754995805, rs758291149, rs1553711564, rs1553780837, rs373331232, rs780697796, rs370898371, rs753942596, rs144484128, rs146591309, rs777309662, rs1554186385, rs1554269053, rs1554270834, rs181169439, rs1554183440, rs930421180, rs1554214453, rs760798455, rs764163418, rs866395428, rs765129639, rs1554519555, rs1449723475, rs1554519651, rs769601671, rs977790637, rs1554857529, rs756678484, rs1554824273, rs906525288, rs1555036138, rs1555037395, rs1555096248, rs1555099048, rs531851447, rs1199012623, rs766096417, rs377257254, rs199830550, rs756806434, rs1352458826, rs189234741, rs752997229, rs771450991, rs1555792415, rs1555811525, rs758316679, rs748531024, rs778612831, rs1555870809, rs749009747, rs1555874538, rs1555961832, rs1555961852, rs1556318633, rs1557106557, rs1555955061, rs1554998040, rs1554628460, rs1461319754, rs770390524, rs1553901823, rs1347914291, rs1554519822, rs555421894, rs1556297584, rs1556300610, rs1556300621, rs1554264613, rs758052634, rs775836730, rs1555208870, rs1409688898, rs763371769, rs1554186463, rs779450345, rs778606847, rs754768875, rs765429911, rs1272411609, rs1349849938, rs1002670900, rs1553781140, rs373792616, rs200335504, rs1369414978, rs1366496013, rs1555202584, rs567573386, rs1365490247, rs141386891, rs534534437, rs769838859, rs1201940872, rs753090404, rs138958917, rs761469964, rs1460604134, rs748357067, rs1429786931, rs201730567, rs1553187162, rs1553188071, rs765063151, rs780910490, rs143344549, rs866982675, rs769215629, rs752521456, rs1553189179, rs751176116, rs1244761864, rs765402802, rs782077721, rs143745703, rs201823777, rs1553188916, rs1309140887, rs1431752515, rs1554963305, rs1555965107, rs142285818, rs1307312865, rs1554269081, rs769512989, rs1555225566, rs1553196583, rs951379922, rs1554963058, rs1555200648, rs1555550617, rs1555968248, rs1555098634, rs199636364, rs768161313, rs1553252499, rs1177257719, rs200871041, rs757676723, rs747160949, rs764917754, rs1295968274, rs764182950, rs747063294, rs367674026, rs779572631, rs1553257707, rs746447649, rs1431048303, rs749452910, rs1553273330, rs779716464, rs1485173724, rs1553261372, rs1553250150, rs1553299079, rs199782530, rs370327669, rs199982344, rs1553261479, rs988693758, rs760302201, rs1553271001, rs1553313810, rs770383273, rs993185407, rs483353054, rs780779563, rs1553270960, rs775293551, rs754374132, rs1553272176, rs745350407, rs756623509, rs767078782, rs1342455785, rs1177198729, rs372927796, rs748961218, rs771583281, rs1188025733, rs868562952, rs1553250952, rs758303489, rs1484339054, rs781223647, rs1187839124, rs767414973, rs1225343345, rs761292021, rs754702823, rs1553409710, rs1476205467, rs1553421626, rs1553941304, rs1326370032, rs1427770112, rs528919874, rs750840208, rs752736741, rs1165454778, rs751629543, rs1554537807, rs747240928, rs143842048, rs1052030, rs1472566324, rs1555067667, rs1156913215, rs760693838, rs1555454566, rs1555521379, rs1273181642, rs1367927635, rs544773389, rs773862084, rs1555520142, rs764164384, rs779690256, rs750506474, rs878962682, rs116733939, rs1565083843, rs748983904, rs1457937638, rs1189889920, rs746141070, rs868349465, rs1562140604, rs1563329888, rs1563983151, rs776289402, rs1566561006, rs777989874, rs750740765, rs574936510, rs771551785, rs1569235803, rs1569237206, rs370210428, rs1280238814, rs1563366896, rs747914869, rs756310864, rs772170760, rs757823463, rs138011813, rs753884599, rs988133284, rs868732642, rs1557783989, rs1562846257, rs1558251742, rs281865520, rs61750171, rs755733328, rs1471994744, rs758660532, rs1557787756, rs970990957, rs1190307769, rs1569237077, rs752263228, rs971610277, rs775957498, rs1557918635, rs1557918544, rs1565653781, rs552517556, rs777215595, rs1562434099, rs373