GPS1 (G protein pathway suppressor 1)

Gene

• Entrez ID: 2873
• Gene name: G protein pathway suppressor 1
• Gene symbol: GPS1
• Synonyms: COPS1, CSN1, SGN1
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024116	hsa-let-7i-5p	Western blot	21530537
MIRT032090	hsa-let-7f-5p	Western blot	21530537
MIRT032096	hsa-let-7e-3p	Western blot	21530537
MIRT032191	hsa-let-7c-5p	Western blot	21530537
MIRT048796	hsa-miR-93-5p	CLASH	23622248
MIRT042663	hsa-miR-196b-5p	CLASH	23622248
MIRT042619	hsa-miR-423-3p	CLASH	23622248
MIRT496148	hsa-miR-1306-5p	PAR-CLIP	22291592
MIRT496147	hsa-miR-1224-3p	PAR-CLIP	22291592
MIRT496146	hsa-miR-4286	PAR-CLIP	22291592
MIRT496145	hsa-miR-1281	PAR-CLIP	22291592
MIRT496144	hsa-miR-668-5p	PAR-CLIP	22291592
MIRT496143	hsa-miR-566	PAR-CLIP	22291592
MIRT496148	hsa-miR-1306-5p	PAR-CLIP	22291592
MIRT496147	hsa-miR-1224-3p	PAR-CLIP	22291592
MIRT496146	hsa-miR-4286	PAR-CLIP	22291592
MIRT496145	hsa-miR-1281	PAR-CLIP	22291592
MIRT496144	hsa-miR-668-5p	PAR-CLIP	22291592
MIRT496143	hsa-miR-566	PAR-CLIP	22291592
MIRT1032329	hsa-miR-1231	CLIP-seq
MIRT1032330	hsa-miR-3130-3p	CLIP-seq
MIRT1032331	hsa-miR-3136-5p	CLIP-seq
MIRT1032332	hsa-miR-3197	CLIP-seq
MIRT1032333	hsa-miR-346	CLIP-seq
MIRT1032334	hsa-miR-3622a-3p	CLIP-seq
MIRT1032335	hsa-miR-3622b-3p	CLIP-seq
MIRT1032336	hsa-miR-4288	CLIP-seq
MIRT1032337	hsa-miR-4439	CLIP-seq
MIRT1032338	hsa-miR-4513	CLIP-seq
MIRT1032339	hsa-miR-4649-3p	CLIP-seq
MIRT1032340	hsa-miR-4793-3p	CLIP-seq
MIRT1032341	hsa-miR-627	CLIP-seq
MIRT1032342	hsa-miR-632	CLIP-seq
MIRT1032343	hsa-miR-767-3p	CLIP-seq
MIRT1032344	hsa-miR-924	CLIP-seq
MIRT1032345	hsa-miR-1227	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT1032347	hsa-miR-3153	CLIP-seq
MIRT1032348	hsa-miR-3192	CLIP-seq
MIRT1032332	hsa-miR-3197	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT1032350	hsa-miR-4252	CLIP-seq
MIRT1032351	hsa-miR-4292	CLIP-seq
MIRT1032352	hsa-miR-4308	CLIP-seq
MIRT1032353	hsa-miR-4314	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT1032355	hsa-miR-4459	CLIP-seq
MIRT1032356	hsa-miR-4646-5p	CLIP-seq
MIRT1032357	hsa-miR-4668-5p	CLIP-seq
MIRT1032358	hsa-miR-4779	CLIP-seq
MIRT1032359	hsa-miR-522	CLIP-seq
MIRT1032360	hsa-miR-622	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT1032362	hsa-miR-661	CLIP-seq
MIRT1032343	hsa-miR-767-3p	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq
MIRT1032345	hsa-miR-1227	CLIP-seq
MIRT1032329	hsa-miR-1231	CLIP-seq
MIRT1032330	hsa-miR-3130-3p	CLIP-seq
MIRT1032331	hsa-miR-3136-5p	CLIP-seq
MIRT1032347	hsa-miR-3153	CLIP-seq
MIRT1032348	hsa-miR-3192	CLIP-seq
MIRT1032333	hsa-miR-346	CLIP-seq
MIRT1032334	hsa-miR-3622a-3p	CLIP-seq
