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GPX3 (glutathione peroxidase 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2878
Gene nameGene Name - the full gene name approved by the HGNC.
Glutathione peroxidase 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GPX3
SynonymsGene synonyms aliases
GPx-P, GSHPx-3, GSHPx-P
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q33.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozy
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049503 hsa-miR-92a-3p CLASH 23622248
MIRT1032505 hsa-let-7a CLIP-seq
MIRT1032506 hsa-let-7b CLIP-seq
MIRT1032507 hsa-let-7c CLIP-seq
MIRT1032508 hsa-let-7d CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004601 Function Peroxidase activity IBA 21873635
GO:0004602 Function Glutathione peroxidase activity IBA 21873635
GO:0004602 Function Glutathione peroxidase activity IDA 1897960, 3693360
GO:0005515 Function Protein binding IPI 25416956
GO:0005576 Component Extracellular region TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P22352
Protein name Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)
Protein function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
PDB 2R37
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00255 GSHPx
40 153
Glutathione peroxidase
Family
Sequence
MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA
GKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLK
YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLK
NSCPPTSELLGTSDRLFWEPMKVHDIR
WNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
Sequence length 226
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Glutathione metabolism
Metabolic pathways
Thyroid hormone synthesis
Amyotrophic lateral sclerosis
Huntington disease
Pathways of neurodegeneration - multiple diseases
  Detoxification of Reactive Oxygen Species
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 21552421
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 21552421
Fanconi syndrome De Toni-Debre-Fanconi Syndrome, Fanconi Syndrome, Adult Fanconi syndrome rs398124646 9851889
Fanconi-bickel syndrome Fanconi-Bickel Syndrome rs121909742, rs121909743, rs121909744, rs121909745, rs1715390589, rs780067980, rs771477447, rs28928874, rs1576838294, rs121909746, rs121909747, rs1114167428, rs371977235, rs1553785033, rs769888108, rs756874949, rs1553784980, rs1553785722, rs1553786361, rs1560035336, rs1560033414, rs1447936042, rs1318756243 9851889
Unknown
Disease name Disease term dbSNP ID References
Benign neoplasm Benign Neoplasm 21684681
Degenerative diseases, central nervous system Degenerative Diseases, Central Nervous System, Degenerative Diseases, Spinal Cord 15964507
Endometrioma Endometrioma 20864642, 21063030
Endometriosis Endometriosis rs1800629, rs1143634 20864642, 21063030

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