203896, rs772917364, rs374410829, rs776727320, rs1559643320, rs751290509, rs772057239, rs779983752, rs1562220891, rs778977288, rs377267777, rs777069665, rs145719998, rs1557767754, rs530749007, rs150412614, rs759662695, rs777878533, rs377029071, rs1000861056, rs781705903, rs201863550, rs771000800, rs1571241930, rs1571241947, rs2297669, rs886039299, rs772421550, rs959069360, rs768210562, rs766357803, rs61755811, rs1582780550, rs74419361, rs1585557752, rs1585567204, rs1225032182, rs281865263, rs368489658, rs759339012, rs1595956595, rs1365926616, rs758001091, rs1598146589, rs776004321, rs1601943268, rs754970095, rs745654673, rs1578097528, rs781377291, rs1581211727, rs968692633, rs1600340117, rs1571264574, rs1570377861, rs1302809734, rs536742386, rs769742202, rs185225547, rs752939204, rs748798324, rs751823180, rs770329105, rs774130993, rs775699005, rs1225304963, rs371032798, rs745656125, rs111033477, rs1294402003, rs759408031, rs200387832, rs776204925, rs758899480, rs746351112, rs1562408256, rs751413984, rs769723975, rs374258471, rs1571158279, rs1571134523, rs778114016, rs561075447, rs1571783742, rs759433119, rs1373168392, rs1571243037, rs1232476760, rs1571257754, rs1571258440, rs1571265125, rs61751401, rs1571265241, rs1570367230, rs1401924846, rs1557787473, rs1366296798, rs761209432, rs746291728, rs1578281565, rs745704627, rs765376986, rs769824975, rs376500610, rs888090139, rs764232082, rs1601917999, rs1601974881, rs761460379, rs111033408, rs1571703801, rs774475956, rs1208195953, rs752619497, rs755429480, rs375548374, rs1600335148, rs1254494198, rs1582929649, rs1571848744, rs1571540258, rs368687374, rs1437993640, rs779743222, rs774215025, rs763272975, rs1585563283, rs1587620892, rs776634113, rs1592521438, rs1592521712, rs1592784618, rs1420750126, rs1594867516, rs281865302, rs890453675, rs1577301137, rs1581735836, rs1656419435, rs1386612395, rs1660298900, rs2039692173, rs1659430629, rs1659900155, rs1661098509, rs1661577361, rs751644763, rs1734066547, rs1737442897, rs1761021773, rs1800111659, rs986748364, rs1488052513, rs1766367970, rs1300490966, rs368159852, rs886210482, rs1806033844, rs1806128576, rs748084580, rs1942169028, rs745934202, rs1400806789, rs1257334132, rs2073964950, rs1314226094, rs1927824776, rs2067124487, rs2067127275, rs1854473658, rs1601943325, rs2067985165, rs2067987832, rs1924521431, rs1662216783, rs1571801788, rs1594280740, rs34713174, rs1197863938, rs1278603247, rs778645644, rs766357080, rs1039053911, rs768445391, rs767729255, rs1570373408, rs747950242, rs151141842, rs369184026, rs768713412, rs1657798642, rs1424639717, rs769609970, rs201529124, rs369973540, rs1306732480, rs1368508052, rs1660843703, rs542919944, rs1661575232, rs1005271380, rs1191816747, rs375110174, rs188492864, rs769632183, rs753107507, rs748396645, rs2063883437, rs749842881, rs201782746, rs771980888, rs759184240, rs2084776162, rs142771862, rs368213921, rs772867912, rs145605739, rs760042062, rs1372091680, rs1745312538, rs754916169, rs1355690902, rs1336317768, rs1299355731, rs184722374, rs1245304444, rs1389794536, rs780433094, rs1388177618, rs748370008, rs767005321, rs1231321479, rs1806041389, rs1365908727, rs761969118, rs927241903, rs1844909478, rs28940275, rs775791299, rs111033187, rs778934538, rs2033943937, rs1033594764, rs535922252, rs745741473, rs138370992, rs759505780, rs76076446, rs749738655, rs1968169319, rs1270675463, rs1386256334, rs1924904597, rs2065670611, rs1659900228, rs529598960, rs777673930, rs1228475082, rs1772614934, rs201086679, rs748946491, rs767630412, rs144169488, rs746128841, rs1174120641, rs199537336, rs767366723, rs1767600988, rs1769267226, rs1955083613, rs1826338661, rs1657981991, rs1658082808