MIRT1032335	hsa-miR-3622b-3p	CLIP-seq
MIRT1032336	hsa-miR-4288	CLIP-seq
MIRT1032353	hsa-miR-4314	CLIP-seq
MIRT1032337	hsa-miR-4439	CLIP-seq
MIRT1032338	hsa-miR-4513	CLIP-seq
MIRT1032356	hsa-miR-4646-5p	CLIP-seq
MIRT1032357	hsa-miR-4668-5p	CLIP-seq
MIRT1032340	hsa-miR-4793-3p	CLIP-seq
MIRT1032359	hsa-miR-522	CLIP-seq
MIRT1032342	hsa-miR-632	CLIP-seq
MIRT2542578	hsa-miR-1205	CLIP-seq
MIRT2542579	hsa-miR-1233	CLIP-seq
MIRT2542580	hsa-miR-1293	CLIP-seq
MIRT2542581	hsa-miR-1321	CLIP-seq
MIRT2542582	hsa-miR-15a	CLIP-seq
MIRT2542583	hsa-miR-15b	CLIP-seq
MIRT2542584	hsa-miR-16	CLIP-seq
MIRT2542585	hsa-miR-1915	CLIP-seq
MIRT2542586	hsa-miR-195	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT2542587	hsa-miR-3130-5p	CLIP-seq
MIRT2542588	hsa-miR-3173-5p	CLIP-seq
MIRT2542589	hsa-miR-3202	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT2542590	hsa-miR-3616-3p	CLIP-seq
MIRT2542591	hsa-miR-3667-3p	CLIP-seq
MIRT2542592	hsa-miR-3677-5p	CLIP-seq
MIRT2542593	hsa-miR-424	CLIP-seq
MIRT2542594	hsa-miR-4270	CLIP-seq
MIRT2542595	hsa-miR-4323	CLIP-seq
MIRT2542596	hsa-miR-4435	CLIP-seq
MIRT2542597	hsa-miR-4438	CLIP-seq
MIRT2542598	hsa-miR-4441	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT2542599	hsa-miR-4476	CLIP-seq
MIRT2542600	hsa-miR-4482	CLIP-seq
MIRT2542601	hsa-miR-4483	CLIP-seq
MIRT2542602	hsa-miR-4505	CLIP-seq
MIRT2542603	hsa-miR-4514	CLIP-seq
MIRT2542604	hsa-miR-4524	CLIP-seq
MIRT2542605	hsa-miR-4537	CLIP-seq
MIRT2542606	hsa-miR-4650-5p	CLIP-seq
MIRT2542607	hsa-miR-4690-3p	CLIP-seq
MIRT2542608	hsa-miR-4692	CLIP-seq
MIRT2542609	hsa-miR-4739	CLIP-seq
MIRT2542610	hsa-miR-4755-3p	CLIP-seq
MIRT2542611	hsa-miR-4756-5p	CLIP-seq
MIRT2542612	hsa-miR-4757-5p	CLIP-seq
MIRT2542613	hsa-miR-4763-5p	CLIP-seq
MIRT2542614	hsa-miR-497	CLIP-seq
MIRT2542615	hsa-miR-503	CLIP-seq
MIRT2542616	hsa-miR-646	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT2542617	hsa-miR-665	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq
MIRT2542578	hsa-miR-1205	CLIP-seq
MIRT2542579	hsa-miR-1233	CLIP-seq
MIRT2542580	hsa-miR-1293	CLIP-seq
MIRT2542581	hsa-miR-1321	CLIP-seq
MIRT2542582	hsa-miR-15a	CLIP-seq
MIRT2542583	hsa-miR-15b	CLIP-seq
MIRT2542584	hsa-miR-16	CLIP-seq
MIRT2542585	hsa-miR-1915	CLIP-seq
MIRT2542586	hsa-miR-195	CLIP-seq
MIRT1032346	hsa-miR-2964a-5p	CLIP-seq
MIRT2542587	hsa-miR-3130-5p	CLIP-seq
MIRT2542588	hsa-miR-3173-5p	CLIP-seq
MIRT2542589	hsa-miR-3202	CLIP-seq
MIRT1032349	hsa-miR-3612	CLIP-seq
MIRT2542590	hsa-miR-3616-3p	CLIP-seq
MIRT2542591	hsa-miR-3667-3p	CLIP-seq
MIRT2542592	hsa-miR-3677-5p	CLIP-seq
MIRT2542593	hsa-miR-424	CLIP-seq
MIRT2542594	hsa-miR-4270	CLIP-seq
MIRT2542595	hsa-miR-4323	CLIP-seq
MIRT2542596	hsa-miR-4435	CLIP-seq
