GPX3 (glutathione peroxidase 3)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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2878 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Glutathione peroxidase 3 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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GPX3 |
SynonymsGene synonyms aliases
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GPx-P, GSHPx-3, GSHPx-P |
ChromosomeChromosome number
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5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5q33.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozy |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P22352 |
Protein name |
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) |
Protein function |
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. |
PDB |
2R37
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00255 |
GSHPx |
40 → 153 |
Glutathione peroxidase |
Family |
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Sequence |
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Sequence length |
226 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Adenocarcinoma |
Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular |
rs121913530, rs886039394, rs121913474 |
21552421 |
Carcinoma |
Carcinoma, Cribriform, Carcinoma, Granular Cell |
rs121912654, rs555607708, rs786202962, rs1564055259 |
21552421 |
Fanconi syndrome |
De Toni-Debre-Fanconi Syndrome, Fanconi Syndrome, Adult Fanconi syndrome |
rs398124646 |
9851889 |
Fanconi-bickel syndrome |
Fanconi-Bickel Syndrome |
rs121909742, rs121909743, rs121909744, rs121909745, rs1715390589, rs780067980, rs771477447, rs28928874, rs1576838294, rs121909746, rs121909747, rs1114167428, rs371977235, rs1553785033, rs769888108, rs756874949, rs1553784980, rs1553785722, rs1553786361, rs1560035336, rs1560033414, rs1447936042, rs1318756243 |
9851889 |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
21552421, 19180532 |
Obesity |
Obesity |
rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 |
11328671, 19270708 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17804715 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Benign neoplasm |
Benign Neoplasm |
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21684681 |
Degenerative diseases, central nervous system |
Degenerative Diseases, Central Nervous System, Degenerative Diseases, Spinal Cord |
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15964507 |
Endometrioma |
Endometrioma |
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20864642, 21063030 |
Endometriosis |
Endometriosis |
rs1800629, rs1143634 |
20864642, 21063030 |
Liver neoplasms |
Liver neoplasms |
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20195826 |
Liver cancer |
Malignant neoplasm of liver |
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20195826 |
Lung neoplasms |
Lung Neoplasms |
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19180532, 21552421 |
Malignant neoplasm |
Malignant Neoplasms |
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21684681 |
Neoplasms |
Neoplasms |
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21684681 |
Neurodegenerative disorders |
Neurodegenerative Disorders |
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15964507 |
Prostatic neoplasms |
Prostatic Neoplasms |
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17804715 |
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