, rs1658656722, rs1167867158, rs1660515780, rs1664290387, rs866822473, rs963201816, rs1664325377, rs1664643556, rs766411096, rs1664671663, rs1426006136, rs1558138741, rs1665100409, rs1665102146, rs1450635782, rs760544654, rs1216093309, rs1656416727, rs1656646221, rs1656901821, rs1657796004, rs1657799720, rs1419913594, rs1485393201, rs755480221, rs1657961646, rs1657976232, rs1657992342, rs1657997730, rs1658179729, rs1659887829, rs762070900, rs1660922779, rs1661140054, rs1661687852, rs1662771528, rs1558121260, rs1663836291, rs1664810877, rs1665132445, rs1665453379, rs755032078, rs2032220940, rs2032459600, rs769198746, rs2034687946, rs2034852728, rs2035704899, rs2036051613, rs2036054600, rs2036066604, rs757154662, rs2037018431, rs766370703, rs2037679829, rs757525434, rs2038566220, rs1195779037, rs2038568675, rs2039690812, rs1643875847, rs1645824260, rs562037932, rs886042220, rs1444234037, rs779585931, rs1659061509, rs62642580, rs1362964563, rs1242866408, rs1659430143, rs1659452428, rs757449019, rs1659538743, rs1659721337, rs1659840790, rs763911476, rs751844313, rs1340989734, rs1659953619, rs1660137001, rs61750148, rs1660166963, rs1046550021, rs1283350532, rs1660480045, rs1660481072, rs373868915, rs1237125868, rs1660532299, rs757302286, rs1661162346, rs1661163134, rs374224955, rs1448468321, rs1661625047, rs1661663692, rs1661669685, rs868543294, rs1641704371, rs771336246, rs1684627892, rs1684979540, rs1252719064, rs774755041, rs1676904823, rs775776288, rs746238212, rs1278226911, rs1238123416, rs1689010156, rs1689011389, rs200711686, rs1685573282, rs1668402514, rs1366937730, rs761147595, rs1182748194, rs1558488513, rs1667504255, rs1667506537, rs1196801124, rs753619551, rs1558490060, rs866543181, rs762973163, rs1270472063, rs1205704532, rs1671925979, rs774594040, rs748709116, rs749339938, rs1315351235, rs541559170, rs1672973685, rs1674967197, rs1412574975, rs376091780, rs556400279, rs2063893838, rs2063918440, rs2078763986, rs2078764558, rs1692508715, rs761554853, rs762668060, rs943314733, rs1227761587, rs1692915919, rs779023431, rs1692928194, rs1692930941, rs201747279, rs183838250, rs779626652, rs1706422873, rs1706423076, rs1706423758, rs771246451, rs1706439944, rs770399625, rs1472199114, rs1706473340, rs1706474422, rs1706627397, rs1706755871, rs746003280, rs1706843510, rs764109533, rs149079952, rs2084757329, rs1415160298, rs1578278438, rs104893788, rs2084785435, rs1560046837, rs1402468701, rs1578280588, rs984572250, rs1578281706, rs2084801700, rs1235835151, rs1715594024, rs1732788163, rs778059585, rs762782183, rs974173261, rs1560708847, rs1328767121, rs1718726537, rs761152494, rs1743846367, rs369063468, rs775749608, rs768694789, rs1738673948, rs1738698692, rs369717052, rs1237954156, rs767438881, rs1734075026, rs1735848896, rs1736334634, rs761619791, rs747970185, rs1737428529, rs1737429976, rs373037737, rs1737503567, rs746552548, rs759563967, rs1754021035, rs1760621228, rs1746018557, rs1185617030, rs1748947002, rs1292664749, rs1754556067, rs1755688091, rs778188580, rs1758488956, rs1764301206, rs1364707671, rs1784887448, rs781198326, rs1770116834, rs751589956, rs766181526, rs774204108, rs760829254, rs1305999116, rs1331834680, rs1768016995, rs1799985749, rs1799986608, rs1799988458, rs1800110629, rs1800110757, rs1800110798, rs1458793437, rs1800111486, rs61755813, rs1442844778, rs779414078, rs61755794, rs1242862941, rs1761921113, rs1409801782, rs1768346880, rs772549804, rs1768389030, rs1431427428, rs1770904723, rs1774743530, rs1766383947, rs909730457, rs1766404452, rs1767312015, rs1767601715, rs1245121527, rs1767699695, rs1295206142, rs548565748, rs1768657480, rs1765727233, rs1765728504, rs1766556883, rs746499