MIRT2542597	hsa-miR-4438	CLIP-seq
MIRT2542598	hsa-miR-4441	CLIP-seq
MIRT1032354	hsa-miR-4443	CLIP-seq
MIRT2542599	hsa-miR-4476	CLIP-seq
MIRT2542600	hsa-miR-4482	CLIP-seq
MIRT2542601	hsa-miR-4483	CLIP-seq
MIRT2542602	hsa-miR-4505	CLIP-seq
MIRT2542604	hsa-miR-4524	CLIP-seq
MIRT2542605	hsa-miR-4537	CLIP-seq
MIRT2542606	hsa-miR-4650-5p	CLIP-seq
MIRT2542607	hsa-miR-4690-3p	CLIP-seq
MIRT2542609	hsa-miR-4739	CLIP-seq
MIRT2542610	hsa-miR-4755-3p	CLIP-seq
MIRT2542611	hsa-miR-4756-5p	CLIP-seq
MIRT2542612	hsa-miR-4757-5p	CLIP-seq
MIRT2542613	hsa-miR-4763-5p	CLIP-seq
MIRT2542614	hsa-miR-497	CLIP-seq
MIRT2542615	hsa-miR-503	CLIP-seq
MIRT2542616	hsa-miR-646	CLIP-seq
MIRT1032361	hsa-miR-650	CLIP-seq
MIRT2542617	hsa-miR-665	CLIP-seq
MIRT1032363	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000188	Process	Inactivation of MAPK activity	TAS	8943324
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0000715	Process	Nucleotide-excision repair, DNA damage recognition	TAS
GO:0005095	Function	GTPase inhibitor activity	TAS	8943324
GO:0005515	Function	Protein binding	IPI	17337451, 18850735, 19444310, 19615732, 20399188, 21145461, 24421388, 27029275
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006283	Process	Transcription-coupled nucleotide-excision repair	TAS
GO:0007254	Process	JNK cascade	TAS	8943324
GO:0008180	Component	COP9 signalosome	IBA	21873635
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0034260	Process	Negative regulation of GTPase activity	IEA
GO:0043687	Process	Post-translational protein modification	TAS

Other IDs

• MIM: 601934
• HGNC: 4549
• e!Ensembl: ENSG00000169727

Protein

• UniProt ID: Q13098
• Protein name: COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
• Protein function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of
• PDB: 4D10, 4D18, 4WSN, 6R6H, 6R7F, 6R7H, 6R7I, 6R7N, 8H38, 8H3A, 8H3F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10602	RPN7	127 → 309	26S proteasome subunit RPN7	Family
  PF01399	PCI	324 → 428	PCI domain	Domain

• Sequence:

  MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERL
  QFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNAPDAIPESG
  VEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSN
  ALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDS
  QTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALAT
  FDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAP
  HVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSH
  SKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTP
  ANSQSRMSTNM

• Sequence length: 491

Pathways

Reactome:

DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18678470