646, rs1766006937, rs1766009155, rs1375767063, rs1459031771, rs779372264, rs986664547, rs1769692830, rs1769707298, rs1793956441, rs1798216037, rs1784156837, rs763759470, rs1797868307, rs749460193, rs371886218, rs1797910388, rs1806020324, rs1806033441, rs1806036718, rs1806037949, rs1488237523, rs1806043158, rs1230883512, rs1806057300, rs779290365, rs746396730, rs1806079331, rs373109791, rs1806160527, rs1822989898, rs202036979, rs141099767, rs1819778559, rs751600925, rs763785730, rs1819787095, rs754275640, rs1819797791, rs1821068883, rs776271026, rs1363491382, rs1042726781, rs1363359148, rs781881541, rs1861132418, rs1865149889, rs1866696630, rs754876029, rs1841315122, rs1841460358, rs1842189258, rs760608593, rs1842324166, rs1844615558, rs1844944116, rs2058399145, rs1403661741, rs746820022, rs1236291370, rs2058673701, rs2041025786, rs1243587288, rs1850697098, rs1850741468, rs1209208472, rs1382219910, rs980876322, rs762398929, rs1942208203, rs1856478505, rs1856787758, rs1856790811, rs775166854, rs2098614719, rs2098676296, rs2098677212, rs782639389, rs1953075862, rs1954927143, rs749747871, rs780609120, rs375135224, rs2033241849, rs2033937635, rs748471942, rs1345994179, rs2037229663, rs762633090, rs774490795, rs769102771, rs1882854195, rs1882945917, rs1883031542, rs1739469293, rs768178406, rs747257567, rs761167763, rs1163040913, rs2038196341, rs140257538, rs760813820, rs751589863, rs766173950, rs779740894, rs769845921, rs2034398158, rs2034427266, rs200047855, rs2074443699, rs1566947860, rs1489149705, rs955766374, rs2054237722, rs2065896039, rs766675673, rs561618945, rs762111572, rs2033706353, rs2034681207, rs2034747055, rs762817061, rs2035847573, rs2046158549, rs1451575280, rs756885471, rs1210263161, rs1960899756, rs1468272829, rs1157108621, rs1193604660, rs121434239, rs1911391944, rs773201535, rs1975949139, rs769818541, rs104894671, rs1968162133, rs1968165008, rs1968165080, rs1968169004, rs1968170098, rs2073701307, rs2073708846, rs2073709089, rs2073817463, rs2073817965, rs2073854068, rs2073855020, rs2073873693, rs2073875313, rs2073876392, rs2073926924, rs2073964314, rs1342475527, rs2073970078, rs2073970450, rs2074043162, rs2064852005, rs759131391, rs2067513100, rs775124094, rs890128759, rs2088652401, rs1300228825, rs2089115544, rs752395624, rs756223600, rs1925733148, rs1927703176, rs1927819239, rs1928220547, rs1928222017, rs2067114709, rs2067117239, rs866524368, rs1186795749, rs2067127718, rs1569235565, rs2067136586, rs2067140471, rs1569235999, rs2067144007, rs2067146007, rs1555961509, rs2067157388, rs2067160273, rs2067161139, rs2067163605, rs2067164096, rs2067169164, rs2067169934, rs2067170858, rs2067172824, rs2067174697, rs1233849070, rs2067175855, rs2067176160, rs2067176379, rs1373833359, rs2067182354, rs2067182636, rs2067182990, rs2067183162, rs2067184023, rs2067185564, rs2067186632, rs2067186762, rs2067187127, rs2067187550, rs2067187618, rs2067188031, rs2067188111, rs2067190364, rs2067190922, rs2067191154, rs2067191335, rs2067191635, rs1305342570, rs2067193056, rs2067194648, rs1569237670, rs2067196140, rs2067201139, rs2067217398, rs2067217662, rs2067217874, rs2067218363, rs2067267431, rs2067277129, rs2067406342, rs2067449854, rs2067451355, rs62642057, rs2067700774, rs2067877357, rs2067878321, rs2067878443, rs2067976665, rs2067985696, rs2064376489, rs2064378728, rs1924521211, rs1924895234, rs1924896735, rs1924897230, rs1924901288, rs1924904407, rs1925035229, rs2065644808, rs2065701414, rs2065717735, rs2065740868, rs2065833366, rs2065833777, rs1244003380, rs1926202704, rs1926208067, rs1926208868, rs1929999634, rs1930006988, rs1930414140, rs1930421028, rs1930424797, rs1930435879, rs1930445401, rs1934694621, rs762837543, rs1927017073, rs1649583816, rs1292874452, rs1654722914, rs760287363, rs1664686689, rs1665282720, rs1235430504, rs1371160062, rs1661818720, rs2031604509, rs1558244152, rs2034951427, rs2037617658, rs912980910, rs2037658254, rs756111113, rs1658918693, rs759513613, rs61750156, rs1659914923, rs751319688, rs1659997092, rs1168144507, rs544428779, rs1662599697, rs1677289241, rs1687854945, rs1005130980, rs1334444660, rs1560664459, rs1577845276, rs1722845773, rs1472802723, rs898144119, rs1383907349, rs781616522, rs369896113, rs1753232409, rs1751572548, rs769286352, rs1761904690, rs1768621810, rs1769469813, rs1826145876, rs1951414426, rs1402893508, rs764824311, rs1865145294, rs769524849, rs1280991447, rs762805265, rs1841921374, rs547198427, rs2058440863, rs1941247515, rs1941898895, rs1856202628, rs1856699646, rs1956849074, rs1957972028, rs1939312423, rs1399741348, rs752197734, rs2035880971, rs2038012556, rs760391688, rs2054201689, rs2065735740, rs748523056, rs2034739931, rs1961362638, rs2073798309, rs2073871791, rs2073961843, rs2073971858, rs752137434, rs2035758739, rs1928365871, rs1928241490, rs2067453631, rs1924915809, rs1925389524, rs782557600, rs2065753439, rs1924181543, rs1930090887, rs1603263147, rs1931625021, rs1934693393, rs748680704, rs765070399, rs765676754, rs1366609497, rs1657036615, rs1467000353, rs1667513233, rs1167380267, rs2084786704, rs1295259849, rs1819778622, rs374517178, rs368984997, rs2040644756, rs775073228, rs148045000, rs2067140574, rs2067148119, rs2067179633, rs2067190976, rs2067200470, rs2067498092, rs1924193863
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20087814, 22505994
Seizure	Tonic - clonic seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130

Show/Hide Unknown Diseases (35)

Unknown
Disease name	Disease term	dbSNP ID	References
Abulia	Abulia
Alexia	Alexia
Anomia	Anomia
Anxiety disorder	Anxiety
Aphasia	Aphasia, Primary Progressive Aphasia (disorder)
Behavioral variant of frontotemporal dementia	Behavioral variant of frontotemporal dementia		23597030, 23392204
Bipolar disorder	Bipolar Disorder		22505994, 24499389
Brain atrophy	Brain atrophy
Broca aphasia	Broca Aphasia
Cerebellar atrophy	Cerebellar atrophy
Cerebral atrophy	Cerebral atrophy
Cerebral cortical atrophy	Cerebral cortical atrophy
Compulsive hoarding	Compulsive hoarding
Dementia	Dementia, Familial Dementia		17436289, 18543312, 18543312, 17436289
Disorder of eye	Disorder of eye
Dyscalculia	Dyscalculia
Dysgraphia	Dysgraphia
Dyslexia	Dyslexia
Dysphasia	Dysphasia
Frontotemporal cerebral atrophy	Frontotemporal cerebral atrophy
Grammar-specific speech disorder	Grammar-specific speech disorder
Frontotemporal lobar degeneration with tdp43 inclusions	FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED		28264768, 16983685, 16862116, 17334266, 21482928, 23338682, 17202431, 18183624, 16950801, 22608501, 20142524, 27258413, 22647257, 17439980
Hallucinations	Hallucinations
Hypersexuality	Hypersexuality state
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	20400120, 22895706, 20667979, 20400120, 20667979, 22895706
Myoclonic seizures	Generalized myoclonic seizures
Nonfluent aphasia	Primary Progressive Nonfluent Aphasia		23597030
Progressive non-fluent aphasia	Progressive non-fluent aphasia
Psychosis	Psychotic Disorders
Repetitive compulsive behavior	Repetitive compulsive behavior
Semantic dementia	Semantic Dementia		23597030, 21454553, 22028881
Senile paranoid dementia	Senile Paranoid Dementia		17436289, 18543312
Senile plaques	Senile Plaques
Stereotyped behavior	Stereotyped Behavior
Temporal cortical atrophy	Temporal cortical atrophy

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